ANXIETY, STRESS-RELATED FACTORS AND BLOOD PRESSURE IN YOUNG ADULTS by Nicola Mucci, Gabriele Giorgi, Stefano De Pasquale Ceratti, Javier Fiz Pérez, Federico Mucci, Giulio Arcangeli

“…Though HT initially presents itself as an asymptomatic condition, it chronically evolves into a major risk factor for cardiovascular, cerebrovascular and renal diseases that, in turn, represent crucial causes of morbidity and mortality in industrialized countries. HT is a complex disorder that it is estimated to afflict more than a quarter of the world's adult population. …”
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Diffuse large B-cell lymphoma in an adolescent female presenting with Epstein-Barr virus-driven hemophagocytic lymphohistiocytosis: a case report by Altaf Sadaf, Atreaga Grace M, Joshi Avni Y, Rodriguez Vilmarie

“…This case report will add to the increasing literature on the diagnosis, complications and management of this complex disorder.</p> <p>Case presentation</p> <p>A 15-year-old Caucasian girl, previously diagnosed with Crohn’s disease and treated with 6-mercaptopurine, developed Epstein-Barr virus infection-driven hemophagocytic lymphohistiocytosis. …”
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Long-term weight-loss in gastric bypass patients carrying melanocortin 4 receptor variants. by Bryn S Moore, Uyenlinh L Mirshahi, Evan A Yost, Ann N Stepanchick, Michael D Bedrin, Amanda M Styer, Kathryn K Jackson, Christopher D Still, Gerda E Breitwieser, Glenn S Gerhard, David J Carey, Tooraj Mirshahi

“…In the absence of complete MC4R deficiency, these differences can be overcome by the powerful weight-reducing effects of bariatric surgery. In a complex disorder such as obesity, genetic variants that cause subtle defects that have cumulative effects can be overcome after appropriate clinical intervention.…”
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Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder by Margaret R. Dunne, Greg Byrne, Fernando G. Chirdo, Conleth Feighery

“…Contribution of each of these factors to pathogenesis is discussed to enhance our view of this complex disorder and to contribute to a wider understanding of chronic immune-mediated disease.…”
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Salivary Free Testosterone and Gingival Health Condition among a Group of Women with Polycystic Ovary Syndrome by Andalus Abid Hassan Tahir, Baydaa Hussien

“…ABSTRACT Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women in their reproductive age.It is characterized by anovulation or oligo-ovulation and hyperandrogensim.Androgen excess is the central defect in polycystic ovary syndrome. It is a complex disorder affects general health in addition to oral health.This study aimed to assess the gingival health status among a group of women with polycystic ovary syndrome as well as to estimate the levels of salivaryfree testosterone in unstimulated saliva in relation to gingival health condition. …”
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The Role of Long Noncoding RNAs on Male Infertility: A Systematic Review and In Silico Analysis by Maria-Anna Kyrgiafini, Theologia Sarafidou, Zissis Mamuris

“…Male infertility is a complex disorder affecting many couples worldwide. Long noncoding RNAs (lncRNAs) regulate important cellular processes; however, a comprehensive understanding of their role in male infertility is limited. …”
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Antipsychotic Drug Development: From Historical Evidence to Fresh Perspectives by Katrina Weston-Green, Katrina Weston-Green, Katrina Weston-Green

“…Schizophrenia is a complex disorder of varied etiology, manifesting symptoms that can differ between patients and change throughout an individual's lifespan. …”
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Resting state FMRI reveals diminished functional connectivity in a mouse model of amyloidosis. by Disha Shah, Elisabeth Jonckers, Jelle Praet, Greetje Vanhoutte, Rafael Delgado Y Palacios, Christian Bigot, Dany V D'Souza, Marleen Verhoye, Annemie Van der Linden

“…Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer's disease (AD). AD is a complex disorder, characterised by several pathological features. …”
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Structural brain network topology underpinning ADHD and response to methylphenidate treatment by Kristi R. Griffiths, Taylor A. Braund, Michael R. Kohn, Simon Clarke, Leanne M. Williams, Mayuresh S. Korgaonkar

“…Our findings demonstrate that graph measures of structural topology provide valuable diagnostic and prognostic markers of ADHD, which may aid in mechanistic understanding of this complex disorder.…”
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Data Byte: An Insight on Fetal Alcohol Spectrum Disorder and Educational Achievement by Carley Piatt, Navjot Lamba, Ruiting Jia, Christine Werk

“…Objectives and Approach Fetal Alcohol Spectrum Disorder (FASD) is a complex disorder caused by alcohol exposure during pregnancy. …”
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The Role at Rehabilitation in Treatment of Thoracic Outlet Syndrome by Mohammad Ali Hosseinian

