The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases by Benoit Coulombe, Thomas M. Durcan, Geneviève Bernard, Asmae Moursli, Christian Poitras, Denis Faubert, Maxime Pinard

“…This procedure combines four components directed towards highly complementary objectives: 1) a high-performance single-cell proteomics (SCP) method (Detect), 2) the development of disease experimental cell models and predictive computational models of cell trajectories (Understand), 3) the discovery of specific targets and personalized therapies (Cure), and 4) the creation of a community of collaborating laboratories to accelerate the development of this novel medical paradigm (Collaborate). …”
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Electric Field Effects on Brain Activity: Implications for Epilepsy and Burst Suppression by Evan D. Doubovikov, Natalya A. Serdyukova, Steven B. Greenberg, David A. Gascoigne, Mohammed M. Minhaj, Daniil P. Aksenov

“…Then, we applied an established computational model of pyramidal cells to simulate neuronal activity in a 3-dimensional grid, with an additional parameter to trigger a suppression phase based on extra-cellular calcium dynamics. …”
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Analysing soliton dynamics and a comparative study of fractional derivatives in the nonlinear fractional Kudryashov’s equation by Asfand Fahad, Salah Mahmoud Boulaaras, Hamood Ur Rehman, Ifrah Iqbal, Muhammad Shoaib Saleem, Dean Chou

“…Our work bridges soliton physics and computer science, underscoring the significance of soliton phenomena in advancing computational modelling and simulations. This research contributes to the intersection of theoretical mathematics and practical computer science, highlighting the vital role of solitons in scientific fields.…”
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Plasmid-mediated phenotypic noise leads to transient antibiotic resistance in bacteria by J. Carlos R. Hernandez-Beltran, Jerónimo Rodríguez-Beltrán, Oscar Bruno Aguilar-Luviano, Jesús Velez-Santiago, Octavio Mondragón-Palomino, R. Craig MacLean, Ayari Fuentes-Hernández, Alvaro San Millán, Rafael Peña-Miller

“…By combining stochastic simulations of a computational model with high-throughput single-cell measurements of b l a TEM-1 expression in Escherichia coli MG1655, we showed that plasmid copy number variability stably maintains populations composed of cells with both low and high plasmid copy numbers. …”
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Resting-state heart rate variability (HRV) mediates the association between perceived chronic stress and ambiguity avoidance by Talita Jiryis, Noa Magal, Eyal Fructher, Uri Hertz, Roee Admon

“…Here, ninety-two healthy adults that exhibit various levels of perceived chronic stress underwent resting-state HRV recording before completing a behavioral task that involves decision-making under either risk or ambiguity. Computational modelling quantified participants’ behavioral attitudes of approach and avoidance separately for risk and ambiguity. …”
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A numerical compass for experiment design in chemical kinetics and molecular property estimation by Matteo Krüger, Ashmi Mishra, Peter Spichtinger, Ulrich Pöschl, Thomas Berkemeier

“…We developed a numerical compass (NC) method that integrates computational models, global optimization, ensemble methods, and machine learning to identify experimental conditions with the greatest potential to constrain model parameters. …”
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Some Slippage Issues in High-Pressure Torsion Using Cu and Ti Samples as an Example by Dmitriy Gunderov, Rashid Asfandiyarov, Vyacheslav Titov, Sofia Gunderova, Vasily Astanin

“…It is assumed that the planes of the upper and lower anvil during HPT are at a slight inclination relative to each other. Computer modeling using the Deform 3D software package has shown that this leads to the accumulations of significant strain during HPT.…”
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Usnic Acid Potassium Salt: Evaluation of the Acute Toxicity and Antinociceptive Effect in Murine Model by Hallysson Douglas A. Araújo, José G. Silva Júnior, João R. Saturnino Oliveira, Maria Helena M. L. Ribeiro, Mônica C. Barroso Martins, Marcos A. Cavalcanti Bezerra, André Lima Aires, Mônica C. P. Azevedo Albuquerque, Mário R. Melo-Júnior, Nicodemos T. Pontes Filho, Eugênia C. Pereira, Diego J. Raposo Silva, Janaína V. dos Anjos, Emerson Peter S. Falcão, Nicácio H. Silva, Vera L. Menezes Lima

“…The structure was determined by ¹H-NMR, IR and elemental analysis, ratified through computational models, as well as identification the site of K⁺ insertion in the molecule. …”
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Modeling cortical synaptic effects of anesthesia and their cholinergic reversal. by Bolaji P Eniwaye, Victoria Booth, Anthony G Hudetz, Michal Zochowski

“…Here we apply a computational model of a network of excitatory and inhibitory neurons to simulate the network-wide effects of anesthesia, due to changes in synaptic inhibition and excitation, and their reversal by cholinergic activation through muscarinic receptors. …”
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i-Modern: Integrated multi-omics network model identifies potential therapeutic targets in glioma by deep learning with interpretability by Xingxin Pan, Brandon Burgman, Erxi Wu, Jason H. Huang, Nidhi Sahni, S. Stephen Yi

