Picosecond X-ray diffraction from shock-compressed metals by Rosolanková, K, Rosolankova, Katarina K.

“…</p> <p>Results from both the Molecular Dynamics simulations and experiments are used to suggest enhancements in computer modelling of shocked crystals, as well as future experimental studies. …”

Using a generative model of affect to characterize affective variability and its response to treatment in bipolar disorder by Pulcu, E, Saunders, KEA, Harmer, CJ, Harrison, PJ, Goodwin, GM, Geddes, JR, Browning, M

“…We assessed the affective variability associated with BD and BPD as well as the effect of lithium using a computational model that defines two subtypes of variability: affective changes that persist (volatility) and changes that do not (noise). …”

Native tandem and ion mobility mass spectrometry highlight structural and modular similarities in clustered-regularly-interspaced shot-palindromic-repeats (CRISPR)-associated prote... by van Duijn, E, Barbu, I, Barendregt, A, Jore, M, Wiedenheft, B, Lundgren, M, Westra, E, Brouns, S, Doudna, J, van der Oost, J, Heck, A

“…For both complexes we here describe the use of native mass spectrometry in combination with ion mobility mass spectrometry to assign a stable core surrounded by more loosely associated modules. Via computational modeling subcomplex structures were proposed that relate to the experimental IMMS data. …”

Visualizing mesoderm and neural crest cell dynamics during chick head morphogenesis by McKinney, M, McLennan, R, Giniunaite, R, Baker, R, Maini, P, Othmer, H, Kulesa, P

“…Here we examine this question during chick head morphogenesis using time-lapse imaging, computational modeling, and experiments. We find that head mesodermal cells in culture move in random directions as individuals and move faster in the presence of neural crest cells. …”

Harm to others outweighs harm to self in moral decision making. by Crockett, M, Kurth-Nelson, Z, Siegel, J, Dayan, P, Dolan, R

“…We independently varied the recipient of the shocks (self vs. other) and whether the choice involved paying to decrease pain or profiting by increasing pain. We built computational models to quantify the relative values subjects ascribed to pain for themselves and others in this setting. …”

Computational insights into the architecture and operation of the rat head direction cell system by Page, H

“…This thesis uses computational modelling to investigate their properties. HD cell preferred firing directions are influenced depending on the discrepancy between sources of directional information, with allothetic information dominating up to a critical discrepancy and body-internal (idiothetic) information dominating after this. …”

Artificial intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease by Oikonomou, E, Siddique, M, Antoniades, C

“…Rapid technological advances in non-invasive imaging, coupled with the availability of large data sets and the expansion of computational models and power, have revolutionized the role of imaging in medicine. …”

Computational pharmacokinetics of solute penetration into human intervertebral discs-Effects of endplate permeability, solute molecular weight and disc size by Motaghinasab, S, Shirazi-Adl, A, Urban, J, Parnianpour, M

“…The current study also demonstrates the capability of computational models in predicting the transport of intravenously injected solutes into the disc. © 2012 Elsevier Ltd.…”

Global atmospheric chemistry from satellites: Results from UARS/ISAMS by Taylor, F, Rodgers, C, Remedios, J, Grainger, R, Lambert, A, LopezValverde, M, GossCustard, M, Reburn, J

“…Sophisticated studies of the radiative-chemical-dynamical system in the stratosphere using satellite data and computer models are now in progress. In the future, even more advanced sensors now being built will obtain improved spatial resolution in the stratosphere, and map the global budgets of tropospheric trace gases as well.…”

String diagram rewrite theory II: rewriting with symmetric monoidal structure by Bonchi, F, Gadducci, F, Kissinger, A, Sobocinski, P, Zanasi, F

“…Recently, string diagrams have become increasingly popular as a graphical syntax to reason about computational models across diverse fields, including programming language semantics, circuit theory, quantum mechanics, linguistics, and control theory. …”

Brain mechanisms underlying apathy by Le Heron, C, Holroyd, C, Salamone, J, Husain, M

