Modeling the Circadian Control of the Cell Cycle and Its Consequences for Cancer Chronotherapy by Courtney Leung, Claude Gérard, Didier Gonze

“…Here, we use a computational model for the circadian clock control of the cell cycle to investigate the entrainment in a population of cells characterized by some variability in the kinetic parameters. …”
Get full text

Antipsychotics inhibit glucose transport: Determination of olanzapine binding site inStaphylococcus epidermidis glucose/H+ symporter by Petr Babkin, Alayna M. George Thompson, Cristina V. Iancu, D. Eric Walters, Jun-yong Choe

“…The glucose transporter fromStaphylococcus epidermidis (GlcPSe) is specific for glucose, inhibited by various human glucose transporter (GLUT) inhibitors, has high sequence and structure homology to GLUTs, and is readily amenable to transport assay, mutagenesis, and computational modeling. We found that olanzapine inhibits glucose transport of GlcPSe with an IC50 0.9 ± 0.1 mM. …”
Get full text

Computational study of the application of Al2O3 nanoparticles to forced convection of high-Reynolds swirling jets for engineering cooling processes by F.-J. Granados-Ortiz, L. Leon-Prieto, J. Ortega-Casanova

“…Thus, the literature on computational modeling of these nanofluid jets is really scarce, with most works on laminar impinging nanofluid jets or turbulent swirling/non-swirling air or water-only jets. …”
Get full text

Examining Occupant-Comfort Responses to Indoor Humidity Ratio in Conventional and Vernacular Dwellings: A Rural Indian Case Study by Suchi Priyadarshani, Roshan R. Rao, Monto Mani, Daniel Maskell

“…The Development and validation of the computational model was demonstrated through a case study in a rural Indian context. …”
Get full text

Machine Learning Approach for Fatigue Estimation in Sit-to-Stand Exercise by Andrés Aguirre, Maria J. Pinto, Carlos A. Cifuentes, Oscar Perdomo, Camilo A. R. Díaz, Marcela Múnera

“…In this work, considering that the sit-to-stand (STS) exercise is one of the most implemented in physical rehabilitation, a computational model for estimating fatigue during this exercise is proposed. …”
Get full text

Modeling of aneurysm progression in anterior cerebral arteries to estimate rupture risk: A computational study by Gurpreet Singh, Prem Nath Yadav, Shubham Gupta, Arnab Chanda

“…In this work, computational modeling was performed to simulate aneurysm progression and to analyze the stress development for a variety of different pressure loading conditions. …”
Get full text

Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling by Mehdi Mirzaie, Elham Gholizadeh, Juho J. Miettinen, Filipp Ianevski, Tanja Ruokoranta, Jani Saarela, Mikko Manninen, Susanna Miettinen, Caroline A. Heckman, Mohieddin Jafari

“…A combination of drugs is required to effectively treat this disease. Computational models are critical for combination therapy discovery due to the tens of thousands of two-drug combinations, even with approved drugs. …”
Get full text

Thermodynamic Analysis of the Interaction of High-speed Composites of Printing Machines Based on Nickel with Oxygen by Тетяна Анатоліївна Роїк, Юлія Юріївна Віцюк

“…The composite’s functional properties level depends on the quantitative ratio of the formed oxides in combination with CaF2 in the friction film at high rotational speeds or operating temperatures. Thermodynamic computer modeling of the interaction of air with individual elements and reinforcing compounds, in the investigated composite allows calculation of the composition of the condensed and gas-vapor phases, over a wide range of temperatures. …”
Get full text

Piezo1 Mechano-Activation Is Augmented by Resveratrol and Differs between Colorectal Cancer Cells of Primary and Metastatic Origin by Joshua D. Greenlee, Kevin Liu, Maria Lopez-Cavestany, Michael R. King

“…However, minimal changes in apoptosis were observed due to calcium saturation, as predicted via a computational model of apoptosis. Furthermore, SW480 cells had increased levels of Piezo1, calcium influx, and TRAIL-mediated apoptosis compared to SW620 cells, highlighting differences in the mechano-activation of metastatic cells, which may be a necessary element for successful dissemination in vivo.…”
Get full text

High‐performance computing of 3D blasting wave propagation in underground rock cavern by using 4D‐LSM on TianHe‐3 prototype E class supercomputer by Meng Fu, Gaofeng Zhao

“…Abstract Parallel computing assigns the computing model to different processors on different devices and implements it simultaneously. …”
Get full text

Ratchet recruitment in the acute respiratory distress syndrome: lessons from the newborn cry by Gary F. Nieman, Jacob Herrmann, Joshua Satalin, Michaela Kollisch-Singule, Penny L. Andrews, Nader M. Habashi, David G. Tingay, Donald P. Gaver, Jason H. T. Bates, David W. Kaczka, David W. Kaczka

