Overview of attention deficit hyperactivity disorder in young children by Ajay Singh, Chia Jung Yeh, Nidhi Verma, Ajay Kumar Das

“…Attention deficit hyperactivity disorder (ADHD) is a complex disorder, which can be seen as a disorder of life time, developing in preschool years and manifesting symptoms (full and/or partial) throughout the adulthood; therefore, it is not surprising that there are no simple solutions. …”
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Using Twitter to investigate opinions about multiple sclerosis treatments: a descriptive, exploratory study [v1; ref status: indexed, http://f1000r.es/4bu] by Sreeram Ramagopalan, Radek Wasiak, Andrew P. Cox

“…Background: Multiple sclerosis (MS) is a common complex disorder, with new treatment options emerging each year. …”
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Deep phenotyping for precision medicine in Parkinson's disease by Ann-Kathrin Schalkamp, Nabila Rahman, Jimena Monzón-Sandoval, Cynthia Sandor

“…A major challenge in medical genomics is to understand why individuals with the same disorder have different clinical symptoms and why those who carry the same mutation may be affected by different disorders. In every complex disorder, identifying the contribution of different genetic and non-genetic risk factors is a key obstacle to understanding disease mechanisms. …”
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Guillain–Barre syndrome outbreak in Peru: Association with polymorphisms in IL‐17, ICAM1, and CD1 by Luis Jaramillo‐Valverde, Kelly S. Levano, Isolina Villanueva, Meylin Hidalgo, Marco Cornejo, Pilar Mazzetti, Mario Cornejo‐Olivas, Cesar Sanchez, Julio A. Poterico, Julio Valdivia‐Silva, Heinner Guio

“…Abstract Background Guillain–Barre Syndrome (GBS) is considered a complex disorder with significant environmental effect and genetic susceptibility. …”
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ADAM33 gene polymorphisms in chronic obstructive pulmonary disease by Pabst S, Touron C Pizarro, Gillissen A, Lennarz M, Tuleta I, Nickenig G, Skowasch D, Grohé C

“…Given the global increase in COPD, research on the genomic variants that affect susceptibility to this complex disorder is reviving. In the present study, we investigated whether single nucleotide polymorphisms in 'a disinter-grin and metalloprotease' 33 (ADAM33) are associated with the development and course of COPD.…”
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Evaluation of the expression of sperm proteins in normozoospermic and asthenozoospermic men using monoclonal antibodies by Jana Capkova, Alena Kubatova, Lukas Ded, Olina Tepla, Jana Peknicova

“…Asthenozoospermia seems to be a complex disorder involving intra-acrosomal proteins.…”
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Channelopathy Pathogenesis in Autism Spectrum Disorders by Galina eSchmunk, Galina eSchmunk, J. Jay eGargus, J. Jay eGargus, J. Jay eGargus

“…Autism spectrum disorder (ASD) is a syndrome that affects normal brain development and is characterized by impaired social interaction as well as verbal and non-verbal communication and by repetitive, stereotypic behavior. ASD is a complex disorder arising from a combination of multiple genetic and environmental factors that are independent from racial, ethnic and socioeconomical status. …”
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Rehabilitation of Aphasia: application of the Melodic-Rhythmic Therapy to the Italian Language by Maria Daniela eCortese, Francesco eRiganello, Francesco eArcuri, Luigina Maria ePignataro, Iolanda eBuglione

“…Aphasia is a complex disorder, frequent after stroke (~38%), with a detailed pathophysiological characterization. …”
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Article Commentary: The Pivotal Role of Aldehyde Toxicity in Autism Spectrum Disorder: The Therapeutic Potential of Micronutrient Supplementation by Frances Jurnak

“…So ASD is assumed to be a complex disorder due to mutations in hundreds of common variants. …”
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Postpartum anal incontinence by A. L. Petrushin, A. V. Pryalukhina

“…Postpartum anal incontinence is a complex disorder that develops mainly in young women and negatively affects their social and professional activity. …”
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Solitary median maxillary central incisor (SMMCI) syndrome by Hall Roger K

“…<p>Abstract</p> <p>Solitary median maxillary central incisor syndrome (SMMCI) is a complex disorder consisting of multiple, mainly midline defects of development resulting from unknown factor(s) operating <it>in utero </it>about the 35th–38th day(s) from conception. …”
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Taxonomy and pathogenicity of fungi associated with oak decline in northern and central Zagros forests of Iran with emphasis on coelomycetous species by Samaneh Bashiri, Jafar Abdollahzadeh

