Electrophysiological mechanisms underlying T wave pseudonormalisation on stress ECGs in hypertrophic cardiomyopathy by Coleman, J, Doste, R, Beltrami, M, Olivotto, I, Raman, B, Bueno-Orovio, A

“…</p> <p><strong>Methods:</strong>&nbsp;Computational models of human HCM ventricles (n = 20) with apical and asymmetric septal hypertrophy phenotypes with variable severities of repolarisation impairment were used to investigate the effects of acute myocardial ischaemia on ECGs with T wave inversions at baseline. …”

Modelling oxygen transport and tissue damage in the human brain by Xue, Y

“…</p> <p>To complement clinical trials to improve the functional outcomes of stroke patients, computational models have been developed to build a virtual platform (i.e. an in silico trial) to test the feasibility of new treatments. …”

Implicit concept formation by Dienes, Z, Dienes, Zoltan

“…A review of theoretical issues highlights the need for computational modelling to elucidate the nature of implicit learning. …”

From actions to agents: value representation in frontal cortex by Wittmann, M

“…Based on these observations, I looked at similar types of behavior in humans using computational modeling and functional magnetic resonance imaging. …”

Computation in generalised probabilisitic theories by Lee, C, Barrett, J

“…Following Aaronson, we extend the computational model by allowing post-selection on measurement outcomes. …”

An investigation of copper(I) active metal template synthesis of interlocked structures for anion binding by Sutton, S

“…</p> <p><b>Chapter Three</b> details computational methods used to determine if a simplified computational model has potential as a predictor for macrocycle viability in an active metal template re- action. …”

Advances in electrochemical simulation and its application to electroanalysis by Barnes, EO

“…In Chapter 3, a computational model to simulate anodic particle coulometry of nanoparticles in the presence of hindered diffusion is developed, and the effect of this hindered diffusion investigated. …”

Comparing costs and benefits over a 10 year period of strategies for familial hypercholesterolaemia screening. by Marks, D, Thorogood, M, Neil, H, Wonderling, D, Humphries, SE

“…This paper compares the costs and benefits over a 10 year period of two strategies found in our previous modelling: population screening of 16-year-olds or tracing family members of affected patients. METHODS: Computer modelling of time-limited data was conducted. The number available for screening and the potential new cases in England and Wales aged 16-54 years were estimated. …”

Melting and melt migration in heterogeneous mantle beneath mid-ocean ridges by Weatherley, S

“…In this thesis, I use computational models of coupled magma/mantle dynamics beneath mid-ocean ridges to question whether a physical connection exists between channelized flow and mantle heterogeneity.…”

Parameterizing the impact of fjord circulation on the ocean forcing of melting ice sheets by Stanway, A

“…</p> <p>This thesis develops theoretical understanding of fjord circulation in a regime dominated by the injection of subglacial discharge at the grounding line. We employ computational modelling of idealised fjords and develop scaling laws for the vertical structure of the flow when averaged across the width of the fjord. …”

Computational and biophysical models of the brain by Ahmad, F

“…Our work also highlights the potential of computational models in exploring neural mechanisms.</p>…”

Methodological considerations and cognitive factors underlying sustained attention by Shalev, N

“…Chapter 7 will present an intervention study combining brain stimulation and a spatially-lateralised CPT paradigm, demonstrating changes in components of Selective Attention as defined by a computational model. The thesis is concluded in Chapter 8, which discusses the contributions of the experimental findings to the understanding of sustained attention and associated experimental methods. …”

Impact of tissue microstructure on a model of cardiac electromechanics based on MRI data by Carapella, V

“…Clinical non-invasive techniques can assess this fundamental connection between motion aberrant behaviour and pathology only to a certain extent. Computational models of cardiac motion would thus be of great help in linking local to global motion abnormalities and to pathology. …”

Channels and circuits: biophysical and network models of neuronal function by Podlaski, W

“…Experimental work explores everything from the molecular machinery within each neuron, to the behavioral output of an organism. Similarly, computational models are designed to operate at many scales, and can address different questions depending upon the complexity of the description.…”

Why do whales exist? cancer resistance in cetaceans by Speight, MAG

“…</p> <p>First, cancer incidence rates across the animal kingdom are collected and assessed, quantitatively revealing the veracity of Peto’s paradox and the relationship between incidence risk and scaling basal metabolic rate. Next, computational models are developed to test the hypothesis that intrinsic metabolic scaling may itself be sufficient to explain Peto’s paradox. …”

ASPASIA: A toolkit for evaluating the effects of biological interventions on SBML model behaviour by Evans, S, Alden, K, Cucurull-Sanchez, L, Larminie, C, Coles, M, Kullberg, M, Timmis, J

“…A calibrated computational model reflects behaviours that are expected or observed in a complex system, providing a baseline upon which sensitivity analysis techniques can be used to analyse pathways that may impact model responses. …”

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment by Elkins, R, Davies, MR, Brough, S, Gavaghan, D, Cui, Y, Abi-Gerges, N, Mirams, G

“…Discussion: Our technique allows confidence intervals to be placed on computational model predictions that are based on high-throughput ion channel screens. …”

Dynamics and mechanisms of interfacial photoinduced electron transfer processes of third generation photovoltaics and photocatalysis. by Bauer, C, Teuscher, J, Brauer, J, Punzi, A, Marchioro, A, Ghadiri, E, De Jonghe, J, Wielopolski, M, Banerji, N, Moser, J

“…We aim to achieve a fundamental understanding of these phenomena by designing experiments that can be used to test and alter modern theory and computational modeling. One example illustrating recent investigations into the details of the ultrafast processes that form the basis for photoinduced charge separation at a molecular/bulk interface relevant to dye-sensitized solar cells is briefly presented here: Kinetics of interfacial PET and charge recombination processes were measured by fs and ns transient spectroscopy in a heterogeneous donor-bridge-acceptor (D-B-A) system, where D is a Ru(II)(terpyridyl-PO3)(NCS)3 complex, B an oligo-p-phenylene bridge, and A nanocrystalline TiO2. …”

Volcanism as an active planetary process on Venus by Airey, M

“…This project uses three methods of investigating these questions. Firstly, computer modelling is used to simulate volcanic processes under Venusian conditions using a steady-state, isothermal, homogeneous flow model. …”

A parameter representing missing charge should be considered when calibrating action potential models by Barral, Y-SHM, Shuttleworth, JG, Clerx, M, Whittaker, DG, Wang, K, Polonchuk, L, Gavaghan, DJ, Mirams, GR

“…<p>Computational models of the electrical potential across a cell membrane are longstanding and vital tools in electrophysiology research and applications. …”