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7841
Modeling the Circadian Control of the Cell Cycle and Its Consequences for Cancer Chronotherapy
Published 2023-04-01“…Here, we use a computational model for the circadian clock control of the cell cycle to investigate the entrainment in a population of cells characterized by some variability in the kinetic parameters. …”
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7842
Antipsychotics inhibit glucose transport: Determination of olanzapine binding site inStaphylococcus epidermidis glucose/H+ symporter
Published 2015-01-01“…The glucose transporter fromStaphylococcus epidermidis (GlcPSe) is specific for glucose, inhibited by various human glucose transporter (GLUT) inhibitors, has high sequence and structure homology to GLUTs, and is readily amenable to transport assay, mutagenesis, and computational modeling. We found that olanzapine inhibits glucose transport of GlcPSe with an IC50 0.9 ± 0.1 mM. …”
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7843
Computational study of the application of Al2O3 nanoparticles to forced convection of high-Reynolds swirling jets for engineering cooling processes
Published 2021-01-01“…Thus, the literature on computational modeling of these nanofluid jets is really scarce, with most works on laminar impinging nanofluid jets or turbulent swirling/non-swirling air or water-only jets. …”
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7844
Examining Occupant-Comfort Responses to Indoor Humidity Ratio in Conventional and Vernacular Dwellings: A Rural Indian Case Study
Published 2023-09-01“…The Development and validation of the computational model was demonstrated through a case study in a rural Indian context. …”
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7845
Machine Learning Approach for Fatigue Estimation in Sit-to-Stand Exercise
Published 2021-07-01“…In this work, considering that the sit-to-stand (STS) exercise is one of the most implemented in physical rehabilitation, a computational model for estimating fatigue during this exercise is proposed. …”
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7846
Modeling of aneurysm progression in anterior cerebral arteries to estimate rupture risk: A computational study
Published 2023-11-01“…In this work, computational modeling was performed to simulate aneurysm progression and to analyze the stress development for a variety of different pressure loading conditions. …”
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7847
Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling
Published 2024-03-01“…A combination of drugs is required to effectively treat this disease. Computational models are critical for combination therapy discovery due to the tens of thousands of two-drug combinations, even with approved drugs. …”
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7848
Thermodynamic Analysis of the Interaction of High-speed Composites of Printing Machines Based on Nickel with Oxygen
Published 2018-09-01“…The composite’s functional properties level depends on the quantitative ratio of the formed oxides in combination with CaF2 in the friction film at high rotational speeds or operating temperatures. Thermodynamic computer modeling of the interaction of air with individual elements and reinforcing compounds, in the investigated composite allows calculation of the composition of the condensed and gas-vapor phases, over a wide range of temperatures. …”
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7849
Piezo1 Mechano-Activation Is Augmented by Resveratrol and Differs between Colorectal Cancer Cells of Primary and Metastatic Origin
Published 2022-08-01“…However, minimal changes in apoptosis were observed due to calcium saturation, as predicted via a computational model of apoptosis. Furthermore, SW480 cells had increased levels of Piezo1, calcium influx, and TRAIL-mediated apoptosis compared to SW620 cells, highlighting differences in the mechano-activation of metastatic cells, which may be a necessary element for successful dissemination in vivo.…”
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7850
High‐performance computing of 3D blasting wave propagation in underground rock cavern by using 4D‐LSM on TianHe‐3 prototype E class supercomputer
Published 2022-09-01“…Abstract Parallel computing assigns the computing model to different processors on different devices and implements it simultaneously. …”
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7851
Ratchet recruitment in the acute respiratory distress syndrome: lessons from the newborn cry
Published 2023-11-01“…Using a simple computational model of the injured lung, we demonstrate that APRV can slowly open even the most recalcitrant alveoli with extended periods of high inspiratory pressure, while reducing alveolar re-collapse with brief expirations. …”
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7852
A theory of hippocampal theta correlations accounting for extrinsic and intrinsic sequences
Published 2023-10-01“…Here, we propose a computational model of cornu ammonis 3 (CA3) and dentate gyrus (DG), where sensorimotor input drives the direction-dependent (extrinsic) theta sequences within CA3 reflecting the two-dimensional spatial topology, whereas the intrahippocampal CA3-DG projections concurrently produce intrinsic sequences that are independent of the specific running trajectory. …”
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7853
Photodynamic therapy of cervical cancer: a scoping review on the efficacy of various molecules
Published 2024-03-01“…Furthermore, the article sheds light on potential molecules for PDT enhancement, examining their properties through computer modeling simulations, molecular docking, and assessing their advantages and disadvantages. …”
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7854
The Effect of Environment on the Evolution and Proliferation of Protocells of Increasing Complexity
Published 2022-08-01“…The hot spring hypothesis suggests that mineral-rich regions near hot springs, subject to dry–wet cycles, provide an ideal environment for the origin of primitive protocells. We develop a computational model to study protocellular evolution in such environments that are distinguished by the occurrence of three distinct phases, a wet phase, followed by a gel phase, and subsequently by a dry phase. …”
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7855
Robust Multiobjective Decision Making in the Acquisition of Energy Assets
Published 2023-08-01“…In Brazil, the NEWAVE computational model is universally used to generate scenarios of hydraulic production and future prices, which result in revenue distributions. …”
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7856
DNC4mC-Deep: Identification and Analysis of DNA N4-Methylcytosine Sites Based on Different Encoding Schemes By Using Deep Learning
Published 2020-07-01“…Herein, we proposed a computational model, DNC4mC-Deep, including six encoding techniques plus a deep learning model to predict 4mC sites in the genome of <i>F. vesca</i>, <i>R. chinensis</i>, and Cross-species dataset. …”
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7857
Next-Generation Blockchain-Enabled Virtualized Cloud Security Solutions: Review and Open Challenges
Published 2021-10-01“…The cloud computing paradigm is instigated from the grid and parallel computing models. It uses virtualization, server consolidation, utility computing, and other computing technologies and models for providing better IT solutions for large-scale computational data centres. …”
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7858
Epitope Tagging of Legume Root Nodule Extensin Modifies Protein Structure and Crosslinking in Cell Walls of Transformed Tobacco Leaves
Published 2005-01-01“…These observations are discussed in the light of a computational model for the RNE glycoprotein that is consistent with an extended rod-like structure. …”
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7859
A mechanistic insight into sources of error of visual working memory in multiple sclerosis
Published 2023-11-01“…Furthermore, computational modeling of the results from the sequential paradigm determined that imprecision in decoding information and swap error (mistakenly reporting the feature of other presented items) was responsible for WM dysfunction in MS. …”
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7860
Reconstructing Nerve Structures from Unorganized Points
Published 2023-10-01“…This sensory restoration relies on the direct electrostimulation of residual peripheral nerves. Computational models are instrumental in simulating these neurostimulation effects, offering solutions to the complexities tied to extensive animal/human trials and costly materials. …”
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