Mapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysis by Taiqi Zhao, Suying Duan, Jiaqi Li, Honglin Zheng, Chenyang Liu, Hang Zhang, Haiyang Luo, Yuming Xu

“…Beyond the standard AUG initiation or adjacent start codons, they are translated into proteins characterized by disease-causing amino acid repeats through repeat-associated non-AUG translation. …”
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Genomic Perspectives on the Emerging SARS-CoV-2 Omicron Variant by Wentai Ma, Jing Yang, Haoyi Fu, Chao Su, Caixia Yu, Qihui Wang, Ana Tereza Ribeiro de Vasconcelos, Georgii A. Bazykin, Yiming Bao, Mingkun Li

“…Moreover, a large number of nonsynonymous mutations occur in the codons for the amino acid residues located on the surface of the Spike protein, which could potentially affect the replication, infectivity, and antigenicity of SARS-CoV-2. …”
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A novel truncated variant in SPAST results in spastin accumulation and defects in microtubule dynamics by Jie Wang, Yihan Wu, Hong Dong, Yunpeng Ji, Lichun Zhang, Yaxian Liu, Yueshi Liu, Xin Gao, Yueqi Jia, Xiaohua Wang

“…Conclusion SPAST mutations leading to premature stop codons do not always act through haploinsufficiency. …”
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Mutations in TSPAN12 gene causing familial exudative vitreoretinopathy by Yuqiao Ju, Tianhui Chen, Lu Ruan, Ye Zhao, Qing Chang, Xin Huang

“…Construction of wild-type and mutant TSPAN12 vector showed the appearance of premature termination codons (PTC). In vitro expression detection showed significant down-regulated expression level of TSPAN12 mRNAs and proteins in cells transfected with mutant vectors compared with in wild-type group. …”
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Unusual phylogenetic tree and circulating actionable ESR1 mutations in an aggressive luminal/HER2-low breast cancer: Case report by Matteo Allegretti, Vittoria Barberi, Cristiana Ercolani, Antonello Vidiri, Elena Giordani, Gennaro Ciliberto, Patrizio Giacomini, Alessandra Fabi

“…Convergent evolution was characterized by a unique asynchronous expansion of three actionable (OncoKB level 3A) mutations at two consecutive ESR1 codons. Low or undetectable in all the sampled tumor tissues, ESR1 mutations expanded rapidly in blood during HER2/hormone double-blockade, and predicted life-threatening local progression at lung and liver metastatic foci. …”
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Role of Envelope Glycoprotein Complexes in Cell-Associated Spread of Human Cytomegalovirus by Nina Weiler, Caroline Paal, Kerstin Adams, Christopher Calcaterra, Dina Fischer, Richard James Stanton, Dagmar Stöhr, Kerstin Laib Sampaio, Christian Sinzger

“…In the genome of Merlin pAL1502, the glycoproteins gB, gH, gL, gM, and gN were deleted by introducing stop codons, and the mutants were analyzed for viral growth. …”
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Recent findings on the role of wild-type and mutant p53 in cancer development and therapy by Mehregan Babamohamadi, Esmaeil Babaei, Esmaeil Babaei, Burhan Ahmed Salih, Burhan Ahmed Salih, Mahshid Babamohammadi, Hewa Jalal Azeez, Goran Othman, Goran Othman

“…Eight TP53 gene mutations are located in codons, constituting 28% of all p53 mutations. The p53 can be used as a biomarker for tumor progression and an excellent target for designing cancer treatment strategies. …”
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Cardiomyocyte-Specific Loss of Glutamyl-prolyl-tRNA Synthetase Leads to Disturbed Protein Homeostasis and Dilated Cardiomyopathy by Jiangbin Wu, Jared Hollinger, Emily Bonanno, Feng Jiang, Peng Yao

“…Glutamyl-prolyl-tRNA synthetase (EPRS1), an aminoacyl-tRNA synthetase (ARS) ligating glutamic acid and proline to their corresponding tRNAs, plays an essential role in decoding proline codons during translation elongation. The physiological function of EPRS1 in cardiomyocytes (CMs) and the potential effects of the CM-specific loss of Eprs1 remain unknown. …”
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Characterization of Two New <i>Apodemus</i> Mitogenomes (Rodentia: Muridae) and Mitochondrial Phylogeny of Muridae by Di Wu, Lizhi Zhou, Jiezhong Xue, Qiliang Xia, Lei Meng

“…All protein-coding genes contained T- and TAA as stop codons. Phylogeny analysis revealed two main branches in the Muridae family. …”
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sgRNA design and in vitro nucleolytic analysis of the Cas9‐RNP complex for transgene‐free genome editing of the eIF4E1 gene from Capsicum an‐ nuum L. by Josefanny Tham, Alfred Patisenah, Tommy Octavianus Soetrisno Tjia, Santiago Signorelli, Intan Taufik, Karlia Meitha

