Profiling of driver mutations in lung adenocarcinoma patients identifies rare compound EGFR mutations sensitive to second-generation EGFR-TKIs by Jun Li, Cuiyun Zhang, Yuping Guan, Siyu Wang, Jiawen Zheng, Junnan Feng, Sile Han, Ruijuan Ma, Pengfei Ren, Shasha Li, Harry J. M. Groen, Klaas Kok, Anke van den Berg, Bing Wei, Jie Ma, Hongle Li, Yongjun Guo

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Second-generation ALK-TKIs have different molecular profiles of drug resistance-associated genetic alterations after failure of second-line treatment for ALK fusion positive advanc... by DING Ning, DING Ning, ZHOU Jiebai

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Osimertinib for an Advanced NSCLC Patient with Two Common EGFR Mutations and a Concomitant MET Exon 14 Skipping Mutation: A Case Report by Liu Z, Song P, Zhou L, Ji D, Shen H, Dong H, Feng X

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Successful sequential tyrosine kinase inhibitors to overcome a rare compound of EGFR exon 18–18 and EGFR amplification: A case report by Pascal Wang, Emmanuelle Fabre, Emmanuelle Fabre, Antoine Martin, Kader Chouahnia, Ambre Benabadji, Lise Matton, Boris Duchemann, Boris Duchemann

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c.1263+1G>A Is a Latent Hotspot for CYP27A1 Mutations in Chinese Patients With Cerebrotendinous Xanthomatosis by Jingwen Jiang, Guang Chen, Guang Chen, Jingying Wu, Xinghua Luan, Haiyan Zhou, Xiaoli Liu, Zeyu Zhu, Xiaoxuan Song, Shige Wang, Xiaohang Qian, Juanjuan Du, Xiaojun Huang, Mei Zhang, Wei Xu, Li Cao

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Afatinib for the Treatment of Non-Small Cell Lung Cancer Harboring Uncommon EGFR Mutations: An Updated Database of 1023 Cases Brief Report by James Chih-Hsin Yang, Martin Schuler, Sanjay Popat, Sanjay Popat, Satoru Miura, Keunchil Park, Antonio Passaro, Filippo De Marinis, Flavio Solca, Angela Märten, Edward S. Kim

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Non-syndromic enlarged vestibular aqueduct caused by novel compound mutations of the SLC26A4 gene: a case report and literature review by Yunhua Huang, Yunhua Huang, Linlin Li, Linlin Li, Liqiu Pan, Liqiu Pan, Xiaoting Ling, Xiaoting Ling, Chenghan Wang, Chenghan Wang, Chaoyu Huang, Chaoyu Huang, Yifang Huang, Yifang Huang

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Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naïve lung adenocarcinoma by Kei Namba, Shuta Tomida, Takehiro Matsubara, Yuta Takahashi, Eisuke Kurihara, Yusuke Ogoshi, Takahiro Yoshioka, Tatsuaki Takeda, Hidejiro Torigoe, Hiroki Sato, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichi Toyooka

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Molecular remission after combination therapy with blinatumomab and ponatinib with relapsed/refractory Philadelphia chromosome-positive acute lymphocytic leukemia: two case reports by Junichiro Yuda, Nobuhiko Yamauchi, Ayumi Kuzume, Yong-Mei Guo, Nobue Sato, Yosuke Minami

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Overcoming CEP85L-ROS1, MKRN1-BRAF and MET amplification as rare, acquired resistance mutations to Osimertinib by Waleed Kian, Bilal Krayim, Hadel Alsana, Betsy Giles, Ofer Purim, Wafeek Alguayn, Farouq Alguayn, Nir Peled, Laila C. Roisman

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Successful treatment of a patient with NSCLC carrying uncommon compound L861Q/G719X epidermal growth factor receptor mutations using Afatinib by Zihan Zhou, Jie Huang, Ming Ding, Jing Huang, Ting Wu, Qun Wang, Shuhua Han, Yuan Lu

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An endothelial growth factor receptor compound mutation of T790M substitution with exon 19 deletion in a previously untreated patient: a case report by Juan C. Falla-Martinez, Daniela Espinosa, Juan C. Baena, Lisa X. Rodriguez, Luz F. Sua, Angela R. Zambrano

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Overcoming resistance by ALK compound mutation (I1171S + G1269A) after sequential treatment of multiple ALK inhibitors in non‐small cell lung cancer by Ken Takahashi, Yosuke Seto, Koutaroh Okada, Shinya Uematsu, Ken Uchibori, Mika Tsukahara, Tomoko Oh‐hara, Naoya Fujita, Noriko Yanagitani, Makoto Nishio, Kenichi Okubo, Ryohei Katayama

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EGFR p.V774M/p.L833V compound mutations in lung adenocarcinoma responded well to almonertinib: a case report by Hai Pan, Linlin Zhang, Fanlu Meng, Shasha Guan, Diansheng Zhong

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Case report of a patient with stage IV lung adenocarcinoma and uncommon/compound EGFR mutations who responded to afatinib by Hisanori Hirokawa, Hirokuni Hirata, Hayase Azuma, Kei Sugitate, Sayo Soda, Jun Matsushima, Yasutsugu Fukushima

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Association Between Late-Onset Leukoencephalopathy With Vanishing White Matter and Compound Heterozygous EIF2B5 Gene Mutations: A Case Report and Review of the Literature by Fanxin Kong, Fanxin Kong, Haotao Zheng, Haotao Zheng, Xuan Liu, Xuan Liu, Songjun Lin, Songjun Lin, Jianjun Wang, Jianjun Wang, Zhouke Guo, Zhouke Guo

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Successful therapy of a critically ill non-small cell lung cancer patient with compound mutations in EGFR G719X and S768I genes using furmonertinib: A case report by Xue Pan, Minhua Shi

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Efficacy of Osimertinib in NSCLC Harboring Uncommon EGFR L861Q and Concurrent Mutations: Case Report and Literature Review by Ruiting Lin, Ruilian Chen, Zhiqiang Chen, Leihao Hu, Wei Guo, Zexin Zhang, Lizhu Lin, Hanrui Chen

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