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3481
Site-directed mutagenesis of newcastle disease VIRUS V protein in virus pathogenicity
Published 2021“…As a result, the stop codon was substituted with other amino acids and the V protein was no longer truncated. …”
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3482
Haematological parameter evaluation in different types of deletional alpha thalassaemia and in coinheritance of deletional alpha thalassaemia and beta thalassaemia in Hospital Univ...
Published 2018“…Coinheritance of α thalassaemia with β thalassaemia/haemoglobinopathy was seen in 13.8% ofcases with the most common coinheritance was seen between SEA heterozygous (αα/--SEA) with codon 26 mutation (HbE). There were significant differences of RBC count, MCV and MCH level in patients with deletional α thalassemia compared to group without α gene deletion (p-value < 0.001). …”
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Thesis -
3483
Introduction of chemically labile substructures into Arabidopsis lignin through the use of LigD, the C-dehydrogenase from Sphingobium sp strain SYK-6
Published 2015“…We explored the possibility of using LigD for biosynthetically engineering lignin by expressing the codon-optimized ligD gene in Arabidopsis thaliana. …”
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3484
PMCA-Based Detection of Prions in the Olfactory Mucosa of Patients With Sporadic Creutzfeldt–Jakob Disease
Published 2022-03-01“…The combination of the polymorphism at codon 129 of the PrP gene (coding either methionine or valine) with the biochemical feature of the proteinase-K resistant PrP (generating either PrPSc type 1 or 2) gives rise to different PrPSc strains, which cause variable phenotypes of sCJD. …”
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3485
Comparison of Bioluminescent Substrates in Natural Infection Models of Neglected Parasitic Diseases
Published 2022-12-01“…Solutions are sought by using codon-optimized red-shifted luciferases that yield higher expression levels and produce relatively more red or near-infrared light, or by using modified bioluminescent substrates with enhanced cell permeability and improved luminogenic or pharmacokinetic properties. …”
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3486
Complete Chloroplast Genome Determination of <i>Ranunculus sceleratus</i> from Republic of Korea (Ranunculaceae) and Comparative Chloroplast Genomes of the Members of the <i>Ranunc...
Published 2023-05-01“…The <i>ndhE</i>, <i>ndhF</i>, <i>rpl23</i>, <i>atpF</i>, <i>rps4</i>, and <i>rpoA</i> genes had a high posterior probability of codon sites in positive selection, while the amino acid site varied between <i>Ranunculus</i> species and other genera. …”
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3487
Genetic and molecular understanding for the development of methionine-rich maize: a holistic approach
Published 2023-09-01“…This review gives insight into improvement strategies including the selection of natural high-methionine mutants, molecular modulation of maize seed storage proteins and target key enzymes for sulphur metabolism and its flux towards the methionine synthesis, expression of synthetic genes, modifying gene codon and promoters employing genetic engineering approaches to enhance its expression. …”
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3488
The Complete Chloroplast Genome of Endangered Species <i>Stemona parviflora</i>: Insight into the Phylogenetic Relationship and Conservation Implications
Published 2022-07-01“…Long repeat sequences and simple sequence repeat (SSR) were detected, and most SSR were distributed in the LSC region. Codon usage bias analyses revealed that the RSCU value of the genus <i>Stemona</i> has almost no difference. …”
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3489
RNA-Seq Analysis of Trans-Differentiated ARPE-19 Cells Transduced by AAV9-AIPL1 Vectors
Published 2023-12-01“…Here, we present the results of the design, production, and in vitro testing of the AAV serotype 9 (AAV9) vector carrying the codon-optimized (co) copy of aryl hydrocarbon receptor-interacting protein like-1 (<i>AIPL1</i>) as a possible treatment for LCA4. …”
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3490
In silico designed novel multi-epitope mRNA vaccines against Brucella by targeting extracellular protein BtuB and LptD
Published 2024-03-01“…Computer simulations are also used to verify the immune response of the vaccine. The codon optimization, in silico cloning showed that the vaccine can efficiently transcript and translate in E. coli. …”
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3491
Population genetic analyses unveiled genetic stratification and differential natural selection signatures across the G-gene of viral hemorrhagic septicemia virus
Published 2022-12-01“…In addition, differential or subpopulation cluster-specific natural selection signatures were identified across the G-gene codon sites among the viral hemorrhagic septicemia virus isolates. …”
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3492
Comparative Chloroplast Genome Analysis of Wax Gourd <i>(Benincasa hispida</i>) with Three Benincaseae Species, Revealing Evolutionary Dynamic Patterns and Phylogenetic Implication...
Published 2022-03-01“…Comparison analyses among <i>B. hispida</i> and three other species from Benincaseae presented a significant conversion regarding nucleotide content, genome structure, codon usage, synonymous and non-synonymous substitutions, putative RNA editing sites, microsatellites, and oligonucleotide repeats. …”
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3493
Multiple Mechanisms Drive the Evolutionary Adaptation of <i>Phytophthora infestans</i> Effector Avr1 to Host Resistance
Published 2021-09-01“…Nearly 80% of the 111 sequences had a point mutation in the 512th nucleotide (T512G), which generated a pre-termination stop codon truncating 38 amino acids in the C-terminal, suggesting that the C-terminal may not be essential to ecological and biological functions of <i>P. infestans.…”
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3494
Comparative and phylogenetic analysis of Asparagus meioclados Levl. and Asparagus munitus Wang et S. C. Chen plastomes and utility of plastomes mutational hotspots
Published 2023-09-01“…In plastomes of A. meioclados and A. munitus, 14,685 and 14,987 codons were detected, among which 9942 and 10,207 had the relative synonymous codon usage (RSCU) values higher than 1, respectively. …”
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3495
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3496
Genome assembly of Medicago truncatula accession SA27063 provides insight into spring black stem and leaf spot disease resistance
Published 2024-02-01“…In rnpm1, these include a loss-of-function in a disease resistance gene due to a premature stop codon, and a 10.85 kbp retrotransposon-like insertion disrupting a ubiquitin conjugating E2. …”
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3497
A novel compound heterozygous mutation of COL6A3 in Chinese patients with isolated cervical dystonia
Published 2023-04-01“…One allele had a c.1264G>A mutation in exon 4 that resulted in an amino acid substitution of methionine for valine at codon 422 (p.Val422Met) and the other a c.8965+9G>A mutation involving a splicing change in exon 40. …”
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3498
Characterization of Firmiana danxiaensis plastomes and comparative analysis of Firmiana: insight into its phylogeny and evolution
Published 2024-02-01“…While the genomes revealed higher biased codon preferences in Karst habitat than those in Danxia habitats. …”
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3499
Prevalence of TP53 gene Pro72Arg (rs1042522) single nucleotide polymorphism among Egyptian breast cancer patients
Published 2023-03-01“…However, Pro72Arg (rs1042522) at codon 72, shows contradictory results in terms of cancer risk. …”
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3500
Recyclable CRISPR/Cas9-mediated gene disruption and deletions in Histoplasma
Published 2023-12-01“…Based on a system developed in Blastomyces, we adapted a CRISPR/Cas9 system to facilitate targeted gene disruption in Histoplasma with high efficiency. We express a codon-optimized version of Cas9 as well as guide RNAs from a single ectopic vector carrying a selectable marker. …”
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