Supplementation with high-content docosahexaenoic acid triglyceride in attention-deficit hyperactivity disorder: a randomized double-blind placebo-controlled trial by Rodríguez C, García T, Areces D, Fernández E, García-Noriega M, Domingo JC

“…Celestino Rodríguez,1 Trinidad García,1 Débora Areces,1,2 Estrella Fernández,1 Marcelino García-Noriega,3 Joan Carles Domingo41Department of Psychology, Faculty of Psychology, University of Oviedo, Oviedo, Spain; 2Child Education Program, Faculty Padre Ossó, Oviedo, Spain; 3Service of Pediatrics, Hospital Valle del Nalón, Langreo, Spain; 4Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Barcelona, SpainBackground: Attention-deficit hyperactivity disorder (ADHD) is a complex disorder in terms of etiology, clinical presentation, and treatment outcome. …”
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Investigation of SNP rs2060546 immediately upstream to NTN4 in a Danish Gilles de la Tourette syndrome cohort by Shanmukha Sampath Padmanabhuni, Rayan Houssari, Ann-Louise Esserlind, Jes Olesen, Thomas Werge, Thomas Folkmann Hansen, Birgitte Berterlsen, Fotis Tsetsos, Peristera Paschou, Zeynep Tumer

“…Gilles de la Tourette syndrome (GTS) is a neuropsychiatric disorder characterized by multiple motor and vocal tics. GTS is a complex disorder, with environmental factors and several genes involved. …”
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Integration of transcriptomic data in a genome-scale metabolic model to investigate the link between obesity and breast cancer by Ilaria Granata, Enrico Troiano, Mara Sangiovanni, Mario Rosario Guarracino

“…Abstract Background Obesity is a complex disorder associated with an increased risk of developing several comorbid chronic diseases, including postmenopausal breast cancer. …”
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Cushing syndrome as a failed cardiac screen in a patient with McCune–Albright syndrome: a case report by Christy Foster, Hiba Al Zubeidi, Alicia Diaz-Thomas

“…Abstract Background McCune–Albright syndrome is a complex disorder encompassing multiple endocrinopathies. …”
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Incidence and risk factors of acute kidney injury among the critically ill neonates by Ayman A El-Badawy, Samuel Makar, Abdel-Rahman A Abdel-Razek, Dalia Abd Elaziz

“…Acute kidney injury (AKI) is a complex disorder with clinical manifestations ranging from mild dysfunction to complete kidney failure. …”
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Epigenome-wide DNA methylation in hearing ability: new mechanisms for an old problem. by Lisa E Wolber, Claire J Steves, Pei-Chien Tsai, Panos Deloukas, Tim D Spector, Jordana T Bell, Frances M K Williams

“…Age-related hearing impairment is a complex disorder, known to be heritable, with heritability estimates of 57-70%. …”
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DNA Methylation of PGC-1α Is Associated With Elevated mtDNA Copy Number and Altered Urinary Metabolites in Autism Spectrum Disorder by Sophia Bam, Erin Buchanan, Caitlyn Mahony, Colleen O’Ryan

“…Autism spectrum disorder (ASD) is a complex disorder that is underpinned by numerous dysregulated biological pathways, including pathways that affect mitochondrial function. …”
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Young Patients with Anorexia Nervosa: The Contribution of Post-Traumatic Stress Disorder and Traumatic Events by Paola Longo, Enrica Marzola, Carlotta De Bacco, Matilde Demarchi, Giovanni Abbate-Daga

“…<i>Background and Objectives</i>: Anorexia nervosa (AN) is a complex disorder whose etiopathogenesis involves both biological and environmental factors. …”
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The futility of long-term predictions in bipolar disorder: mood fluctuations are the result of deterministic chaotic processes by Abigail Ortiz, Kamil Bradler, Maxine Mowete, Stephane MacLean, Julie Garnham, Claire Slaney, Benoit H. Mulsant, Martin Alda

“…Abstract Background Understanding the underlying architecture of mood regulation in bipolar disorder (BD) is important, as we are starting to conceptualize BD as a more complex disorder than one of recurring manic or depressive episodes. …”
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Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer’s disease –conformist, nonconformist, and realistic prospects for AD pathogenesis by Hongmei Li, Chia-Chen Liu, Hui Zheng, Timothy Y. Huang

“…Conclusion AD is a multi-factor complex disorder, which likely requires a combinatorial therapeutic approach to successfully slow or reduce symptomatic memory decline. …”
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Genetic and functional involvement of ZEB1 and FEN1 genes in FECD pathogenesis by Gargi G. Nanda, Sujata Das, Debasmita P. Alone

“…Fuchs’ endothelial corneal dystrophy (FECD) is a dominantly inherited complex disorder, clinically manifested as thickened collagenous deposition on corneal Descemet’s membrane with excrescences called guttae [1, 2]. …”
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Short-Term Surveillance of Cytokines and C-Reactive Protein Cannot Predict Efficacy of Fecal Microbiota Transplantation for Ulcerative Colitis. by Ting Zhang, Bota Cui, Pan Li, Zhi He, Chuyan Long, Lu Wei, Zhaoyuan Peng, Guozhong Ji, Faming Zhang

