Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase. by Huiying Zhi, Jing Dai, Junling Liu, Jieqing Zhu, Debra K Newman, Cunji Gao, Peter J Newman

“…Future studies may be warranted to determine whether patients suffering from immune complex disorders might benefit from treatment with anti-αIIbβ3-directed therapeutics.…”
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Prioritization of rs187728237 and rs80320514 as miRNA-related Variants of Human AEG-1 Gene by Semira Kheiri, Azadeh Aliarab, Hamid Haghighatfard, Hossein Sadeghi

“…ABSTRACT          Background and objectives: 3chr('39') untranslated  region  (3chr('39')UTR) single  nucleotide  polymorphisms (SNPs) represent genetic variations that may potentially affect binding of miRNA to coding genes, potentially leading to complex disorders. We aimed to perform in silico analysis of the potential phenotypic effect of 3chr('39')UTR SNPs on human astrocyte elevated gene-1 (AEG-1), a newly identified candidate cancer gene.          …”
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Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples by Li Chuan-Yun, Walther Donna, Zhang Ping-Wu, Liu Qing-Rong, Drgon Tomas, Johnson Catherine, Anthony James C, Ding Yulan, Eaton William W, Uhl George R

“…<p>Abstract</p> <p>Background</p> <p>Dependences on addictive substances are substantially-heritable complex disorders whose molecular genetic bases have been partially elucidated by studies that have largely focused on research volunteers, including those recruited in Baltimore. …”
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Comparison of conventional pharmacological therapy and holistic approaches (Naturopathy and Yoga) in the management of chronic orofacial pain: A randomized controlled study by Khushboo Bhalla, Nagaraju Kamarthi, Sangeeta Singh Malik, Sumit Goel, Swati Gupta

“…Only oral physicians are well-trained to provide non-surgical treatment of these complex disorders. Today, the escalating costs of drugs and several adverse effects associated with modern medicines have led to the search of alternative systems all over the world. …”
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Rare Variants in NOD1 Associated with Carotid Bifurcation Intima-Media Thickness in Dominican Republic Families. by Nicole D Dueker, Ashley Beecham, Liyong Wang, Susan H Blanton, Shengru Guo, Tatjana Rundek, Ralph L Sacco

“…One strategy to identify loci influencing these complex disorders is to study subclinical phenotypes, such as carotid bifurcation intima-media thickness (bIMT). …”
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Analysis and Interpretation of the Impact of Missense Variants in Cancer by Maria Petrosino, Leonore Novak, Alessandra Pasquo, Roberta Chiaraluce, Paola Turina, Emidio Capriotti, Valerio Consalvi

“…Our analysis suggests that the integration of experimental and computational approaches may contribute to evaluate the risk for complex disorders and develop more effective treatment strategies.…”
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Exploring Promising Biomarkers for Alzheimer’s Disease through the Computational Analysis of Peripheral Blood Single-Cell RNA Sequencing Data by Marios G. Krokidis, Aristidis G. Vrahatis, Konstantinos Lazaros, Panagiotis Vlamos

“…Furthermore, the present approach paves the way for the application of ML techniques to scRNA-seq data from complex disorders, providing new challenges to identify key biological processes from a molecular perspective.…”
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Purifying selection in deeply conserved human enhancers is more consistent than in coding sequences. by Dilrini R De Silva, Richard Nichols, Greg Elgar

“…Discovery pipelines should validate non-coding variants to aid in identifying causal and risk-enhancing variants in complex disorders, in contrast to the current focus on exome sequencing.…”
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Practicing precision medicine with intelligently integrative clinical and multi-omics data analysis by Zeeshan Ahmed

“…In clinical settings, we need to timely model clinical and multi-omics data to find statistical patterns across millions of features to identify underlying biologic pathways, modifiable risk factors, and actionable information that support early detection and prevention of complex disorders, and development of new therapies for better patient care. …”
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Genetics of osteoporotic fracture by Chuan Qiu, Christopher J Papasian, Hong-Wen Deng, et al

“…Recent advances in high-throughput genotyping technology and knowledge of common human genetic variants have shifted the approach for studying human complex disorders from candidate gene studies to large-scale genome-wide association studies. …”
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Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer by Takashi Shiromizu, Mizuki Yuge, Kousuke Kasahara, Daishi Yamakawa, Takaaki Matsui, Yasumasa Bessho, Masaki Inagaki, Yuhei Nishimura

