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7921
Picosecond X-ray diffraction from shock-compressed metals
Published 2005“…</p> <p>Results from both the Molecular Dynamics simulations and experiments are used to suggest enhancements in computer modelling of shocked crystals, as well as future experimental studies. …”
Thesis -
7922
Using a generative model of affect to characterize affective variability and its response to treatment in bipolar disorder
Published 2022“…We assessed the affective variability associated with BD and BPD as well as the effect of lithium using a computational model that defines two subtypes of variability: affective changes that persist (volatility) and changes that do not (noise). …”
Journal article -
7923
Native tandem and ion mobility mass spectrometry highlight structural and modular similarities in clustered-regularly-interspaced shot-palindromic-repeats (CRISPR)-associated prote...
Published 2012“…For both complexes we here describe the use of native mass spectrometry in combination with ion mobility mass spectrometry to assign a stable core surrounded by more loosely associated modules. Via computational modeling subcomplex structures were proposed that relate to the experimental IMMS data. …”
Journal article -
7924
Visualizing mesoderm and neural crest cell dynamics during chick head morphogenesis
Published 2020“…Here we examine this question during chick head morphogenesis using time-lapse imaging, computational modeling, and experiments. We find that head mesodermal cells in culture move in random directions as individuals and move faster in the presence of neural crest cells. …”
Journal article -
7925
Harm to others outweighs harm to self in moral decision making.
Published 2014“…We independently varied the recipient of the shocks (self vs. other) and whether the choice involved paying to decrease pain or profiting by increasing pain. We built computational models to quantify the relative values subjects ascribed to pain for themselves and others in this setting. …”
Journal article -
7926
Computational insights into the architecture and operation of the rat head direction cell system
Published 2015“…This thesis uses computational modelling to investigate their properties. HD cell preferred firing directions are influenced depending on the discrepancy between sources of directional information, with allothetic information dominating up to a critical discrepancy and body-internal (idiothetic) information dominating after this. …”
Thesis -
7927
Artificial intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease
Published 2020“…Rapid technological advances in non-invasive imaging, coupled with the availability of large data sets and the expansion of computational models and power, have revolutionized the role of imaging in medicine. …”
Journal article -
7928
Computational pharmacokinetics of solute penetration into human intervertebral discs-Effects of endplate permeability, solute molecular weight and disc size
Published 2012“…The current study also demonstrates the capability of computational models in predicting the transport of intravenously injected solutes into the disc. © 2012 Elsevier Ltd.…”
Journal article -
7929
Global atmospheric chemistry from satellites: Results from UARS/ISAMS
Published 1995“…Sophisticated studies of the radiative-chemical-dynamical system in the stratosphere using satellite data and computer models are now in progress. In the future, even more advanced sensors now being built will obtain improved spatial resolution in the stratosphere, and map the global budgets of tropospheric trace gases as well.…”
Conference item -
7930
String diagram rewrite theory II: rewriting with symmetric monoidal structure
Published 2022“…Recently, string diagrams have become increasingly popular as a graphical syntax to reason about computational models across diverse fields, including programming language semantics, circuit theory, quantum mechanics, linguistics, and control theory. …”
Journal article -
7931
Brain mechanisms underlying apathy
Published 2018“…These developments have occurred at several different conceptual levels, from work linking neural structures and neuromodulatory systems to specific aspects of motivated behaviour, to higher order computational models that aim to unite these findings within frameworks for normal goal-directed behaviour. …”
Journal article -
7932
PISA design methods for offshore wind turbine monopiles
Published 2019“…The resulting design model introduces new procedures for site specific calibration of soil reaction curves that can be applied within a one-dimensional (1D), Winkler-type, computational model. This paper summarises the results and key conclusions from PISA, including design methods for (a) stiff glacial clay till (Cowden till), (b) brittle stiff plastic clay (London clay), (c) soft clay (Bothkennar clay), (d) sand of varying densities (Dunkirk), and, (e) layered profiles (combining soils from (a) to (d)). …”
Conference item -
7933
De novo and inherited loss-of-function variants in TLK2: clinical and genotype-phenotype evaluation of a distinct neurodevelopmental disorder
Published 2018“…Genotype-phenotype analysis and comparison of computationally modeled faces showed that phenotypes of these and other individuals with loss-of-function variants significantly overlapped with phenotypes of individuals with other variant types (missense and C-terminal truncating). …”
Journal article -
7934
The design and mechanism of synthetic homing endonuclease gene drives
Published 2023“…Here, we investigate through computational modelling how unintended nuclease processes affect gene drive performance. …”
Thesis -
7935
Emergence of spatial structure in cell groups and the evolution of cooperation
Published 2010“…Here we use a multi-agent computational model to study the origin of spatial structure within growing cell groups. …”
Journal article -
7936
Context modulates early stimulus processing when resolving stimulus-response conflict.
Published 2006“…When responding to stimuli in our environment, the presence of multiple items associated with task-relevant responses affects both ongoing response selection and subsequent behavior. Computational modeling of conflict monitoring and neuroimaging data predict that the recent context of response competition will bias the selection of certain stimuli over others very early in the processing stream through increased focal spatial attention. …”
Journal article -
7937
Stimulating human prefrontal cortex increases reward learning
Published 2023“…Learning rates on the tasks were quantified using computational models. Stimulation over dorsolateral prefrontal cortex (DLPFC) but not motor cortex (M1) increased learning rates specifically for reward outcomes. …”
Journal article -
7938
Word frequency effects in sound change as a consequence of perceptual asymmetries: an exemplar-based model
Published 2019“…We present an exemplar-based computational model of regular sound change in which the listener plays a large role, and we demonstrate that it generates sound changes with properties and word frequency effects seen in corpora. …”
Journal article -
7939
Transcranial ultrasound stimulation: using patient specific lenses to focus on deep targets for non-invasive neuromodulation
Published 2023“…Ultrasound frequency (500 kHz), transducer aperture size (d = 64 mm), and lens material (PDMS) were selected based on acoustic simulations (k-Wave). Through computational modeling, the utility of this concept was confirmed for deep brain targets such as the perirhinal cortex, anterior hippocampus, globus pallidus internus, and subthalamic nucleus. …”
Thesis -
7940
Model for the regulation of Arabidopsis thaliana leaf margin development
Published 2011“…Here, we use a combination of developmental genetics and computational modeling to show that serration development is the morphological read-out of a spatially distributed regulatory mechanisms, which creates interspersed activity peaks of the growth-promoting hormone auxin and the CUP-SHAPED COTYLEDON2 (CUC2) transcription factor. …”
Journal article