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8141
Mapping ontology vertices to a line using hypergraph framework
Published 2020-06-01“…In recent years, various machine learning methods and computational models have been widely used in ontology optimization and computation. …”
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8142
Agent-Based Modeling for Integrating Human Behavior into the Food–Energy–Water Nexus
Published 2020-12-01“…The nexus of food, energy, and water systems (FEWS) has become a salient research topic, as well as a pressing societal and policy challenge. Computational modeling is a key tool in addressing these challenges, and FEWS modeling as a subfield is now established. …”
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8143
Functional Characterization of Four Known Cav2.1 Variants Associated with Neurodevelopmental Disorders
Published 2023-01-01“…Structural analysis revealed the loss of interactions with S1, S2, and S3 helices upon R1359W and R1667W substitutions, but a lack of obvious structural changes with S1799L. Computational modeling suggests that biophysical changes induced by Cav2.1 pathogenic mutations might affect action potential frequency in Purkinje cells.…”
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8144
An artificial intelligence method for predicting postoperative urinary incontinence based on multiple anatomic parameters of MRI
Published 2023-10-01“…A series of clinical MRI anatomical measurements from these patients was used to discover continence features, and their impact on continence was primarily evaluated using a series of statistical methods and computational models. Results: Age and six other anatomical measurements were identified as the top seven features of continence by the proposed model UINet7 with an accuracy of 0.97, and the first four of these features were also found by primary statistical analysis. …”
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8145
A 3D Agent-Based Model of Lung Fibrosis
Published 2022-01-01“…In this context, mathematical and computational models have the potential to shed light on key underlying pathological mechanisms, shorten the time needed for clinical trials, parallelize hypotheses testing, and improve personalized drug development. …”
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8146
A pre-docking source for the power-law behavior of spontaneous quantal release: application to the analysis of LTP
Published 2015-02-01“…While in control conditions a fractal exponent greater than zero was rarely observed, its value was greatly increased by α-latrotoxin (α-LTX), a potent stimulator of spontaneous release, known to act at the very last step of vesicle fusion. Based on computer modeling, we confirmed that at an increase in fusion probability would unmask a pre-docking phenomenon with 1/f structure, where α estimated from the release series appears to sense the increase in release probability independently from the number of active sites. …”
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8147
Finding New VEGFR2 Inhibitors Using Support Vector Machine Classification Model
Published 2024-01-01“…Therefore, finding reliable computational models to identify inhibitors can be effective in reducing time and cost. …”
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8148
A novel modular modeling approach for understanding different electromechanics between left and right heart in rat
Published 2022-09-01“…While ion channels and transporters involved in excitation-contraction coupling have been linked and constructed as comprehensive computational models, validation of whether each individual component of a model can be reused has not been previously attempted. …”
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8149
Numerical investigation of residual stresses in thin-walled additively manufactured structures from selective laser melting
Published 2023-09-01“…This work uses a thermo-mechanical computational modeling approach to investigate the formation of residual stresses in thin-walled structures and also investigates the effects of varying taper on the evolution of residual stress profiles of the build. …”
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8150
Impacts of bedding directions of shale gas reservoirs on hydraulically induced crack propagation
Published 2016-03-01“…On this basis, a 3D hydraulic fracturing computation model was established for shale gas reservoirs. …”
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8151
New Insights into the Type II Toxins from the Sea Anemone <i>Heteractis crispa</i>
Published 2020-01-01“…The absence of Arg13 in the RTX-VI structure does not prevent toxin binding with the channel but it has changed its pharmacological profile and potency. According to computer modeling data, the δ-SHTX-Hcr1f binds within the extracellular region of the rNa<sub>V</sub>1.2 voltage-sensing domain IV and pore-forming domain I through a network of strong interactions, and an additional fixation of the toxin at the channel binding site is carried out through the phospholipid environment. …”
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8152
Striatal fast-spiking interneurons: from firing patterns to postsynaptic impact
Published 2011-07-01“…In this study, we combined computational modeling with in vitro and in vivo electrophysiological measurements to investigate FS cells in terms of their discharge properties and their synaptic efficacies onto MS neurons. …”
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8153
An Investigation of Natural Convection Heat Transfer in a Square Enclosure Filled with Nanofluid
Published 2011-09-01“…There are agreement in results and found the maximum difference between results reach to 6.5% approximately at Ra=105 which validate the present computational model.…”
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8154
An Investigation of Natural Convection Heat Transfer in a Square Enclosure Filled with Nanofluid
Published 2011-08-01“…There are agreement in results and found the maximum difference between results reach to 6.5% approximately at Ra=105 which validate the present computational model.…”
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8155
Mem3DG: Modeling membrane mechanochemical dynamics in 3D using discrete differential geometry
Published 2022-09-01“…Many studies use computational modeling to understand how various mechanochemical factors contribute to membrane shape transformations. …”
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8156
CancerNet: a unified deep learning network for pan-cancer diagnostics
Published 2022-06-01“…Conclusions Beyond detection of primary cancers, our proposed computational model also robustly detects tissues of origin of secondary cancers, including metastatic cancers, second primary cancers, and cancers of unknown primaries. …”
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8157
Forecasting global spread of invasive pests and pathogens through international trade
Published 2023-12-01“…While the study of non‐native pest spread has used computational models to provide insights into drivers and dynamics of biological invasions and inform management, efforts have focused on local or regional scales and are challenged by complex transmission networks arising from bridgehead population establishment. …”
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8158
Federated Learning for Intrusion Detection in the Critical Infrastructures: Vertically Partitioned Data Use Case
Published 2022-03-01“…Federated learning is a computational model for distributed machine learning that allows different collaborating entities to train one global model without sharing data. …”
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8159
THE PROBLEM OF CRACK OPENING WIDTH AND STIFFNESS OF REINFORCED CONCRETE STRUCTURES, BUILDINGS AND CONSTRUCTIONS
Published 2023-03-01“…The general principle from Loleith to the "opening - closing" of cracks, the stiffness of the mechanics of reinforced concrete is obtained in the form of the method of the computational model of resistance. …”
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8160
Comprehensive Benefit Assessment of the Middle Route of South-to-North Water Diversion Project Based on Markowitz Theory
Published 2023-12-01“…Through the calculation of the Markovsky theoretical model, the results show that when 79.9% of the water conveyance is used to generate social benefits, 15.8% of the water conveyance is used to generate ecological benefits, and 4.5% of the water conveyance is used to generate economic benefits, the project achieves the maximum comprehensive benefits. This computational model method can be used to provide technical support and scientific reference for the optimal allocation of water resources in cross regional water transfer projects.…”
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