Triose-phosphate isomerase deficiency is associated with a dysregulation of synaptic vesicle recycling in Drosophila melanogaster by Aelfwin Stone, Oliver Cujic, Angel Rowlett, Sophia Aderhold, Emma Savage, Bruce Graham, Joern R. Steinert

“…Wstd1 larvae also showed enhanced vesicle depletion rates at higher frequency stimulation, and subsequent recovery times for evoked synaptic responses were prolonged. A computational model showed that TPI mutant larvae exhibited a significant decline in activity-dependent vesicle recycling, which manifests itself as increased recovery times for the readily-releasable vesicle pool. …”
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Computational systems biology approach for permanent tumor elimination and normal tissue protection using negative biasing: Experimental validation in malignant melanoma as case st... by Bindu Kumari, Chandrashekhar Sakode, Raghavendran Lakshminarayanan, Prasun K. Roy

“…All three components quantitatively followed the same activation profiles predicted by our computational model (Smirnov-Kolmogorov statistical test satisfied, α = 5%). …”
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Rainfall modeling using two different neural networks improved by metaheuristic algorithms by Saad Sh. Sammen, Ozgur Kisi, Mohammad Ehteram, Ahmed El-Shafie, Nadhir Al-Ansari, Mohammad Ali Ghorbani, Shakeel Ahmad Bhat, Ali Najah Ahmed, Shamsuddin Shahid

“…Six hybrid soft computing models, including multilayer perceptron (MLP)–Henry gas solubility optimization (HGSO), MLP–bat algorithm (MLP–BA), MLP–particle swarm optimization (MLP–PSO), radial basis neural network function (RBFNN)–HGSO, RBFNN–PSO, and RBFGNN–BA, were used in this study to forecast monthly rainfall at two stations in Malaysia (Sara and Banding). …”
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Bibliometric-analysis visualization and review of non-invasive methods for monitoring and managing the portal hypertension by XiaoHan Sun, Hong Bo Ni, Jian Xue, Shuai Wang, Afaf Aljbri, Liuchun Wang, Tian Hang Ren, Xiao Li, Meng Niu

“…Portal hypertension is increasingly being assessed non-invasively, and hematological indices, imaging data, and statistical or computational models are studied to surrogate HVPG. This paper discusses the existing non-invasive methods based on measurement principles and reviews the methodological developments in the last 20 years.MethodsFirst, we used VOSviewer to learn the architecture of this field. …”
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Associations of polycyclic aromatic hydrocarbons mixtures with cardiovascular diseases mortality and all-cause mortality and the mediation role of phenotypic ageing: A time-to-even... by Siyu Duan, Yafei Wu, Junmin Zhu, Xing Wang, Ya Fang

“…Further, time-dependent Probit extension of Bayesian Kernel Machine Regression and quantile-based g-computation models were conducted to test the joint effect of PAHs on mortality. …”
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Green seaweed Caulerpa racemosa - Chemical constituents, cytotoxicity in breast cancer cells and molecular docking simulation by Grace Sanger, Djuhria Wonggo, Nurmelita Taher, Verly Dotulong, Aurielle Annalicia Setiawan, Happy Kurnia Permatasari, Sidik Maulana, Fahrul Nurkolis, Apollinaire Tsopmo, Bonglee Kim

“…This study aimed to determine the anticancer activity of C. racemosa extracts in breast cancer cells, identify compounds, and determine the mechanism using computational models. Seaweed (C. racemosa) was taken from North Sulawesi, Indonesia; Followed by authentication and identification according to the previously published protocol and extracted with three different solvent: hexane, ethyl acetate, and ethanol. …”
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System level modeling and analysis of TNF-α mediated sphingolipid signaling pathway in neurological disorders for the prediction of therapeutic targets by Sanam Banaras, Rehan Zafar Paracha, Maryum Nisar, Ayesha Arif, Jamil Ahmad, Muhammad Tariq Saeed, Zartasha Mustansar, Malik Nawaz Shuja, Rizwan Nasir Paracha

