Genetics of Tinnitus: Still in its Infancy by Barbara Vona, Indrajit Nanda, Wafaa Shehata-Dieler, Thomas Haaf

Subjects: “…complex disorders…”
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An Introductory Review of Parallel Independent Component Analysis (p-ICA) and a Guide to Applying p-ICA to Genetic Data and Imaging Phenotypes to Identify Disease-Associated Biological Pathways and Systems in Common Complex Disorders by Godfrey D Pearlson, Godfrey D Pearlson, Godfrey D Pearlson, Vince D Calhoun, Jingyu eLiu

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Hematoma Subdural pada Bayi dengan Acquired Prothrombine Complex Deficiency (Apcd) Syndrome Di Rs. Hasan Sadikin Dari Juli 2010 Sampai Februari 2011 by Fitri Sepviyanti Sumardi, Dewi Yulianti Bisri, Tatang Bisri

Subjects: “…acquired prothrombine time complex disorders, subdural hematoma…”
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The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad by Kumuda Irgam, Battini Sriteja Reddy, Sai Gayathri Hari, Swathi Banapuram, Battini Mohan Reddy

Subjects: “…Complex disorder…”
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Genomic Instability Evolutionary Footprints on Human Health: Driving Forces or Side Effects? by Laura Veschetti, Mirko Treccani, Elisa De Tomi, Giovanni Malerba

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Linkage and exome analysis implicate multiple genes in non-syndromic intellectual disability in a large Swedish family by Eva Lindholm Carlström, Jonatan Halvardson, Mitra Etemadikhah, Lennart Wetterberg, Karl-Henrik Gustavson, Lars Feuk

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Complex Disorder in Type-I Clathrates: Synthesis and Structural Characterization of <i>A</i>₈Ga<i>_x</i>Sn_{46−<i>x</i>} (<i>A</i> = Rb, Cs; 6.9 < <i>x</i> < 7.5) by Sviatoslav A. Baranets, Amanda B. Childs, Hua He, Svilen Bobev

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Involvement of NINJ2 Protein in Inflammation and Blood–Brain Barrier Transmigration of Monocytes in Multiple Sclerosis by Melissa Sorosina, Silvia Peroni, Elisabetta Mascia, Silvia Santoro, Ana Maria Osiceanu, Laura Ferrè, Ferdinando Clarelli, Antonino Giordano, Miryam Cannizzaro, Filippo Martinelli Boneschi, Massimo Filippi, Federica Esposito

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Subjective memory complaints among patients on sick leave are associated with symptoms of fatigue and anxiety by Julie Kristine Aasvik, Astrid eWoodhouse, Astrid eWoodhouse, Astrid eWoodhouse, Henrik eBørsting Jacobsen, Henrik eBørsting Jacobsen, Henrik eBørsting Jacobsen, Petter C Borchgrevink, Petter C Borchgrevink, Petter C Borchgrevink, Tore C Stiles, Tore C Stiles, Tore C Stiles, Nils Inge eLandrø, Nils Inge eLandrø, Nils Inge eLandrø

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From chaos to a sense of coherence and meaning: Patient-experiences with Norwegian psychomotor physiotherapy by Irene Kristiansen, Kirsten Ekerholt

“…Purpose: To explore patients with complex disorders`experiences with Norwegian Psychomotor Physiotherapy (NPMF). …”
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A population genetic approach to mapping neurological disorder genes using deep resequencing. by Rachel A Myers, Ferran Casals, Julie Gauthier, Fadi F Hamdan, Jon Keebler, Adam R Boyko, Carlos D Bustamante, Amelie M Piton, Dan Spiegelman, Edouard Henrion, Martine Zilversmit, Julie Hussin, Jacklyn Quinlan, Yan Yang, Ronald G Lafrenière, Alexander R Griffing, Eric A Stone, Guy A Rouleau, Philip Awadalla

