Family origin and mortality: prospective Finnish cohort study by Finnäs Fjalar, Saarela Jan

“…</p> <p>Methods</p> <p>Using intergenerational data, we studied the impact of parental birth area on all-cause mortality risks of middle-aged men in Finland 1985-2003, assuming that geographic family origin reflects genetic predisposition to complex disorders. Relative death risks at ages 30-49 years were estimated by parental birth region and ethnicity, according to Cox regressions standardised for own education, family type at childhood, and year of birth.…”
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Genome-wide analysis of runs of homozygosity in Pakistani controls with no history of speech or language-related developmental phenotypes by Tahira Yasmin, Erin M. Andres, Komal Ashraf, Muhammad Asim Raza Basra, Muhammad Hashim Raza

“…Background Runs of homozygosity (ROHs) analysis of controls provide a convenient resource to minimize the association of false positive results of disease-associated ROHs and genetic variants for simple and complex disorders in individuals from the same population. …”
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Meta-analysis of repository data: impact of data regularization on NIMH schizophrenia linkage results. by Kimberly A Walters, Yungui Huang, Marco Azaro, Kathleen Tobin, Thomas Lehner, Linda M Brzustowicz, Veronica J Vieland

“…Human geneticists are increasingly turning to study designs based on very large sample sizes to overcome difficulties in studying complex disorders. This in turn almost always requires multi-site data collection and processing of data through centralized repositories. …”
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Dosage transmission disequilibrium test (dTDT) for linkage and association detection. by Zhehao Zhang, Jen-Chyong Wang, William Howells, Peng Lin, Arpana Agrawal, Howard J Edenberg, Jay A Tischfield, Marc A Schuckit, Laura J Bierut, Alison Goate, John P Rice

“…As one of the traditional family-based studies, the Transmission/Disequilibrium Test (TDT) measures the over-transmission of an allele in a trio from its heterozygous parents to the affected offspring and can be potentially useful to identify genetic determinants for complex disorders. However, there is reduced information when complete trio information is unavailable. …”
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Visual contrast sensitivity in patients with impairment of functional independence after stroke by dos Santos Natanael, Andrade Suellen

“…<p>Abstract</p> <p>Background</p> <p>Stroke has been considered a serious public health problem in many countries, accounting for complex disorders involving perception, such as visual, cognitive and functional deficits. …”
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Novel method for combined linkage and genome-wide association analysis finds evidence of distinct genetic architecture for two subtypes of autism. by Vieland, V, Hallmayer, J, Huang, Y, Pagnamenta, A, Pinto, D, Khan, H, Monaco, A, Paterson, A, Scherer, S, Sutcliffe, J, Szatmari, P

“…The possibility of distinct genetic architecture across subtypes of ASD has implications for further research and perhaps for research approaches to other complex disorders as well.…”

Novel method for combined linkage and genome-wide association analysis finds evidence of distinct genetic architecture for two subtypes of autism by Vieland, V, Hallmayer, J, Huang, Y, Pagnamenta, A, Pinto, D, Khan, H, Monaco, A, Paterson, A, Scherer, S, Sutcliffe, J, Szatmari, P

“…The possibility of distinct genetic architecture across subtypes of ASD has implications for further research and perhaps for research approaches to other complex disorders as well. © 2011 The Author(s).…”

Evidence for genetic basis of multiple sclerosis. The Canadian Collaborative Study Group. by Sadovnick, A, Ebers, G, Dyment, D, Risch, N

“…INTERPRETATION Besides demonstrating the power and the feasibility of using half-sib studies to throw light on the aetiology of complex disorders, our findings show that a shared environment does not account for familial risk in MS and that maternal effects (such as intrauterine and perinatal factors, breastfeeding, and genomic imprinting) have no demonstrable effect on familial risk. …”

Using Phenotypic Heterogeneity to Increase the Power of Genome-Wide Association Studies: Application to Age at Onset of Ischaemic Stroke Subphenotypes by Traylor, M, Bevan, S, Rothwell, P, Sudlow, C, Dichgans, M, Markus, H, Lewis, C

“…Genome-wide association studies (GWAS) have been successful in identifying common variants related to complex disorders. However, some disorders have proved resistant to this strategy with few associations confirmed, despite evidence from twin and family studies of a genetic component. …”

Using phenotypic heterogeneity to increase the power of genome-wide association studies: application to age at onset of ischaemic stroke subphenotypes. by Traylor, M, Bevan, S, Rothwell, P, Sudlow, C, Dichgans, M, Markus, H, Lewis, C

“…Genome-wide association studies (GWAS) have been successful in identifying common variants related to complex disorders. However, some disorders have proved resistant to this strategy with few associations confirmed, despite evidence from twin and family studies of a genetic component. …”

Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. by Noor, A, Whibley, A, Marshall, C, Gianakopoulos, P, Piton, A, Carson, A, Orlic-Milacic, M, Lionel, A, Sato, D, Pinto, D, Drmic, I, Noakes, C, Senman, L, Zhang, X, Mo, R, Gauthier, J, Crosbie, J, Pagnamenta, A, Munson, J, Estes, A, Fiebig, A, Franke, A, Schreiber, S, Stewart, A, Roberts, R

“…It is one of the most highly heritable of the complex disorders, although the underlying genetic factors remain largely unknown. …”

Prioritization of Deleterious Variations in the Human Hypoxanthine-Guanine Phosphoribosyltransferase Gene by Semira Kheiri, Mahdieh Safarzad, Mohammad Shariati, Hoda Sohrabi

“…ABSTRACT             Background and Objectives: Non-synonymous single nucleotide polymorphisms are typical genetic variations that may potentially affect the structure or function of expressed proteins, and therefore could be involved in complex disorders. A computational-based analysis has been done to evaluate the phenotypic effect of non-synonymous single nucleotide polymorphisms in the gene encoding the human hypoxanthine-guanine phosphoribosyltransferase (HGPRT-1). …”
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Case report: Development of central precocious puberty in a girl with late-diagnosed simple virilizing congenital adrenal hyperplasia complicated with Williams syndrome by Eun Young Joo, Myung Ji Yoo, Su Jin Kim, Woori Jang, Ji-Eun Lee

“…This case report delves into the pubertal change patterns in a patient affected by overlapping genetic conditions, providing valuable insights in to the intricate clinical manifestation and management of these rare complex disorders.…”
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Understanding alcoholism through microRNA signatures in brains of human alcoholics by R. Dayne eMayfield, Yury O. Nunez

“…By the same token, we can use these properties of microRNAs to develop novel, targeted strategies to combat complex disorders. In this review, we will focus on recent discoveries of microRNA signatures in brain of human alcoholics supporting the hypothesis that changes in gene expression and regulation by microRNAs are responsible for long-term neuroadaptations occurring during development of alcoholism. …”
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Blood coagulation parameters and platelet indices: changes in normal and preeclamptic pregnancies and predictive values for preeclampsia. by Lei Han, Xiaojie Liu, Hongmei Li, Jiaqun Zou, Zhiling Yang, Jian Han, Wei Huang, Lili Yu, Yingru Zheng, Li Li

“…In PE patients with different severities, MPV showed the largest AUC (0.671) and ideal predictive efficiency.Normal pregnancy causes a maternal physiological hypercoagulable state in late pregnancy. PE may trigger complex disorders in the endogenous coagulative pathways and consume platelets and FIB, subsequently activating thrombopoiesis and fibrinolysis. …”
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Central venous catheterization in patients with liver disease and coagulopathy by Behnam Sanei, Shahab Shahabi, Seyed Ali Malek-Hosseini, Saman Nikeghbalian, Ali Shamsaeifar, Farzad Kakaei, Kourosh Kazemi, Erfan Sheikhbahaei

“…Background: Patients with end-stage liver disease frequently acquired complex disorders in hemostasis secondary to liver dysfunction. …”
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Role of the endocrine disorders in pregnancy in the pathogenesis of intrauterine and postnatal developmental disorders in children: modern view within the concept of nutritional pr... by L. Ya. Klimov, R. A. Atanesyan, N. Е. Verisokina, S. V. Shanina, S. V. Dolbnya, V. A. Kuryaninova, L. S. Alaverdyan, D. V. Bobryshev

“…Due to the growth of non-infectious morbidity of the world’s child and adult population, the concept of nutritional programming connecting cardiovascular and certain endocrine diseases with the fetoplacental complex disorders in the antenatal period has been developed over the past 25 years. …”
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Using animal models for the studies of schizophrenia and depression: The value of translational models for treatment and prevention by Daniela L. Uliana, Daniela L. Uliana, Daniela L. Uliana, Xiyu Zhu, Felipe V. Gomes, Anthony A. Grace, Anthony A. Grace, Anthony A. Grace

“…We discuss why animal models of complex disorders, when strongly cross-validated by clinical research, are essential to understand disease etiology as well as pathophysiology, and direct new drug discovery. …”
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Research models of neurodevelopmental disorders: The right model in the right place by Eleni Damianidou, Lidia Mouratidou, Lidia Mouratidou, Christina Kyrousi, Christina Kyrousi

“…Additionally, we will describe the recent development of 3-dimensional brain (3D) organoids which offer a promising approach as human-specific in vitro models to decipher these complex disorders.…”
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Next-Generation Sequencing Based HLA Typing: Deciphering Immunogenetic Aspects of Sarcoidosis by Amit Kishore, Martin Petrek

“…These range from coeliac disease and rheumatological conditions to even more complex disorders, such as type-1 diabetes, systemic lupus erythematosus and sarcoidosis. …”
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