To supplement or not to supplement: a metabolic network framework for human nutritional supplements. by Christopher D Nogiec, Simon Kasif

“…Similar to any study in a model organism, the computational modeling of this research has some limitations. …”
Get full text

In Silico Analysis of the MitraClip in a Realistic Human Left Heart Model by Salvatore Pasta

“…By predicting possible adverse events and complications in a patient-specific manner, computational modeling supports evidence-based decision making and enhances the overall effectiveness and safety of transcatheter mitral valve repairs.…”
Get full text

Intersection and Flattening of Surfaces in 3D Models through Computer-Extended Descriptive Geometry (C<span style="font-variant: small-caps">e</span>DG) by Manuel Prado-Velasco, Laura García-Ruesgas

“…Computer-extended Descriptive Geometry (C<span style="font-variant: small-caps;">e</span>DG) is a new approach to solving and building computer models of three-dimensional (3D) geometrical systems through descriptive geometry procedures (thus inheriting invariant-symmetry properties from projective geometry) that have demonstrated reliability and accuracy. …”
Get full text

Modeling the Temperature Field in Frozen Soil under Buildings in the City of Salekhard Taking into Account Temperature Monitoring by Mikhail Yu. Filimonov, Yaroslav K. Kamnev, Aleksandr N. Shein, Nataliia A. Vaganova

“…The proposed approach, based on a combination of the soil temperature monitoring and computer modeling methods, can be used to improve geotechnical monitoring methods.…”
Get full text

Experimental and Simulation Modal Analysis of a Prismatic Battery Module by Bizhong Xia, Fan Liu, Chao Xu, Yifan Liu, Yongzhi Lai, Weiwei Zheng, Wei Wang

“…Additionally, a proper computational model for simulations of battery module also plays a key role in correctly predicting the dynamic response of battery packs. …”
Get full text

Computational 3D Modeling-Based Identification of Inhibitors Targeting Cysteine Covalent Bond Catalysts for JAK3 and CYP3A4 Enzymes in the Treatment of Rheumatoid Arthritis by Abdelmoujoud Faris, Radwan Alnajjar, Jingjing Guo, Mohammed H. AL Mughram, Adnane Aouidate, Mufarreh Asmari, Menana Elhallaoui

“…Eight possible inhibitors were found, and six new inhibitors were designed in silico using these computational models. The pharmacokinetic and safety characteristics of these candidates were thoroughly assessed. …”
Get full text

A Highly Configurable High-Level Synthesis Functional Pattern Library by Lan Huang, Teng Gao, Dalin Li, Zihao Wang, Kangping Wang

“…In this paper, we propose a set of functional patterns libraries based on the MapReduce model, implemented by C++ templates, which can quickly implement high-performance parallel pipelined computing models on FPGA with specified simple parameters. …”
Get full text

Modeling of long-term train loads impacts on subgrade soils: a review by Victor Yavna, Vladimir Shapovalov, Maksim Okost, Andrey Morozov, Yakov Ermolov, Andrei Kochur

“…We describe the stages of creating the subgrade computer modelling taking into account the analysis of trains load impact, the properties of model’s structural layers, and the change of soil properties under long-term loads.…”
Get full text

Optimizing Size Consistency in Batch Roller Production: A Mixed Strategy Approach by Weifeng Liu, Chengzu Ren

“…To elucidate the operational principles of DCMS, we have developed a computational model grounded in DDSGL, designed simulation test plans under different mixing parameters, and summarized the number of direct comparisons, total comparisons, and differences in roller cycle times to determine the optimal combination of mixing parameters. …”
Get full text

Real-space observation of ergodicity transitions in artificial spin ice by Michael Saccone, Francesco Caravelli, Kevin Hofhuis, Scott Dhuey, Andreas Scholl, Cristiano Nisoli, Alan Farhan

“…In condensed matter physics, ergodicity remains a concept largely investigated via theoretical and computational models. Here, we demonstrate the direct real-space observation of ergodicity transitions in a vertex-frustrated artificial spin ice. …”
Get full text

Computational assessment of hybrid nanofluid flow with the influence of hall current and chemical reaction over a slender stretching surface by Samia Elattar, Maha M. Helmi, Mohamed Abdelghany Elkotb, M.A. El-Shorbagy, Anas Abdelrahman, Muhammad Bilal, Aatif Ali

“…The flow distribution takes into consideration the effects of variable magnetic fields, heat production, Hall current and chemical reactions. A computational model is established for the purpose to amplify the energy communication rate and enhance the productivity and performance of thermal energy propagation for several industrial and biological purposes. …”
Get full text