“…Therefore, this study explores the potential of CRISPR‐Cas9‐based genome editing to enhance chili resistance by introducing premature stop codons or truncated proteins. Two sgRNAs were designed, targeting the first and second intron of the eIF4E1 gene. …”
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Drosophila Embryonic Cell-Cycle Mutants by Unhavaithaya, Yingdee, Park, Eugenia A., Royzman, Irena, 1970-, Orr-Weaver, Terry

“…Five new alleles of Cyclin E were recovered, ranging from a missense mutation that is viable to stop codons causing embryonic lethality. These permitted us to investigate the requirements for Cyclin E function in neuroblast cell fate determination, a role previously shown for a null Cyclin E allele. …”
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Next generation sequencing reveals the antibiotic resistant variants in the genome of Pseudomonas aeruginosa by Ramanathan, B., Jindal, H.M., Le, C.F., Gudimella, R., Anwar, A., Razali, R., Poole-Johnson, J., Manikam, R., Sekaran, S.D.

“…In addition, nucleotide deletions in the genome and mutations leading to generation of stop codons were also observed in the antibiotic resistant clinical isolates. …”
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The garden asparagus (Asparagus officinalis L.) mitochondrial genome revealed rich sequence variation throughout whole sequencing data by Wentao Sheng, Jianlan Deng, Chao Wang, Quan Kuang

“…It was found that the codons of edited sites located in the amino acids showed a leucine-formation trend, and RNA editing sites mainly caused the mutual transformation of amino acids with the same properties. …”
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Anticancer properties and mechanism of action of the fungal nucleoside clitocine and its derivatives by Christian Bailly

“…Moreover, CLT can promote translational readthrough of stop codons. This emerging mechanism reinforces further the interest of the natural product to address different types of cancers and nonsense mutation-related genetic disorders. …”
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Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of <it>sel-12 </it>mutants with amber stop mutations in <it>Caenorhabditis elegans</it> by Aubert Sylvie, Gontijo Alisson M, Roelens Ingele, Lakowski Bernard

“…</p> <p>Results</p> <p>We show that <it>spr-2 </it>mutations increase the levels of <it>sel-12 </it>transcripts with Premature translation Termination Codons (PTCs) in embryos and L1 larvae. mRNA transcripts from <it>sel-12 </it>alleles with PTCs undergo degradation by a process known as Nonsense Mediated Decay (NMD). …”
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Mitochondrial Genomes of the Genus <i>Claassenia</i> (Plecoptera: Perlidae) and Phylogenetic Assignment to Subfamily Perlinae by Yanan Xiang, Mengyuan Zhao, Qingbo Huo, Yuzhou Du

“…In general, standard ATN start and TAN termination codons were evident in the PCGs. Although the dihydrouridine arm was absent in <i>trnSer</i>, the remaining 21 tRNAs displayed the characteristic cloverleaf secondary structure. …”
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Identification of Novel Rare <i>ABCC1</i> Transporter Mutations in Tumor Biopsies of Cancer Patients by Onat Kadioglu, Mohamed Saeed, Markus Munder, Andreas Spuller, Henry Johannes Greten, Thomas Efferth

“…Diverse <i>ABCC1</i> mutations were found, including nonsense mutations causing premature stop codons, and compared with the wild-type protein in terms of their protein structure. …”
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Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory Parameters by Marie Gombert, Vanessa Martin-Carbonell, Gonzalo Pin-Arboledas, Joaquín Carrasco-Luna, Álvaro Carrasco-García, Pilar Codoñer-Franch

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Proteins à la carte: riboproteogenomic exploration of bacterial N-terminal proteoform expression by Igor Fijalkowski, Valdes Snauwaert, Petra Van Damme

“…This suggests that TIS selection is subject to regulatory control, adding yet another layer of complexity to our understanding of bacterial proteomes.IMPORTANCEWith the emerging theme of genes within genes comprising the existence of alternative open reading frames (ORFs) generated by translation initiation at in-frame start codons, mechanisms that control the relative utilization of annotated and alternative TIS need to be unraveled and our molecular understanding of resulting proteoforms broadened. …”
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Atmosphere and room temperature plasma alters the m6A methylome profiles and regulates gene expression associated with color mutation in clownfish (Amphiprion ocellaris) by Li-Bin He, Hui-Yu Luo, Le-Yun Zheng

“…These modification sites were mainly distributed around stop codons, and the number of corresponding genes exceeded 10,000. …”
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