Novel homozygous silent mutation of ITGB3 gene caused Glanzmann thrombasthenia by Zhengrong Wang, Zhengrong Wang, Yuqing Xu, Yuqing Xu, Yixi Sun, Yixi Sun, Shuang Wang, Shuang Wang, Minyue Dong, Minyue Dong

“…RT-PCR and sequencing revealed that the variant caused a deletion of 95 base pairs and frameshift, and subsequently created a premature stop codon in exon 10 of ITGB3 (p. G477Afs*30). It was indicated that the variant c.1431C > T (p. …”
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Comparative mitogenomic analysis of subterranean and surface amphipods (Crustacea, Amphipoda) with special reference to the family Crangonyctidae by Joseph B. Benito, Megan L. Porter, Matthew L. Niemiller

“…Mitogenome size, AT content, GC-skew, gene order, uncommon start codons, location of putative control region (CR), length of rrnL and intergenic spacers differed between surface and subterranean amphipods. …”
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Complete chloroplast genome sequence and characteristics analysis of Qingda no.1 alfalfa (Medicago sativa L. cv. Qingda no.1) by Yuling Ren, Yajun Ma, Xue Li, Xiaoan Li, Guozhu Yang, Ping Li

“…The relative synonymous codon usage showed that 68.67% of the codons RSCU > 1 in Qingda no.1, with the preference ending with A and T. …”
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The mitochondrial genome of the 'twisted-wing parasite' <it>Mengenilla australiensis </it>(Insecta, Strepsiptera): a comparative study by Kathirithamby Jeyaraney, Hayward Alexander, McMahon Dino P

“…Compared with <it>M. australiensis</it>, codon bias in <it>X. vesparum </it>is more balanced. …”
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A Case Report: Mucinous Tubular and Spindle Cell Carcinoma of Kidney with Spindle Cell Predominance Mimicking Mesenchymal Tumour by Ramya Natarajan, Murhekar Kanchan, Raja Anand, Sundersingh Shirley

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Assembly of the Complete Mitochondrial Genome of Chinese Plum (<i>Prunus salicina</i>): Characterization of Genome Recombination and RNA Editing Sites by Bo Fang, Jingling Li, Qian Zhao, Yuping Liang, Jie Yu

“…Among them, the initiation codon of the <i>nad</i>1 gene confirmed that an RNA editing event occurred, and the genomic encoded ACG was edited as AUG in the transcript. …”
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Genome-wide effects of the antimicrobial peptide apidaecin on translation termination in bacteria by Kyle Mangano, Tanja Florin, Xinhao Shao, Dorota Klepacki, Irina Chelysheva, Zoya Ignatova, Yu Gao, Alexander S Mankin, Nora Vázquez-Laslop

“…Here genome-wide analysis reveals that in bacteria, Api arrests translating ribosomes at stop codons and causes pronounced queuing of the trailing ribosomes. …”
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Impact of a Novel W2027L Mutation and Non-Target Site Resistance on Acetyl-CoA Carboxylase-Inhibiting Herbicides in a French <i>Lolium multiflorum</i> Population by Shiv Shankhar Kaundun, Joe Downes, Lucy Victoria Jackson, Sarah-Jane Hutchings, Eddie Mcindoe

“…It also highlights the versatility and robustness of the dPACS method to simultaneously identify different resistance-causing alleles at a single ACCase codon.…”
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Nitrofuran resistance in Salmonella enterica from human consumption meat samples by Sandra Martínez-Puchol, Maria J. Pons, Lidia Ruiz-Roldán, Laura Laureano-Adame, Alfredo Corujo, Theresa J. Ochoa, Joaquim Ruiz

“…All nitrofuran-resistant isolates showed amino acid codon alterations at both snrA and cnr (S. infantis: snrA STOP-151; cnr STOP-137; S. enteritidis: snrA STOP-180; cnr STOP-179). …”
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RNA structure-altering mutations underlying positive selection on Spike protein reveal novel putative signatures to trace crossing host-species barriers in Betacoronavirus by Alexis Felipe Rojas-Cruz, Juan Carlos Gallego-Gómez, Clara Isabel Bermúdez-Santana

“…Phylogenetic analyses suggest that bat viruses are the most closely related to the time of most recent common ancestor of Betacoronavirus, and missense mutations in viral proteins, mainly in the S protein S1 subunit: SARS-CoV (G > T; A577S); MERS-CoV (C > T; S746R and C > T; N762A); and SARS-CoV-2 (A > G; D614G) appear to have driven viral diversification. We also found that codon sites under positive selection on S protein overlap with non-compensatory mutations that disrupt secondary RNA structures in the RNA genome complement. …”
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Echocardiographic Changes in Patients with End-Stage Renal Disease at Initiation of Dialysis by Shabana Nazneen, Muzamil Latief, Manjusha Yadla

