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Relative synonymous codon usage and codon pair analysis of depression associated genes
Published 2024-02-01“…Information based on codon usage, preferred codons, rare, and codon context might be used in constructing a deliverable synthetic construct to correct the gene expression level of the human body, which is altered in the depressive state. …”
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Extended stop codon context predicts nonsense codon readthrough efficiency in human cells
Published 2024-03-01“…Abstract Protein synthesis terminates when a stop codon enters the ribosome’s A-site. Although termination is efficient, stop codon readthrough can occur when a near-cognate tRNA outcompetes release factors during decoding. …”
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Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides
Published 2020-01-01Subjects: Get full text
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Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli
Published 2017“…The degeneracy of the genetic code allows nucleic acids to encode amino acid identity as well as noncoding information for gene regulation and genome maintenance. The rare arginine codons AGA and AGG (AGR) present a case study in codon choice, with AGRs encoding important transcriptional and translational properties distinct from the other synonymous alternatives (CGN). …”
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Codon Usage Bias in Phytoplankton
Published 2022-01-01Subjects: “…codon usage bias…”
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The imprint of codons on protein structure.
Published 2011“…Here, past and present research regarding synonymous codons and codon translation speed are reviewed within the context of protein structure attainment.…”
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Codon usage bias in phytoplankton
Published 2022“…Non-random usage of synonymous codons, known as “codon bias”, has been described in many organisms, from bacteria to Drosophila, but little is known about it in phytoplankton. …”
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Codon-specific Ramachandran plots show amino acid backbone conformation depends on identity of the translated codon
Published 2022-05-01“…This study uncovers a dependence between local amino acid conformation in folded proteins and the identity of the codon from which that amino acid was translated.…”
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Stop codons in bacteria are not selectively equivalent
Published 2012-09-01“…<p>Abstract</p> <p>Background</p> <p>The evolution and genomic stop codon frequencies have not been rigorously studied with the exception of coding of non-canonical amino acids. …”
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Genome landscapes and bacteriophage codon usage.
Published 2008-02-01“…Across all kingdoms of biological life, protein-coding genes exhibit unequal usage of synonymous codons. Although alternative theories abound, translational selection has been accepted as an important mechanism that shapes the patterns of codon usage in prokaryotes and simple eukaryotes. …”
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Trypanosomatidae codon usage and GC distribution
Published 1992-12-01Subjects: Get full text
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Evolution of codon usage bias in diatoms
Published 2019“…Codon usage bias (CUB)—preferential use of one of the synonymous codons, has been described in a wide range of organisms from bacteria to mammals, but it has not yet been studied in marine phytoplankton. …”
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Heterogeneity in codon usages of sobemovirus genes.
Published 2005“…Most interestingly, the codon usages of the viral ORF-2 that encodes the replicase showed affinity to that of the plants whereas codon usages of the other viral ORFs were not relevant to the host species. …”
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An Evolutionary Perspective of Codon Usage Pattern, Dinucleotide Composition and Codon Pair Bias in Prunus Necrotic Ringspot Virus
Published 2023-08-01Subjects: Get full text
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Calculating and comparing codon usage values in rare disease genes highlights codon clustering with disease-and tissue- specific hierarchy.
Published 2022-01-01“…We designed a novel strategy to define codon usage bias (CUB) in 6 specific small cohorts of human genes. …”
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Amino acid repeats avert mRNA folding through conservative substitutions and synonymous codons, regardless of codon bias
Published 2017-12-01“…A close examination of their codon pattern and analysis of RNA structure propensity led to the following set of empirical rules: (1) One class of amino acid repeats (Class I) uses a mixture of synonymous codons, some of which approximate the codon bias ratio in the overall human proteome; (2) The second class (Class II) disregards the codon bias ratio, and appears to have originated by simple repetition of the same codon (or just a few codons); and finally, (3) In all AARs (including Class I, Class II, and the in-betweens), the codons are chosen in a manner that precludes the formation of RNA secondary structure. …”
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On the origin of the genetic code: a 27-codon hypothetical precursor of an intricate 64-codon intermediate shaped the modern code
Published 2021-04-01Subjects: Get full text
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Gene- and genome-based analysis of significant codon patterns in yeast, rat and mice genomes with the CUT Codon UTilization tool
Published 2018“…There are 64 possible codons in the genetic code, with codons for the ∼20 amino acids and 3 stop codons having 1- to 6-fold degeneracy. …”
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