Biosynthesis, Engineering, and Delivery of Selenoproteins by David E. Wright, Patrick O’Donoghue

Subjects: “…amber codon…”
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A Korean child diagnosed with malonic aciduria harboring a novel start codon mutation following presentation with dilated cardiomyopathy by Seung Hoon Lee, Jung Min Ko, Mi‐Kyoung Song, Junghan Song, Kyung Sun Park

“…Elevated plasma C3DC level and excessive excretion of urinary malonate were observed, and two pathogenic variants, including a novel start codon mutation (c.1A>G), were identified in MLYCD. …”
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Effect of Multiple Vaccinations with Tumor Cell-Based Vaccine with Codon-Modified GM-CSF on Tumor Growth in a Mouse Model by Jiantai Timothy Qiu, Donia Alson, Ta-Hsien Lee, Ching-Chou Tsai, Ting-We Yu, Yu-Sing Chen, Ya-Fang Cheng, Chu-Chi Lin, Scott C. Schuyler

“…Ectopic expression of codon-modified granulocyte-macrophage colony-stimulating factor (cGM-CSF) in TC-1 cells (TC-1/cGM-CSF), a model cell line for human papillomavirus (HPV)-infected cervical cancer cells, increased the expression level of GM-CSF and improved the efficacy of tumor cell-based vaccines in a cervical cancer mouse model. …”
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Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough by Rhianna E. Lee, Catherine A. Lewis, Lihua He, Emily C. Bulik-Sullivan, Samuel C. Gallant, Teresa M. Mascenik, Hong Dang, Deborah M. Cholon, Martina Gentzsch, Lisa C. Morton, John T. Minges, Jonathan W. Theile, Neil A. Castle, Michael R. Knowles, Adam J. Kimple, Scott H. Randell

“…The remaining individuals with CF harbor premature termination codons (PTCs) or rare CFTR variants with limited treatment options. …”
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High prevalence of an alpha variant lineage with a premature stop codon in ORF7a in Iraq, winter 2020-2021. by Nihad A M Al-Rashedi, Hussein Alburkat, Abas O Hadi, Murad G Munahi, Ali Jasim, Alaa Hameed, Basel Saber Oda, Kareem Moamin Lilo, Laith A H AlObaidi, Olli Vapalahti, Tarja Sironen, Teemu Smura

“…A notable frequency (43.33%) of stop codon mutation (NS7a Q62stop) was detected among the B.1.1.7 lineage sequences. …”
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Strong Selectional Forces Fine-Tune CpG Content in Genes Involved in Neurological Disorders as Revealed by Codon Usage Patterns by Rekha Khandia, Anushri Sharma, Taha Alqahtani, Ali M. Alqahtani, Yahya I. Asiri, Saud Alqahtani, Ahmed M. Alharbi, Mohammad Amjad Kamal, Mohammad Amjad Kamal, Mohammad Amjad Kamal, Mohammad Amjad Kamal

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RET codon 618 mutations in Saudi families with multiple endocrine neoplasia Type 2A and familial medullary thyroid carcinoma by Faiza Qari

“…Among the 5 families with MEN 2A, 3 had a mutation at codon 634, whereas 2 had a mutation at codon 618. …”
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CMV-Promoter Driven Codon-Optimized Expression Alters the Assembly Type and Morphology of a Reconstituted HERV-K(HML-2) by Oliver Hohn, Kirsten Hanke, Veronika Lausch, Anja Zimmermann, Saeed Mostafa, Norbert Bannert

“…We investigated the particle morphology of a recently reconstituted HERV-K113 element termed oriHERV-K113 using thin-section electron microscopy (EM) and could demonstrate that strong overexpression by substitution of the 5'LTR for a CMV promoter and partial codon optimization altered the virus assembly type and morphology. …”
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The Supersymmetry Genetic Code Table and Quadruplet Symmetries of DNA Molecules Are Unchangeable and Synchronized with Codon-Free Energy Mapping during Evolution by Marija Rosandić, Vladimir Paar

Subjects: “…classification of trinucleotides/codons…”
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Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons by Yoshifumi Sonobe, Soojin Lee, Gopinath Krishnan, Yuanzheng Gu, Deborah Y Kwon, Fen-Biao Gao, Raymond P Roos, Paschalis Kratsios

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P590: Evaluation of stop-loss and frameshift variants extending translation beyond the reference stop codon detected by carrier screening by Shahida Flores, Matthew Prego, Trevor Smart, Jocelyn Wang, Julie Agapite, Sindhu Arun, Melissa Chowning, Svetlana Gramatikova, Kim Hohlt, Lili Li, Rebecca Ross, Priyanka Arya, Nina Sanapareddy

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Codon Usage for Genetic Diversity, and Evolutionary Dynamics of Novel Porcine Parvoviruses 2 through 7 (PPV2–PPV7) by Changzhan Xie, Yimo Tao, Ying Zhang, Ping Zhang, Xiangyu Zhu, Zhuo Ha, He Zhang, Yubiao Xie, Xianzhu Xia, Ningyi Jin, Huijun Lu

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A meta-analysis of single base-pair substitutions in translational termination codons ('nonstop' mutations) that cause human inherited disease by Hamby Stephen E, Thomas Nick ST, Cooper David N, Chuzhanova Nadia

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Genome-Wide Analysis of Codon Usage Patterns of SARS-CoV-2 Virus Reveals Global Heterogeneity of COVID-19 by Saadullah Khattak, Mohd Ahmar Rauf, Qamar Zaman, Yasir Ali, Shabeen Fatima, Pir Muhammad, Tao Li, Hamza Ali Khan, Azhar Abbas Khan, Ebenezeri Erasto Ngowi, Dong-Dong Wu, Xin-Ying Ji

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Insights into Comparative Genomics, Codon Usage Bias, and Phylogenetic Relationship of Species from Biebersteiniaceae and Nitrariaceae Based on Complete Chloroplast Genomes by Xiaofeng Chi, Faqi Zhang, Qi Dong, Shilong Chen

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Association between TP53 codon 72 G>C Polymorphism and Thyroid Carcinoma Risk: An Up-to-Date Meta-Analysis by Jamal Jafari Nedooshan, Mohammad Forat Yazdi, Hossein Neamatzadeh, Masoud Zare Shehneh, Saeed Kargar, Niloofar Seddighi

Subjects: “…thyroid cancer- p53- codon 72- polymorphism- meta-analysis…”
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Efficient Simultaneous Introduction of Premature Stop Codons in Three Tumor Suppressor Genes in PFFs via a Cytosine Base Editor by Haoyun Jiang, Qiqi Jing, Qiang Yang, Chuanmin Qiao, Yaya Liao, Weiwei Liu, Yuyun Xing

“…Interestingly, the premature stop codon introduced into the <i>TP53</i> gene did not eliminate the expression of its full-length protein in the Tri-Mut cells, suggesting that stop codon read-through occurred. …”
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Premature Termination Codon in 5′ Region of Desmoplakin and Plakoglobin Genes May Escape Nonsense-Mediated Decay through the Reinitiation of Translation by Marta Vallverdú-Prats, Ramon Brugada, Mireia Alcalde

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The Adenine/Thymine Deleterious Selection Model for GC Content Evolution at the Third Codon Position of the Histone Genes in <i>Drosophila</i> by Yoshinori Matsuo

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Natural Selection Plays an Important Role in Shaping the Codon Usage of Structural Genes of the Viruses Belonging to the <i>Coronaviridae</i> Family by Dimpal A. Nyayanit, Pragya D. Yadav, Rutuja Kharde, Sarah Cherian

Subjects: “…codon usage bias…”
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