Using machine intelligence to uncover Alzheimer’s disease progression heterogeneity by Bessi Qorri, Mike Tsay, Abhishek Agrawal, Rhoda Au, Joseph Geraci

“…Conclusions: Using a limited transcriptomic public database, six different classes that drive AD were uncovered, supporting the premise that AD is a heterogeneously complex disorder. The perspective classes highlighted genetic pathways associated with vasculogenesis, cellular signaling and differentiation, metabolic function, mitochondrial function, nitric oxide, and metal ion metabolism. …”
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Relationship of Bacteria Isolated from Antral Gastric Biopsy with the Incidence of Dyspepsia in Patients Referred to Mehrad and Labbafinejad Hospitals, Tehran, Iran, in 2018 by Mahnaz Mohammadi, Amin Talebi Bezmin Abadi, Farid Rahimi, Mojgan Forootan

“…Discussion & Conclusion: Bacterial species living in this area can be highly diverse, and therefore, in addition to other epigenetic involved factors, the studying of other factors, such as environment, nutrition, lifestyle, and the host's genetic, will increase our understanding of the pathogenesis of this complex disorder…”
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Characterization of a novel mutation V136L in bone morphogenetic protein 15 identified in a woman affected by POI by Eleonora Ferrarini, Giuseppina De Marco, Francesca Orsolini, Elena Gianetti, Elena Benelli, Franca Fruzzetti, Tommaso Simoncini, Patrizia Agretti, Massimo Tonacchera

“…We identified and characterized a novel BMP15 mutation, providing an additional elucidation of molecular basis of this complex disorder.…”
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The susceptibility of FSHB -211G > T and FSHR G-29A, 919A > G, 2039A > G polymorphisms to men infertility: an association study and meta-analysis by Qiuyue Wu, Jing Zhang, Peiran Zhu, Weijun Jiang, Shuaimei Liu, Mengxia Ni, Mingchao Zhang, Weiwei Li, Qing Zhou, Yingxia Cui, Xinyi Xia

“…Abstract Background Male infertility is a complex disorder caused by genetic, developmental, endocrine, or environmental factors as well as unknown etiology. …”
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Long-term effects of GH therapy in adult patients with Prader-Willi syndrome: a longitudinal study by Graziano Grugni, Alessandro Sartorio, Davide Soranna, Antonella Zambon, Lucia Grugni, Giuseppe Zampino, Antonino Crinò

“…IntroductionPrader-Willi syndrome (PWS) is a complex disorder resulting from the failure of expression of paternal alleles in the PWS region of chromosome 15. …”
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Reference Genes across Nine Brain Areas of Wild Type and Prader-Willi Syndrome Mice: Assessing Differences in <i>Igfbp7</i>, <i>Pcsk1</i>, <i>Nhlh2</i> and <i>Nlgn3</i> Expression by Delf-Magnus Kummerfeld, Boris V. Skryabin, Juergen Brosius, Sergey Y. Vakhrushev, Timofey S. Rozhdestvensky

“…We provide a valuable tool for expression analysis of specific genes across different areas of the mouse brain and for comparative investigation of <i>PWScr</i> mouse models to discover and verify different regulatory pathways affecting this complex disorder.…”
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The Vastus Lateralis Muscle Interstitium Proteome Changes after an Acute Nociception in Patients with Fibromyalgia Compared to Healthy Subjects—A Microdialysis Study by Bijar Ghafouri, Daria Matikhan, Nikolaos Christidis, Malin Ernberg, Eva Kosek, Kaisa Mannerkorpi, Björn Gerdle, Karin Wåhlén

“…Fibromyalgia (FM) is a complex disorder and a clinical challenge to diagnose and treat. …”
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Comparative Study of Ultrasonographic and Anthropometric Measurements of Regional Adiposity in Metabolic Syndrome by Rudresh Hiremath, Jebin Ibrahim, Krishna Prasanthi, Harish T Reddy, Rushit Sandeep Shah, CH Haritha

“…Introduction: Metabolic syndrome is complex disorder unifying dyslipidemia, insulin resistance and hyper insulinemia. …”
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Peripheral Blood-Based Gene Expression Studies in Schizophrenia: A Systematic Review by Vipul Vilas Wagh, Parin Vyas, Suchita Agrawal, Tejaswini A. Pachpor, Vasudeo Paralikar, Satyajeet P. Khare

“…We conclude that well-designed cohort studies across diverse populations, use of high-throughput sequencing technology, and use of artificial intelligence (AI) based computational analysis will significantly improve our understanding and diagnostic capabilities for this complex disorder.…”
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Effect of a nutrition education programme on the metabolic syndrome in type 2 diabetes mellitus patients at a level 5 Hospital in Kenya: “a randomized controlled trial” by Ann Watetu. Thuita, Beatrice Nyanchama Kiage, Arnold N. Onyango, Anselimo O. Makokha

“…It worsens in the presence of the metabolic syndrome (MetS), a complex disorder characterized by co-occurrence of at least three of such factors as hypertension, obesity, dyslipidemia and insulin resistance. …”
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Fenotipos clínicos en el síndrome de apnea obstructiva del sueño by Jorge Jorquera, Pilar Sanchez

