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4961
The Caenorhabditis elegans Gene mfap-1 Encodes a Nuclear Protein That Affects Alternative Splicing
Published 2012“…This mutant contains missense mutations in two adjacent codons of the C. elegans microfibrillar-associated protein 1 gene mfap-1. mfap-1(n4564 n5214) suppresses the Unc phenotypes of different rubberband Unc mutants in a pattern similar to that of mutations in the splicing factor genes uaf-1 (the C. elegans U2AF large subunit gene) and sfa-1 (the C. elegans SF1/BBP gene). …”
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4962
Chloroplast Genome of Rambutan and Comparative Analyses in Sapindaceae
Published 2021-02-01“…Sixty-three simple sequence repeats (SSRs) and 98 repetitive sequences were detected. Twenty-nine codons showed biased usage and 49 potential RNA editing sites were predicted across 18 protein-coding genes in the rambutan chloroplast genome. …”
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4963
Molecular characterization of Salmonella spp. and Listeria monocytogenes strains from biofilms in cattle and poultry slaughterhouses located in the federal District and State of Go...
Published 2021-01-01“…In the sequence analysis, no premature stop codons were detected in the inlA gene of Listeria. …”
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4964
Mitochondrial genome characteristics of six Phylloscopus species and their phylogenetic implication
Published 2023-10-01“…ATG and TAA were the most frequent initiating and terminating codons, respectively. Several conserved boxes were identified in CR1, including C-string in domain I; F, E, D, and C boxes, as well as bird similarity and B boxes, in domain II; and CSB1 in domain III. …”
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4965
Analyses of Chloroplast Genome of <i>Eutrema japonicum</i> Provide New Insights into the Evolution of <i>Eutrema</i> Species
Published 2021-12-01“…It contains 290 simple sequence repeats and prefers to end their codons with an A or T, which is the same as other Brassicaceae species. …”
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4966
Molecular Detection of gyrA Mutation in Clinical Strains of Klebsiella pneumoniae
Published 2022-10-01“…The data obtained from the sequencing confirmed the RFLP results and indicated the presence of point mutations in codons 83 and 87 in the gyrA gene which leads to the substitution of different amino acids in gyrA protein. …”
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4967
The genome of <it>Aeromonas salmonicida </it>subsp. <it>salmonicida </it>A449: insights into the evolution of a fish pathogen
Published 2008-09-01“…A large number of genes encoding potential virulence factors were identified; however, many appear to be pseudogenes since they contain insertion sequences, frameshifts or in-frame stop codons. A total of 170 pseudogenes and 88 insertion sequences (of ten different types) are found in the <it>A. salmonicida </it>genome. …”
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4968
Multiple origins of resistance-conferring mutations in <it>Plasmodium vivax dihydrofolate reductase</it>
Published 2008-04-01“…The double mutant (58R/117N) <it>dhfr </it>allele has evolved from several origins, because the 58R is encoded by at least 3 different codons. The triple (58R/61M/117T) and quadruple (57L/61M/117T/173F, 57I/58R/61M/117T and 57L/58R/61M/117T) mutant alleles had at least three independent origins in Thailand, Indonesia, and Papua New Guinea/Vanuatu.…”
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4969
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4970
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4971
Drug susceptibility profiling and genetic determinants of drug resistance in Mycobacterium simiae isolates obtained from regional tuberculosis reference laboratories of Iran.
Published 2022-01-01“…Sequence analysis showed mutations in positions 2058 and 2059 of the rrl gene, as well non-synonymous mutation at codons 389, 444, and 571 of the gyrB gene. Sequence analysis showed no mutation in the gyrA gene. drug-resistant isolates with mutations showed higher MICs compared to non-mutant resistant isolates.…”
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4972
In Vitro Cross-Linking MS Reveals SMG1–UPF2–SMG7 Assembly as Molecular Partners within the NMD Surveillance
Published 2024-03-01“…mRNAs containing premature stop codons are responsible for various genetic diseases as well as cancers. …”
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4973
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4974
Hepatitis B Virus preS/S Truncation Mutant rtM204I/sW196* Increases Carcinogenesis through Deregulated <i>HIF1A, MGST2,</i> and <i>TGFbi</i>
Published 2020-09-01“…Some of these mutants introduce premature stop codons in the overlapping surface (s) gene, including rtA181T/sW172*, which has been shown to enhance oncogenicity. …”
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4975
Targeted deletion of floral development genes in Arabidopsis with CRISPR/Cas9 using the RNA endoribonuclease Csy4 processing system
Published 2019-08-01“…DNA sequencing analysis of RT-PCR products showed that targeted deletions of AP1 and TFL1 could lead to frameshift mutations and introduce premature stop codons to disrupt the open-reading frames of the target genes. …”
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4976
The Mitochondrial Genome of <i>Cylicocyclus elongatus</i> (Strongylida: Strongylidae) and Its Comparative Analysis with Other <i>Cylicocyclus</i> Species
Published 2022-06-01“…ATT and TAA were the most common start and termination codons of 12 PCGs, respectively. Comparative analyses of mt genomes nucleotide sequence and amino acid sequence showed that there were higher identities between <i>C. elongatus</i> and five other <i>Cylicocyclus</i>, rather than with <i>P. imparidentatum</i>. …”
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4977
N6-Methyladenosine Methylome Profiling of Muscle and Adipose Tissues Reveals Methylase–mRNA Metabolic Regulatory Networks in Fat Deposition of Rex Rabbits
Published 2022-06-01“…Our findings showed that there were 12,876 and 10,973 m<sup>6</sup>A peaks in the rabbit muscle and adipose tissue transcriptomes, respectively. Stop codons, 3′-untranslated regions, and coding regions were found to be mainly enriched for m<sup>6</sup>A peaks. …”
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4978
Identification and analysis of evolutionary selection pressures acting at the molecular level in five forkhead subfamilies
Published 2008-09-01“…</p> <p>Results</p> <p>Application of site models, which estimate overall selection pressures on individual codons throughout the phylogeny, showed that the amino acid changes observed were either neutral or under negative selection. …”
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4979
<it>Thermoanaerobacterium thermosaccharolyticum</it> β-glucosidase: a glucose-tolerant enzyme with high specific activity for cellobiose
Published 2012-07-01“…By replacing the rare codons for the N-terminal amino acids of the target protein, the expression level of <it>bgl</it> was increased from 6.6 to 11.2 U/mg in LB medium. …”
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4980
Influence of mutation bias and hydrophobicity on the substitution rates and sequence entropies of protein evolution
Published 2018-10-01“…In this case, the substitution rates are faster in genomes that evolve under mutational bias that favor hydrophobic amino acids by preferentially incorporating the nucleotide Thymine that is more frequent in hydrophobic codons. This appearingly contradictory result arises because buried sites occupied by hydrophobic amino acids are characterized by larger selective factors that largely amplify the substitution rate between hydrophobic amino acids, while the selective factors of exposed sites have a weaker effect. …”
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