Genetic epidemiology of multiple sclerosis. by Sadovnick, A, Dyment, D, Ebers, G

“…Nevertheless, we are entering into a very exciting era with respect to the genetics and treatment of common complex disorders such as breast cancer, Alzheimer disease, and multiple sclerosis. …”

Visualization of Global Disease Burden for the Optimization of Patient Management and Treatment by Winfried Schlee, Deborah A. Hall, Deborah A. Hall, Niklas K. Edvall, Berthold Langguth, Barbara Canlon, Christopher R. Cederroth

“…BackgroundThe assessment and treatment of complex disorders is challenged by the multiple domains and instruments used to evaluate clinical outcome. …”
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Identifying Phronotypes in Psychiatry by F. Andrew eKozel

“…Utilizing techniques learned in other areas of medicine to deal with symptoms that lead to complex disorders can provide insight into improving diagnostic models in psychiatry. …”
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Healthcare professionals’ experiences of interdisciplinary collaboration in pain centres – A qualitative study by Nøst Torunn Hatlen, Dahl-Michelsen Tone, Aandahl Hanne, Steinsbekk Aslak

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Editorial: The Post-Exome Era by Mina Ohadi

“…The Iranian Rehabilitation Journal (IRJ) invites research papers on the genetic basis of single gene and complex disorders. This vastly dynamic branch of science will complement the multidisciplinary wealth of expertise in the fields of social welfare and rehabilitation. …”
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Update on chromosomal locations for psychiatric disorders: report of the interim meeting of chromosome workshop chairpersons from the VIIth World Congress of Psychiatric Genetics,... by DeLisi, L, Craddock, N, Detera-Wadleigh, S, Foroud, T, Gejman, P, Kennedy, J, Lendon, C, Macciardi, F, McKeon, P, Mynett-Johnson, L, Nurnberger, J, Paterson, A, Schwab, S, Van Broeckhoven, C, Wildenauer, D, Crow, T

“…The use of linkage strategies alone to localize genes for these complex disorders remains to be established and alternative approaches should continue to be explored.…”

Models of community treatments in schizophrenia: do they travel? by Burns, T

“…CONCLUSION: There is more to be gained in understanding complex disorders such as schizophrenia by interpreting the impact of context on treatment study outcomes than by simply dismissing contradictory findings as failures of implementation of either research or clinical practice.…”

The genetic and epigenetic basis of type 2 diabetes and obesity. by Drong, A, Lindgren, C, McCarthy, M

“…Type 2 diabetes (T2D) and obesity are complex disorders that constitute major public health problems. …”

Genetics of multiple sclerosis. by Dyment, D, Ebers, G, Sadovnick, A

“…The future of MS genetics, as for most common complex disorders, will be dependent on the resources available, ranging from biological samples and comprehensive databases of clinical and epidemiological information to the development of new technologies and statistical methods.…”

Translating immunology into therapeutic concepts for inflammatory bowel disease by Uhlig, HH, Powrie, F

“…Inflammatory bowel disease (IBD) defines a spectrum of complex disorders. Understanding how environmental risk factors, alterations of the intestinal microbiota, and polygenetic and epigenetic susceptibility impact on immune pathways is key for developing targeted therapies. …”

Models of community treatments in schizophrenia: Do they travel? by Burns, T

“…Conclusion: There is more to be gained in understanding complex disorders such as schizophrenia by interpreting the impact of context on treatment study outcomes than by simply dismissing contradictory findings as failures of implementation of either research or clinical practice. © Munksgaard 2000.…”

Personalised medicine in interstitial lung diseases by Maria A. Kokosi, George A. Margaritopoulos, Athol U. Wells

“…Interstitial lung diseases in general, and idiopathic pulmonary fibrosis in particular, are complex disorders with multiple pathogenetic pathways, various disease behaviour profiles and different responses to treatment, all facets that make personalised medicine a highly attractive concept. …”
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Prediction of drug combinations by integrating molecular and pharmacological data. by Xing-Ming Zhao, Murat Iskar, Murat Iskar, Georg Zeller, Michael Kuhn, Vera van Noort, Peer Bork

“…Combinatorial therapy is a promising strategy for combating complex disorders due to improved efficacy and reduced side effects. …”
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Medical Treatment of Obstructive Sleep Apnea in Children by Almala Pinar Ergenekon, Yasemin Gokdemir, Refika Ersu

“…Although persistent OSA following adenotonsillectomy is usually associated with obesity and underlying complex disorders, it can also affect otherwise healthy children. …”
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An unsupervised computational pipeline identifies potential repurposable drugs to treat Huntington's disease and multiple sclerosis by Luca Menestrina, Maurizio Recanatini

“…Finally, this pipeline could potentially provide new suggestions also for other complex disorders.…”
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What Research Evidence Is Valid for Psychotherapy Research? by Björn Philips, Fredrik Falkenström

“…Therefore, we propose that the top of the research evidence hierarchy for psychotherapy should encompass: (1) RCT for circumscribed disorders, (2) cohort studies for complex disorders, and (3) advanced process studies for change mechanisms.…”
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Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia by O. A. Ershova, T. A. Bairova

“…Genetic variations that predispose individuals to complex disorders, such as essential hypertension, may be found in gene coding regions, intronic regions or in gene promoter region. …”
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Molecular genetics of neuropsychiatric illness: some musings by Meghana Janardhanan, Somdatta Sen, Bhagylakshmi Shankarappa, Meera Purushottam

“…Even so, the results of studies on well-characterised clinical datasets of modest sizes can be enlightening and provide important clues to understanding these complex disorders. We describe the use of common variants, at multiallelic loci like TOMM40 and APOE to study dementia, weighted genetic risk scores for alcohol-induced liver cirrhosis and whole exome sequencing to identify rare variants in genes like PLA2G6 in familial psychoses and schizophrenia in our Indian population.…”
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Gene-Environment Interactions in Schizophrenia: A Literature Review by Marah H. Wahbeh, Dimitrios Avramopoulos

“…Discovering these interactions is crucial to our understanding of the pathogenesis of complex disorders. It can help in identifying individuals at high risk, in developing individualized treatments and prevention plans, and can influence clinical management.…”
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Molecular Modeling of Histamine Receptors—Recent Advances in Drug Discovery by Pakhuri Mehta, Przemysław Miszta, Sławomir Filipek

“…Furthermore, the pharmacological profiles of ligands clearly indicate that these receptors may be considered as targets not only for selective but also for multi-target drugs that could be used for treatment of complex disorders such as Alzheimer’s disease. Therefore, analysis of protein-ligand recognition in the binding site of histamine receptors and also other molecular targets has become a valuable tool in drug design toolkit. …”
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