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3821
Construction and immunogenicity of an mRNA vaccine against chikungunya virus
Published 2023-03-01“…Moreover, compared with the wild-type vaccine, the codon-optimized vaccine elicited robust CD8+ T-cell responses and mild neutralizing antibody titers. …”
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3822
Novel frameshift mutation in LIS1 gene is a probable cause of lissencephaly: a case report
Published 2022-09-01“…The insertion causes a change in the reading frame, and produces a premature stop codon, severely affecting the protein function and probably the silencing of one allele. …”
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3823
Synthesis and assembly of full-length cyanophage A-4L genome
Published 2023-03-01“…We propose a clone strategy abandoned the promotor and the start codon that could be applied for unclonable ORFs. …”
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3824
Conformational determinants necessary for secretion of Paecilomyces thermophila β-1,4-xylosidase that lacks a signal peptide
Published 2018-01-01“…These mutants were expressed as recombinant, codon-optimized proteins in E. coli. Notably, only mutants containing blades 2–4 were effectively secreted. …”
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3825
Inter- and Intra-specific Genetic Diversity in Diospyros Using SCoT and IRAP Markers
Published 2020-03-01“…In this study, we investigated the genetic diversity and relationship among 268 Diospyros accessions from different regions in China using start codon-targeted (SCoT) and inter-retrotransposon-amplified polymorphism (IRAP) markers. …”
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3826
The complete mitochondrial genome of Aglaia odorata, insights into its genomic structure and RNA editing sites
Published 2024-03-01“…Additionally, we analyzed codon usage and mitochondrial plastid DNAs (MTPTs). …”
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3827
Stress Response in Entamoeba histolytica Is Associated with Robust Processing of tRNA to tRNA Halves
Published 2023-04-01“…In particular, tRNA halves, a class of tRNA fragments produced by the cleavage of tRNAs in the anti-codon loop, have been widely reported to accumulate under stress and regulate translation in cells. …”
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3828
A computational approach to identify point mutations associated with occult hepatitis B: significant mutations affect coding regions but not regulative elements of HBV
Published 2011-08-01“…All viral proteins, with the only exception of the X, were affected. Stop codons in the S, that might account for absence of serum HBsAg, were not significantly enriched in OBI sequences. …”
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3829
The Alteration of m6A Modification at the Transcriptome-Wide Level in Human Villi During Spontaneous Abortion in the First Trimester
Published 2022-06-01“…These m6A peaks were mainly located in the coding region near the stop codon and were mainly characterized by AUGGAC and UGGACG motif. …”
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3830
Computational approach for identifying immunogenic epitopes and optimizing peptide vaccine through in-silico cloning against Mycoplasma genitalium
Published 2024-04-01“…Our immune simulation analysis demonstrates immune memory development and robust immunity, while codon adaptation suggests optimal expression in E. coli using the pET-28a(+) vector. …”
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3831
Complete Chloroplast Genome Sequence of Endangered Species in the Genus <i>Opisthopappus</i> C. Shih: Characterization, Species Identification, and Phylogenetic Relationships
Published 2022-12-01“…The repeat sequences, codon usage, RNA-editing sites, and comparative analyses revealed a high degree of conservation between the two species. …”
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3832
A novel viral vaccine platform based on engineered transfer RNA
Published 2023-12-01“…Controlling the replication of premature termination codon (PTC)-containing viruses is a promising approach to generate live but replication-defective viruses that can be used for potent vaccines. …”
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3833
Characteristics of plastid genomes in the genus Ceratostigma inhabiting arid habitats in China and their phylogenomic implications
Published 2023-06-01“…All plastomes are highly conservative and similar in gene order, simple sequence repeats (SSRs), long repeat repeats and codon usage patterns, but some structural variations in the border of single copy and inverted repeats. …”
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3834
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3835
Characterization and Comparative Analysis of the Complete Plastomes of Five <i>Epidendrum</i> (Epidendreae, Orchidaceae) Species
Published 2023-09-01“…Analysis of relative synonymous codon usage (RSCU) indicated that leucine (Leu) was the most and cysteine (Cys) was the least. …”
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3836
5′-UTR allelic variants and expression of the lycopene-ɛ-cyclase <i>LCYE</i> gene in maize (<i>Zea mays</i> L.) inbred lines of Russian selection
Published 2023-09-01“…Compared to A2, allele A5 contained two deletions (at positions -267–260 and -296–290 from the ATG codon) and a G251→T substitution, while allele A6 contained one deletion (-290–296) and two SNPs (G251→T, G265→T). …”
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3837
Genome sequences of BCG Pasteur ATCC 35734 and its derivative, the vaccine candidate BCGΔBCG1419c
Published 2023-02-01“…Results: The complete catalog of variants in genes relative to the reference genome BCG Pasteur 1173P2 (GenBank NC008769) showed that the parental strain BCG Pasteur ATCC 35734, from which the mutant BCGΔBCG1419c originated, showed five synonymous mutations, three missense mutations, and five codon insertions, whereas the BCGΔBCG1419c mutant reported the same changes. …”
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3838
<em>PSEN1</em> Compound Heterozygous Mutations Associated with Cerebral Amyloid Angiopathy and Cognitive Decline Phenotype
Published 2021-04-01“…However, mutations after codon 200 in the presenilin 1 (<i>PSEN1</i>) gene have been reported to facilitate CAA onset. …”
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3839
Identification of novel branch points reveals insights into RNA processing
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3840
An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis
Published 2017“…This modification occurs at high frequency at position 37 of most tRNAs that decode ANN codons, and stabilizes cognate anticodon–codon interactions. …”
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