Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant by Jingwen Jiang, Hai-Ning Chen, Ping Jin, Li Zhou, Liyuan Peng, Zhao Huang, Siyuan Qin, Bowen Li, Hui Ming, Maochao Luo, Na Xie, Wei Gao, Edouard C. Nice, Qiang Yu, Canhua Huang

“…Abstract The single-nucleotide polymorphism (SNP) of p53, in particular the codon 72 variants, has recently been implicated as a critical regulator in tumor progression. …”
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Characterization of Four Complete Mitogenomes of <i>Monolepta</i> Species and Their Related Phylogenetic Implications by Rong-Rong Gao, Qi-Long Lei, Xu Jin, Iqbal Zafar, Xing-Ke Yang, Cheng-Yong Su, Jia-Sheng Hao, Rui-E Nie

“…The substitution saturation of three datasets (13 <i>PCGs</i>_codon1, 13 <i>PCGs</i>_codon2, 13 <i>PCGs</i>_codon3) showed that there was no saturation across all datasets. …”
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Estimating sequence diversity of prion protein gene (PRNP) in Portuguese populations of two cervid species: red deer and fallow deer by Jorge C. Pereira, Nuno Gonçalves-Anjo, Leonor Orge, Maria A. Pires, Sara Rocha, Luís Figueira, Ana C. Matos, João Silva, Paula Mendonça, Paulo Carvalho, Paula Tavares, Carla Lima, Anabela Alves, Alexandra Esteves, Maria L. Pinto, Isabel Pires, Adelina Gama, Roberto Sargo, Filipe Silva, Fernanda Seixas, Madalena Vieira-Pinto, Estela Bastos

“…Three single nucleotide polymorphisms (SNPs) were found in red deer – codon A136A, codon T98A, codon Q226E – and no sequence variation was detected in fallow deer. …”
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Detection of variant of hepatitis B virus and beta-globin through DNA technology by Chia, Chee Poh.

“…Three PCR-based methods were employed to detect the HBV precore stop codon mutant. They are RG-PCR, SSCP analysis and non-radioactive direct DNA cycle sequencing.…”
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The First Mitogenomes of the Subfamily Odontiinae (Lepidoptera, Crambidae) and Phylogenetic Analysis of Pyraloidea by Mujie Qi, Huifeng Zhao, Fang Yu, Aibing Zhang, Houhun Li

“…Most PCGs are initiated with an ATN codon and terminated by a codon of TAR. All tRNAs could be folded into the clover-leaf structure with the exception of trnS1 (AGN), in which the dihydrouridine (DHU) arm formed a simple loop, and the motif ‘ATAG’ and ‘ATTTA’ in the A + T-rich region was also founded. …”
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Technical Data of Heterologous Expression and Purification of SARS-CoV-2 Proteases Using <i>Escherichia coli</i> System by Rafida Razali, Vijay Kumar Subbiah, Cahyo Budiman

“…Meanwhile, PLpro-CoV2 was successfully expressed in a fully soluble form in either BL21(DE3) or BL21-CodonPlus(DE3) strains. In contrast, the single affinity chromatography step was only applicable for PLpro-CoV2 expressed using <i>E. coli</i> BL21-CodonPlus(DE3) at 18 or 37 °C, with a yield and purification fold of 86% (18 °C) or 83.36% (37 °C) and 112 (18 °C) or 71 (37 °C), respectively. …”
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A novel autism-associated UBLCP1 mutation impacts proteasome regulation/activity by Jihane Soueid, Zeinab Hamze, Joe Bedran, Maria Chahrour, Rose-Mary Boustany

“…The deletion in UBLCP1 exon 10 (g.158,710,261CAAAG > C) generates a premature stop codon interrupting the phosphatase domain and is predicted as pathogenic. …”
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The Characterization and Phylogenetic Implications of the Mitochondrial Genomes of <i>Antheminia varicornis</i> and <i>Carpocoris purpureipennis</i> (Hemiptera: Pentatomidae) by Ying Wang, Ruijuan Yang, Xiuxiu Zhu, Chenguang Zheng, Wenjun Bu

“…Nucleotide composition is highly biased with the third codon in PCGs displaying the highest A + T content. …”
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Understanding protein diffusion on force-induced stretched DNA conformation by Anupam Mondal, Arnab Bhattacherjee

“…The functional role of such a DNA base triplet was hypothesized to be coupled with the ease of recognition of DNA bases by DNA-binding proteins (DBPs) and the physical origin of three letters (codon/anti-codon) in the genetic code. However, the underlying mechanism of base-triplet formation and the ease of DNA base-pair recognition by DBPs remain elusive. …”
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Two New Variants in FYCO1 Are Responsible for Autosomal Recessive Congenital Cataract in Iranian Population by Ebrahim Shirzadeh, Fahimeh Piryaei, Hanieh Naddaf, Zahra Barabadi

