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1541
Spontaneous Mutations in HIV-1 Gag, Protease, RT p66 in the First Replication Cycle and How They Appear: Insights from an In Vitro Assay on Mutation Rates and Types
Published 2020-12-01“…Mutational free energies of the ‘A to G’ mutations revealed an avoidance of destabilizing effects, with the natural p66 gene codon usage providing barriers to disruptive amino acid changes. …”
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1542
Improving Expression of Pepsinogen A from <i>Homo sapiens</i> in <i>Aspergillus niger</i> by Using a Multi-Copy Gene Knock-in Strategy
Published 2023-05-01“…The <i>hPGA5</i> gene codon was optimized according to the codon bias of <i>A. niger</i> and then connected to a strong promoter and signal peptide to construct an <i>hPGA5</i> expression cassette. …”
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1543
The complete chloroplast genome of Hibiscus syriacus using long-read sequencing: Comparative analysis to examine the evolution of the tribe Hibisceae
Published 2023-02-01“…Among them, ndhD and rpoC1, containing traces of RNA-editing events associated with adaptive evolution, were identified by analysis of putative RNA-editing sites. Codon usage analysis revealed a preference for A/U-terminated codons. …”
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1544
MicroRNAs control mRNA fate by compartmentalization based on 3′ UTR length in male germ cells
Published 2017-06-01“…Result Among all small noncoding RNAs studied, miRNAs displayed the most dynamic changes in both abundance and subcytoplasmic localization. mRNAs with shorter 3′ UTRs became increasingly enriched in RNPs from pachytene spermatocytes to round spermatids, and the enrichment of shorter 3′ UTR mRNAs in RNPs coincided with newly synthesized miRNAs that target these mRNAs at sites closer to the stop codon. In contrast, the translocation of longer 3′ UTR mRNAs from RNPs to polysomes correlated with the production of new miRNAs that target these mRNAs at sites distal to the stop codon. …”
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1545
Case Report: β-thalassemia major on the East African coast [version 1; peer review: 2 approved]
Published 2022-07-01“…One of the mutations identified was a rare β-globin gene initiation codon mutation (ATG➝ACG) (rs33941849). Here we present a patient with β-thalassemia major resulting from this mutation, only the second homozygous patient to have been reported. …”
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1546
Structural organization and sequence diversity of the complete nucleotide sequence encoding the Plasmodium malariae merozoite surface protein-1
Published 2022-09-01“…The rate of nonsynonymous nucleotide substitutions significantly exceeded that of synonymous nucleotide substitutions in block IV, suggesting positive selection in this region. Codon-based analysis of deviation from neutrality has identified a codon under purifying selection located in close proximity to the homologous region of the 38 kDa/42 kDa cleavage site of P. falciparum MSP1. …”
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1547
Resistance to thyroid hormone due to a novel mutation in the thyroid beta receptor (THRβ) gene coexisting with autoimmune thyroid disease—A case report
Published 2023-04-01“…The mutation has not been described in the literature yet; however, THRβ codon 453 represents a mutational hot spot, frequently altered in the TH receptor ß gene. …”
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1548
Conserved Double Translation Initiation Site for Δ160p53 Protein Hints at Isoform’s Key Role in Mammalian Physiology
Published 2022-12-01“…Here, we identified a translation initiation site nine codons downstream of codon 160—the known initiation codon for the translation of Δ160p53—that is recognized by the translation machinery. …”
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1549
Patterns of Genetic Diversity among Alphasatellites Infecting <i>Gossypium</i> Species
Published 2022-07-01“…However, unlike other begomoviruses and satellites, the first codon position of alpha-Rep rapidly changed compared to the second and third codon positions. …”
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1550
Association of P53 (+16ins-Arg) Haplotype with the Increased Susceptibility to Breast Cancer in Iranian-Azeri Women