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Multiplex Amplification Refractory Mutation System Polymerase Chain Reaction (ARMS-PCR) for diagnosis of natural infection with canine distemper virus by Wong Min-Liang, Hsu Tien-Huan, Lin Fong-Yuan, Lin Kuan-Hsun, Chiou Shyan-Song, Wang Chi-Young, Lee Min-Shiuh, Chulakasian Songkhla, Chang Tien-Jye, Hsu Wei-Li

“…A track of AAA residue located 35 nucleotides downstream from F gene start codon highly conserved in three vaccine strains were replaced with TGC in the local strains; that severed as target sequences for deign of discrimination primers. …”
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Clinical, radiographic and molecular characterization of two unrelated families with multicentric osteolysis, nodulosis, and arthropathy by Tayyaba Ishaq, Petra Loid, Hafiza Abida Ishaq, Go Hun Seo, Outi Mäkitie, Sadaf Naz

“…In-silico analysis predicted that the splicing variant may eventually introduce a premature stop codon in MMP2. Molecular modeling for the p.(Ser396Arg) variant suggested that the change may disturb MMP2 collagen-binding region. …”
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The complete chloroplast genome of the medicinal plant Polygonum cuspidatum (Polygonaceae) and its phylogenetic implications within the subfamily Polygonoideae by Xiaofeng Ye, Jiuguo Lin, Manjia Zhou, Xiangyu He, Meixiu Yan, Rubin Cheng

“…The 86 protein-coding genes encode 27,597 amino acids in total, most of which use the initiation codon ATG, except the ndhD gene which starts with ACG. …”
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Knowledge and DdeI Based Confirmation of Sickle Cell Anemia Among the Tharu Community by Sajani Ghaju, Karan Khadayat, Raju Shrestha, Salan Ghaju, Trishna Manandhar, Bishnu P. Marasini

“… Background: Sickle cell anemia is an inherited blood disorder caused due to a point mutation at the sixth codon of the ?-globin gene of both alleles. Sickle cell traits occur when the mutation is in one of the two alleles of the ?…”
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Resistance genes of Neisseria gonorrhoeae to cefixime and azithromycin by Louisa Ivana Utami, Yeva Rosana

“…Meanwhile, N. gonorrhoeae resistance to azithromycin reportedly occurs through two strategies, namely overexpression of the efflux pump (mutation of the mtrR codon region) and decreased affinity for antibiotics (single base mutation in the 23S rRNA gene). …”
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A novel mutation c.457C > T p.Q153 in the HMBS gene in a Mexican woman with acute intermittent porphyria by Jose Malagon‐Rangel, Jose Gabriel Solis, Luis Fernando Zavala‐Jonguitud, Martín Roberto Basile‐Alvarez, Andrea Malagon‐Liceaga

“…This mutation induces a premature translational stop codon and had not been previously reported in medical literature among individuals with AIP. …”
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Performance, microbial growth and community interactions of iron-dependent denitrification in freshwaters by Shengjie Li, Muhe Diao, Yinhao Liao, Guodong Ji

“…Metagenomics recovered genomes of the five most abundant microorganisms, which accounted for over 99% of the community in every triplicate of the iron-based system. Based on codon usage bias, all of them were fast-growing organisms. …”
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Computational evaluation of TIS annotation for prokaryotic genomes by Zhu Huaiqiu, Ju Li-Ning, Zheng Xiaobin, Hu Gang-Qing, She Zhen-Su

“…With convincing proofs, we show two general preferential biases in the RefSeq annotation, <it>i.e</it>. over-annotating the longest open reading frame (LORF) and under-annotating ATG start codon. Finally, we have established a new TIS database, SupTISA, based on the best prediction of all the predictors; SupTISA has achieved an average accuracy of 92% over all 532 complete genomes.…”
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MHC-I alleles mediate clearance and antibody response to the zoonotic Lassa virus in Mastomys rodent reservoirs. by Ayodeji Olayemi, Dominik Werner Schmid, Ramona Fleischer, Kerstin Wilhelm, Alexander Christoph Heni, Nadine Mueller-Klein, Lavinia Haikukutu, Elisabeth Fichet-Calvet, Stephan Günther, Simone Sommer

“…Alleles associated with susceptibility shared a glutamic acid at the positively selected codon 57, while ManaMHC-I*006 featured an arginine. …”
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