Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture by Xingjie Hao, Zhonghe Shao, Ning Zhang, Minghui Jiang, Xi Cao, Si Li, Yunlong Guan, Chaolong Wang

“…Abstract Kidney stone disease (KSD) is a complex disorder with high heritability and prevalence. …”
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Exome sequencing analysis of Japanese autism spectrum disorder case-control sample supports an increased burden of synaptic function-related genes by Hiroki Kimura, Masahiro Nakatochi, Branko Aleksic, James Guevara, Miho Toyama, Yu Hayashi, Hidekazu Kato, Itaru Kushima, Mako Morikawa, Kanako Ishizuka, Takashi Okada, Yoshinori Tsurusaki, Atsushi Fujita, Noriko Miyake, Tomoo Ogi, Atsushi Takata, Naomichi Matsumoto, Joseph Buxbaum, Norio Ozaki, Jonathan Sebat

“…Abstract Autism spectrum disorder (ASD) is a highly heritable, complex disorder in which rare variants contribute significantly to disease risk. …”
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Bioactive Peptides Obtained from Legume Seeds as New Compounds in Metabolic Syndrome Prevention and Diet Therapy by Kaja Kiersnowska, Anna Jakubczyk

“…Metabolic syndrome (MS) is a complex disorder defined as a set of interrelated factors that increase the risk of cardiovascular disease, atherosclerosis, type 2 diabetes, or dyslipidemia. …”
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Male refractory hypospadias with sexual reversal: a case report by Jianfeng Zhao, Gang Chen, Jun Chen, Le Qian

“…However, some hypospadias may have a more complex disorder of sex development. Usually, hypospadias in these patients is severe. …”
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Management of metabolic syndrome through probiotic and prebiotic interventions by Rashmi H Mallappa, Namita Rokana, Raj Kumar Duary, Harsh Panwar, Virender Kumar Batish, Sunita Grover

“…Metabolic syndrome is a complex disorder caused by a cluster of interrelated factors that increases the risk of cardiovascular diseases and type 2 diabetes. …”
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Neonatal presentation of growth hormone deficiency in CHARGE syndrome: the benefit of early treatment on long-term growth by Carla Costa, Eduarda Coutinho, Rita Santos-Silva, Cíntia Castro-Correia, Manuel Carlos Lemos, Manuel Fontoura

“…SUMMARY CHARGE syndrome is a complex disorder involving multiple congenital anomalies and is caused by heterozygous mutations in the CHD7 gene. …”
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Eagle syndrome. A narrative review by Heber Arbildo, Luis Gamarra, Sandra Rojas, Edward Infantes, Hernán Vásquez

“…Eagle syndrome is a complex disorder demanding a thorough knowledge of its signs and symptoms to make a correct diagnosis and provide an appropriate subsequent treatment. …”
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From Synapse to Function: A Perspective on the Role of Neuroproteomics in Elucidating Mechanisms of Drug Addiction by Luis A. Natividad, Matthew W. Buczynski, Daniel B. McClatchy, John R. Yates

“…Drug addiction is a complex disorder driven by dysregulation in molecular signaling across several different brain regions. …”
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Structural, Genetic, and Functional Signatures of Disordered Neuro-Immunological Development in Autism Spectrum Disorder by Saxena, Vishal, Ramdas, Shweta, Ochoa, Courtney Rothrock, Wallace, David Robert, Bhide, Pradeep, Kohane, Isaac

“…The underlying pattern may be identified by an integrative approach, especially since ASD is a complex disorder manifested through many loci. Method: Autism spectrum disorder (ASD) was studied through two different and independent genome-scale measurement modalities. …”
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Dissecting the roles of the Tuberin protein in the subcellular localization of the G2/M Cyclin, Cyclin B1. by Adam Pillon, Jessica Dare-Shih, Jackie Fong, Elizabeth Fidalgo da Silva, Lisa A Porter

“…Mutations in the Tuberin gene, TSC2, lead to the formation of benign tumors in many organ systems and causes the Tuberous Sclerosis Complex disorder. Genotypes ranging from point mutations to large deletions in the TSC2 gene have been clinically characterized with a wide range of phenotypes from skin tumors to large brain tumors. …”
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Proteomics to metabolomics: A new insight into the pathogenesis of hypertensive nephropathy by Yasin Eshraghi, Maryam Abedi, Yousof Gheisari

“…Systems biology is a promising approach to provide a comprehensive insight towards this complex disorder. Methods: Protein expression profiles of kidney tubule and cortex sub-compartments were retrieved from the PRIDE database and the quality of the datasets were assessed using principal component analysis (PCA) and hierarchical clustering. …”
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Sarcopenia and bone health: new acquisitions for a firm liaison by Umberto Tarantino, Chiara Greggi, Virginia Veronica Visconti, Ida Cariati, Roberto Bonanni, Beatrice Gasperini, Italo Nardone, Elena Gasbarra, Riccardo Iundusi

“…This narrative review aims to provide an overview of the latest scientific evidence associated with OS, a complex disorder that will pave the way for future research aimed at understanding the bone–muscle-associated pathogenetic mechanisms.…”
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Psilocybin for the treatment of posttraumatic stress disorder: A magic to treat a harmony of illusions? by Rakesh Khanna

“…A review of the literature on posttraumatic stress disorder (PTSD) suggests it to be a complex disorder with many contributing factors. The concept of PTSD has continued to evolve over time. …”
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Overview of attention deficit hyperactivity disorder in young children by Ajay Singh, Chia Jung Yeh, Nidhi Verma, Ajay Kumar Das

“…Attention deficit hyperactivity disorder (ADHD) is a complex disorder, which can be seen as a disorder of life time, developing in preschool years and manifesting symptoms (full and/or partial) throughout the adulthood; therefore, it is not surprising that there are no simple solutions. …”
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The landscape of non-coding RNAs in the immunopathogenesis of Endometriosis by Mohammad Abbaszadeh, Mohammadreza Karimi, Samira Rajaei

“…Endometriosis is a complex disorder that is characterized by the abnormal growth of endometrial-like tissue outside the uterus. …”
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Alzheimer's disease: analyzing the missing heritability. by Perry G Ridge, Shubhabrata Mukherjee, Paul K Crane, John S K Kauwe, Alzheimer’s Disease Genetics Consortium

“…Alzheimer's disease (AD) is a complex disorder influenced by environmental and genetic factors. …”
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Backtracking Dynamical Cavity Method by Freya Behrens, Barbora Hudcová, Lenka Zdeborová

“…We illustrate that this rather elementary twist on the dynamical cavity method leads to new insight into some of the very basic questions about the dynamics of complex disordered systems. This method is as versatile as the cavity method itself, and we hence anticipate that our paper will open many avenues for future research of dynamical, out-of-equilibrium properties in complex systems.…”
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New cross-roads for second line medical therapy in acromegaly by Adina Ghemigian, Andra Cocolos, Eugenia Petrova, Ana Valea, Nicoleta Dumitru, Mara Carsote

“…Acromegaly is a complex disorder caused by growth hormone excess mostly due to a pituitary adenoma. …”
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Stress in Obesity and Associated Metabolic and Cardiovascular Disorders by Paul Holvoet

“…This syndrome is a common and complex disorder combining obesity, dyslipidemia, hypertension, and insulin resistance. …”
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The Role of the Microbiome in Autism: All That We Know about All That We Don’t Know by Maude M. David

“…ABSTRACT Autism spectrum disorder (ASD) is a remarkably complex disorder influenced by both genetic and environmental factors. …”
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