Diffusion tensor imaging of periventricular leukomalacia – Initial experience by Eman M. Abdelsalam, Mohamed Gomaa, Lamiaa Elsorougy

“…This is owing to the capability of fiber-tracking techniques to provide more information for understanding the pathophysiologic features of sensorimotor and cognitive disability associated with PVL. This will allow for the early intervention and initiation of rehabilitation programs aiming for minimizing the associated neurological deficit.…”
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Polarization of Microglia and Its Therapeutic Potential in Sepsis by Léo Victor G. Castro, Cassiano F. Gonçalves-de-Albuquerque, Adriana R. Silva

“…Sepsis-associated encephalopathy (SAE) is the most frequent sepsis-associated organ dysfunction, with symptoms such as deliriums, seizures, and coma, linked to increased mortality, morbidity, and cognitive disability. However, the current therapy does not avoid those patients’ symptoms, evidencing the search for a more optimal approach. …”
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Meta-Analysis of Down Syndrome Cortical Development Reveals Underdeveloped State of the Science by Kirstin A. Risgaard, Isabella A. Sorci, Sruti Mohan, Anita Bhattacharyya, Anita Bhattacharyya

“…Neurodevelopmental impairment contributes to the hallmark cognitive disability in individuals with Down syndrome (DS, trisomy 21, T21). …”
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Immature Responses to GABA in Fragile X Neurons Derived from Human Embryonic Stem Cells by Michael eTelias, Michael eTelias, Michael eTelias, Menahem eSegal, Dalit eBen-Yosef, Dalit eBen-Yosef

“…Fragile X Syndrome (FXS) is the most common form of inherited cognitive disability. However, functional deficiencies in FX neurons have been described so far almost exclusively in animal models. …”
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Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. by Goldstein, L, Fisher, A, Tagge, C, Zhang, X, Velisek, L, Sullivan, J, Upreti, C, Kracht, J, Ericsson, M, Wojnarowicz, M, Goletiani, C, Maglakelidze, G, Casey, N, Moncaster, J, Minaeva, O, Moir, R, Nowinski, C, Stern, R, Cantu, R, Geiling, J, Blusztajn, J, Wolozin, B, Ikezu, T, Stein, T, Budson, A

“…Blast exposure is associated with traumatic brain injury (TBI), neuropsychiatric symptoms, and long-term cognitive disability. We examined a case series of postmortem brains from U.S. military veterans exposed to blast and/or concussive injury. …”

Interplay Between Cognitive and Bowel/Bladder Function in Multiple Sclerosis by Antonio Carotenuto, Teresa Costabile, Marcello Moccia, Fabrizia Falco, Maria Petracca, Barbara Satelliti, Cinzia Valeria Russo, Francesco Saccà, Roberta Lanzillo, Vincenzo Brescia Morra

“…Conclusions Bowel/bladder disorders are common in MS and are associated with both physical and cognitive disability burdens. As SDMT is embedded into routine clinical assessments, a lower score may warrant investigating bowel/bladder dysfunction due to the strong interplay of these factors.…”
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Impact of a Histone Deacetylase Inhibitor—Trichostatin A on Neurogenesis after Hypoxia-Ischemia in Immature Rats by Teresa Zalewska, Joanna Jaworska, Joanna Sypecka, Malgorzata Ziemka-Nalecz

“…Hypoxia-ischemia (HI) in the neonatal brain frequently results in neurologic impairments, including cognitive disability. Unfortunately, there are currently no known treatment options to minimize ischemia-induced neural damage. …”
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Effect of teriflunomide on cortex-basal ganglia-thalamus (CxBGTh) circuit glutamatergic dysregulation in the Theiler's Murine Encephalomyelitis Virus mouse model of multiple sclero... by Claire M Modica, Ferdinand Schweser, Michelle L Sudyn, Nicola Bertolino, Marilena Preda, Paul Polak, Danielle M Siebert, Jacqueline C Krawiecki, Michele Sveinsson, Jesper Hagemeier, Michael G Dwyer, Suyog Pol, Robert Zivadinov

“…Pathology of gray matter is associated with development of physical and cognitive disability in patients with multiple sclerosis. …”
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Computational Drug Repurposing Algorithm Targeting TRPA1 Calcium Channel as a Potential Therapeutic Solution for Multiple Sclerosis by Dragos Paul Mihai, George Mihai Nitulescu, George Nicolae Daniel Ion, Cosmin Ionut Ciotu, Cornel Chirita, Simona Negres

“…Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS) through neurodegeneration and demyelination, leading to physical/cognitive disability and neurological defects. A viable target for treating MS appears to be the Transient Receptor Potential Ankyrin 1 (TRPA1) calcium channel, whose inhibition has been shown to have beneficial effects on neuroglial cells and protect against demyelination. …”
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PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia. by Kristy R Howell, Kirsten Floyd, Amanda J Law

“…Here, we investigated the role of AKT3 as it relates to aspects of learning and memory and behavioral function, relevant to schizophrenia and cognitive disability, utilizing a novel murine model of Akt3 genetic deficiency. …”
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Very mild isolated intellectual disability caused by adenylosuccinate lyase deficiency: a new phenotype by Marina Macchiaiolo, Paola Sabrina Buonuomo, Gerarda Mastrogiorgio, Matteo Bordi, Beatrice Testa, Gerrit Weber, Emanuele Bellacchio, Marco Tartaglia, Francesco Cecconi, Andrea Bartuli