“…Apreviously reported missense mutation, c.265C>T (p.Arg89Cys), was found in one Iranian family for the first time,and a combination of two variants in a single codon, c.[265C>T;267C>A] (p.Arg89X), was identified in the three otherfamilies. …”
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Bioinformatical Study and Evaluation of Expression of Cholera Toxin Subunit B Optimized Gene as a Vaccine Candidate by Shahram Nazarian, Mohhamad Ali Arefpour, Mohhamd Javad Bagheripour, Golamreza Olad

“…Percentage of codon having high-frequency distribution was improved to 67%. …”
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Comparison of chloroplast genomes and phylogenomics in the Ficus sarmentosa complex (Moraceae). by Zhen Zhang, De-Shun Zhang, Lu Zou, Chi-Yuan Yao

“…The number of simple sequence repeat (SSR) loci varied from 175 (F. dinganensis and F. howii) to 190 (F. polynervis), with the dinucleotide motif appearing the most frequently. Relative synonymous codon usage (RSCU) analysis indicated that codons ending with A/T were prior to those ending with C/T. …”
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Variability in prion protein genotypes by spatial unit to inform susceptibility to chronic wasting disease by Alberto F. Fameli, Jessie Edson, Jeremiah E. Banfield, Christopher S. Rosenberry, W. David Walter

“…We sequenced the prion protein gene (PRNP) of 565 elk samples collected over 7 years (2014–2020) and found two polymorphic sites (codon 21 and codon 132). The allele associated with reduced susceptibility to CWD is present in the population, and there was no evidence of deviations from Hardy-Weinberg equilibrium in any of our sampling years (p-values between 0.14 and 1), consistent with the lack of selective pressure on the PRNP. …”
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Design of Adenovirus 5 Vector with Adenovirus 26 Hexon Hypervariable Region Sequence using In Silico Approach by Afina Firdaus Syuaib, Ernawati Arifin Giri-Rachman, Aluicia Anita Artarini

“…The splice site prediction of Ad5HVR26 chimera vector was found at HVR5, 6, and 7. The codon change in the splice site was performed to decrease the possibility of incorrect splicing, while retaining the original amino acid sequence. …”
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Bacteriophage Infection of the Marine Bacterium <i>Shewanella glacialimarina</i> Induces Dynamic Changes in tRNA Modifications by Mirka Lampi, Pavlina Gregorova, M. Suleman Qasim, Niklas C. V. Ahlblad, L. Peter Sarin

“…Furthermore, we observe a preference for the UAC codon in viral transcripts expressed at the late stage of infection, which coincides with an increase in queuosine modification. …”
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Antimicrobial resistance of Mycobacterium tuberculosis clinical isolates from patients with tuberculous spondylitis by Lavrenchuk L.S., Minogina T.V., Vakhrusheva D.V., Skornyakov S.N.

“…For rifampicin and isoniazid, the dominant mutations associated with resistance were: serine replacement for leucine in the 531 codon of the rpoB gene for rifampicin and serine replacement for threonine in the 315 codon of the katG gene for isoniazid. …”
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Assessing Mutations in Treatment Response-related Genes in Egyptian Patients with Non-small Cell Lung Cancer by Anan Omar, Abeer Bahnassy, Rabab Gaafer, Eman El Desouky, Amina Mohamed Medhat

“…EGFR mutations were detected in 22.3% (12.2% in exon 19, 8.6% in exon 21, and 1.4% in exon 18) and K-RAS mutations in 17.3% (15.8% in codon 12 and 1.4% in codon 13), whereas combined mutations were detected in nine patients (6.5%). …”
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Mitochondrial genome features and systematic evolution of diospyros kaki thunb 'Taishuu' by Yunliang Yang, Chao Duan

“…There are four types of stop codons: CGA, TAA, TAG, and TGA, with TAA being the most frequently used stop codon (45.24%). …”
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The complete mitochondrial genome of Gobio huanghensis (Cypriniformes: Cyprinidae) in the Yellow River, China by Yanyan Du, Zijun Su, Zhuoyu Yang, Yanping Zhang, Zhongyu Lou, Shunwen Yang, Tai Wang

“…Notably, COX1 initiates with the start codon GTG, distinct from the typical ATG start codon of other PCGs. …”
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Whole-Genome Sequencing of Rice Mutant Library Members Induced by N-Methyl-N-Nitrosourea Mutagenesis of Fertilized Egg Cells by Takahiko Kubo, Yoshiyuki Yamagata, Hiroaki Matsusaka, Atsushi Toyoda, Yutaka Sato, Toshihiro Kumamaru

“…Although this mutant library was a small population, nonsynonymous mutations were found in nearly 61% of all annotated rice genes, and 8.6% (3248 genes) had point mutations with large effects on gene function, such as gaining a stop codon or losing a start codon. WGS showed MNU-mutagenesis using rice fertilized egg cells induces mutations efficiently and is suitable for constructing mutant libraries for an in silico mutant screening system. …”
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