“…We incorporated the intensity values of genes from the microarray data of control individuals from the AD study in the input entities of the pathway model. Computational modeling and simulation of the inflammatory pathway enabled the comprehensive study of the system dynamics. …”
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Elimination of Left-Right Reciprocal Coupling in the Adult Lamprey Spinal Cord Abolishes the Generation of Locomotor Activity by J. A. Messina, Alison St. Paul, Sarah Hargis, Wengora E. Thompson, Andrew D. McClellan, Andrew D. McClellan

“…For experimental animals with ML spinal lesions, sensory stimulation could elicit well-coordinated locomotor muscle burst activity, but with some significant differences in the parameters of locomotor activity compared to those for normal animals. Computer models representing normal animals or experimental animals with ML spinal lesions could mimic many of the differences in locomotor activity. …”
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Personalised modelling of clinical heterogeneity between medium-chain acyl-CoA dehydrogenase patients by Christoff Odendaal, Emmalie A. Jager, Anne-Claire M. F. Martines, Marcel A. Vieira-Lara, Nicolette C. A. Huijkman, Ligia A. Kiyuna, Albert Gerding, Justina C. Wolters, Rebecca Heiner-Fokkema, Karen van Eunen, Terry G. J. Derks, Barbara M. Bakker

“…Abstract Background Monogenetic inborn errors of metabolism cause a wide phenotypic heterogeneity that may even differ between family members carrying the same genetic variant. Computational modelling of metabolic networks may identify putative sources of this inter-patient heterogeneity. …”
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Evaluation of the Air Oxygen Enrichment Effects on Combustion and Emissions of Natural Gas/Diesel Dual-Fuel Engines at Various Loads and Pilot Fuel Quantities by Roussos G. Papagiannakis, Dimitrios C. Rakopoulos, Constantine D. Rakopoulos

“…The study is carried out by using an in-house, comprehensive, computational model, which is a two-zone (phenomenological) one. …”
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Dorsal root ganglion stimulation produces differential effects on action potential propagation across a population of biophysically distinct C-neurons by Robert D. Graham, Robert D. Graham, Amolak S. Jhand, Amolak S. Jhand, Scott F. Lempka, Scott F. Lempka, Scott F. Lempka

“…To test this hypothesis, we utilized a computational modeling approach in which we developed a population of one thousand biophysically distinct C-neuron models which each produced electrophysiological characteristics (e.g., AP height, AP duration) reported in previous experimental studies. …”
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A Computational Approach to Investigate TDP-43 RNA-Recognition Motif 2 C-Terminal Fragments Aggregation in Amyotrophic Lateral Sclerosis by Greta Grassmann, Mattia Miotto, Lorenzo Di Rienzo, Federico Salaris, Beatrice Silvestri, Elsa Zacco, Alessandro Rosa, Gian Gaetano Tartaglia, Giancarlo Ruocco, Edoardo Milanetti

“…Here, we investigate the CTFs aggregation process, providing a computational model of interaction based on the evaluation of shape complementarity at the molecular interfaces. …”
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IMDAILM: Inferring miRNA-Disease Association by Integrating lncRNA and miRNA Data by Yuhua Yao, Binbin Ji, Sihong Shi, Junlin Xu, Xiaofang Xiao, Enchao Yu, Bo Liao, Jialiang Yang

“…It is known that experimental methods to validate miRNA-disease associations typically involve miRNA knockout or knockdown, which is time and labor-intensive. As a result, computational models have been developed to predict unknown miRNA-disease associations from available information related to miRNAs, diseases, genes, and so on. …”
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Automated detection of hippocampal sclerosis using real-world clinical MRI images by Jingwen Jiang, Jingwen Jiang, Jiajun Qiu, Jiajun Qiu, Jin Yin, Jin Yin, Junren Wang, Junren Wang, Xinyue Jiang, Zuo Yi, Yang Chen, Xiaobo Zhou, Xiutian Sima