Minimal Collagen-Binding Epitope of Glycoprotein VI in Human and Mouse Platelets by Chao Han, Pengxuan Ren, Medina Mamtimin, Linus Kruk, Edita Sarukhanyan, Chenyu Li, Hans-Joachim Anders, Thomas Dandekar, Irena Krueger, Margitta Elvers, Silvia Goebel, Kristin Adler, Götz Münch, Thomas Gudermann, Attila Braun, Elmina Mammadova-Bach

“…Although the blockade of GPVI function is widely recognized as a potent anti-thrombotic approach, there are limited studies focused on site-specific targeting of GPVI. Using computational modeling and bioinformatics, we analyzed collagen- and CRP-binding surfaces of GPVI monomers and dimers, and compared the interacting surfaces with other mammalian GPVI isoforms. …”
Get full text

Using network analysis to identify leverage points based on causal loop diagrams leads to false inference by Loes Crielaard, Rick Quax, Alexia D. M. Sawyer, Vítor V. Vasconcelos, Mary Nicolaou, Karien Stronks, Peter M. A. Sloot

“…This application of network analysis, employed to quantitatively identify leverage points without having to use computational modelling approaches that translate CLDs into sets of mathematical equations, has however not been duly reflected upon. …”
Get full text

New advances in the computational simulation of Aqueous Homogeneous Reactor for medical isotopes production by Daniel Milian Pérez, Liván Hernández Pardo, Daylen Milian Pérez, Abel Gámez Rodríguez, Daniel Evelio Milian Lorenzo, Carlos Alberto Brayner de Oliveira Lira

“…Accordingly, this paper aims to show the advances made to improve the predictive capabilities during the multi-physics computational modeling of AHRs.…”
Get full text

Multilayer In Vitro Human Skin Tissue Platforms for Quantitative Burn Injury Investigation by Sean Brocklehurst, Neda Ghousifam, Kameel Zuniga, Danielle Stolley, Marissa Nichole Rylander

“…This information is needed to elucidate high-temperature, short-duration burn injury kinetics and enables determination of relevant input parameters for computational models to facilitate treatment planning. Multilayer in vitro skin platforms were constructed using human dermal keratinocytes and fibroblasts embedded in collagen I hydrogels. …”
Get full text

Adopted walking condition for computational simulation approach on bearing of hip joint prosthesis: review over the past 30 years by J. Jamari, Muhammad Imam Ammarullah, Gatot Santoso, S. Sugiharto, Toto Supriyono, Muki Satya Permana, Tri Indah Winarni, Emile van der Heide

“…Appropriate selection and addition of gait cycles in computation modelling are crucial for accurate and reliable prediction and analysis of bearing performance such as wear a failure of implants. …”
Get full text

A disease-related essential protein prediction model based on the transfer neural network by Sisi Chen, Chiguo Huang, Lei Wang, Lei Wang, Shunxian Zhou, Shunxian Zhou, Shunxian Zhou

“…Due to high costs of traditional biological experiments, an improved Transfer Neural Network (TNN) was designed to extract raw features from multiple biological information of proteins first, and then, based on the newly-constructed Transfer Neural Network, a novel computational model called TNNM was designed to infer essential proteins in this paper. …”
Get full text

From Monitoring and Modeling to Management: How to Improve Water Quality in Brazilian Rivers? A Case Study: Piabanha River Watershed by David de Andrade Costa, Luis Carlos Soares da Silva Junior, José Paulo Soares de Azevedo, Marco Aurélio dos Santos, Rafaela dos Santos Facchetti Vinhaes Assumpção

“…Thus, simulations of the river water quality have been performed through computational modeling suggesting organic load reductions in some sub-basins. …”
Get full text

Human cystatin C induces the disaggregation process of selected amyloid beta peptides: a structural and kinetic view by Adriana Żyła, Anne Martel, Przemysław Jurczak, Augustyn Moliński, Aneta Szymańska, Maciej Kozak

“…To characterize the interactions between Aβ and HCC, we used a complementary approach based on the combination of small-angle neutron scattering analysis, atomic force microscopy and computational modelling, allowing the exploration of the structures of multicomponent protein complexes. …”
Get full text

Numerical Investigation of Darcy–Forchheimer Hybrid Nanofluid Flow with Energy Transfer over a Spinning Fluctuating Disk under the Influence of Chemical Reaction and Heat Source by Muhammad Riaz Khan, Aisha M. Alqahtani, Sharifah E. Alhazmi, Mohamed Abdelghany Elkotb, Maawiya Ould Sidi, Haifaa F. Alrihieli, Elsayed Tag-Eldin, Mansour F. Yassen

“…The present computational model is built to analyze the energy and mass transition rate through a copper and cobalt ferrite water-based hybrid nanofluid (hnf) flow caused by the fluctuating wavy spinning disk. …”
Get full text