“…Adenylosuccinate lyase deficiency is a rare neurometabolic recessive disorder of purine metabolism characterized by a wide range of clinical manifestations.We present a very mild phenotype of two siblings characterized by mild isolated cognitive disability, in absence of brain anomalies, seizures, EEG anomalies and without progression of disease. …”
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Fatigue, pain interference, and psychiatric morbidity in multiple sclerosis: The role of childhood stress. by Carri S Polick, Robert Ploutz-Snyder, Tiffany J Braley, Cathleen M Connell, Sarah A Stoddard

“…Despite the existence of immunomodulatory therapies to slow physical and cognitive disability progression, interventions to ameliorate common symptoms of MS, including fatigue and pain, remain limited. …”
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Relationship between non-communicable diseases and background characteristics among homeless people in Nagoya City, Japan. by Akihiro Nishio, Ryo Horita, Tadahiro Sado, Takahiro Watanabe, Ryosuke Uehara, Seiko Mizutani, Mayumi Yamamoto

“…Fisher's exact test was performed to compare between subgroups (by participants' socio-demographic data or the presence of mental illness/cognitive disability) according to non-communicable disease test values, and to calculate the odds ratio.…”
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Biomarker-guided neuromodulation aids memory in traumatic brain injury by Michael J. Kahana, Youssef Ezzyat, Paul A. Wanda, Ethan A. Solomon, Richard Adamovich-Zeitlin, Bradley C. Lega, Barbara C. Jobst, Robert E. Gross, Kan Ding, Ramon R. Diaz-Arrastia

“…Traumatic brain injury (TBI) is a leading cause of cognitive disability in adults, often characterized by marked deficits in episodic memory and executive function. …”
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The trisomy 18 syndrome by Cereda Anna, Carey John C

“…The recognizable syndrome pattern consists of major and minor anomalies, prenatal and postnatal growth deficiency, an increased risk of neonatal and infant mortality, and marked psychomotor and cognitive disability. Typical minor anomalies include characteristic craniofacial features, clenched fist with overriding fingers, small fingernails, underdeveloped thumbs, and short sternum. …”
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Web Page Design Recommendations for People with Down Syndrome Based on Users’ Experiences by Lucía Alonso-Virgós, Luís Rodríguez Baena, Jordán Pascual Espada, Rubén González Crespo

“…Many of these alterations are caused by cognitive disability. After assessing the needs, the benefits of Web Content Accessibility Guidelines 2.0 (WCAG 2.0), and the existing usability guidelines are analyzed and those that may be useful for this profile are extracted. …”
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Neocortical and cerebellar malformations affect flurothyl-induced seizures in female C57BL/6J mice by Katherine M. Keever, Ying Li, Paige D. Womble, D. Gregory Sullens, Gonzalo H. Otazu, Joaquin N. Lugo, Raddy L. Ramos

“…Brain malformations cause cognitive disability and seizures in both human and animal models. …”
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Effect of edible bird’s nest extract on lipopolysaccharide-induced impairment of learning and memory in Wistar rats by Shobana, Careena, Sani, Dahiru, Tan, Sin Nee, Lim, Chee Woei, Hasan, Shariful, Mohtarrudin, Norhafizah, Kirby, Brian P., Ideris, Aini, Stanslas, Johnson, Basri, Hamidon, Lim, Christopher Thiam Seong

“…Cognitive disability is a common feature associated with a variety of neurological conditions including Alzheimer’s Disease (AD), Parkinson’s Disease (PD), brain injury, and stroke. …”
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Ten-year follow-up of a randomised trial of drainage, irrigation and fibrinolytic therapy (DRIFT) in infants with post-haemorrhagic ventricular dilatation by Karen Luyt, Sally Jary, Charlotte Lea, Grace J Young, David Odd, Helen Miller, Grazyna Kmita, Cathy Williams, Peter S Blair, Aída Moure Fernández, William Hollingworth, Michelle Morgan, Adam Smith-Collins, N Jade Thai, Steven Walker-Cox, Kristian Aquilina, Ian Pople, Andrew Whitelaw

“…The binary outcome, alive without severe cognitive disability, gave strong evidence that DRIFT improved cognition [unadjusted odds ratio (OR) 3.6 (95% CI 1.2 to 11.0; p = 0.026) and adjusted OR 10.0 (95% CI 2.1 to 46.7; p = 0.004)]; the number needed to treat was three. …”
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An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder by Manjot S. Virdee, Nipun Saini, Colin D. Kay, Andrew P. Neilson, Sze Ting Cecilia Kwan, Kaylee K. Helfrich, Sandra M. Mooney, Susan M. Smith

“…Abstract Prenatal alcohol exposure (PAE) causes permanent cognitive disability. The enteric microbiome generates microbial-dependent products (MDPs) that may contribute to disorders including autism, depression, and anxiety; it is unknown whether similar alterations occur in PAE. …”
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