“…Using a simple computational model of the injured lung, we demonstrate that APRV can slowly open even the most recalcitrant alveoli with extended periods of high inspiratory pressure, while reducing alveolar re-collapse with brief expirations. …”
Get full text

A theory of hippocampal theta correlations accounting for extrinsic and intrinsic sequences by Yuk-Hoi Yiu, Christian Leibold

“…Here, we propose a computational model of cornu ammonis 3 (CA3) and dentate gyrus (DG), where sensorimotor input drives the direction-dependent (extrinsic) theta sequences within CA3 reflecting the two-dimensional spatial topology, whereas the intrahippocampal CA3-DG projections concurrently produce intrinsic sequences that are independent of the specific running trajectory. …”
Get full text

Photodynamic therapy of cervical cancer: a scoping review on the efficacy of various molecules by Nasrulla Abdullaevich Shanazarov, Afshin Zare, Nadiar Maratovich Mussin, Rustam Kuanyshbekovich Albayev, Asset Askerovich Kaliyev, Yerbolat Maratovich Iztleuov, Sandugash Bakhytbekovna Smailova, Amin Tamadon

“…Furthermore, the article sheds light on potential molecules for PDT enhancement, examining their properties through computer modeling simulations, molecular docking, and assessing their advantages and disadvantages. …”
Get full text

The Effect of Environment on the Evolution and Proliferation of Protocells of Increasing Complexity by Suvam Roy, Supratim Sengupta

“…The hot spring hypothesis suggests that mineral-rich regions near hot springs, subject to dry–wet cycles, provide an ideal environment for the origin of primitive protocells. We develop a computational model to study protocellular evolution in such environments that are distinguished by the occurrence of three distinct phases, a wet phase, followed by a gel phase, and subsequently by a dry phase. …”
Get full text

Robust Multiobjective Decision Making in the Acquisition of Energy Assets by Rafael Bambirra, Lais Schiavo, Marina Lima, Giovanna Miranda, Iolanda Reis, Michael Cassemiro, Antônio Andrade, Fernanda Laender, Rafael Silva, Douglas Vieira, Petr Ekel

“…In Brazil, the NEWAVE computational model is universally used to generate scenarios of hydraulic production and future prices, which result in revenue distributions. …”
Get full text

DNC4mC-Deep: Identification and Analysis of DNA N4-Methylcytosine Sites Based on Different Encoding Schemes By Using Deep Learning by Abdul Wahab, Omid Mahmoudi, Jeehong Kim, Kil To Chong

“…Herein, we proposed a computational model, DNC4mC-Deep, including six encoding techniques plus a deep learning model to predict 4mC sites in the genome of <i>F. vesca</i>, <i>R. chinensis</i>, and Cross-species dataset. …”
Get full text

Next-Generation Blockchain-Enabled Virtualized Cloud Security Solutions: Review and Open Challenges by Mueen Uddin, Anjum Khalique, Awais Khan Jumani, Syed Sajid Ullah, Saddam Hussain

“…The cloud computing paradigm is instigated from the grid and parallel computing models. It uses virtualization, server consolidation, utility computing, and other computing technologies and models for providing better IT solutions for large-scale computational data centres. …”
Get full text

Epitope Tagging of Legume Root Nodule Extensin Modifies Protein Structure and Crosslinking in Cell Walls of Transformed Tobacco Leaves by Sébastien Gucciardo, Elizabeth A. Rathbun, Michael Shanks, Susan Jenkyns, Lora Mak, Marcus C. Durrant, Nicholas J. Brewin

“…These observations are discussed in the light of a computational model for the RNE glycoprotein that is consistent with an extended rod-like structure. …”
Get full text

A mechanistic insight into sources of error of visual working memory in multiple sclerosis by Ali Motahharynia, Ahmad Pourmohammadi, Armin Adibi, Vahid Shaygannejad, Fereshteh Ashtari, Iman Adibi, Mehdi Sanayei

“…Furthermore, computational modeling of the results from the sequential paradigm determined that imprecision in decoding information and swap error (mistakenly reporting the feature of other presented items) was responsible for WM dysfunction in MS. …”
Get full text

Reconstructing Nerve Structures from Unorganized Points by Jelena Kljajić, Goran Kvaščev, Željko Đurović

“…This sensory restoration relies on the direct electrostimulation of residual peripheral nerves. Computational models are instrumental in simulating these neurostimulation effects, offering solutions to the complexities tied to extensive animal/human trials and costly materials. …”
Get full text