Published 2018-01-01“…Results: Our findings did not show a significant association of P53 intron 3 and codon 72 polymorphisms with the risk of breast neoplastic tumors among Iranian-Azeri women. …”
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1551
Novel Polymorphisms and Genetic Features of the Prion Protein Gene (<i>PRNP</i>) in Cats, Hosts of Feline Spongiform Encephalopathy
Published 2020-12-01“…In addition, asparagine at codon 166 of cat PrP was predicted to have longer hydrogen bond than aspartic acid at codon 163 of canine PrP. …”
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1552
A Listeria monocytogenes ST2 clone lacking chitinase ChiB from an outbreak of non-invasive gastroenteritis
Published 2019-01-01“…A comparative genomic approach identified a premature stop codon in the chiB gene, encoding one of the two L. monocytogenes chitinases, which clustered with disease outcome. …”
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1553
Caracterização de Mutações no Gene BRCA1 em Pacientes com Câncer de Mama e ou Ovário Hereditários do Instituto Nacional de Câncer-RJ
Published 2004-03-01“…Sete mutações (15%) foram encontradas em BRCA1 entre os 47 pacientes incluídos na investigação: uma idêntica inserção (insC 5382) foi encontrada no éxon 20 de quatro pacientes, uma deleção de quatro pares de bases (3450 del4 CAAG) no éxon 11, resultando em um códon de parada, no quinto paciente; uma transição (T>C IVS 17+2) no íntron 17, afetando o sítio de processamento do ARNm no sexto paciente; e uma transição C>T resultante em um códon de parada (Q1135X) no éxon 11 do sétimo paciente. …”
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1554
Gain of function in somatic TP53 mutations is associated with immune‐rich breast tumors and changes in tumor‐associated macrophages
Published 2019-12-01“…Results Within TP53‐mutated samples, a mutation at codon p.R175H was shown to be present at higher frequency in immune‐rich tumors. …”
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1555
Monoallelic variants resulting in substitutions of MAB21L1 Arg51 Cause Aniridia and microphthalmia.
Published 2022-01-01“…Substitutions of the same codon (Arg51) in MAB21L2, a close homolog of MAB21L1, cause severe ocular and skeletal malformations in humans and mice. …”
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1556
<i>Microbacterium</i> Cluster EA Bacteriophages: Phylogenomic Relationships and Host Range Predictions
Published 2023-01-01“…Interestingly, bacteriophages of all sub-clusters exhibit codon usage preference patterns that resemble those of bacterial strains different from ones used for isolation, suggesting that they might be able to infect additional hosts. …”
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1557
Prevalence and mutations of β-thalassemia trait and abnormal hemoglobins in premarital screening in Çanakkale province, Turkey
Published 2016-06-01“…These mutations were found to be HBB: c.93-21G>A [IVS-I-110 (G>A)], 26.08% (12/46); HBB: c.17_ 18delCT [codon 5 (‒CT)], 10.85% (5/46); HBB: c.20delA [codon 6 (‒A)] 8.69% (4/46). …”
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1558
Complete Mitogenome Analysis of Five Leafhopper Species of Idiocerini (Hemiptera: Cicadellidae)
Published 2022-11-01“…The less pronounced genes (0.5 < dN/dS < 1) were <i>nad5</i> and <i>nad4l</i> in Idiocerin, whereas in the family Cicadellidae including the sequences of Idiocerin, <i>nad1</i>-<i>nad6</i> and <i>cox1</i> genes were less pronounced. The codon encoding leucine was the most common in all species, and the codon encoding serine 1 was the most common in all species except for <i>P. opacus</i>. …”
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1559
Expression and enzymatic activity analysis of non-structure protein 14 of SARS-CoV-2
Published 2023-01-01“…Methods This study firstly analyzed the rare codons in the gene of nsp14 according to the codon usage bias of E. coli, followed by codon optimization. …”
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1560
Characterization and phylogenetic implications of newly sequenced mitogenomes of Five Mileewa and Processina species from China (Hemiptera: Cicadellidae: Mileewinae)
Published 2022-12-01“…For protein-coding genes (PCGs), ATN was the start codon, while atp8 and nad5 genes were initiated with TTG, and a great majority of them used TAA or TAG as stop codons, whereas cox2 and nad1 ended with an incomplete codon T–. …”
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