A start codon mutation of the TSPAN12 gene in Chinese families causes clinical heterogeneous familial exudative vitreoretinopathy by Wei Li, Ziwei Wang, Yan Sun, Zhuoshi Wang, Jinyue Bai, Bo Xing, Xiao Sun, Lusheng Wang, Jiankang Li, Wei He

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Polymorphism at codon 31 of CDKN1A (p21) as a predictive factor for bevacizumab therapy in glioblastoma multiforme by Wen-Yu Cheng, Chiung-Chyi Shen, Yea-Jiuen Liang, Ming-Tsang Chiao, Yi-Chin Yang, Wan-Yu Hsieh, Cheng-Hui Lin, Jun-Peng Chen

“…In this retrospective study, our objective was to identify polymorphic variants of CDKN1A, specifically c.93C > A (codon 31 Ser31Arg), and investigate its potential impact within the scope of bevacizumab therapy for glioblastoma multiforme. …”
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Mutational Bias and Natural Selection Driving the Synonymous Codon Usage of Single-Exon Genes in Rice (Oryza sativa L.) by Huan Hu, Boran Dong, Xiaoji Fan, Meixia Wang, Tingzhang Wang, Qingpo Liu

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Deep amplicon sequencing of preselected isolates of Parascaris equorum in β-tubulin codons associated with benzimidazole resistance in other nematodes by Eva Tydén, Johan Dahlberg, Olof Karlberg, Johan Höglund

“…Methods Two isotype-specific primer pairs were designed, one on either side of the codon 167 and one on either side of codons 198 and 200. …”
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Investigation of p53 codon72 polymorphism in oral squamous cell carcinoma (SCC) specimens and normal population by PCR by Deyhimi P., Nikbakht Dastjerdi M., Morsali F., Kazemi Sh.

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Suppression of amber codons in Caulobacter crescentus by the orthogonal Escherichia coli histidyl-tRNA synthetase/tRNAHis pair. by Jae-hyeong Ko, Paula Montero Llopis, Jennifer Heinritz, Christine Jacobs-Wagner, Dieter Söll

“…While translational read-through of stop codons by suppressor tRNAs is common in many bacteria, archaea and eukaryotes, this phenomenon has not yet been observed in the α-proteobacterium Caulobacter crescentus. …”
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Chicken Ovotransferrin Variants OTFB and OTFC Harboring Substitution of GAT (Asp) to AAT (Asn) in the Codon 500 and their Antimicrobial Activity by Keiji Kinoshita, Si Lhyam Myint, Takeshi Shimogiri, Hisham R. Ibrahim, Kotaro Kawabe, Shin Okamoto, Yen-Pei Lee, Yoichi Matsuda, Yoshizane Maeda

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Molecular bases for strong phenotypic effects of single synonymous codon substitutions in the E. coli ccdB toxin gene by Priyanka Bajaj, Munmun Bhasin, Raghavan Varadarajan

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Selective Loss of Codon 72 Proline p53 and Frequent Mutational Inactivation of the Retained Arginine Allele in Colorectal Cancer by Regine Schneider-Stock, Carsten Boltze, Brigitte Peters, Reinhard Szibor, Olfert Landt, Frank Meyer, Albert Roessner

Subjects: “…Codon 72 polymorphism…”
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Comprehensive Analysis of Codon Usage in <i>Quercus</i> Chloroplast Genome and Focus on <i>psbA</i> Gene by Sheng-Lin Shi, Yan-Qun Liu, Run-Xi Xia, Li Qin

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Complete chloroplast genome of Hordeum brevisubulatum: Genome organization, synonymous codon usage, phylogenetic relationships, and comparative structure analysis. by Guangxin Cui, Chunmei Wang, Xiaoxing Wei, Hongbo Wang, Xiaoli Wang, Xinqiang Zhu, JinHua Li, Hongshan Yang, Huirong Duan

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Optimising the zebrafish Cre/Lox toolbox. Codon improved iCre, new gateway tools, Cre protein and guidelines by Alisha Tromp, Haitao Wang, Thomas E. Hall, Bryan Mowry, Bryan Mowry, Jean Giacomotto, Jean Giacomotto

“…First, we implemented a codon-improved Cre version (iCre) designed for rodent studies to counteract some of the aforementioned problems. …”
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Codon modification of Tuba1a alters mRNA levels and causes a severe neurodevelopmental phenotype in mice by Ines Leca, Alexander William Phillips, Lyubov Ushakova, Thomas David Cushion, David Anthony Keays

“…In this manuscript we compare two Tuba1a mouse models, both of which express wild-type TUBA1A protein but employ different codon usage. We show that modification of the Tuba1a mRNA sequence results in homozygous lethality and a severe neurodevelopmental phenotype. …”
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Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responses by Endres, Lauren, Dedon, Peter C., Begley, Thomas J.

“…In this review we note that the MoTTs translational model is also applicable to the process of stop-codon recoding for selenocysteine incorporation, as stop-codon recoding involves a selective codon bias and modified tRNA to decode selenocysteine during the translation of a key subset of oxidative stress response proteins. …”
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Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases by Jackson, Walker S., Borkowski, Andrew W., Watson, Nicki E., King, Oliver D., Faas, Henryk, Jasanoff, Alan Pradip, Lindquist, Susan

“…We conclude that single codon differences in a single gene in an otherwise normal genome can cause remarkably different neurodegenerative diseases and are sufficient to create distinct protein-based infectious elements.…”
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High-level expression and rapid purification of rare-codon genes from hyperthermophilic archaea by the GST gene fusion system. by Wu, X, Oppermann, U

“…In this study, we compared two gene fusion expression strategies using two rare codon genes (Ssh10b and MtGrxM) from archaea as a model system. …”

Polymorphism in codon 17 of the CTLA-4 gene (+49 A/G) is not associated with susceptibility to rheumatoid arthritis in British Caucasians. by Milicic, A, Brown, M, Wordsworth, B

P53 codon 72 polymorphism and BRCA 1 and 2 mutations in ovarian epithelial malignancies in black South Africans. by Pegoraro, R, Moodley, M, Rom, L, Chetty, R, Moodley, J

“…None of the BRCA 1 or 2 mutations were detected in the patient group. The codon 72 Arg allele frequency in lymphocytic DNA was not significantly different compared with the control group. …”

Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138. by Ren, J, Nichols, C, Stamp, A, Chamberlain, P, Ferris, R, Weaver, K, Short, SA, Stammers, D

Cracking the genetic code with neural networks by Marc Joiret, Marine Leclercq, Gaspard Lambrechts, Francesca Rapino, Pierre Close, Gilles Louppe, Liesbet Geris, Liesbet Geris, Liesbet Geris

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