Optogenetic Mimicry of the Transient Activation of Dopamine Neurons by Natural Reward Is Sufficient for Operant Reinforcement by Kim, Kyung Man, Baratta, Michael V., Yang, Aimei, Lee, Doheon, Fiorillo, Christopher D., Boyden, Edward

“…Although RPE drives reinforcement learning (RL) in computational models, it has not been possible to directly test whether the transient dopamine signal actually drives RL. …”
Get full text
Get full text

Instantaneous monitoring of heart beat dynamics during anesthesia and sedation by Valenza, Gaetano, Akeju, Oluwaseun, Pavone, Kara J, Citi, Luca, Hartnack, Katharine E, Sampson, Aaron, Barbieri, Riccardo, Purdon, Patrick Lee, Brown, Emery N.

“…To this extent, instantaneous monitoring of ANS outflow, based on neurophysiological and computational modeling, may provide a more accurate assessment of the action of anesthetic agents on the cardiovascular system. …”
Get full text
Get full text
Get full text
Get full text

Symmetry perception with spiking neural networks by George, Jonathan K., Soci, Cesare, Miscuglio, Mario, Sorger, Volker J.

“…However, many neuromorphic computing models ignore time delay between nodes, choosing instead to approximate connections between neurons as instantaneous weighting. …”
Get full text

Development of 3D VR models and animations by Wu, Hao

“…The use virtual reality is widely used in market as of today, it is a computer modelling technique that simulates the real world environment. …”
Get full text

Crowd control: reducing individual estimation bias by sharing biased social information by Jayles, Bertrand, Sire, Clément, Kurvers, Ralf H. J. M.

“…Underlying our results are a human tendency to herd, to trust larger estimates than one's own more than smaller estimates, and to follow disparate social information less. Using a computational modeling approach, we demonstrate that these effects are indeed key to explain the experimental results. …”
Get full text

Effectiveness of Pseudomonas aeruginosa type VI secretion system relies on toxin potency and type IV pili-dependent interaction by Rudzite, Marta, Subramoni, Sujatha, Endres, Robert G., Filloux, Alain

“…Finally, we implemented a computational model to better understand how changes in T6SS firing behaviours or cell-cell contacts lead to population level competitive advantages, thus providing conceptual insight applicable to all types of contact-based competition.…”
Get full text

RmsdXNA: RMSD prediction of nucleic acid-ligand docking poses using machine-learning method by Tan, Lai Heng, Kwoh, Chee Keong, Mu, Yuguang

“…Small molecule drugs can be used to target nucleic acids (NA) to regulate biological processes. Computational modeling methods, such as molecular docking or scoring functions, are commonly employed to facilitate drug design. …”
Get full text

Factors regulating MAPK microdomain dynamics and the flow of spatial information in a spatially restricted neuron signaling network. by Tan, Sock Yee.

“…An integration of both the experimental data and computational modeling is essential to gain a mechanistic understanding of the complexity in the neuronal signaling network. …”
Get full text

Amino acids substitution to improve PhyFAUIA1 phytase activity for animal feed production by Samsudin , Nurhusna, Mohd. Salleh, Hamzah, Noorbatcha, Ibrahim Ali, Amid, Azura

“…Phytase, a type of histidine acid phosphatase hydrolyzes phytin phosphorus and when present in an animal's digestive tract, benefits the animal while reducing total phosphorus levels in manure. Computer modelling is used to identify and examine the active site of phytase. …”
Get full text

Steel box girder with profiled webs / Yasmin Sari Nursal by Sari Nursal, Yasmin

“…Three dimensional (3D) computer models analysed using the finite element method were used throughout the study. …”
Get full text

Rainfall-runoff modeling using HEC-HMS / Siti Munirah Ismail by Ismail, Siti Munirah

“…For more than thirty years, computer models have been used as an essential tool for flood analysis. …”
Get full text

A study on behaviour of lift core due to loading combinations / Zuhaira Mat Zain by Mat Zain, Zuhaira

“…Real building structure is so complex that even an elaborate computational model will be a considerer able simplification, and the result from the analysis almost is approximate. …”
Get full text

Atom-based bond-order potentials for modelling mechanical properties of metals by Aoki, M, Nguyen-Manh, D, Pettifor, D, Vitek, V

“…Both experimental observations and theoretical treatments of such complex atomic scale phenomena and structures are rather limited and it is the atomic level computer modelling that is the most promising approach in such research. …”

The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations. by Oliveira, R, Terrin, A, Di Benedetto, G, Cannon, R, Koh, W, Kim, M, Zaccolo, M, Blackwell, K

“…This paper investigates the mechanism of localized cAMP signaling using a computational model of the biochemical network in the HEK293 cell, which is a subset of pathways involved in PKA-dependent synaptic plasticity. …”

Different patterns of short-term memory deficit in Alzheimer's disease, Parkinson's disease and subjective cognitive impairment by Zokaei, N, Sillence, A, Kienast, A, Drew, D, Plant, O, Slavkova, E, Manohar, SG, Husain, M

“…This paradigm also enabled us to explore the underlying sources of error contributing to impaired STM in patients with LOAD and PD using computational modelling of response error. Patients with LOAD performed significantly worse than other groups on this task. …”

DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment by Saunders, R, Kaul, H, Berair, R, Gonem, S, Singapuri, A, Sutcliffe, AJ, Chachi, L, Biddle, MS, Kaur, D, Bourne, M, Pavord, ID, Wardlaw, AJ, Siddiqui, SH, Kay, RA, Brook, BS, Smallwood, RH, Brightling, CE

“…We developed a computational model to capture airway remodeling. Our model predicted that a reduction in airway eosinophilia alone was insufficient to explain the clinically observed decrease in airway smooth muscle mass without a concomitant reduction in the recruitment of airway smooth muscle cells or their precursors to airway smooth muscle bundles that comprise the airway smooth muscle layer. …”

Quantitative regulation of inducible genes: comparing models of 'on/off' against continuously variable switches by Schneider, C

“…Finally, a simplified computational model of the interface is presented, which confirms that dynamic regulation linking rate of initiation to the turnover of phosphorylation of TFs would better convey quantitative responses.…”

New developments in a strongly coupled cardiac electromechanical model by Nickerson, D, Smith, N, Hunter, P

“…AIM: The aim of this study is to develop a coupled three-dimensional computational model of cardiac electromechanics to investigate fibre length transients and the role of electrical heterogeneity in determining left ventricular function. …”

Structural connectivity in schizophrenia and its impact on the dynamics of spontaneous functional networks. by Cabral, J, Fernandes, H, Van Hartevelt, T, James, A, Kringelbach, M, Deco, G

“…In this work, we used a computational model of spontaneous large-scale brain activity to explore the role of the structural connectivity in the large-scale dynamics of the brain in health and schizophrenia. …”

Bayesian modeling of cell neighborhoods from ClumpSeq data by Demian, AS

“…We generate a novel ClumpSeq dataset and show that our computational model provides insights about the composition of the niche surrounding the emerging hemogenic endothelium.…”