Endocannabinoid System as Therapeutic Target of PTSD: A Systematic Review by Luca Steardo, Elvira Anna Carbone, Giulia Menculini, Patrizia Moretti, Luca Steardo, Alfonso Tortorella

“…Post-Traumatic Stress Disorder (PTSD) is a complex disorder involving dysregulation of stress-related hormones and neurotransmitter systems. …”
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Virtual Reality Technology to Enhance Conventional Rehabilitation Program: Results of a Single-Blind, Randomized, Controlled Pilot Study in Patients with Global Developmental Delay by Carmela Settimo, Maria Cristina De Cola, Erica Pironti, Rosalia Muratore, Fabio Mauro Giambò, Angelo Alito, Maria Tresoldi, Margherita La Fauci, Carmela De Domenico, Emanuela Tripodi, Caterina Impallomeni, Angelo Quartarone, Francesca Cucinotta

“…Global developmental delay (GDD) is a complex disorder that requires multimodal treatment involving different developmental skills. …”
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Towards Unification of General Relativity and Quantum Theory: Dendrogram Representation of the Event-Universe by Oded Shor, Felix Benninger, Andrei Khrennikov

“…In this way our theory is connected with p-adic physics; in particular, p-adic string theory and complex disordered systems (p-adic representation of the Parisi matrix for spin glasses). …”
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Pax7 lineage contributions to the mammalian neural crest. by Barbara Murdoch, Casey DelConte, Martín I García-Castro

“…Abnormal development of the neural crest is associated with several human maladies including cleft/lip palate, aggressive cancers such as melanoma and neuroblastoma, and rare syndromes, like Waardenburg syndrome, a complex disorder involving hearing loss and pigment defects. …”
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A new mouse model to explore therapies for preeclampsia. by Abdulwahab Ahmed, Jameel Singh, Ysodra Khan, Surya V Seshan, Guillermina Girardi

“…The CBA/J x DBA/2 model, that recapitulates this complex disorder, helped us identify pravastatin as a candidate therapy to prevent preeclampsia and its related complications. …”
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Negative affect and respiratory sinus arrhythmia are differentially related to social anxiety and autism features in autistic preschoolers contrasted to fragile X syndrome by Carla A. Wall, Jane E. Roberts

“…IntroductionAutism spectrum disorder (ASD) is a highly heterogeneous and complex disorder with co-occurring disorders commonplace. …”
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A pilot investigation of audiovisual processing and multisensory integration in patients with inherited retinal dystrophies by Mark H. Myers, Alessandro Iannaccone, Gavin M. Bidelman

“…Methods Two groups were analyzed for this pilot study: Group 1 was composed of IRD participants: two with autosomal dominant retinitis pigmentosa (RP), two with autosomal recessive cone-rod dystrophy (CORD), and two with the related complex disorder, Bardet-Biedl syndrome (BBS); Group 2 was composed of 15 non-IRD participants (controls). …”
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Surgical management of high-grade spondylolisthesis: Current recommendations by Karthik Kailash, Sudhir Ganesan, Nalli Ramanathan Yuvaraj, Appaji Krishnan, Charanjith S Dhillon, Kalale Sudarshan Pramod, Saikrishna Gadde

“…The level of evidence was low in ascertaining the superiority of one technique over the other. HGS is a complex disorder that can be addressed with varying procedures for it. …”
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Hysterosalpingographic (HSG) pattern of infertility in women of reproductive age by Chinwe R Onwuchekwa, Vaduneme K Oriji

“…Background: Infertility is a complex disorder with significant medical, psychological and economic problems. …”
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Convergent evidence from multimodal imaging reveals amygdala abnormalities in schizophrenic patients and their first-degree relatives. by Lin Tian, Chun Meng, Hao Yan, Qiang Zhao, Qi Liu, Jun Yan, Yonghua Han, Huishu Yuan, Lifang Wang, Weihua Yue, Yanbo Zhang, Xinmin Li, Chaozhe Zhu, Yong He, Dai Zhang

