Impute.me: An Open-Source, Non-profit Tool for Using Data From Direct-to-Consumer Genetic Testing to Calculate and Interpret Polygenic Risk Scores by Lasse Folkersen, Oliver Pain, Andrés Ingason, Thomas Werge, Cathryn M. Lewis, Cathryn M. Lewis, Jehannine Austin, Jehannine Austin

“…Often, applications report results from single-nucleotide polymorphisms (SNPs) and disregard effect size, which is highly inappropriate for common, complex disorders where everybody carries risk variants. …”
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Massive withdrawal symptoms and affective vulnerability are associated with variants of the CHRNA4 gene in a subgroup of smokers. by Judit Lazary, Peter Dome, Iren Csala, Gabor Kovacs, Gabor Faludi, Mari Kaunisto, Balazs Dome

“…Heterogeneous phenotypes of complex disorders pose a great challenge for genetic association studies and for the development of personalized treatment strategies. …”
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Exome sequencing in schizophrenic patients with high levels of homozygosity identifies novel and extremely rare mutations in the GABA/glutamatergic pathways. by Edoardo Giacopuzzi, Massimo Gennarelli, Alessandra Minelli, Rita Gardella, Paolo Valsecchi, Michele Traversa, Cristian Bonvicini, Antonio Vita, Emilio Sacchetti, Chiara Magri

“…Inbreeding is a known risk factor for recessive Mendelian diseases and previous studies have suggested that it could also play a role in complex disorders, such as psychiatric diseases. Recent inbreeding results in the presence of long runs of homozygosity (ROHs) along the genome, which are also defined as autozygosity regions. …”
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Differences in mtDNA haplogroup distribution among 3 Jewish populations alter susceptibility to T2DM complications by Dadon Sarah, Raz Itamar, Wainstein Julio, Amar Shirly, Ovadia Ofer, Blech Ilana, Feder Jeanette, Arking Dan E, Glaser Benjamin, Mishmar Dan

“…</p> <p>Conclusion</p> <p>Our findings support the possibility that recent bottleneck events leading to over-representation of minor mtDNA alleles in specific genetic isolates, could result in population-specific susceptibility loci to complex disorders.</p>…”
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Cellular and molecular mechanisms of chronic kidney disease with diabetes mellitus and cardiovascular diseases as its comorbidities by Prathibha Reddy Gajjala, Joachim eJankowski, Maryam eSanati

“…Chronic kidney disease (CKD), diabetes mellitus (DM) and cardiovascular diseases (CVD) are complex disorders of partly unknown genesis and mostly known progression factors. …”
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An Investigation of the Role of Common and Rare Variants in a Large Italian Multiplex Family of Multiple Sclerosis Patients by Nadia Barizzone, Rachele Cagliani, Chiara Basagni, Ferdinando Clarelli, Laura Mendozzi, Cristina Agliardi, Diego Forni, Martina Tosi, Elisabetta Mascia, Francesco Favero, Davide Corà, Lucia Corrado, Melissa Sorosina, Federica Esposito, Miriam Zuccalà, Domizia Vecchio, Maria Liguori, Cristoforo Comi, Giancarlo Comi, Vittorio Martinelli, Massimo Filippi, Maurizio Leone, Filippo Martinelli-Boneschi, Domenico Caputo, Manuela Sironi, Franca Rosa Guerini, Sandra D’Alfonso

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The relationship between insomnia and complex diseases—insights from genetic data by Enda M. Byrne

“…Large genetic studies have provided insights into the etiology of insomnia, highlighting biological pathways that are shared with other complex disorders. Increased focus on treating sleep problems in the clinic and through public health interventions may reduce the overall burden of disease in human populations.…”
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Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders. Multi-organ whole-genome measurements and reverse engineering to uncover gene networks... by Jesper Tegnér, Josefin Skogsberg, Johan Björkegren

“…We also address how gene networks will probably play a key role in the development of early diagnostics and treatments for complex disorders in the coming era of individualized medicine.…”
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The role of the clinical nurse specialist in haemoglobinopathies by Bernadette Hylton

“…Haemoglobinopathies are complex disorders that require specialist knowledge to deliver the very best care. …”
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Gastroparesis in a Patient with Gastric AL Amyloidosis by Matthew Hoscheit, Afrin Kamal, Michael Cline

“…Systemic amyloidosis is a group of complex disorders characterized by the extracellular deposition of nonbranching fibrils in various tissues, ultimately leading to a variety of clinical presentations including isolated or multiorgan dysfunction. …”
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Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome by Karsten Suhre, Irena Trbojević-Akmačić, Ivo Ugrina, Dennis O. Mook-Kanamori, Tim Spector, Johannes Graumann, Gordan Lauc, Mario Falchi

“…Our study reveals a detailed picture of protein N-glycosylation and suggests new avenues for the investigation of its role and function in the associated complex disorders.…”
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Treating lysosomal storage disorders: current practice and future prospects. by Platt, F, Lachmann, R

“…The greatest current challenge is in developing effective therapies for treating the CNS manifestations of these complex disorders. In this article, we will review the current therapies/approaches being considered for treating lysosomal storage diseases and give a perspective on the scientific, medical, social and ethical issues they raise.…”

Insights into the genetic risk factors for the development of pancreatic disease by Zachary Zator, David C Whitcomb

“…The failure of traditional approaches to identify primary mechanisms underlying these progressive disorders illustrates a greater problem of failure of the germ theory of disease for complex disorders. Multiple genetic discoveries and new complex disease models force consideration of a new paradigm of ‘precision medicine’, requiring a new mechanistic definition of CP. …”
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The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story by Dan Mishmar

“…Complex disorders are common in the human population and are caused by interplay between genetic and environmental factors. …”
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Can polygenic risk scores help explain disease prevalence differences around the world? A worldwide investigation by Pritesh R. Jain, Myson Burch, Melanie Martinez, Pablo Mir, Jakub P. Fichna, Cezary Zekanowski, Renata Rizzo, Zeynep Tümer, Csaba Barta, Evangelia Yannaki, John Stamatoyannopoulos, Petros Drineas, Peristera Paschou

“…Abstract Complex disorders are caused by a combination of genetic, environmental and lifestyle factors, and their prevalence can vary greatly across different populations. …”
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Solving the puzzle of neurological diseases: an interview with Huda Zoghbi by Huda Y. Zoghbi

“…As highlighted in this interview, her work is now paying dividends by starting to reveal potential therapeutic targets for these intractable and complex disorders.…”
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Clinical Interpretation of Genomic Variations by Müge Sayitoğlu

“…Novel high-throughput sequencing technologies generate largescale genomic data and are used extensively for disease mapping of monogenic and/or complex disorders, personalized treatment, and pharmacogenomics. …”
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The New Specialties of Orofacial Pain and Oral Medicine: Practical Strategies to Improve Access to Care for Orofacial Disorders by James Fricton, Nelson L. Rhodus

“…ABSTRACTOrofacial disorders are common and complex disorders with an estimated collective prevalence of over 40% of the general population. …”
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Testing genetic association by regressing genotype over multiple phenotypes. by Kai Wang

“…Complex disorders are typically characterized by multiple phenotypes. …”
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Molecular basis for phenotypic similarity of genetic disorders by Vijay Kumar Pounraja, Santhosh Girirajan

“…This study highlights how structural similarity among genes contributes to shared phenotypes, and shows how this relationship can contribute to our understanding of the genetic basis of complex disorders.…”
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