A method for the identification of biological pathways by Honti, F

“…I have advanced a framework for the identification of biological pathways disrupted in complex disorders, also demonstrating the suitability of this method to functionally sub-cluster the gene variants underlying a complex disorder, with implications for the understanding of disease mechanisms.…”

Epigenetic signatures of gestational diabetes mellitus on cord blood methylation by Larissa Haertle, Nady El Hajj, Marcus Dittrich, Tobias Müller, Indrajit Nanda, Harald Lehnen, Thomas Haaf

“…Abstract Background Intrauterine exposure to gestational diabetes mellitus (GDM) confers a lifelong increased risk for metabolic and other complex disorders to the offspring. GDM-induced epigenetic modifications modulating gene regulation and persisting into later life are generally assumed to mediate these elevated disease susceptibilities. …”
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A new perspective on Alzheimer’s disease: microRNAs and circular RNAs by Shahidee Zainal Abidin, Shahidee Zainal Abidin, Nurul Asykin Mat Pauzi, Nur Izzati Mansor, Nurul Iffah Mohd Isa, Adila A. Hamid

“…The current stage of research on miRNA expression profiles for diagnostic purposes in complex disorders such as Alzheimer’s disease is still in its early phase, primarily due to the intricate nature of the underlying pathological causes, which encompass a diverse range of pathways and targets. …”
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Replication of type 2 diabetes candidate genes variations in three geographically unrelated Indian population groups. by Shafat Ali, Rupali Chopra, Siddharth Manvati, Yoginder Pal Singh, Nabodita Kaul, Anita Behura, Ankit Mahajan, Prabodh Sehajpal, Subash Gupta, Manoj K Dhar, Gagan B N Chainy, Amarjit S Bhanwer, Swarkar Sharma, Rameshwar N K Bamezai

“…Further, we noted that the moderate risk provided by the independently associated loci in combined population with Odds Ratio (OR)<1.38 increased to OR = 2.44, (95%CI = 1.67-3.59) when the risk providing genotypes of TCF7L2, HHEX, ENPP1 and FTO genes were combined, suggesting the importance of gene-gene interactions evaluation in complex disorders like T2D.…”
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Targeting immunometabolic pathways for combination therapy in Alzheimer's disease by Jennifer Erichsen, Suzanne Craft

“…These limitations suggest that fully efficacious AD treatment may require combination therapy regimens, as are used in other complex disorders such as cancer and HIV. One reasonable strategy may be to use agents that address the biological changes that predict future amyloid accumulation, or accompany amyloid accumulation in preclinical disease states. …”
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Arterial pulmonary hypertension in noncardiac intensive care unit by Mykola V Tsapenko, Arseniy V Tsapenko, Thomas BO Comfere, Girish K Mour, Sunil V Mankad, Ognjen Gajic

“…Mykola V Tsapenko1,5, Arseniy V Tsapenko2, Thomas BO Comfere3,5, Girish K Mour1,5, Sunil V Mankad4, Ognjen Gajic1,51Division of Pulmonary and Critical Care Medicine; 3Division of Critical Care Medicine; 4Division of Cardiovascular Diseases, Mayo Epidemiology and Translational Research in Intensive Care (M.E.T.R.I.C), Mayo Clinic, Rochester, MN, USA; 2Division of Pulmonary and Critical Care Medicine, Brown University, Miriam Hospital, Providence, RI, USAAbstract: Pulmonary artery pressure elevation complicates the course of many complex disorders treated in a noncardiac intensive care unit. …”
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A Mini-Review Regarding the Modalities to Study Neurodevelopmental Disorders-Like Impairments in Zebrafish—Focussing on Neurobehavioural and Psychological Responses by Alexandrina S. Curpăn, Ioana-Miruna Balmus, Romeo P. Dobrin, Alin Ciobica, Gabriela E. Chele, Dragos Lucian Gorgan, Alexandra Boloș

“…Neurodevelopmental disorders (NDDs) are complex disorders which can be associated with many comorbidities and exhibit multifactorial-dependent phenotypes. …”
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A novel scoring strategy combining statistics and functional genomics supports a possible role for common polygenic variation in autism by Jérôme eCarayol, Gerard D Schellenberg, Beth eDombroski, Claire eAmiet, Claire eAmiet, Bérengère eGénin, Karine eFontaine, Francis eRousseau, Céline eVazart, David eCohen, Thomas W Frazier, Antonio Y Hardan, Geraldine eDawson, Thomas eRio Frio

“…To increase the power of GWASs in complex disorders, methods like convergent functional genomics (CFG) have emerged to extract true association signals from noise and to identify and prioritize genes from SNPs using a scoring strategy combining statistics and functional genomics. …”
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The Need for Comprehensive Care for Persons with Chronic Immune Thrombocytopenic Purpura by Ansteatt KT, Unzicker CJ, Hurn ML, Olaiya OO, Nugent DJ, Tarantino MD

“…The model of comprehensive care in Hemophilia Treatment Centers (HTCs) has been recognized as highly effective, improving life expectancy for persons with hemophilia. cITP, and other CPDs, are complex disorders requiring specialized care. However, an integrated care model with a systematic and reliable population-based surveillance program does not exist. …”
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Role of Mitochondria in Inflammatory Bowel Diseases: A Systematic Review by María José Sánchez-Quintero, Cristina Rodríguez-Díaz, Francisco J. Rodríguez-González, Alejandra Fernández-Castañer, Eduardo García-Fuentes, Carlos López-Gómez

