Gut microbiota from sigma-1 receptor knockout mice induces depression-like behaviors and modulates the cAMP/CREB/BDNF signaling pathway by Jia-Hao Li, Jia-Li Liu, Xiu-Wen Li, Yi Liu, Jian-Zheng Yang, Li-Jian Chen, Kai-Kai Zhang, Xiao-Li Xie, Qi Wang

“…Much remains unknown about the molecular mechanisms underlying this complex disorder. Sigma-1 receptor (Sig-1R) is expressed at high levels in the central nervous system. …”
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P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations by Romain Aubonnet, Ovidiu C. Banea, Ovidiu C. Banea, Roberta Sirica, Eric M. Wassermann, Sahar Yassine, Deborah Jacob, Brynja Björk Magnúsdóttir, Brynja Björk Magnúsdóttir, Magnús Haraldsson, Sigurjon B. Stefansson, Viktor D. Jónasson, Eysteinn Ívarsson, Aron D. Jónasson, Mahmoud Hassan, Mahmoud Hassan, Paolo Gargiulo, Paolo Gargiulo

“…Schizophrenia is a complex disorder about which much is still unknown. Potential treatments, such as transcranial magnetic stimulation (TMS), have not been exploited, in part because of the variability in behavioral response. …”
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A Subset of Patients With Autism Spectrum Disorders Show a Distinctive Metabolic Profile by Dried Blood Spot Analyses by Rita Barone, Rita Barone, Salvatore Alaimo, Marianna Messina, Alfredo Pulvirenti, Jean Bastin, Jean Bastin, MIMIC-Autism Group, Alfredo Ferro, Richard E. Frye, Richard E. Frye, Renata Rizzo, Agata Fiumara, Concetta Meli, Mariangela Gulisano, Federica Maugeri, Adriana Prato, Giovanna Russo, Giovanni Tabbì

“…Biomarkers that identify children with ASD could lead to more accurate and early diagnosis. ASD is a complex disorder with multifactorial and heterogeneous etiology supporting recognition of biomarkers that identify patient subsets. …”
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Long-term follow-up in common variable immunodeficiency: the pediatric-onset and adult-onset landscape by Maria Carrabba, Marco Salvi, Lucia Augusta Baselli, Serena Serafino, Marina Zarantonello, Elena Trombetta, Maria Cristina Pietrogrande, Giovanna Fabio, Rosa Maria Dellepiane

“…In the adult-onset group, the percentage of transitional B cells measured at diagnosis showed a significant accuracy (ROC AUC = 0.625) in identifying patients at risk of developing immune dysregulation.DiscussionThe longitudinal evaluation of lymphocyte subsets combined with clinical phenotype can improve the prediction of lymphoid proliferation and allow experts to achieve early detection and better management of such complex disorder.…”
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The diagnostic workup for systemic mastocytosis differs from consensus recommendations: Results of a worldwide survey by Polina Pyatilova, MD, Jonathan A. Bernstein, MD, Felix Aulenbacher, Msc, Mario Sanchez Borges, MD, Saša Dimitrijević, PhD, Gerard Hoehn, PhD, Marcus Maurer, MD, Pavel Kolkhir, MD, Frank Siebenhaar, MD

“…Objective: Mastocytosis is a complex disorder affecting various organs. The diagnostic workup can be challenging and requires a multidisciplinary approach including the use of uncommon tests. …”
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O impacto da genética na asma infantil Impact of genetics in childhood asthma by Leonardo A. Pinto, Renato T. Stein, Michael Kabesch

“…These data may help general physicians understand the impact of genetics on this complex disorder and how genes and polymorphisms influence asthma and atopy. …”
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Association between metabolic syndrome and colorectal cancer incidence and all-cause mortality: a hospital-based observational study by Kuan-Chih Chung, Sin-Ei Juang, Hong-Hwa Chen, Kung-Chuan Cheng, Kuen-Lin Wu, Ling-Chiao Song, Ko-Chao Lee

“…Abstract Background Metabolic syndrome (MetS) is a worldwide pandemic and complex disorder associated with colorectal cancer (CRC). …”
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Role of Spexin and Leptin in Obesity Among Male Pakistani Population by Rabiya Ali, Mussarat Ashraf, Sher Khan

“…Obesity is considered as a leading complex disorder that has increased worldwide at shocking speed affecting mankind including Pakistan [1]. …”
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Alterações nos parâmetros pré e pós-operatórios de pacientes com síndrome metabólica, submetidos a Bypass gastrointestinal em Y de Roux Changes in the pre- and postoperative parame... by Paulo Afonso Nunes Nassif, Andre Donato Lopes, Gabriel Lima Lopes, Priscila Reis Martins, Lucas Eduardo Pedri, Michelle Varaschim, Denise Serpa Bopp

“…Metabolic syndrome is a complex disorder associated with insulin resistance and abdominal obesity, causing changes in glucose metabolism in various tissues and hyperinsulinemia. …”
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Rebecca Bird - Thesis submitted in partial fulfilment of the degree of Doctor of Clinical Psychology (DClinPsych) by Bird, R

“…<p><strong>Critical Review of the Literature</strong></p> <p><strong>Background:</strong> Chronic Fatigue Syndrome (CFS) is a complex disorder characterised by extreme exhaustion not improved with rest (NICE, 2021). …”