“…In both Response group and Non-response group, none of the eleven detectable cytokines showed a significant difference between the value at three days after FMT and that before FMT (p>0.05).Patients with moderate to severe UC presented a complex disorder of cytokines. However, the efficacy of FMT for UC might not be predicted by the short-term surveillance of cytokines and CRP.…”
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Risk factors for specific subtypes of ischaemic stroke by Schulz, U, Schulz, Ursula

“…<p>Ischaemic stroke is a complex disorder with many different aetiologies, but previous studies of stroke often did not differentiate aetiological subtypes of ischaemic stroke. …”

Structural analogues of complex magnetic phases by Wolpert, EH

“…At phase boundaries we identify complex disordered states that we show sometimes provide a more convincing descriptor of the polytypism than established models. …”

Identification of microbial agents in tissue specimens of ocular and periocular sarcoidosis using a metagenomics approach [version 1; peer review: 2 approved] by Amde Selassie Shifera, Christopher Pockrandt, Natalia Rincon, Yuchen Ge, Jennifer Lu, Steven L. Salzberg, Charles Eberhart, Jennifer E. Thorne, Ales Varabyou, Anne E. Jedlicka, Karen Sun, Alan L. Scott

“…Sarcoidosis is a complex disorder whose etiology remains unknown and for which a variety of infectious causes have been hypothesized. …”
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Long‐term clinical and magnetic resonance imaging follow‐up of dogs with osseous‐associated cervical spondylomyelopathy by Carolyn Nye, Eric Hostnik, Elizabeth Parker, Thomas Wittum, Stephen Jones, Sarah Moore, Laurie Cook, Ronaldo C. da Costa

“…Abstract Background Osseous‐associated cervical spondylomyelopathy (OA‐CSM) is a complex disorder with limited long‐term survival. The longitudinal progression is currently unknown. …”
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Systematic Review of Prevalence Studies and Familial Aggregation in Vestibular Migraine by Ana Paz-Tamayo, Patricia Perez-Carpena, Patricia Perez-Carpena, Jose A. Lopez-Escamez, Jose A. Lopez-Escamez, Jose A. Lopez-Escamez

“…Background: Vestibular migraine (VM) is complex disorder consisting of episodes of migraine and vertigo with an estimated prevalence of 1–3%. …”
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Long-term environmental exposure of darkness induces hyperandrogenism in PCOS via melatonin receptor 1A and aromatase reduction by Weiwei Chu, Weiwei Chu, Shang Li, Shang Li, Xueying Geng, Xueying Geng, Dongshuang Wang, Dongshuang Wang, Junyu Zhai, Junyu Zhai, Gang Lu, Wai-Yee Chan, Zi-Jiang Chen, Zi-Jiang Chen, Zi-Jiang Chen, Yanzhi Du, Yanzhi Du

“…Polycystic ovary syndrome (PCOS) is a common and complex disorder impairing female fertility, yet its etiology remains elusive. …”
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In Vitro Antiviral Effect and Potential Neuroprotection of <i>Salvadora persica</i> L. Stem Bark Extract against Lipopolysaccharides-Induced Neuroinflammation in Mice: LC-ESI-MS/MS... by Reem Binsuwaidan, Walaa A. Negm, Engy Elekhnawy, Nashwah G. M. Attallah, Eman Ahmed, Sameh Magdeldin, Ehssan Moglad, Sally Abdallah Mostafa, Suzy A. El-Sherbeni

“…Neuroinflammation is a serious immunomodulatory complex disorder that causes neurological and somatic ailments. …”
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Canadians Seeking Solutions and Innovations to Overcome Chronic Kidney Disease (Can-SOLVE CKD): Form and Function by Adeera Levin, Evan Adams, Brendan J. Barrett, Heather Beanlands, Kevin D. Burns, Helen Hoi-Lun Chiu, Kate Chong, Allison Dart, Jack Ferera, Nicolas Fernandez, Elisabeth Fowler, Amit X. Garg, Richard Gilbert, Heather Harris, Rebecca Harvey, Brenda Hemmelgarn, Matthew James, Jeffrey Johnson, Joanne Kappel, Paul Komenda, Michael McCormick, Christopher McIntyre, Farid Mahmud, York Pei, Graham Pollock, Heather Reich, Norman D. Rosenblum, James Scholey, Etienne Sochett, Mila Tang, Navdeep Tangri, Marcello Tonelli, Catherine Turner, Michael Walsh, Cathy Woods, Braden Manns

“…Issue Chronic kidney disease (CKD) is a complex disorder that affects more than 4 million Canadians and costs the Canadian health care system more than $40 billion per year. …”
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