Showing 81 - 100 results of 5,147 for search '"codon"', query time: 0.11s Refine Results
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    Supplementary material for "Evolutionary dynamics of abundant stop codon readthrough" by Jungreis, Irwin, Fields, Gabriel, Lin, Michael F., Chan, Clara S., Waterhouse, Robert, Kellis, Manolis

    Published 2017
    “…Evolutionary dynamics of abundant stop codon readthrough. Molecular Biology and Evolution. doi:10.1093/molbev/msw189…”
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  3. 83

    tRNA epitranscriptomics and biased codon are linked to proteome expression in by Ng, Chee Sheng, Sinha, Ameya, Aniweh, Yaw, Nah, Qianhui, Babu, Indrakanti Ramesh, Gu, Chen, Chionh, Yok Hian, Dedon, Peter C, Preiser, Peter R

    Published 2019
    “…Quantitative analysis of ~2,100 proteins across the IDC revealed that up- and down-regulated proteins in late but not early stages have a marked codon bias that directly correlates with parallel changes in tRNA modifications and enhanced translational efficiency. …”
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    Dysfunctional tRNA reprogramming and codon-biased translation in cancer by Dedon, Peter C, Begley, Thomas J

    Published 2023
    “…Many cancers hijack translation to increase the synthesis of tumor-driving proteins, the messenger mRNAs of which have specific codon usage patterns. Termed 'codon-biased translation' and originally identified in stress response regulation, this mechanism is supported by diverse studies demonstrating how the 50 RNA modifications of the epitranscriptome, specific tRNAs, and codon-biased mRNAs are used by oncogenic programs to promote proliferation and chemoresistance. …”
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    Article
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    Evidence of abundant stop codon readthrough in Drosophila and other Metazoa by Jungreis, Irwin, Lin, Michael F., Spokony, Rebecca, Chan, Clara Sophia, Negre, Nicolas, Victorsen, Alec, White, Kevin P., Kellis, Manolis

    Published 2012
    “…While translational stop codon readthrough is often used by viral genomes, it has been observed for only a handful of eukaryotic genes. …”
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    Article
  9. 89

    Heterologous Stop Codon Readthrough of Metazoan Readthrough Candidates in Yeast by Jungreis, Irwin, Kellis, Manolis, Chan, Clara Sophia

    Published 2013
    “…Recent analysis of genomic signatures in mammals, flies, and worms indicates that functional translational stop codon readthrough is considerably more abundant in metazoa than previously recognized, but this analysis provides only limited clues about the function or mechanism of readthrough. …”
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    Article
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    Codon choice directs constitutive mRNA levels in trypanosomes by Nascimento, J, Kelly, S, Sunter, J, Carrington, M

    Published 2018
    “…First, a novel codon usage metric, the gene expression codon adaptation index (geCAI), was developed that maximised the relationship between codon choice and the measured abundance for a transcriptome. …”
    Journal article
  12. 92

    Synonymous codon usage influences the local protein structure observed by Saunders, R, Deane, C

    Published 2010
    “…CSandS facilitates a comprehensive analysis of codon usage over many organisms. In assigning translation speed, we find that relative codon usage is less informative than tRNA concentration. …”
    Journal article
  13. 93

    Synonymous codon usage influences the local protein structure observed. by Saunders, R, Deane, C

    Published 2010
    “…CSandS facilitates a comprehensive analysis of codon usage over many organisms. In assigning translation speed, we find that relative codon usage is less informative than tRNA concentration. …”
    Journal article
  14. 94

    Codon optimization reveals critical factors for high level expression of two rare codon genes in Escherichia coli: RNA stability and secondary structure but not tRNA abundance. by Wu, X, Jörnvall, H, Berndt, K, Oppermann, U

    Published 2004
    “…Expression patterns in Escherichia coli of two small archaeal proteins with a natural content of about 30% rare codons were analyzed. The proteins, a histone-like protein from Sulfolobus shibatae (Ssh10), and a glutaredoxin-like protein from Methanobacterium thermoautotrophicum (mtGrx), were produced with expression plasmids encoding wild-type genes, codon-optimized synthetic, and GST-fusion genes. …”
    Journal article
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    Novel start codons introduce novel coding sequences in the human genomes by He Zhang, Yang Xie

    Published 2023-05-01
    “…Abstract Start-gain mutations can introduce novel start codons and generate novel coding sequences that may affect the function of genes. …”
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    Article
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