A System of RNA Modifications and Biased Codon Use Controls Cellular Stress Response at the Level of Translation by Begley, Thomas J., Dedon, Peter C

“…When present at the tRNA wobble position, the modified ribonucleosides enhance the translation of mRNAs in which the cognate codons of the tRNAs are highly over-represented and that represent critical stress response proteins. …”
Get full text
Get full text

Structural characterization of eRF1 mutants indicate a complex mechanism of stop codon recognition by Pillay, Shubhadra, Li, Yan, Wong, Leo E, Pervushin, Konstantin

“…Eukarya translation termination requires the stop codon recognizing protein eRF1. In contrast to the multiple proteins required for translation termination in Bacteria, eRF1 retains the ability to recognize all three of the stop codons. …”
Get full text
Get full text

Attenuation of an amino-terminal premature stop codon mutation in the ATRX gene by an alternative mode of translational initiation. by Howard, M, Malik, N, Anderson, C, Voskuil, J, Atkins, J, Gibbons, R

Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study. by Burgess-Brown, N, Sharma, S, Sobott, F, Loenarz, C, Oppermann, U, Gileadi, O

“…The efficiency of heterologous protein production in Escherichia coli (E. coli) can be diminished by biased codon usage. Approaches normally used to overcome this problem include targeted mutagenesis to remove rare codons or the addition of rare codon tRNAs in specific cell lines. …”

The susceptibility of Mycobacterium tuberculosis to isoniazid and the Arg-->Leu mutation at codon 463 of katG are not associated. by Van Doorn, H, Kuijper, E, van der Ende, A, Welten, A, van Soolingen, D, de Haas, P, Dankert, J

“…A mutation (CCG-->CTG [Arg-->Leu]) in codon 463 of katG (catalase peroxidase) of Mycobacterium tuberculosis has been found in isoniazid (INH)-resistant strains. …”

The p53 codon 72 polymorphism (rs1042522) is associated with proliferative vitreoretinopathy: the Retina 4 Project. by Pastor-Idoate, S, Rodriguez-Hernández, I, Rojas, J, Fernández, I, García-Gutierrez, M, Ruiz-Moreno, J, Rocha-Sousa, A, Ramkissoon, Y, Harsum, S, Maclaren, R, Charteris, D, van Meurs, J, González-Sarmiento, R, Pastor, J

“…CONCLUSIONS: Results indicate that the Pro variant of p53 codon 72 polymorphism is associated with a higher risk of PVR developing after a primary RD. …”

Towards danger theory based artificial APC model: novel metaphor for danger susceptible data codons by Iqbal, Anjum, Maarof, Mohd. Aizani

Analysis of 3.5 million SARS-CoV-2 sequences reveals unique mutational trends with consistent nucleotide and codon frequencies by Sarah E. Fumagalli, Nigam H. Padhiar, Douglas Meyer, Upendra Katneni, Haim Bar, Michael DiCuccio, Anton A. Komar, Chava Kimchi-Sarfaty

Subjects: Get full text

From Recoding to Peptides for MHC Class I Immune Display: Enriching Viral Expression, Virus Vulnerability and Virus Evasion by John F. Atkins, Kate M. O’Connor, Pramod R. Bhatt, Gary Loughran

Subjects: Get full text

Synonymous Codon Pattern of Cowpea Mild Mottle Virus Sheds Light on Its Host Adaptation and Genome Evolution by Siqi Yang, Ye Liu, Xiaoyun Wu, Xiaofei Cheng, Xiaoxia Wu

Subjects: Get full text

EXPRESSION OF WILD-TYPE AND CODON-OPTIMIZED MORINGA OLEIFERA LECTIN GENES IN PICHIA PASTORIS AS COAGULANT IN WATER TREATMENT / by Muhamad Azhar Abd Wahid, author 654581, Hirofumi Hara, supervisor 654582, Megat Johari Megat Mohd. Noor, supervisor 244904, Fakulti Teknologi dan Informatik Razak 619091

EXPRESSION OF WILD-TYPE AND CODON-OPTIMIZED MORINGA OLEIFERA LECTIN GENES IN PICHIA PASTORIS AS COAGULANT IN WATER TREATMENT / by Muhamad Azhar Abd Wahid, author 654581, Hirofumi Hara, supervisor 654582, Megat Johari Megat Mohd. Noor, supervisor 244904, Fakulti Teknologi dan Informatik Razak 619091

Synonymous Codon Pair Recoding of the HIV-1 <i>env</i> Gene Affects Virus Replication Capacity by Ana Jordan-Paiz, Sandra Franco, Miguel Angel Martinez

Subjects: “…codon pair bias…”
Get full text

Expression, Purification, and Characterization of <i>Plasmodium vivax</i> Lactate Dehydrogenase from Bacteria without Codon Optimization by Yeon-Jun Kim, Jun-Seop Shin, Kang Woo Lee, Hyo-Ji Eom, Byung Gwan Jo, Jin Woo Lee, Jun Hyoung Kim, So Yeon Kim, Jung Hoon Kang, Jae-Won Choi

“…The PvLDH expressed and purified from transformed bacteria without codon optimization was successfully demonstrated to exhibit its potential tetramer structure and enzyme activity. …”
Get full text

Regulation of A-to-I RNA editing and stop codon recoding to control selenoprotein expression during skeletal myogenesis by Yuta Noda, Shunpei Okada, Tsutomu Suzuki

“…Stop codon recoding is a unique mechanism for selenoprotein biogenesis. …”
Get full text

First report from Turkey of a rare frameshift mutation [codons 9/10 (+T)] in the beta-globin gene by Ramazan Güneşaçar, M. Murat Çelik

Get full text

Codon Usage and Context Analysis of Genes Modulated during SARS-CoV-2 Infection and Dental Inflammation by Rekha Khandia, Megha Katare Pandey, Azmat Ali Khan, Igor Vladimirovich Rzhepakovsky, Pankaj Gurjar, Mohmed Isaqali Karobari

“…The data are derived from the studies on genes’ molecular patterns, including nucleotide composition, dinucleotide patterns, relative synonymous codon usage, codon usage bias, codon context, and rare and abundant codons. …”
Get full text

Codon Pair Deoptimization (CPD)-Attenuated PRRSV-1 Vaccination Exhibit Immunity to Virulent PRRSV Challenge in Pigs by Min-A Lee, Su-Hwa You, Usharani Jayaramaiah, Eun-Gyeong Shin, Seung-Min Song, Lanjeong Ju, Seok-Jin Kang, Sun Hee Cho, Bang-Hun Hyun, Hyang-Sim Lee

Subjects: Get full text

Codon-Optimized NADH Oxidase Gene Expression and Gene Fusion with Glycerol Dehydrogenase for Bienzyme System with Cofactor Regeneration. by Baishan Fang, Wei Jiang, Qiang Zhou, Shizhen Wang

“…Two strategies, the high AT-content in the region adjacent to the initiation codon and codon usage of the whole gene sequence consistent with the host, obtained the NOX activity of 59.9 U/mg and 73.3 U/mg (crude enzyme), with enhanced expression level of 2.0 and 2.5-folds, respectively. …”
Get full text

Correction: Exploring Codon Optimization and Response Surface Methodology to Express Biologically Active Transmembrane RANKL in E. coli

Get full text