“…Additionally, the AUC, accuracy and F1 scores of our model all increased by around 3 percentage points when the inputs were augmented with the ROIs of the textures enhanced using the FD method.ConclusionsOur computational model has the potential to be used for the diagnosis of HS in real clinical MRI images, which could assist physicians, particularly junior physicians, in improving the accuracy of discrimination.…”
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Fine-tuning CRISPR/Cas9 gene editing in common bean (Phaseolus vulgaris L.) using a hairy root transformation system and in silico prediction models by Ramon de Koning, Hana Daryanavard, Joyce Garmyn, Raphaël Kiekens, Mary Esther Muyoka Toili, Mary Esther Muyoka Toili, Geert Angenon

“…Although most of the computational models used to predict the sgRNA efficiency did not match the in planta results, the Lindel model proved to be the most reliable for P. vulgaris, accurately predicting the sgRNA efficiency and the type of induced mutation in most hairy roots. …”
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Neural excitatory rebound induced by valproic acid may predict its inadequate control of seizures by Xiang Zou, Zilu Zhu, Yu Guo, Hongmiao Zhang, Yuchen Liu, Zhengyu Cui, Zunji Ke, Shize Jiang, Yusheng Tong, Zehan Wu, Ying Mao, Liang Chen, Deheng Wang

“…Combined with the evidence from computational models and animal experiments, our findings suggested that ineffective ASMs may be because of the excitatory rebound, which is mediated by increased inhibitory power. …”
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A Multiscale Spatiotemporal Model Including a Switch from Aerobic to Anaerobic Metabolism Reproduces Succession in the Early Infant Gut Microbiota by David M. Versluis, Ruud Schoemaker, Ellen Looijesteijn, Daniël Muysken, Prescilla V. Jeurink, Marcel Paques, Jan M. W. Geurts, Roeland M. H. Merks

“…Bifidobacterium species became dominant in the model by their use of the bifid shunt, which allows Bifidobacterium to switch to suboptimal yield metabolism with fast growth at high lactose concentrations, as predicted here using flux balance analysis. The computational model thus allows us to test the internal plausibility of hypotheses for bacterial colonization and succession in the infant colon. …”
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Transforaminal Fusion Using Physiologically Integrated Titanium Cages with a Novel Design in Patients with Degenerative Spinal Disorders: A Pilot Study by Renat Nurmukhametov, Medet Dosanov, Manuel De Jesus Encarnacion, Rossi Barrientos, Yasser Matos, Alexander Ivanovich Alyokhin, Ismael Peralta Baez, Ibrahim Efecan Efe, Manuela Restrepo, Vishal Chavda, Bipin Chaurasia, Nicola Montemurro

“…The goal of this study is to compare the radiographic and clinical outcomes of lumbar posterior interbody fusion with a 3D porous titanium alloy cage versus a titanium-coated polyetheretherketone (PEEK) cage, including fusion quality, time to fusion, preoperative and postoperative patient assessments, and the presence, severity, and other side effect characteristics. (1) Methods: According to the preceding technique, patients who were operated on with physiologically integrated titanium cages of a unique design based on 3D computer modeling were included in the study group. This post-surveillance study was conducted as a randomized, prospective, interventional, single-blind, center study to look at the difference in infusion rates and the difference compared to PEEK cages. …”
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Mixture effects of trace element levels on cardiovascular diseases and type 2 diabetes risk in adults using G-computation analysis by Borhan Mansouri, Ayoob Rezaei, Kiomars Sharafi, Nammamali Azadi, Meghdad Pirsaheb, Maryam Rezaei, Samaneh Nakhaee

“…For T2D, the serum Pb (weighted at 0.32), Ni (weighted at 0.19), Cr (weighted at 0.17), and Cd (weighted at 0.14) were the most weighted in the G-computation model. The results showed the significant role of toxic and essential elements in CVDs and T2D risk. …”
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Enhanced photodegradation of dimethoxybenzene isomers in/on ice compared to in aqueous solution by T. Hullar, T. Tran, Z. Chen, F. Bononi, O. Palmer, O. Palmer, D. Donadio, C. Anastasio

“…Relative to aqueous solution, we find modest photodegradation enhancements (3- and 6-fold) in LLRs for two of the isomers and larger enhancements (15- to 30-fold) at the air–ice interface for all three isomers. We use computational modeling to assess the impact of light absorbance changes on photodegradation rate enhancements at the interface. …”
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