PATOFISIOLOGI DAN NEUROBIOLOGI FIBROMIALGIA DENGAN DEPRESI by Perpustakaan UGM, i-lib

“…Fibromialgia Is a complex disorder. So far, not all parts of Fibromialgia are understood, though the main component is already,known. …”

Psychological treatments in the management of severe late-life depression: At least as important as ECT by Wilkinson, P

“…Depressive illness in late life is a complex disorder that warrants complex interventions. It needs to be viewed as a long-term illness which in some sufferers will include severe episodes. …”

Microbiota-Induced Epigenetic Alterations in Depressive Disorders Are Targets for Nutritional and Probiotic Therapies by Shabnam Nohesara, Hamid Mostafavi Abdolmaleky, Jin-Rong Zhou, Sam Thiagalingam

“…Major depressive disorder (MDD) is a complex disorder and a leading cause of disability in 280 million people worldwide. …”
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Genetics of congenital hypothyroidism: Modern concepts by Athanasia Stoupa, Dulanjalee Kariyawasam, Michel Polak, Aurore Carré

“…CH is no longer simply a dominant disease for cases of CH due to TD and recessive for cases of CH due to DH, but a far more complex disorder.…”
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Association of Functional Polymorphism in <i>TPH2</i> Gene with Alcohol Dependence and Personality Traits: Study in Cloninger’s Type I and Type II Alcohol-Dependent Inpatients by Marcela Konjevod, Mirta Rešetar, Ana Matošić, Lipa Čičin-Šain, Jasminka Štefulj

“…Alcohol dependence (AD) is a complex disorder with a poorly understood etiology. In this study, we investigated the relationship between genetic variation in the <i>TPH2</i> gene, which encodes the enzyme responsible for serotonin synthesis in the brain, and both AD and personality traits, with attention to Cloninger’s types of AD. …”
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Genetics and Molecular Basis of Congenital Heart Defects in Down Syndrome: Role of Extracellular Matrix Regulation by Nunzia Mollo, Roberta Scognamiglio, Anna Conti, Simona Paladino, Lucio Nitsch, Antonella Izzo

“…Down syndrome (DS), a complex disorder that is caused by the trisomy of chromosome 21 (Hsa21), is a major cause of congenital heart defects (CHD). …”
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Human pluripotent stem cell (hPSC) and organoid models of autism: opportunities and limitations by Savannah Kilpatrick, Courtney Irwin, Karun K. Singh

“…When complemented with multi-omics, genome editing, and electrophysiology analysis, they can be used as a powerful tool to profile the neurobiological mechanisms underlying this complex disorder. In this review, we will explore the recent advancements in hPSC-based modeling, discuss present and future applications of the model to ASD research, and finally consider the limitations and future directions within the field to make this system more robust and broadly applicable.…”
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The neurobiology of misophonia and implications for novel, neuroscience-driven interventions by Andrada D. Neacsiu, Victoria Szymkiewicz, Jeffrey T. Galla, Brenden Li, Yashaswini Kulkarni, Cade W. Spector

“…In this theoretical paper, we begin by reviewing the candidate networks that may be at play in this complex disorder (e.g., regulatory, sensory, and auditory). …”
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Modulation of the Inflammatory Response in Polycystic Ovary Syndrome (PCOS)—Searching for Epigenetic Factors by Dariusz Szukiewicz, Seweryn Trojanowski, Anna Kociszewska, Grzegorz Szewczyk

“…The heterogenous nature of this complex disorder results from the combined occurrence of genetic, environmental, endocrine, and behavioral factors. …”
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A Distinctive Explainable Machine Learning Framework for Detection of Polycystic Ovary Syndrome by Varada Vivek Khanna, Krishnaraj Chadaga, Niranajana Sampathila, Srikanth Prabhu, Venkatesh Bhandage, Govardhan K. Hegde