“…Not surprisingly, dysregulation of cilia can cause various diseases, including cancer and ciliopathies, which are complex disorders caused by mutations in genes regulating ciliary function. …”
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Driving an intervention model for the treatment of symptoms of attention-deficit/hyperactivity disorder in adults by referring to the grounded theory by Mahboubeh Moradi Siah Afshadi, Shole Amiri, Hooshang Talebi

“…Background: Attention-Deficit/Hyperactivity Disorder (ADHD) in adulthood is one of the most complex disorders known in recent years, and the improvement of the symptoms of ADHD has been treated only by relying on medication. …”
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DNA methyl transferase (DNMT) gene polymorphisms could be a primary event in epigenetic susceptibility to schizophrenia. by Koramannil Radha Saradalekshmi, Nanoth Vellichiramal Neetha, Sanish Sathyan, Indu V Nair, Chandrasekharan M Nair, Moinak Banerjee

“…DNA methylation has been implicated in the etiopathology of various complex disorders. DNA methyltransferases are involved in maintaining and establishing new methylation patterns. …”
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Digital Mental Health for Young People: A Scoping Review of Ethical Promises and Challenges by Blanche Wies, Constantin Landers, Marcello Ienca

“…Mental health disorders are complex disorders of the nervous system characterized by a behavioral or mental pattern that causes significant distress or impairment of personal functioning. …”
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Antidiabetic effects of chamomile flowers extract in obese mice through transcriptional stimulation of nutrient sensors of the peroxisome proliferator-activated receptor (PPAR) fam... by Christopher Weidner, Sylvia J Wowro, Morten Rousseau, Anja Freiwald, Vitam Kodelja, Heba Abdel-Aziz, Olaf Kelber, Sascha Sauer

“…Plant extracts from edible biomaterial provide a potential resource of structurally diverse molecules that can synergistically interfere with complex disorders. In this study we describe the safe application of ethanolic chamomile (Matricaria recutita) flowers extract (CFE) for the treatment and prevention of type 2 diabetes and associated disorders. …”
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The Mitochondrial Proteomic Signatures of Human Skeletal Muscle Linked to Insulin Resistance by Rikke Kruse, Navid Sahebekhtiari, Kurt Højlund

“…Protein profiling by proteomics is a powerful tool to investigate mechanisms underlying complex disorders. However, despite significant advances in proteomics within the past two decades, the technologies have not yet been fully exploited in the field of skeletal muscle proteome. …”
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Five Years’ Experience of Multidisciplinary Approach to Chronic Inflammatory Diseases by Rheumatology, Dermatology and Gastroenterology Departments by Burcu Yağız, Belkıs Nihan Coşkun, Altuğ Güner, Aslı Macunluoglu, Yavuz Pehlivan, Serkan Yazici, Hüseyin Ediz Dalkılıç, Emel Başkan, Tugba Ocak, Murat Kıyıcı

“…Introduction: Chronic inflammatory diseases (CIDs) are lifelong complex disorders that affect quality of life, and this study aimed to summarize 5 years of experience with a multidisciplinary approach for these complex diseases as a result of medical council meetings. …”
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Allelic Imbalance in Regulation of ANRIL through Chromatin Interaction at 9p21 Endometriosis Risk Locus. by Hirofumi Nakaoka, Aishwarya Gurumurthy, Takahide Hayano, Somayeh Ahmadloo, Waleed H Omer, Kosuke Yoshihara, Akihito Yamamoto, Keisuke Kurose, Takayuki Enomoto, Shigeo Akira, Kazuyoshi Hosomichi, Ituro Inoue

“…Genome-wide association studies (GWASs) have discovered numerous single nucleotide polymorphisms (SNPs) associated with human complex disorders. However, functional characterization of the disease-associated SNPs remains a formidable challenge. …”
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A linkage disequilibrium-based approach to selecting disease-associated rare variants. by Rajesh Talluri, Sanjay Shete

“…Rare variants have increasingly been cited as major contributors in the disease etiology of several complex disorders. Recently, several approaches have been proposed for analyzing the association of rare variants with disease. …”
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Increased Transcript Complexity in Genes Associated with Chronic Obstructive Pulmonary Disease. by Lela Lackey, Evonne McArthur, Alain Laederach

“…This led us to hypothesize that other genes associated with COPD, and complex disorders in general, are highly transcriptionally diverse. …”
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