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New mutation of the TP53 gene associated with the hereditary breast cancer in a young Tuvinian woman
Published 2022-01-01“…In accordance with proteinpaint tool, the lrg_321t1: c.80c>t mutation is located in functionally specialized transactivation domains and codon of the tp53 gene, where the pathogenic mutation associated with li-Fraumeni syndrome has been earlier described. …”
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1763
Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events
Published 2023-02-01“…We show that depletion of Not1 and Not4 inversely impacts mRNA solubilities and, for soluble mRNAs, ribosome dwelling according to codon optimality. Depletion of Not4 solubilizes mRNAs with lower non-optimal codon content and higher expression that are rendered insoluble by Not1 depletion. …”
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1764
Decoding the complete organelle genomic architecture of Stewartia gemmata: an early-diverging species in Theaceae
Published 2024-01-01“…In organelle genomes, the protein-coding genes exhibited a strong A/U bias at codon endings; ENC-GC3 analysis implies selection-driven codon bias. …”
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Complete mitochondrial genome of the endangered Prunus pedunculata (Prunoideae, Rosaceae) in China: characterization and phylogenetic analysis
Published 2023-12-01“…The most frequently used codon was UUU (Phe), with a relative synonymous codon usage (RSCU) value of 1.12. …”
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1766
On origin of genetic code and tRNA before translation
Published 2011-02-01“…Formally, the concomitant presence of codons and anticodons is also expected in the reverse situation, with codons containing palindrome-dinucleotides at their 2-3 positions, and anticodons exhibiting them at 1-2 positions. …”
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Characterization of <i>Angraecum</i> (Angraecinae, Orchidaceae) Plastomes and Utility of Sequence Variability Hotspots
Published 2023-12-01“…A total of 30 to 46 long repeats and 55 to 63 SSRs were identified. Relative synonymous codon usage (RSCU) analysis indicated a high degree of conservation in codon usage bias. …”
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A systematic optimization of styrene biosynthesis in Escherichia coli BL21(DE3)
Published 2018-01-01“…Systematic optimization of styrene biosynthesis, such as enzyme screening, codon and plasmid optimization, metabolic flow balance, and in situ fermentation was performed. …”
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Genome-Wide Identification and Characterization of <i>DnaJ</i> Gene Family in Grape (<i>Vitis vinifera</i> L.)
Published 2021-12-01“…Gene duplication analysis demonstrated that segmental and tandem duplication may not be the dominant pathway of gene expansion in the <i>VvDnaJ</i> gene family. Codon usage pattern analysis showed that the codon usage pattern of <i>VvDnaJs</i> differs obviously from the monocotyledon counterparts. …”
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Rapid Screening and Comparison of Chimeric Lysins for Antibacterial Activity against <i>Staphylococcus aureus</i> Strains
Published 2023-03-01“…ALS2 expressed in <i>E. coli</i> showed two major bands, and the smaller one (subprotein) was shown to be expressed by an innate downstream promoter and start codon (ATG). The introduction of synonymous mutations in the promoter resulted in clearly reduced expression of the subprotein, whereas missense mutations in the start codon abolished antibacterial activity as well as subprotein production. …”
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Analysis of cell-free DNA concentration, fragmentation patterns and TP53 gene expression in mammary tumor-bearing dogs: A pilot study
Published 2023-03-01“…In addition, although no detection of the point mutation in codon 245 of TP53 gene could be detected neither in plasma nor tumor tissue, an increased TP53 expression was detected in animals with tumors bearing malignant characteristics. …”
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Profiling of Transcriptome-Wide N6-Methyladenosine (m6A) Modifications and Identifying m6A Associated Regulation in Sperm Tail Formation in <i>Anopheles sinensis</i>
Published 2022-04-01“…Distinct from mammals and yeast but similar to <i>Arabidopsis thaliana</i>, m6A in <i>An. sinensis</i> is enriched not only around the stop codon and within 3′-untranslated regions but also around the start codon and 5′-UTR. …”
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Enhanced Biosynthesis of 2-Deoxy-scyllo-inosose in Metabolically Engineered Bacillus subtilis Recombinants
Published 2018-09-01“…After that, three different DOI synthase–encoding genes, which were artificially synthesized according to the codon preference of the B. subtilis host, were separately introduced into the engineered recombinants. …”
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<i>YPK9</i> and <i>WHI2</i> Negatively Interact during Oxidative Stress
Published 2021-12-01“…Together, these results demonstrate a novel premature stop codon in <i>WHI2</i> that renders yeast sensitive to hydrogen peroxide; they also reveal a negative genetic interaction between <i>WHI2</i> and <i>YPK9</i> in the presence of hydrogen peroxide in the BY4741 background.…”
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<i>yaaJ</i>, the tRNA-Specific Adenosine Deaminase, Is Dispensable in <i>Bacillus subtilis</i>
Published 2023-07-01“…A β−galactosidase reporter assay revealed that the translational activity of CGN codons was not impaired in the <i>yaaJ</i>-deletion mutant. …”
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Werewolf, There Wolf: Variants in <i>Hairless</i> Associated with Hypotrichia and Roaning in the Lykoi Cat Breed
Published 2020-06-01“…The lykoi cat was a compound heterozygote for two loss of function variants in <i>HR</i>, an exon 3 c.1255_1256dupGT (chrB1:36040783), which should produce a stop codon at amino acid 420 (p.Gln420Serfs*100) and, an exon 18 c.3389insGACA (chrB1:36051555), which should produce a stop codon at amino acid position 1130 (p.Ser1130Argfs*29). …”
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Investigation of Isocitrate Dehydrogenase 1 and 2 Mutations in Acute Leukemia Patients in Saudi Arabia
Published 2021-12-01“…Mutations in IDH1 were detected in 7 out of 43 (16.2%) AML patients; 5 of them occurred at codon R132. The other two mutations included a single-nucleotide polymorphism, which affected codon G105 in one patient. …”
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Mitogenomic Characterization and Phylogenetic Placement of African Hind, <i>Cephalopholis taeniops</i>: Shedding Light on the Evolution of Groupers (Serranidae: Epinephelinae)
Published 2024-02-01“…The relative synonymous codon usage analysis revealed the maximum abundance of leucine, proline, serine, and threonine. …”
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Structural Features and Phylogenetic Implications of Crinoid Echinoderms Based on Thirteen Novel Mitochondrial Genomes
Published 2024-02-01“…Additionally, our analysis of protein-coding genes highlights a preference for A + T nucleotides, along with specific start and stop codon usage, offering insights into codon bias and its implications for protein synthesis and function. …”
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Isopropanol production with engineered Cupriavidus necator as bioproduction platform
Published 2016“…These synthetic production pathways were rationally designed through codon optimization, gene placement, and gene dosage in order to efficiently divert carbon flow from P(3HB) precursors toward isopropanol. …”
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