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3781
The complete mitochondrial genome of the Indian dammer bee, Tetragonula iridipennis, and the phylogenomics of Meliponini
Published 2023-06-01“…Additionally, genome organization, including gene content, nucleotide composition, codon usage, and gene rearrangement, was investigated to better comprehend, utilize, and conserve this germplasm resource. …”
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3782
The Helicobacter pylori single nucleotide polymorphisms SNPs associated with multiple therapy resistance in Colombia
Published 2023-07-01“…The most common mutations in the rdxA gene associated with metronidazole resistance were a stop codon, and mutations at D59N and D59S, resulting in a resistance rate of 99.3%. …”
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3783
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3784
Predicting heterosis via genetic distance and the number of SNPs in selected segments of chromosomes in maize
Published 2023-02-01“…The objectives of this study were to 1) investigate if the numbers of selected PEUS SNPs (the SNP in the Promoters (1 kb upstream of the start codon), Exons, Untranslated region (UTR), and Stop codons) could be used for predicting MPH or BPH of GY; 2) if the number of PEUS SNPs is a better predictor of MPH and/or BPH of GY than genetic distance (GD). …”
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3785
Complete Chloroplast Genome Sequence of <i>Fortunella venosa</i> (Champ. ex Benth.) C.C.Huang (Rutaceae): Comparative Analysis, Phylogenetic Relationships, and Robust Support for I...
Published 2021-07-01“…In addition, there is a preference for codon usage with the non-coding regions being more conserved than the coding regions. …”
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3786
High Production of LukMF’ in Staphylococcus aureus Field Strains Is Associated with Clinical Bovine Mastitis
Published 2018-05-01“…Analysis of their global toxin gene regulators revealed a point mutation in the Repressor of toxins (rot) gene which results in a non-functional start codon, preventing translation of rot. This mutation was only identified in high LukMF’ producing isolates and not in low LukMF’ producing isolates. …”
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3787
Matrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B
Published 2023-03-01“…Matrin3 knockdown results in increased inclusion of an exon containing a premature termination codon in the CDC14B transcript and simultaneous down-regulation of the standard CDC14B transcript. …”
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3788
Engineering Saccharomyces cerevisiae for efficient production of recombinant proteins
Published 2024-03-01“…This review focuses on the strategies that enhance protein production by regulating transcription through promoter engineering, codon optimization, and expression system optimization. …”
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3789
Reasons for misdiagnosis of polymyositis in patients with dysferlinopathy: a clinical case
Published 2022-12-01“…When conducting an immunohistochemical reaction, the absence of the dysferlin protein in the sarcoplasmic membrane was revealed.Whole‑exome sequencing (NGS) revealed a mutation in exon 39 of the DYSF gene (p.Gln1428Ter) in the heterozygous state, which leads to the appearance of a stop codon and premature termination of protein translation. …”
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3790
Clinical and haematological characteristics of 38 individuals with Hb G‐Makassar in Malaysia
Published 2023-11-01“…Both have point mutations in codon 6, exon 1 in the β‐globin (HBB) gene with different pathogenicities. …”
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3791
The majority of patients with multidrug-resistant tuberculosis in Sub-Saharan Africa present a concomitant resistance to pyrazinamide
Published 2016-01-01“…Isolates presented 109 different profiles of mutations, including 73 occurring only once. Codon 12 was most frequently affected (15 isolates), including 10 isolates with Asp12Ala. …”
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3792
An Alternative Splice Variant of HIPK2 with Intron Retention Contributes to Cytokinesis
Published 2020-02-01“…This novel splice variant lacks the last two exons and retains intron13 with a stop codon after 89 bp of the intron, generating a short isoform, HIPK2-S, that is detectable by 2D Western blots. …”
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3793
Novel Splicing Mutation in <i>MTM1</i> Leading to Two Abnormal Transcripts Causes Severe Myotubular Myopathy
Published 2022-09-01“…The first aberrant transcript, induced by the activation of a cryptic splice site in intron 11, includes four intronic nucleotides upstream of exon 12, resulting in a shift in the transcript reading frame and introducing a new premature stop codon in the catalytic domain of the protein (p.Arg421SerfsTer7). …”
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3794
Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain
Published 2023-05-01“…Methods Here we used CRISPR/Cas9 techniques to generate a knockin mouse line (Nrg1Cre/+) that expresses a P2A-Cre cassette right before the stop codon of Nrg1 gene. Since Cre recombinase and Nrg1 are expressed in the same types of cells in Nrg1Cre/+ mice, the Nrg1 expression pattern can be revealed through the Cre-reporting mice or adeno-associated virus (AAV) that express fluorescent proteins in a Cre-dependent way. …”
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3795
A large population sample of African HIV genomes from the 1980s reveals a reduction in subtype D over time associated with propensity for CXCR4 tropism
Published 2022-12-01“…Lastly, we find a subtype D specific codon deletion at position 24 of the V3 loop, which may explain the higher propensity for subtype D to utilise X4 tropism.…”
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3796
The first two whole mitochondrial genomes for the genus Dactylis species: assembly and comparative genomics analysis
Published 2024-03-01“…Further, our mitochondrial genome characteristics investigation of the genus Dactylis included codon usage, sequences repeats, RNA editing and selective pressure. …”
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3797
Molecular understanding of unusual HbE-β+-thalassemia with Hb phenotype similar to HbE heterozygote: simple and rapid differentiation using HbE levels
Published 2023-12-01“…Two rare α-thalassemia mutations (Cap +14(C>G) and initiation codon (ATG>-TG)) of α2-globin genes were identified. …”
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3798
System-Wide Analysis of the GATC-Binding Nucleoid-Associated Protein Gbn and Its Impact on Streptomyces Development
Published 2022-06-01“…Exceptions are SCO1311 and SCOt32, for a tRNA editing enzyme and a tRNA that recognizes the rare leucine codon CUA, respectively, which nearly exclusively bound during vegetative growth. …”
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3799
Yeast eIF2A has a minimal role in translation initiation and uORF-mediated translational control in vivo
Published 2024-01-01“…Initiating translation of most eukaryotic mRNAs depends on recruitment of methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation factor 2 (eIF2) to the small (40S) ribosomal subunit, forming a 43S preinitiation complex (PIC) that attaches to the mRNA and scans the 5′-untranslated region (5′ UTR) for an AUG start codon. Previous studies have implicated mammalian eIF2A in GTP-independent binding of Met-tRNAi to the 40S subunit and its recruitment to specialized mRNAs that do not require scanning, and in initiation at non-AUG start codons, when eIF2 function is attenuated by phosphorylation of its α-subunit during stress. …”
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3800
Triamterene Functions as an Effective Nonsense Suppression Agent for MPS I-H (Hurler Syndrome)
Published 2023-02-01“…This new function of triamterene operates through premature termination codon (PTC) dependent mechanisms that are unaffected by epithelial sodium channel activity, the target of triamterene’s diuretic function. …”
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