“…To begin to resolve this difficulty, we developed i-Modern, an integrated Multi-omics deep learning network method, and optimized a sophisticated computational model in gliomas that can accurately stratify patients based on their prognosis. …”
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Effective Mistuning Identification Method of Integrated Bladed Discs of Marine Engine Turbochargers by Václav Píštěk, Pavel Kučera, Oleksij Fomin, Alyona Lovska

“…Unlike approaches that use costly scanning laser Doppler vibrometers, this method is based on using only a simple laser vibrometer in combination with a computational model of the integrated bladed disc. The added value of this method is, in particular, a significant reduction in the cost of laboratory equipment and a reduction in the time required to obtain the results.…”
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Potential accuracy of quasi-optimal radar meters of angular coordinates with scanning multi-channel antenna system by S. V. Kozlov, Vu Thanh Ha

“…The research demonstrates the convergence of exact and approximate analytical estimates and the results of computer modeling. We present the results of studying the accuracy of determining the angular coordinates of the reflected signal for typical space-energy cases. …”
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Induced neural phase precession through exogenous electric fields by Miles Wischnewski, Harry Tran, Zhihe Zhao, Sina Shirinpour, Zachary J. Haigh, Jonna Rotteveel, Nipun D. Perera, Ivan Alekseichuk, Jan Zimmermann, Alexander Opitz

“…In three experiments, we modulated LFPs in humans, a non-human primate, and computational models using alternating current stimulation. …”
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A system of feed-forward cerebellar circuits that extend and diversify sensory signaling by Harsh N Hariani, A Brynn Algstam, Christian T Candler, Isabelle F Witteveen, Jasmeen K Sidhu, Timothy S Balmer

“…A Brainbow reporter was used to label UBCs of the same ON or OFF subtype with different fluorescent proteins, which showed that UBCs innervate their own subtypes as well. Computational models predict that these feed-forward networks of UBCs extend the length of bursts or pauses and introduce delays—transformations that may be necessary for cerebellar functions from modulation of eye movements to adaptive learning across time scales.…”
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Decomposition-Assisted Computational Technique Based on Surrogate Modeling for Real-Time Simulations by Nariman Fouladinejad, Nima Fouladinejad, Mohamad Kasim Abdul Jalil, Jamaludin Mohd Taib

“…The results showed that the developed surrogate-based model was able to significantly reduce the computing costs, unlike the expensive computational model. The response time in surrogate-based simulation was considerably faster than the conventional model. …”
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Feature–Classifier Pairing Compatibility for sEMG Signals in Hand Gesture Recognition under Joint Effects of Processing Procedures by Mohammed Asfour, Carlo Menon, Xianta Jiang

“…Additionally, our ranking showed that the proper pairing enables low-computational models to surpass complex ones. The Histogram feature with linear discriminant analysis classifier (HIST-LDA) was the top pair with 88.6% accuracy. …”
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Modelling communication-enabled traffic interactions by O. Siebinga, A. Zgonnikov, D. A. Abbink

“…A better understanding and computational modelling of human interactive behaviour could help address this challenge. …”
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Estimating Algorithmic Information Using Quantum Computing for Genomics Applications by Aritra Sarkar, Zaid Al-Ars, Koen Bertels

“…In this research, we present a quantum computing framework using the circuit model, for estimating algorithmic information metrics. The canonical computation model of the Turing machine is restricted in time and space resources, to make the target metrics computable under realistic assumptions. …”
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The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schi... by Daniela Rodrigues-Amorim, Marta Iglesias-Martínez-Almeida, Tania Rivera-Baltanás, Patricia Fernández-Palleiro, Luis Freiría-Martínez, Cynthia Rodríguez-Jamardo, María Comís-Tuche, María del Carmen Vallejo-Curto, María Álvarez-Ariza, Marta López-García, Elena de las Heras, Alejandro García-Caballero, Jose Manuel Olivares, Carlos Spuch

“…Co-immunoprecipitation (co-IPs) showed protein interactions with Co-IP NEText–NT-3 and Co-IP NEText–TrkC. Computational modelling of protein–peptide docking by CABS-dock provided a medium–high accuracy model for NT-3–NEText (4.6935 Å) and TrkC–NEText (2.1365 Å). …”
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Uncovering the organization of neural circuits with Generalized Phase Locking Analysis. by Shervin Safavi, Theofanis I Panagiotaropoulos, Vishal Kapoor, Juan F Ramirez-Villegas, Nikos K Logothetis, Michel Besserve

“…We demonstrate the statistical benefits and interpretability of this approach in various computational models and Utah array recordings. The results suggest that GPLA, used jointly with biophysical modeling, can help uncover the contribution of recurrent microcircuits to the spatio-temporal dynamics observed in multi-channel experimental recordings.…”
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