Temporal ordering of input modulates connectivity formation in a developmental neuronal network model of the cortex by Hartley, C, Farmer, S, Berthouze, L

“…We investigated, in a computational model of leaky integrate-and-fire neurones, whether the temporal ordering of burst activity within an external driving input could modulate connectivity formation in the network. …”

Growth of confined cancer spheroids: a combined experimental and mathematical modelling approach. by Loessner, D, Flegg, J, Byrne, H, Clements, J, Hutmacher, D

“…The mathematical model predictions were in agreement with the experimental data set and simulated how the growth of cancer spheroids was influenced by mechanical and biochemical stimuli including matrix stiffness, culture duration and administration of a chemotherapeutic drug. Our computational model provides new perspectives on experimental results and has informed the design of new 3D studies of chemoresistance of multicellular cancer spheroids.…”

A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics. by Labro, A, Grottesi, A, Sansom, MS, Raes, A, Snyders, D

“…The switch in gating mode was observed even with very short depolarization steps, but recovery to the initial "fast" mode was extremely slow. Computational modeling suggested that switching occurred during channel deactivation. …”

Neural network modelling of the primate ventral visual pathway by Eguchi, A

“…This thesis approaches this problem through the use of computational modelling. In particular, I first show how the brain may learn to represent the spatial structure of objects and faces through a series of processing stages along the ventral visual pathway. …”

Quantifying decision-making in dynamic, continuously evolving environments by Ruesseler, M, Weber, LA, Marshall, TR, O'Reilly, J, Hunt, LT

“…A complementary triphasic component over occipito-parietal cortex encodes the sum of recently accumulated sensory evidence, and its magnitude covaries with parameters describing how different individuals integrate sensory evidence over time. A computational model based on leaky evidence accumulation suggests that these findings can be accounted for by a shift in decision threshold between different environments, which is also reflected in the magnitude of pre-decision EEG activity. …”

Model for the regulation of Arabidopsis thaliana leaf margin development. by Bilsborough, G, Runions, A, Barkoulas, M, Jenkins, H, Hasson, A, Galinha, C, Laufs, P, Hay, A, Prusinkiewicz, P, Tsiantis, M

“…Here, we use a combination of developmental genetics and computational modeling to show that serration development is the morphological read-out of a spatially distributed regulatory mechanism, which creates interspersed activity peaks of the growth-promoting hormone auxin and the cup-shaped cotyledon2 (CUC2) transcription factor. …”

Deep learning segmentation of the right ventricle in cardiac MRI: the M&Ms challenge by Martin-Isla, C, Campello, VM, Izquierdo, C, Kushibar, K, Sendra-Balcells, C, Gkontra, P, Sojoudi, A, Fulton, MJ, Arega, TW, Punithakumar, K, Li, L, Sun, X, Al Khalil, Y, Liu, D, Jabbar, S, Queiros, S, Galati, F, Mazher, M, Gao, Z, Beetz, M, Tautz, L, Galazis, C, Varela, M, Hullebrand, M, Grau, V, Zhuang, X, Puig, D, Zuluaga, MA, Mohy-Ud-Din, H, Metaxas, D, Breeuwer, M, van der Geest, RJ, Noga, M, Bricq, S, Rentschler, ME, Guala, A, Petersen, SE, Escalera, S, Palomares, JFR, Lekadir, K

“…As part of the 12th Workshop on Statistical Atlases and Computational Models of the Heart (STACOM 2021), the M&Ms-2 challenge was organized to promote the interest of the research community around right ventricle segmentation in multi-disease, multi-view, and multi-center cardiac MRI. …”

Residual stresses in a welded superalloy disc: Characterization using synchrotron diffraction and numerical process modeling by Jensen, M, Dye, D, James, K, Korsunsky, A, Roberts, S, Reed, R

“…The residual stress state in an electron-beam welded assembly of IN718 nickel-based superalloy has been studied both experimentally and using computer modeling. Diffraction measurements were made at the European Synchrotron Radiation Facility (ESRF), using the ID11 beamline. …”

Disentangling juxtacrine from paracrine signalling in dynamic tissue by Momiji, H, Hassall, K, Featherstone, K, McNamara, A, Patist, A, Spiller, D, Christian, H, White, M, Davis, J, Finkenstädt, B, Rand, D