“…Summary: Obstructive sleep apnea and hypopnea syndrome is characterized by repetitive episodes of upper airway obstruction and is increasingly recognized as a heterogeneous and complex disorder, proposing multiple phenotypes based on its pathogenic mechanism, polysomnographic alterations, and clinical presentation. …”
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Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5. by Nellie Y Loh, Liz Bentley, Henrik Dimke, Sjoerd Verkaart, Paolo Tammaro, Caroline M Gorvin, Michael J Stechman, Bushra N Ahmad, Fadil M Hannan, Sian E Piret, Holly Evans, Ilaria Bellantuono, Tertius A Hough, William D Fraser, Joost G J Hoenderop, Frances M Ashcroft, Steve D M Brown, René J M Bindels, Roger D Cox, Rajesh V Thakker

“…Hypercalciuria is a major cause of nephrolithiasis, and is a common and complex disorder involving genetic and environmental factors. …”
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An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. by Yi-Hsiang Hsu, M Carola Zillikens, Scott G Wilson, Charles R Farber, Serkalem Demissie, Nicole Soranzo, Estelle N Bianchi, Elin Grundberg, Liming Liang, J Brent Richards, Karol Estrada, Yanhua Zhou, Atila van Nas, Miriam F Moffatt, Guangju Zhai, Albert Hofman, Joyce B van Meurs, Huibert A P Pols, Roger I Price, Olle Nilsson, Tomi Pastinen, L Adrienne Cupples, Aldons J Lusis, Eric E Schadt, Serge Ferrari, André G Uitterlinden, Fernando Rivadeneira, Timothy D Spector, David Karasik, Douglas P Kiel

“…Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. …”
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Atypical gaze patterns in autistic adults are heterogeneous across but reliable within individuals by Umit Keles, Dorit Kliemann, Lisa Byrge, Heini Saarimäki, Lynn K. Paul, Daniel P. Kennedy, Ralph Adolphs

“…Conclusions These findings pave the way for the investigation of autism subtypes, and for elucidating the specific visual features that best discriminate gaze patterns—directions that will also combine with and inform neuroimaging and genetic studies of this complex disorder.…”
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Genome-wide association Scan of dental caries in the permanent dentition by Wang Xiaojing, Shaffer John R, Zeng Zhen, Begum Ferdouse, Vieira Alexandre R, Noel Jacqueline, Anjomshoaa Ida, Cuenco Karen T, Lee Myoung-Keun, Beck James, Boerwinkle Eric, Cornelis Marilyn C, Hu Frank B, Crosslin David R, Laurie Cathy C, Nelson Sarah C, Doheny Kimberly F, Pugh Elizabeth W, Polk Deborah E, Weyant Robert J, Crout Richard, McNeil Daniel W, Weeks Daniel E, Feingold Eleanor, Marazita Mary L

“…Dental caries is a complex disorder affected by both individual susceptibility and environmental factors. …”
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Role of glycated hemoglobin in microvascular complications in type 2 diabetes mellitus: cross sectional study by Deepika Puri, Jaspreet Kaur, Naveen Gaur, Satyanath Reddy Kodidala

“…Diabetes mellitus (DM) is a complex disorder which defects mainly vascular complications. …”
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Síndrome metabólica, resistência à ação da insulina e doença cardiovascular no diabete melito tipo 1 Síndrome metabólico, resistencia a la acción de la insulina y enfermedad cardio... by Ticiana C. Rodrigues, Luis Henrique Canani, Jorge L. Gross

“…<br>Metabolic syndrome (MS) is a complex disorder represented by a cluster of cardiovascular risk factors related to central fat distribution and insulin resistance (IR), and is associated with early mortality in non-diabetic individuals and in patients with type-2 diabetes mellitus (DM). …”
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Genetic subtypes and phenotypic characteristics of 110 patients with Prader-Willi syndrome by Lu Zhang, Xiaoliang Liu, Yunjing Zhao, Qingyi Wang, Yuanyuan Zhang, Haiming Gao, Bijun Zhang, Wanting Cui, Yanyan Zhao

“…Abstract Background Prader-Willi syndrome (PWS) is a complex disorder caused by impaired paternally expressed genes on chromosome 15q11-q13. …”
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Time-course analysis of frontal gene expression profiles in the rat model of posttraumatic stress disorder and a comparison with the conditioned fear model by Shao-Han Chang, Yao-Ming Chang, Huan-Yuan Chen, Fu-Zen Shaw, Bai-Chuang Shyu

“…Posttraumatic stress disorder (PTSD) is a complex disorder that involves physiological, emotional, and cognitive dysregulation that may occur after exposure to a life-threatening event. …”
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Aryl Hydrocarbon Receptor Activation Ameliorates Acute Respiratory Distress Syndrome through Regulation of Th17 and Th22 Cells in the Lungs by Bryan Latrell Holloman, Alkeiver Cannon, Kiesha Wilson, Prakash Nagarkatti, Mitzi Nagarkatti

“…Collectively, the current study suggests that AhR activation can attenuate ARDS and may serve as a therapeutic modality by which to treat this complex disorder. IMPORTANCE Acute respiratory distress syndrome (ARDS) is a type of respiratory failure that is triggered by a variety of bacterial and viral infections, including the coronavirus SARS-CoV2. …”
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