“…Objective: Thoracic outlet syndrome is a complex disorder caused by neurovascular irritation in the region of the thoracic outlet. …”
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Machine learning and microsimulation techniques on the prognosis of dementia: A systematic literature review. by Ana Luiza Dallora, Shahryar Eivazzadeh, Emilia Mendes, Johan Berglund, Peter Anderberg

“…Dementia is a complex disorder characterized by poor outcomes for the patients and high costs of care. …”
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Investigation of the Association between GFPT2 Gene Polymorphism and Risk of Type 2 Diabetes by Soyar Sari

“…Background and Objectives: Type 2 diabetes is one of the most common metabolic diseases and a complex disorder with a strong genetic predisposition, which significantly affects mortality. …”
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Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME/EAST syndrome. by Paulais, M, Bloch-Faure, M, Picard, N, Jacques, T, Ramakrishnan, S, Keck, M, Sohet, F, Eladari, D, Houillier, P, Lourdel, S, Teulon, J, Tucker, S

“…The functional importance of Kir4.1/Kir5.1 in renal ion transport has recently been highlighted by mutations in the human Kir4.1 gene (KCNJ10) that result in seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME)/epilepsy, ataxia, sensorineural deafness, and renal tubulopathy (EAST) syndrome, a complex disorder that includes salt wasting and hypokalemic alkalosis. …”

Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. by Pajukanta, P, Cargill, M, Viitanen, L, Nuotio, I, Kareinen, A, Perola, M, Terwilliger, J, Kempas, E, Daly, M, Lilja, H, Rioux, J, Brettin, T, Viikari, J, Rönnemaa, T, Laakso, M, Lander, E, Peltonen, L

“…Coronary heart disease (CHD) is a complex disorder constituting a major health problem in Western societies. …”

Multifactoriality of Parkinson’s Disease as Explored Through Human Neural Stem Cells and Their Transplantation in Middle-Aged Parkinsonian Mice by Anna Nelke, Anna Nelke, Silvia García-López, Silvia García-López, Alberto Martínez-Serrano, Alberto Martínez-Serrano, Marta P. Pereira, Marta P. Pereira

“…Overall, these findings demonstrate that hVM1 clone 32 cell transplant prevented motor and non-motor impairments and that PD is a complex disorder with many influencing factors, thus reinforcing the idea of novel targets for PD treatment that tend to be focused on dopamine and nigrostriatal damage.…”
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Extracellular Vesicles Are More Potent Than Adipose Mesenchymal Stromal Cells to Exert an Anti-Fibrotic Effect in an In Vitro Model of Systemic Sclerosis by Pauline Rozier, Marie Maumus, Claire Bony, Alexandre Thibault Jacques Maria, Florence Sabatier, Christian Jorgensen, Philippe Guilpain, Danièle Noël

“…Systemic sclerosis (SSc) is a complex disorder resulting from dysregulated interactions between the three main pathophysiological axes: fibrosis, immune dysfunction, and vasculopathy, with no specific treatment available to date. …”
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The First Report of Differences in Gut Microbiota Composition between Obese and Normal Weight Iranian Subjects by Fateme Ettehad Marvasti, Arfa Moshiri, Mina Sadat Taghavi, Soheil Riazi, Majid Taati, Seyedeh Fatemeh Sadati, Azadeh Ghaheri, Morteza Masoomi, Farzam Vaziri, Abolfazl Fateh, Pejman Rohani, Samira Tarashi, Andrea Masotti, Sara Ahmadi Badi, Seyed Davar Siadat

“…Background: Obesity is a complex disorder influenced by various genetic and environmental factors. …”
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Age-related changes of protein SUMOylation balance in the A&amp;beta;PP Tg2576 mouse model of Alzheimer&#39;s disease by Robert eNisticò, Robert eNisticò, Caterina eFerraina, Veronica eMarconi, Fabio eBlandini, Lucia eNegri, Jan eEgebjerg, Marco eFeligioni

“…Alzheimer's disease (AD) is a complex disorder that affects the central nervous system causing a severe neurodegeneration. …”
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Persistent post-traumatic headache: a migrainous loop or not? The preclinical evidence by Silvia Benemei, Alejandro Labastida-Ramírez, Ekaterina Abramova, Nicoletta Brunelli, Edoardo Caronna, Paola Diana, Roman Gapeshin, Maxi Dana Hofacker, Ilaria Maestrini, Enrique Martínez Pías, Petr Mikulenka, Olga Tikhonova, Paolo Martelletti, Antoinette MaassenVanDenBrink, On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)

“…Despite representing a simplification of a complex disorder and displaying different limitations concerning the human condition, animal models are still a mainstay to study in vivo the mechanisms of PTH and have provided valuable insight into the pathophysiology and possible treatment strategies. …”
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