“…Additionally, our findings support the hypothesis that rare mutations account for a proportion of the phenotypic variance of these complex disorders.…”
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Systems Biology as a Comparative Approach to Understand Complex Gene Expression in Neurological Diseases by Francisco J. Esteban, Dennis P. Wall, Carlos Cano, Leticia Diaz-Beltran

“…Systems biology interdisciplinary approaches have become an essential analytical tool that may yield novel and powerful insights about the nature of human health and disease. Complex disorders are known to be caused by the combination of genetic, environmental, immunological or neurological factors. …”
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Copy number variants and common disorders: filling the gaps and exploring complexity in genome-wide association studies. by Xavier Estivill, Lluís Armengol

“…Since CNVs are not easily tagged by SNPs, might have a wide range of copy number variability, and often fall in genomic regions not well covered by whole-genome arrays or not genotyped by the HapMap project, current GWASs have largely missed the contribution of CNVs to complex disorders. In fact, some CNVs have already been reported to show association with several complex disorders using candidate gene/region approaches, underpinning the importance of regions not investigated in current GWASs. …”
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Evolutionary history of disease‐susceptibility loci identified in longitudinal exome‐wide association studies by Yoshiki Yasukochi, Jun Sakuma, Ichiro Takeuchi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Yoshiji Yamada

“…Abstract Background Our longitudinal exome‐wide association studies previously detected various genetic determinants of complex disorders using ~26,000 single‐nucleotide polymorphisms (SNPs) that passed quality control and longitudinal medical examination data (mean follow‐up period, 5 years) in 4884–6022 Japanese subjects. …”
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Peripheral gene interactions define interpretable clusters of core ASD genes in a network-based investigation of the omnigenic theory by Ábel Fóthi, Csaba Pintér, Péter Pollner, András Lőrincz

“…Abstract According to the recently proposed omnigenic theory, all expressed genes in a relevant tissue are contributing directly or indirectly to the manifestation of complex disorders such as autism. Thus, holistic approaches can be complementary in studying genetics of these complex disorders to focusing on a limited number of candidate genes. …”
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Crohn's disease: Genes, viruses and microbes. by Simmons, A

“…Variations in several genes can increase an individual's susceptibility to complex disorders. But what tips the balance to cause the full-blown disease? …”

Mining literature for a comprehensive pathway analysis: A case study for retrieval of homocysteine related genes for genetic and epigenetic studies by Mahajan Anubha, Sundaramoorthy Elayanambi, Brahmachari Vani, Senthilkumar RD, Sharma Priyanka, Sharma Amitabh, Sengupta Shantanu

“…It is also known to be associated with a variety of complex disorders. While there are a large number of independent studies implicating homocysteine in isolated pathways, the mechanism of homocysteine induced adverse effects are not clear. …”
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Nodes with high centrality in protein interaction networks are responsible for driving signaling pathways in diabetic nephropathy by Maryam Abedi, Yousof Gheisari

“…Also, this study suggests a computational method for inferring underlying mechanisms of complex disorders from raw high-throughput data.…”
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Genotype combination contributes to psoriasis: An exhaustive algorithm perspective. by Jinfa Dou, Huimin Guo, Fang Cheng, Hequn Huang, Liying Fu, Longnian Li, Chao Yang, Lei Ye, Leilei Wen, Yuyan Cheng, Lili Tang, Caihong Zhu, Zhengwei Zhu, Wenjun Wang, Yujun Sheng, Zaixing Wang, Shengxiu Liu, Xing Fan, Xianbo Zuo, Fusheng Zhou, Liangdan Sun, Xiaodong Zheng, Xuejun Zhang

“…With the benefit of technological advances, many single-nucleotide polymorphisms (SNPs) have been found to be associated with the risk of complex disorders by using genome wide association studies (GWASs). …”
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Joint GWAS Analysis: Comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases by Michael J. McGeachie, George L. Clemmer, Jessica Lasky-Su, Amber Dahlin, Benjamin A. Raby, Scott T. Weiss

“…We make concrete hypotheses regarding novel pathway associations for several complex disorders considered, based on the results of Joint GWAS Analysis. …”
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