“…Oak decline is a complex disorder that seriously threatens the survival of Zagros forests. …”
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Cognitive versus emotional modulation within a Stroop paradigm in patients with schizophrenia by Verónica Romero-Ferreiro, Ana García-Gutiérrez, Iosune Torio, Paloma Marí-Beffa, Pablo Rodríguez-Gómez, José A. Periáñez, Eva M. Moreno, Carmen Romero, Miguel Ángel Alvarez-Mon, Roberto Rodriguez-Jimenez

“… Background Schizophrenia is a complex disorder involving deficits in both cognitive and emotional processes. …”
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Disclosure of Genetic Risk Factors for Alzheimer’s Disease to Cognitively Healthy Individuals—From Current Practice towards a Personalised Medicine Scenario by Samantha Galluzzi, Michela Pievani, Orazio Zanetti, Luisa Benussi, The Italian-DIAfN Working Group, Giovanni B. Frisoni, Emilio Di Maria

“…Alzheimer’s disease (AD) is a genetically complex disorder. In addition to the relatively small number of pathogenic variants causing autosomal dominant AD, many others have been associated with the much more common sporadic form. …”
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Relationship between rs3918242 Polymorphism of Matrix Methaloproteinase-9 Gene and Preeclampsia in Pregnant Women by Mehdi Sahmani, Nilofar Ahmadi, Somayeh Asadian, Talaat Dabaghi Ghaleh, Amir Javadi

“…Background Preeclampsia is a complex disorder of pregnancy with an unknown etiology. …”
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Opinion: more mouse models and more translation needed for ALS by Elizabeth M.C. Fisher, Linda Greensmith, Andrea Malaspina, Pietro Fratta, Michael G. Hanna, Giampietro Schiavo, Adrian M. Isaacs, Richard W. Orrell, Thomas J. Cunningham, Abraham Acevedo Arozena

“…Abstract Amyotrophic lateral sclerosis is a complex disorder most of which is ‘sporadic’ of unknown origin but approximately 10% is familial, arising from single mutations in any of more than 30 genes. …”
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Derepression of inflammation-related genes link to microglia activation and neural maturation defect in a mouse model of Kleefstra syndrome by Ayumi Yamada, Takae Hirasawa, Kayako Nishimura, Chikako Shimura, Naomi Kogo, Kei Fukuda, Madoka Kato, Masaki Yokomori, Tetsutaro Hayashi, Mana Umeda, Mika Yoshimura, Yoichiro Iwakura, Itoshi Nikaido, Shigeyoshi Itohara, Yoichi Shinkai

“…Summary: Haploinsufficiency of EHMT1, which encodes histone H3 lysine 9 (H3K9) methyltransferase G9a-like protein (GLP), causes Kleefstra syndrome (KS), a complex disorder of developmental delay and intellectual disability. …”
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Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1. by Fuencisla Matesanz, Antonio González-Pérez, Miguel Lucas, Serena Sanna, Javier Gayán, Elena Urcelay, Ilenia Zara, Maristella Pitzalis, María L Cavanillas, Rafael Arroyo, Magdalena Zoledziewska, Marisa Marrosu, Oscar Fernández, Laura Leyva, Antonio Alcina, Maria Fedetz, Concha Moreno-Rey, Juan Velasco, Luis M Real, Juan Luis Ruiz-Peña, Francesco Cucca, Agustín Ruiz, Guillermo Izquierdo

“…From a genetic point of view, MS is a complex disorder resulting from the combination of genetic and non-genetic factors. …”
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The gut microbiota as a booster for radiotherapy: novel insights into radio-protection and radiation injury by Yuxi Yi, Weiqing Lu, Lijun Shen, Yang Wu, Zhen Zhang

“…In this review, we summarize the state-of-the-art landmark researches related with radio-protection to provide illuminating insights for oncologists, gastroenterologists and laboratory scientists interested in this overlooked complexed disorder.…”
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Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity by Saran Lotfollahzadeh, Chaoshuang Xia, Razie Amraei, Ning Hua, Konstantin V. Kandror, Stephen R. Farmer, Wenyi Wei, Catherine E. Costello, Vipul Chitalia, Nader Rahimi

“…Objective: Obesity is a complex disorder and is linked to chronic diseases such as type 2 diabetes. …”
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