“…These developments have occurred at several different conceptual levels, from work linking neural structures and neuromodulatory systems to specific aspects of motivated behaviour, to higher order computational models that aim to unite these findings within frameworks for normal goal-directed behaviour. …”

PISA design methods for offshore wind turbine monopiles by Byrne, B, Burd, H, Zdravkovic, L, Abadie, C, Houlsby, G, Jardine, R, Martin, C, McAdam, R, Andrade, M, Pedro, A, Potts, D, Taborda, D

“…The resulting design model introduces new procedures for site specific calibration of soil reaction curves that can be applied within a one-dimensional (1D), Winkler-type, computational model. This paper summarises the results and key conclusions from PISA, including design methods for (a) stiff glacial clay till (Cowden till), (b) brittle stiff plastic clay (London clay), (c) soft clay (Bothkennar clay), (d) sand of varying densities (Dunkirk), and, (e) layered profiles (combining soils from (a) to (d)). …”

De novo and inherited loss-of-function variants in TLK2: clinical and genotype-phenotype evaluation of a distinct neurodevelopmental disorder by Reijnders, M, Miller, K, Alvi, M, Calpena, E, Koelling, N, McGowan, S, Twigg, S, Nellaker, C, Wilkie, A, al., E

“…Genotype-phenotype analysis and comparison of computationally modeled faces showed that phenotypes of these and other individuals with loss-of-function variants significantly overlapped with phenotypes of individuals with other variant types (missense and C-terminal truncating). …”

The design and mechanism of synthetic homing endonuclease gene drives by Verkuijl, S

“…Here, we investigate through computational modelling how unintended nuclease processes affect gene drive performance. …”

Emergence of spatial structure in cell groups and the evolution of cooperation by Nadell, C, Foster, K, Xavier, J

“…Here we use a multi-agent computational model to study the origin of spatial structure within growing cell groups. …”

Context modulates early stimulus processing when resolving stimulus-response conflict. by Scerif, G, Worden, MS, Davidson, M, Seiger, L, Casey, B

“…When responding to stimuli in our environment, the presence of multiple items associated with task-relevant responses affects both ongoing response selection and subsequent behavior. Computational modeling of conflict monitoring and neuroimaging data predict that the recent context of response competition will bias the selection of certain stimuli over others very early in the processing stream through increased focal spatial attention. …”

Stimulating human prefrontal cortex increases reward learning by Overman, MJ, Sarrazin, V, Browning, M, O'Shea, J

“…Learning rates on the tasks were quantified using computational models. Stimulation over dorsolateral prefrontal cortex (DLPFC) but not motor cortex (M1) increased learning rates specifically for reward outcomes. …”

Word frequency effects in sound change as a consequence of perceptual asymmetries: an exemplar-based model by Todd, S, Pierrehumbert, J, Hay, J

“…We present an exemplar-based computational model of regular sound change in which the listener plays a large role, and we demonstrate that it generates sound changes with properties and word frequency effects seen in corpora. …”

Transcranial ultrasound stimulation: using patient specific lenses to focus on deep targets for non-invasive neuromodulation by Cheng, X

“…Ultrasound frequency (500 kHz), transducer aperture size (d = 64 mm), and lens material (PDMS) were selected based on acoustic simulations (k-Wave). Through computational modeling, the utility of this concept was confirmed for deep brain targets such as the perirhinal cortex, anterior hippocampus, globus pallidus internus, and subthalamic nucleus. …”

Model for the regulation of Arabidopsis thaliana leaf margin development by Bilsborough, G, Runions, A, Barkoulas, M, Jenkins, H, Hasson, A, Galinha, C, Laufs, P, Hay, A, Prusinkiewicz, P, Tsiantis, M

“…Here, we use a combination of developmental genetics and computational modeling to show that serration development is the morphological read-out of a spatially distributed regulatory mechanisms, which creates interspersed activity peaks of the growth-promoting hormone auxin and the CUP-SHAPED COTYLEDON2 (CUC2) transcription factor. …”