“…We developed a computational model that involves an inter-cell juxtacrine coupling, yielding simulation results that show space-time coordination in the transcription level that is in agreement with the above analysis. …”

Electrophysiological correlates of anterior cingulate function in a go/no-go task: effects of response conflict and trial type frequency. by Nieuwenhuis, S, Yeung, N, van den Wildenberg, W, Ridderinkhof, K

“…Neuroimaging and computational modeling studies have led to the suggestion that response conflict monitoring by the anterior cingulate cortex plays a key role in cognitive control. …”

Structural modelling of transmembrane domains by Kelm, S

“…In the absence of experimental data, computational modelling tools can be used to close the gap between the numbers of known protein sequences and structures. …”

Alloys-by-design: applications to polycrystalline nickel superalloys for turbine disc applications by Crudden, DJ

“…</p> <p>The scope of this research has been to apply the computational model to the design of a polycrystalline nickel-based superalloy for turbine disc applications in next generation jet engines. …”

Three-dimensional colloidal crystals in liquid crystalline blue phases. by Ravnik, M, Alexander, G, Yeomans, J, Žumer, S

“…We show, by means of computer modeling, that colloidal particles can self-assemble into stable, 3D, periodic structures in blue phase LCs. …”

ABodyBuilder: automated antibody structure prediction with data-driven accuracy estimation by Leem, J, Dunbar, J, Georges, G, Shi, J, Deane, C

“…Computational modelling of antibody structures plays a critical role in therapeutic antibody design. …”

Organization of ventricular fibrillation in the human heart: experiments and models. by ten Tusscher, K, Mourad, A, Nash, M, Clayton, R, Bradley, C, Paterson, D, Hren, R, Hayward, M, Panfilov, A, Taggart, P

“…In this paper, we studied the organization of human VF by combining clinical recordings of electrical excitation patterns on the epicardial surface during in vivo human VF with simulations of VF in an anatomically and electrophysiologically detailed computational model of the human ventricles. We find both in the computational studies and in the clinical recordings that epicardial surface excitation patterns during VF contain around six rotors. …”

Residual stresses in a welded superalloy disc: characterization using synchrotron diffraction and numerical process modelling by Jensen, M, Dye, D, James, K, Korsunsky, A, Roberts, S, Reed, R

“…The residual stress state in an electron-beam welded assembly of In718 nickel-based superalloy has been studied both experimentally and using computer modeling. Diffraction measurements were made at the European Synchrotron Radiation Facility (ESRF), using the ID11 beamline. …”

Development of a semi-empirical physical model for transient NOx emissions prediction from a high-speed diesel engine by Bajwa, A, Zou, G, Zhong, F, Fang, X, Leach, F, Davy, M

“…Progress in experimental engine development and computational modelling has led to the generation of a large amount of high-fidelity emissions and in-cylinder data, making it attractive to use data-driven emissions prediction and control models. …”

Cooperative Electrostatic Interactions Drive Functional Evolution in the Alkaline Phosphatase Superfamily by Barrozo, A, Duarte Gonzalez, F, Bauer, P, Carvalho, ATP, Kamerlin, S

“…We have performed extensive simulations of the enzymatic reaction of both wild-type enzymes and several experimentally characterized mutants. Our computational models are in agreement with key experimental observables, such as the observed activities of the wild-type enzymes, qualitative interpretations of experimental pH-rate profiles, and activity trends among several active site mutants. …”

Evaluation of the Growth Environment of a Hydrostatic Force Bioreactor for Preconditioning of Tissue−Engineered Constructs by Reinwald, Y, Leonard, K, Henstock, J, Whiteley, J, Osborne, J, Waters, S, Levesque, P, Haj, A

“…In addition, computational modeling showed that the distribution and magnitude of physical forces depends on the shape and position of the cell-hydrogel constructs in the tissue culture format. …”

Computational pharmacokinetics of solute penetration into human intervertebral discs - effects of endplate permeability, solute molecular weight and disc size. by Motaghinasab, S, Shirazi-Adl, A, Urban, J, Parnianpour, M

“…The current study also demonstrates the capability of computational models in predicting the transport of intravenously injected solutes into the disc.…”