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8401
Optogenetic Mimicry of the Transient Activation of Dopamine Neurons by Natural Reward Is Sufficient for Operant Reinforcement
Published 2012“…Although RPE drives reinforcement learning (RL) in computational models, it has not been possible to directly test whether the transient dopamine signal actually drives RL. …”
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Article -
8402
Instantaneous monitoring of heart beat dynamics during anesthesia and sedation
Published 2014“…To this extent, instantaneous monitoring of ANS outflow, based on neurophysiological and computational modeling, may provide a more accurate assessment of the action of anesthetic agents on the cardiovascular system. …”
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Article -
8403
Symmetry perception with spiking neural networks
Published 2021“…However, many neuromorphic computing models ignore time delay between nodes, choosing instead to approximate connections between neurons as instantaneous weighting. …”
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Journal Article -
8404
Development of 3D VR models and animations
Published 2022“…The use virtual reality is widely used in market as of today, it is a computer modelling technique that simulates the real world environment. …”
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Final Year Project (FYP) -
8405
Crowd control: reducing individual estimation bias by sharing biased social information
Published 2022“…Underlying our results are a human tendency to herd, to trust larger estimates than one's own more than smaller estimates, and to follow disparate social information less. Using a computational modeling approach, we demonstrate that these effects are indeed key to explain the experimental results. …”
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Journal Article -
8406
Effectiveness of Pseudomonas aeruginosa type VI secretion system relies on toxin potency and type IV pili-dependent interaction
Published 2023“…Finally, we implemented a computational model to better understand how changes in T6SS firing behaviours or cell-cell contacts lead to population level competitive advantages, thus providing conceptual insight applicable to all types of contact-based competition.…”
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Journal Article -
8407
RmsdXNA: RMSD prediction of nucleic acid-ligand docking poses using machine-learning method
Published 2024“…Small molecule drugs can be used to target nucleic acids (NA) to regulate biological processes. Computational modeling methods, such as molecular docking or scoring functions, are commonly employed to facilitate drug design. …”
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Journal Article -
8408
Factors regulating MAPK microdomain dynamics and the flow of spatial information in a spatially restricted neuron signaling network.
Published 2012“…An integration of both the experimental data and computational modeling is essential to gain a mechanistic understanding of the complexity in the neuronal signaling network. …”
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Final Year Project (FYP) -
8409
Amino acids substitution to improve PhyFAUIA1 phytase activity for animal feed production
Published 2010“…Phytase, a type of histidine acid phosphatase hydrolyzes phytin phosphorus and when present in an animal's digestive tract, benefits the animal while reducing total phosphorus levels in manure. Computer modelling is used to identify and examine the active site of phytase. …”
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Article -
8410
Steel box girder with profiled webs / Yasmin Sari Nursal
Published 2013“…Three dimensional (3D) computer models analysed using the finite element method were used throughout the study. …”
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Thesis -
8411
Rainfall-runoff modeling using HEC-HMS / Siti Munirah Ismail
Published 2006“…For more than thirty years, computer models have been used as an essential tool for flood analysis. …”
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Student Project -
8412
A study on behaviour of lift core due to loading combinations / Zuhaira Mat Zain
Published 2007“…Real building structure is so complex that even an elaborate computational model will be a considerer able simplification, and the result from the analysis almost is approximate. …”
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Student Project -
8413
Atom-based bond-order potentials for modelling mechanical properties of metals
Published 2006“…Both experimental observations and theoretical treatments of such complex atomic scale phenomena and structures are rather limited and it is the atomic level computer modelling that is the most promising approach in such research. …”
Journal article -
8414
The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations.
Published 2010“…This paper investigates the mechanism of localized cAMP signaling using a computational model of the biochemical network in the HEK293 cell, which is a subset of pathways involved in PKA-dependent synaptic plasticity. …”
Journal article -
8415
Different patterns of short-term memory deficit in Alzheimer's disease, Parkinson's disease and subjective cognitive impairment
Published 2020“…This paradigm also enabled us to explore the underlying sources of error contributing to impaired STM in patients with LOAD and PD using computational modelling of response error. Patients with LOAD performed significantly worse than other groups on this task. …”
Journal article -
8416
DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment
Published 2019“…We developed a computational model to capture airway remodeling. Our model predicted that a reduction in airway eosinophilia alone was insufficient to explain the clinically observed decrease in airway smooth muscle mass without a concomitant reduction in the recruitment of airway smooth muscle cells or their precursors to airway smooth muscle bundles that comprise the airway smooth muscle layer. …”
Journal article -
8417
Quantitative regulation of inducible genes: comparing models of 'on/off' against continuously variable switches
Published 2015“…Finally, a simplified computational model of the interface is presented, which confirms that dynamic regulation linking rate of initiation to the turnover of phosphorylation of TFs would better convey quantitative responses.…”
Thesis -
8418
New developments in a strongly coupled cardiac electromechanical model
Published 2005“…AIM: The aim of this study is to develop a coupled three-dimensional computational model of cardiac electromechanics to investigate fibre length transients and the role of electrical heterogeneity in determining left ventricular function. …”
Journal article -
8419
Structural connectivity in schizophrenia and its impact on the dynamics of spontaneous functional networks.
Published 2013“…In this work, we used a computational model of spontaneous large-scale brain activity to explore the role of the structural connectivity in the large-scale dynamics of the brain in health and schizophrenia. …”
Journal article -
8420
Bayesian modeling of cell neighborhoods from ClumpSeq data
Published 2023“…We generate a novel ClumpSeq dataset and show that our computational model provides insights about the composition of the niche surrounding the emerging hemogenic endothelium.…”
Thesis