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3281
Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease.
Published 2009-01-01“…Upon activation, dectin-1 signaling converges, similar to NOD2, on the adaptor molecule CARD9 which is associated with inflammatory bowel disease (IBD). An early stop codon polymorphism (c.714T>G) in DECTIN-1 results in a loss-of-function (p.Y238X) and impaired cytokine responses, including TNF-alpha, interleukin (IL)-1beta and IL-17 upon in vitro stimulation with Candida albicans or beta-glucan. …”
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3282
Increasing on-target cleavage efficiency for CRISPR/Cas9-induced large fragment deletion in Myxococcus xanthus
Published 2017-08-01“…We revealed that the high expression of a codon-optimized cas9 gene in M. xanthus was cytotoxic, and developed a temporally high expression strategy to reduce the cell damage from high expressions of Cas9. …”
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3283
An Analysis of Genetic Variability and Population Structure in Wheat Germplasm Using Microsatellite and Gene-Based Markers
Published 2022-04-01“…In the current study, the genetic diversity and population structure of 100 individuals from four <i>Triticum</i> and <i>Aegilops</i> species (including <i>T. aestivum</i>, <i>Ae. tauschii</i>, <i>Ae. cylindrica</i>, and <i>Ae. crassa</i>) were investigated using two gene-based markers (start codon targeted (SCoT) polymorphism and CAAT-box derived polymorphism (CBDP)) and simple-sequence repeats (SSRs). …”
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3284
Comparative chloroplast genomes and phylogenetic relationships of Aglaonema modestum and five variegated cultivars of Aglaonema.
Published 2022-01-01“…The molecular structure, gene order, content, codon usage, long repeats, and simple sequence repeats (SSRs) were generally conserved among the six sequenced genomes, but the IR-SSC boundary regions were significantly different, and 'Red Vein' had a distinct long repeat number and type frequency. …”
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3285
Immunoinformatics-guided approach for designing a pan-proteome multi-epitope subunit vaccine against African swine fever virus
Published 2024-01-01“…Moreover, this study designed an optimized codon for efficient translation of the ASFV vaccine construct into the Escherichia coli K-12 expression system using the pET28a(+) vector. …”
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3286
Disorder of Sex Development Due to 17-Beta-Hydroxysteroid Dehydrogenase Type 3 Deficiency: A Case Report and Review of 70 Different <i>HSD17B3</i> Mutations Reported in 239 Patient...
Published 2022-09-01“…Several mutations were recurrent and missense mutations at codon 80 and the splice-site mutation c.277+4A>T each represented 17% of all mutated alleles. …”
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3287
Strategies for Successful Over-Expression of Human Membrane Transport Systems Using Bacterial Hosts: Future Perspectives
Published 2022-03-01“…Moreover, differences in codon usage between humans and bacteria hamper translation. …”
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3288
Long-term response to pimitespib in postoperative recurrent gastrointestinal stromal tumors with PDGFRA D842V mutation: a case report
Published 2023-04-01“…Abstract Background Exon 18 D842V, which is a point mutation from aspartic acid to valine at codon 842, is the most frequent mutation in Platelet-Derived Growth Factor Receptor alpha (PDGFRA)-mutated gastrointestinal stromal tumor (GIST). …”
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3289
Mutations in pseudohypoparathyroidism 1a and pseudopseudohypoparathyroidism in ethnic Chinese.
Published 2014-01-01“…The latter was the most probable mechanism which caused a frameshift, changing Arg to Ser at residue 280 and invoking a premature termination of translation at codon 300 (R280Sfs*21). Five GNAS mutations in ethnic Chinese with PHP1A and PPHP were reported. …”
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3290
A novel homozygous TUB mutation associated with autosomal recessive retinitis pigmentosa in a consanguineous Chinese family
Published 2023-01-01“…Phylogenetic analysis indicated that the Asn residue at codon 460 of TUB is highly conserved across diverse species from tropicalis to humans. …”
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3291
Exploring Renal Malignancies in Saudi Arabia: Insights from a Tertiary Care Center Study
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3292
Case report: a novel deep intronic splice-altering variant in DMD as a cause of Becker muscular dystrophy
Published 2023-09-01“…Eventually, after more than 10 years, an RNA analysis captured abnormal splicing where 154 nucleotides from intron 43 were inserted between exon 43 and 44 resulting in a frameshift and a premature stop codon. Normal splicing of the DMD gene was also observed. …”
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3293
Enhanced Expression of Alcohol Dehydrogenase I in <i>Pichia pastoris</i> Reduces the Content of Acetaldehyde in Wines
Published 2023-12-01“…In this study, <i>ADH1</i> was successfully expressed in <i>Pichia pastoris</i> GS115 based on codon optimization. Then, the expression level of <i>ADH1</i> was enhanced by replacing its promoter with optimized promoters and increasing the copy number of the expression cassette, with ADH1 being purified using nickel column affinity chromatography. …”
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3294
Complete chloroplast genomes and comparative analysis of Ligustrum species
Published 2023-01-01“…Including six other published Ligustrum species, we compared various characteristics such as gene structure, sequence alignment, codon preference, and nucleic acid diversity, and performed positive-selection genes screening and phylogenetic analysis. …”
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3295
The complete mitochondrial genome of Coccotorus beijingensis Lin et Li, 1990 (Coleoptera, Curculionidae, Curculioninae, Anthonomini) and its phylogenetic implications
Published 2022-12-01“…All protein-coding genes initiated with ATN and TTG codons and ended with TAA, TAG or incomplete stop codons (TA, T). …”
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3296
Contribution to the Knowledge of Dicranoptychini (Diptera, Tipuloidea, Limoniidae) in China, with the First Mitochondrial Genome of the Tribe and Its Phylogenetic Implications
Published 2023-06-01“…In addition, the complete mt genome of <i>D. shandongensis</i> sp. nov. is sequenced and annotated, indicating that it is a typical circular DNA molecule with a length of 16,157 bp and shows a similar gene order, nucleotide composition, and codon usage to mt genomes of other Tipuloidea species. …”
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3297
Ligustrazine Inhibits the Migration and Invasion of Renal Cell Carcinoma
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3298
Zearalenone Removal from Corn Oil by an Enzymatic Strategy
Published 2020-02-01“…Herein, we targeted enhancing the secretion of ZEN degrading enzyme by <i>Pichia pastoris</i> through constructing an expression plasmid containing three optimized expression cassettes of <i>zlhy-6</i> codon and signal peptides. Further, we explored various parameters of enzymatic detoxification in neutralized oil and analyzed tocopherols and sterols losses in the corn oil. …”
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3299
Resistance to 16-Membered Macrolides, Tiamulin and Lincomycin in a Swine Isolate of <i>Acholeplasma laidlawii</i>
Published 2021-11-01“…Five mutations were found in the L22 protein, one of them at the stop codon. In addition, two mutations were found in the amino acid sequence of L4. …”
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3300
Update on Dihydropteroate Synthase (DHPS) Mutations in <i>Pneumocystis jirovecii</i>
Published 2021-10-01“…The presence of dihydropteroate synthase (DHPS) mutations has been described at codon 55 and 57 and found almost around the world. …”
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