“…This plethora of critical functions within the cell is the reason mitochondrial function is involved in several complex disorders (apart from pure mitochondrial disorders), among them inflammatory bowel diseases (IBD). …”
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JWES: a new pipeline for whole genome/exome sequence data processing, management, and gene‐variant discovery, annotation, prediction, and genotyping by Zeeshan Ahmed, Eduard Gibert Renart, Deepshikha Mishra, Saman Zeeshan

“…We have successfully applied JWES for processing, management, and gene‐variant discovery, annotation, prediction, and genotyping of WGS and WES data to analyze variable complex disorders. In summary, we report the performance of JWES with some reproducible case studies, using open access and in‐house generated, high‐quality datasets.…”
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Role of electrolyte abnormalities and unmeasured anions in the metabolic acid‐base abnormalities in dogs with parvoviral enteritis by Richard K. Burchell, Arnon Gal, Ryan Friedlein, Andrew L. Leisewitz

“…Abstract Background The strong ion model (SIM) is an alternative paradigm in the characterization of acid‐base disturbances particularly in complex disorders. Hypothesis/Objectives To compare the acid‐base changes in dogs with parvoviral enteritis (PE) using the Henderson‐Hasselbalch (HH) approach, with 2 strong ion approaches. …”
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Sj&ouml;gren&#39;s syndrome and systemic lupus erythematosus: links and risks by Pasoto SG, Adriano de Oliveira Martins V, Bonfa E

“…Sandra Gofinet Pasoto,1,2 Victor Adriano de Oliveira Martins,1 Eloisa Bonfa1 1Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil; 2Laboratory Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Sao Paulo, Brazil Abstract: Systemic lupus erythematosus (SLE) and Sj&ouml;gren&rsquo;s syndrome (SS) may coexist, and they are chronic complex disorders, with an autoimmune background, multifactorial etiology, multiple circulating autoantibodies, and variable prognosis. …”
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Striatal oxidative damages and neuroinflammation correlate with progression and survival of Lewy body and Alzheimer diseases by Huifangjie Li, William C Knight, Jinbin Xu

“…Neurodegenerative diseases are a class of chronic and complex disorders featuring progressive loss of neurons in distinct brain areas. …”
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Symptom burden of people with progressive ataxia, and its wider impact on their friends and relatives: a cross-sectional study [version 2; peer review: 1 approved, 2 approved with... by Julie Greenfield, Anja Lowit, Ruby Wallis, Emily Cutting, Marios Hadjivassiliou

“…Background: Progressive ataxias are complex disorders that result in a wide variety of symptoms. …”
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Effects of black grapes juice extract on the blood biochemical factors in alloxan-induced diabetic and hyperlipidemic rats by Mohammad Malekaneh, Bahareh Haratizadeh, Mohmmadreza Miri

“…Background and Aim: Regarding the multi-dimensional activity of medicinal herbs in complex disorders like diabetes, the present study was undertaken to evaluate the effect of freezed and dried extract of black grapes juice on serum glucose and lipid profile of alloxan induced diabetic rats. …”
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Metabolite interactions between host and microbiota during health and disease: Which feeds the other? by Yan Zhang, Rui Chen, DuoDuo Zhang, Shuang Qi, Yan Liu

“…Microbiome-modulated metabolites are promising targets for new drug discovery due to their endocrine function in various complex disorders. In humans, metabolotherapy for the prevention or treatment of various disorders will be possible if we better understand the metabolic preferences of bacteria and the host in specific tissues and organs. …”
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Prevalence of disorders recorded in dogs attending primary-care veterinary practices in England. by Dan G O Neill, David B Church, Paul D McGreevy, Peter C Thomson, Dave C Brodbelt

“…The results suggest that, for maximal impact, breeding reforms should target commonly-diagnosed complex disorders that are amenable to genetic improvement and should place special focus on at-risk breeds. …”
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Return of Genomic Results in the Genomic Medicine Projects of the eMERGE Network by Iftikhar J. Kullo, Ra'ad eHaddad, Cynthia A. Prows, Ingrid eHolm, Saskia C. Sanderson, Nanibaa' A. Garrison, Richard R. Sharp, Maureen E. Smith, Helena eKuivaniemi, Erwin P. Bottinger, John eConnolly, Brendan J. Keating, Catherine A. McCarty, Marc S. Williams, Gail P. Jarvik

“…These genomic medicine pilot studies include returning individual genetic variants associated with disease susceptibility or drug response, as well as genetic risk scores for common ‘complex’ disorders. Additionally, as part of a network-wide pharmacogenomics-related project, targeted resequencing of 84 pharmacogenes is being performed and select genotypes of pharmacogenetic relevance are being placed in the EHR to guide individualized drug therapy. …”
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The pedunculopontine tegmentum controls renal sympathetic nerve activity and cardiorespiratory activities in nembutal-anesthetized rats. by Anne M Fink, Caron Dean, Mariann R Piano, David W Carley

“…Elevated renal sympathetic nerve activity (RSNA) accompanies a variety of complex disorders, including obstructive sleep apnea, heart failure, and chronic kidney disease. …”
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