“…Polycystic Ovary Syndrome (PCOS) is a complex disorder predominantly defined by biochemical hyperandrogenism, oligomenorrhea, anovulation, and in some cases, the presence of ovarian microcysts. …”
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Concomitant Calcium Channelopathies Involving <i>CACNA1A</i> and <i>CACNA1F:</i> A Case Report and Review of the Literature by Donna Schaare, Sara M. Sarasua, Laina Lusk, Shridhar Parthasarathy, Liangjiang Wang, Ingo Helbig, Luigi Boccuto

“…Moreover, the detailed case description and natural history along with the comprehensive review of the literature contribute to the understanding of this complex disorder and point to the need for comprehensive clinical assessments of SHM1.…”
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Effects of an Intensive 6-Week Rehabilitation Program with the HUBER Platform in the Treatment of Non-Specific Chronic Low Back Pain: A Pilot Study by Mélanie Tantot, Vincent Le Moal, Éric Mévellec, Isabelle Nouy-Trollé, Emmanuelle Lemoine-Josse, Florent Besnier, Thibaut Guiraud

“…Non-specific chronic low back pain (NSCLBP) is defined as a complex disorder involving structural, biomechanical, cognitive, psychological, social, and lifestyle factors. …”
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Barocrinology: The Endocrinology of Obesity from Bench to Bedside by Sanjay Kalra, Nitin Kapoor, Saptarshi Bhattacharya, Hassan Aydin, Ankia Coetzee

“…Moreover, many lower middle-income countries lack appropriate resources, super-specialists, and affordability to manage this complex disorder. Of late, there has been a substantial increase in both obesity and diabesity in India. …”
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Phenotypic polymorphism in Wilson’s disease – between genetics and epigenetics by Veronica Cumpata

“…Conclusions: Wilson’s disease is a genetically and clinically complex disorder. Although the results of genotype-phenotype correlation studies are not well defined, and in some cases are completely contradictory, some peculiarities related to the age of onset, sex, clinical phenotype, and the evolution of the disease have been highlighted. …”
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A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family. by Kunjan Patel, Arnaud P Giese, J M Grossheim, Rashmi S Hegde, Maria Delio, Joy Samanich, Saima Riazuddin, Gregory I Frolenkov, Jinlu Cai, Zubair M Ahmed, Bernice E Morrow

“…Hearing loss is a complex disorder caused by both genetic and environmental factors. …”
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Blood platelet research in autism spectrum disorders: In search of biomarkers by Manisha Padmakumar, Eveline Van Raes, Chris Van Geet, Kathleen Freson

“…The present review enumerates studies of different biomarkers detected in ASD using platelets and highlights the future needs to bring this research to the next level and advance our understanding of this complex disorder.…”
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Biosocial characteristics of patients with paranoid schizophrenia by Gergana K. Panayotova, Vesela D. Chengeliyska, Evgeniya N. Ivanova

“…Schizophrenia is known as a complex disorder that combines both genetic and environmental factors. …”
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Gait Classification in Unilateral Cerebral Palsy by Stefanos Tsitlakidis, Axel Horsch, Felix Schaefer, Fabian Westhauser, Marco Goetze, Sebastien Hagmann, Matthias C. M. Klotz

“…As unilateral cerebral palsy represents a complex disorder, gait classification is difficult. Knowledge of the most frequent gait patterns and functional impairment is crucial for proper decision-making. …”
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Developmental Coordination Disorder (DCD): Relevance for Clinical Psychologists in Europe by Emily J. Meachon, Martina Zemp, Georg W. Alpers

“…[Results] DCD is a highly prevalent, disruptive, and complex disorder, which should be investigated further in many areas (e.g., co-occurrence to ADHD). …”
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Examining Neural Connectivity in Schizophrenia Using Task-Based EEG: A Graph Theory Approach by Sergio Iglesias-Parro, María F. Soriano, Antonio J. Ibáñez-Molina, Ana V. Pérez-Matres, Juan Ruiz de Miras

“…Schizophrenia (SZ) is a complex disorder characterized by a range of symptoms and behaviors that have significant consequences for individuals, families, and society in general. …”
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