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8921
Electrophysiological mechanisms underlying T wave pseudonormalisation on stress ECGs in hypertrophic cardiomyopathy
Published 2023“…</p> <p><strong>Methods:</strong> Computational models of human HCM ventricles (n = 20) with apical and asymmetric septal hypertrophy phenotypes with variable severities of repolarisation impairment were used to investigate the effects of acute myocardial ischaemia on ECGs with T wave inversions at baseline. …”
Journal article -
8922
Modelling oxygen transport and tissue damage in the human brain
Published 2022“…</p> <p>To complement clinical trials to improve the functional outcomes of stroke patients, computational models have been developed to build a virtual platform (i.e. an in silico trial) to test the feasibility of new treatments. …”
Thesis -
8923
Implicit concept formation
Published 1990“…A review of theoretical issues highlights the need for computational modelling to elucidate the nature of implicit learning. …”
Thesis -
8924
From actions to agents: value representation in frontal cortex
Published 2016“…Based on these observations, I looked at similar types of behavior in humans using computational modeling and functional magnetic resonance imaging. …”
Thesis -
8925
Computation in generalised probabilisitic theories
Published 2015“…Following Aaronson, we extend the computational model by allowing post-selection on measurement outcomes. …”
Journal article -
8926
An investigation of copper(I) active metal template synthesis of interlocked structures for anion binding
Published 2019“…</p> <p><b>Chapter Three</b> details computational methods used to determine if a simplified computational model has potential as a predictor for macrocycle viability in an active metal template re- action. …”
Thesis -
8927
Advances in electrochemical simulation and its application to electroanalysis
Published 2014“…In Chapter 3, a computational model to simulate anodic particle coulometry of nanoparticles in the presence of hindered diffusion is developed, and the effect of this hindered diffusion investigated. …”
Thesis -
8928
Comparing costs and benefits over a 10 year period of strategies for familial hypercholesterolaemia screening.
Published 2003“…This paper compares the costs and benefits over a 10 year period of two strategies found in our previous modelling: population screening of 16-year-olds or tracing family members of affected patients. METHODS: Computer modelling of time-limited data was conducted. The number available for screening and the potential new cases in England and Wales aged 16-54 years were estimated. …”
Journal article -
8929
Melting and melt migration in heterogeneous mantle beneath mid-ocean ridges
Published 2013“…In this thesis, I use computational models of coupled magma/mantle dynamics beneath mid-ocean ridges to question whether a physical connection exists between channelized flow and mantle heterogeneity.…”
Thesis -
8930
Parameterizing the impact of fjord circulation on the ocean forcing of melting ice sheets
Published 2022“…</p> <p>This thesis develops theoretical understanding of fjord circulation in a regime dominated by the injection of subglacial discharge at the grounding line. We employ computational modelling of idealised fjords and develop scaling laws for the vertical structure of the flow when averaged across the width of the fjord. …”
Thesis -
8931
Computational and biophysical models of the brain
Published 2015“…Our work also highlights the potential of computational models in exploring neural mechanisms.</p>…”
Thesis -
8932
Methodological considerations and cognitive factors underlying sustained attention
Published 2017“…Chapter 7 will present an intervention study combining brain stimulation and a spatially-lateralised CPT paradigm, demonstrating changes in components of Selective Attention as defined by a computational model. The thesis is concluded in Chapter 8, which discusses the contributions of the experimental findings to the understanding of sustained attention and associated experimental methods. …”
Thesis -
8933
Impact of tissue microstructure on a model of cardiac electromechanics based on MRI data
Published 2011“…Clinical non-invasive techniques can assess this fundamental connection between motion aberrant behaviour and pathology only to a certain extent. Computational models of cardiac motion would thus be of great help in linking local to global motion abnormalities and to pathology. …”
Conference item -
8934
Channels and circuits: biophysical and network models of neuronal function
Published 2018“…Experimental work explores everything from the molecular machinery within each neuron, to the behavioral output of an organism. Similarly, computational models are designed to operate at many scales, and can address different questions depending upon the complexity of the description.…”
Thesis -
8935
Why do whales exist? cancer resistance in cetaceans
Published 2021“…</p> <p>First, cancer incidence rates across the animal kingdom are collected and assessed, quantitatively revealing the veracity of Peto’s paradox and the relationship between incidence risk and scaling basal metabolic rate. Next, computational models are developed to test the hypothesis that intrinsic metabolic scaling may itself be sufficient to explain Peto’s paradox. …”
Thesis -
8936
ASPASIA: A toolkit for evaluating the effects of biological interventions on SBML model behaviour
Published 2017“…A calibrated computational model reflects behaviours that are expected or observed in a complex system, providing a baseline upon which sensitivity analysis techniques can be used to analyse pathways that may impact model responses. …”
Journal article -
8937
Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment
Published 2013“…Discussion: Our technique allows confidence intervals to be placed on computational model predictions that are based on high-throughput ion channel screens. …”
Journal article -
8938
Dynamics and mechanisms of interfacial photoinduced electron transfer processes of third generation photovoltaics and photocatalysis.
Published 2011“…We aim to achieve a fundamental understanding of these phenomena by designing experiments that can be used to test and alter modern theory and computational modeling. One example illustrating recent investigations into the details of the ultrafast processes that form the basis for photoinduced charge separation at a molecular/bulk interface relevant to dye-sensitized solar cells is briefly presented here: Kinetics of interfacial PET and charge recombination processes were measured by fs and ns transient spectroscopy in a heterogeneous donor-bridge-acceptor (D-B-A) system, where D is a Ru(II)(terpyridyl-PO3)(NCS)3 complex, B an oligo-p-phenylene bridge, and A nanocrystalline TiO2. …”
Journal article -
8939
Volcanism as an active planetary process on Venus
Published 2016“…This project uses three methods of investigating these questions. Firstly, computer modelling is used to simulate volcanic processes under Venusian conditions using a steady-state, isothermal, homogeneous flow model. …”
Thesis -
8940
A parameter representing missing charge should be considered when calibrating action potential models
Published 2022“…<p>Computational models of the electrical potential across a cell membrane are longstanding and vital tools in electrophysiology research and applications. …”
Journal article