“…Such information could help future efforts to identify the endophenotypes that characterize the complex disorder of schizophrenia.…”
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Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration by Gozal Yair M, Seyfried Nicholas T, Gearing Marla, Glass Jonathan D, Heilman Craig J, Wuu Joanne, Duong Duc M, Cheng Dongmei, Xia Qiangwei, Rees Howard D, Fritz Jason J, Cooper Deborah S, Peng Junmin, Levey Allan I, Lah James J

“…</p> <p>Conclusions</p> <p>The proteomic discovery of insoluble SEPT11 accumulation in FTLD-U, along with novel pathological associations, highlights a role for this cytoskeleton-associated protein in the pathogenesis of this complex disorder.</p>…”
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Serological investigation of Chlamydia pneumonia in Patients with Coronary Artery Disease by Z Shahandeh, F Sedighian, MT Salehi Omran, F Saberian

“…Atherosclerosis is a complex disorder and many factors cause it . In recent years , a relationship between infectious agents, particularly Chlamydia pneumonia, and atherosclerosis was found. …”
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Beyond Dopamine Receptor Antagonism: New Targets for Schizophrenia Treatment and Prevention by Felipe V. Gomes, Anthony A. Grace

“…Therefore, therapeutic approaches based on our current understanding of the circuitry of SCZ and its etiology are likely to enable development of more effective therapeutic interventions for this complex disorder.…”
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Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways by Twisk Frank NM, Maes Michael

“…</p> <p>Conclusions</p> <p>In contrast to Harvey and Wessely's (bio)psychosocial model for ME/CFS a bio(psychosocial) model based upon IO&NS abnormalities is likely more appropriate to this complex disorder. In clinical practice, we suggest physicians should also explore the IO&NS pathophysiology by applying laboratory tests that examine the pathways involved.…”
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Metabolic syndrome, hypertension, and nervous system injury: Epidemiological correlates by Giovanna Ricci, Isabel Pirillo, Daniele Tomassoni, Ascanio Sirignano, Iolanda Grappasonni

“…Metabolic syndrome (MetS) is a common and complex disorder combining hypertension, obesity, dyslipidemia, and insulin resistance. …”
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Genetic copy number variants in sib pairs both affected with schizophrenia by Chang Shun-Min, Wen Chun-Chiang, Liu Chih-Min, Lee Chia-Huei, Hwu Hai-Gwo

“…<p>Abstract</p> <p>Background</p> <p>Schizophrenia is a complex disorder with involvement of multiple genes.</p> <p>Methods</p> <p>In this study, genome-wide screening for DNA copy-number variations (CNVs) was conducted for ten pairs, a total of 20 cases, of affected siblings using oligonucleotide array-based CGH.…”
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Profile of anti-IL-5 mAb mepolizumab in the treatment of severe refractory asthma and hypereosinophilic diseases by Menzella F, Lusuardi M, Galeone C, Taddei S, Zucchi L

“…Sebastiano Hospital, Correggio, Italy Abstract: Asthma is a complex disorder frequently associated with a poor symptom control, concomitant morbidity, mortality, and significant health care costs due to lack of compliance or inadequate therapeutic options. …”
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Fine-mapping an association of FSHR with preterm birth in a Finnish population. by Sung Chun, Jevon Plunkett, Kari Teramo, Louis J Muglia, Justin C Fay

“…Preterm birth is a complex disorder defined by gestations of less than 37 weeks. …”
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Inflammatory myopathy in the context of an unusual overlapping laminopathy by Cristina Guillín-Amarelle, Sofía Sánchez-Iglesias, Antonio Mera, Elena Pintos, Ana Castro-Pais, Leticia Rodríguez-Cañete, Julio Pardo, Felipe F. Casanueva, David Araújo-Vilar

“…The patient presented with a complex disorder, including metabolic syndrome associated with mild partial lipodystrophy (Köbberling-like); mild hypertrophic cardiomyopathy, with Wolff–Parkinson– White syndrome and atrial fibrillation; and limb-girdle inflammatory myopathy. …”
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Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression. by Faezeh Sarayloo, Alexandre Dionne-Laporte, Helene Catoire, Daniel Rochefort, Gabrielle Houle, Jay P Ross, Fulya Akçimen, Rachel De Barros Oliveira, Gustavo Turecki, Patrick A Dion, Guy A Rouleau

“…Restless legs syndrome is a common complex disorder with different genetic and environmental risk factors. …”
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