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9521
Human umbilical cord blood cells suffer major modification by fixatives and anticoagulants
Published 2023-03-01“…Additionally, such information is crucial in computational models increasingly being employed to simulate biological events.…”
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9522
NeuroBridge ontology: computable provenance metadata to give the long tail of neuroimaging data a FAIR chance for secondary use
Published 2023-07-01“…The NeuroBridge ontology is a computable model of provenance terms to implement FAIR principles and together with an international effort to annotate full text articles with ontology terms, the ontology enables users to locate relevant neuroimaging datasets.MethodsBuilding on our previous work in metadata modeling, and in concert with an initial annotation of a representative corpus, we modeled diagnosis terms (e.g., schizophrenia, alcohol usage disorder), magnetic resonance imaging (MRI) scan types (T1-weighted, task-based, etc.), clinical symptom assessments (PANSS, AUDIT), and a variety of other assessments. …”
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9523
Possibilities of personalized finite element segmental analysis of the cervical spine for predicting the course of dorsopathy
Published 2022-08-01“…Based on the combined data of computed and magnetic resonance imaging of the patient (female, born in 1951), a model of the C5 – C7 segment was generated, including: vertebrae C5, C6, C7, IVD, anterior and posterior longitudinal ligaments, two pairs of facet joints, spinal cord, nuchal ligament. Computer modeling and finite element method were used to analyze the stress-strain state of the cervical spine of a patient with degenerative-dystrophic changes in the C2 – C7 segments. …”
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9524
The importance of parameterization when simulating the hydrologic response of vegetative land-cover change
Published 2017-08-01“…Computer models of hydrologic systems are frequently used to investigate the hydrologic response of land-cover change. …”
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9525
Colloidal Physics Modeling Reveals How Per-Ribosome Productivity Increases with Growth Rate in Escherichia coli
Published 2023-02-01“…Yet, faster-growing cells are more crowded, seemingly making it harder for each ribosome to do its work. Our computational model of the physics of translation elongation reveals the underlying mechanism for how individual ribosomes become more productive: proximity and stoichiometry of translation molecules overcome crowding. …”
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9526
Conserved allosteric inhibition mechanism in SLC1 transporters
Published 2023-03-01“…Our results show that UCPH-101 slows substrate translocation rather than substrate or Na+ binding, confirming a non-competitive inhibitory mechanism, but only partially inhibits wild-type ASCT2. Guided by computational modeling using ligand docking and molecular dynamics simulations, we selected two residues involved in UCPH-101/EAAT1 interaction, which were mutated in ASCT2 (F136Y, I237M, F136Y/I237M) in the corresponding positions. …”
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9527
Harnessing Rare Actinomycete Interactions and Intrinsic Antimicrobial Resistance Enables Discovery of an Unusual Metabolic Inhibitor
Published 2022-06-01“…Genome sequencing of partially resistant mutants revealed a 2-oxo acid dehydrogenase E2 subunit as the likely molecular target of the dynaplanins, and this finding was supported by computational modeling of the dynaplanin scaffold within the active site of this enzyme. …”
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9528
A Looming Spatial Localization Neural Network Inspired by MLG1 Neurons in the Crab Neohelice
Published 2022-01-01“…However, little computational modeling has been done for implementing looming spatial localization analogous to the specific functionality of MLG1s ensemble. …”
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9529
Therapeutic Study of Cinnamic Acid Derivative for Oxidative Stress Ablation: The Computational and Experimental Answers
Published 2023-11-01“…This study aimed to examine the therapeutic activity of the cinnamic acid derivative KAD-7 (N′-(2,4-dichlorobenzylidene)-3-(4-methoxyphenyl) acrylohydrazide) on Fe<sup>2+</sup>-induced oxidative hepatic injury via experimental and computational models. In addition, the role of ATPase and ectonucleoside triphosphate diphosphohydrolase (ENTPDase) in the coordination of cellular signals is speculated upon to proffer suitable therapeutics for metabolic stress disorder upon their inhibition. …”
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9530
An overview of Hadoop applications in transportation big data
Published 2023-10-01“…Additionally, the optimization framework of Hadoop has been studied in two main areas: the optimization of the computational model of Hadoop and the optimization of Hadoop combined with Spark. …”
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9531
MVNMDA: A Multi-View Network Combing Semantic and Global Features for Predicting miRNA–Disease Association
Published 2023-12-01“…To overcome the above limitations, this study proposes a multi-view computational model called MVNMDA, which predicts potential miRNA-disease associations by integrating features of miRNA and diseases from local views, global views, and semantic views. …”
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9532
Computational simulation of the ore-forming processes associated with the Sanshandao-Haiyu gold belt, Jiaodong Peninsula, eastern China: implications for the duration of ore format...
Published 2023-05-01“…In this paper, we use computational modeling to study the spatial distribution of dilation (positive volumetric strain) and the mineralization rate, which can predict the mineralization patterns from a chemical perspective, so as to solve the fully coupled problem during ore-forming processes. …”
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9533
The Impact of Amino Acids on Postprandial Glucose and Insulin Kinetics in Humans: A Quantitative Overview
Published 2020-10-01“…The extracted information is publicly available and can serve multiple purposes such as computational modeling.…”
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9534
Auditory and reward structures reflect the pleasure of musical expectancies during naturalistic listening
Published 2023-10-01“…Here, we assessed concurrent liking ratings and hemodynamic fMRI signals as 24 participants listened to 50 naturalistic, real-world musical excerpts that varied across wide spectra of computationally modeled uncertainty and surprise. As in previous studies, liking ratings exhibited an interaction between uncertainty and surprise, with the strongest preferences for high uncertainty/low surprise and low uncertainty/high surprise. …”
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9535
Computational fluid dynamics model to predict the dynamical behavior of the cerebrospinal fluid through implementation of physiological boundary conditions
Published 2022-11-01“…In conclusion, a computational model of the CSF has been developed that can simulate CSF pressures and velocities by incorporating boundary conditions based on physiological processes. …”
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9536
Rethinking statistical learning as a continuous dynamic stochastic process, from the motor systems perspective
Published 2022-11-01“…The empirically derived continuous Gamma process smoothly converges to predictive Gaussian signatures comparable to those observed for the error-corrective mode that is captured by current optimization-driven computational models. We coin this initially seemingly purposeless stage exploratory. …”
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9537
Anteroinferior bundle of the acromioclavicular ligament plays a substantial role in the joint function during shoulder elevation and horizontal adduction: a finite element model
Published 2022-02-01“…Therefore, our goal was to build a quasi-static finite element model to study the function of the acromioclavicular ligament based on its biomechanical performance patterns using the benefits of computational models. Methods A three-dimensional bone model is reconstructed using images from a healthy shoulder. …”
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9538
Limited-Information Signal De-Embedding for a Grain Bin Electromagnetic Imaging System
Published 2022-01-01“…A second experiment on a grain bin where the authors did not have physical access, shows that de-embedding the signal improves the computational model of the signals (a key indicator for future imaging success).…”
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9539
Differences in running biomechanics between young, healthy men and women carrying external loads
Published 2023-10-01“…Using individualized computational models, we quantified the running biomechanics and estimated tibial SF risk over 10 weeks of BCT, for each load condition. …”
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9540
Prenatal exposure to per- and polyfluoroalkyl substances and infant sleep disturbance: A prospective cohort study
Published 2023-08-01“…We utilized a quantile-based g-computation model to determine the joint effects of the PFAS mixture on infant sleep outcomes. …”
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