Ice crystal icing in gas turbine engines by Bucknell, A

“…This thesis describes the development and validation of a new comprehensive computational model to aid prediction of ice crystal icing in turbofan compressors. …”

The complexity of meta-computational problems by Rajgopal, N

“…We show that this barrier applies to many current instantiations of hardness magnification, that involve a wide range of restricted computational models.</p> <p>Next we consider learnability, and initiate a top-down study of hardness of learning circuit classes, i.e. we consider hardness of learning circuit classes more powerful than P/poly. …”

Hardness magnification for natural problems by Santhanam, R, Oliveira, IC

“…We show that for several natural problems of interest, complexity lower bounds that are barely non-trivial imply super-polynomial or even exponential lower bounds in strong computational models. We term this phenomenon "hardness magnification". …”

Development of fuzzy logic for demand response and storage management in hybrid energy system by Maghami, Mohammad Reza

“…The first objective of this thesis is to develop an existing computational model for optimising the sizing of micro-scale HES using Particle Swarm Optimisation (PSO). …”
Get full text

A study on thermal environmental performance in atria in the tropics with special reference to Malaysia by Abdullah, Abd Halid

“…The combined research methods are as follows: developing a conceptual low energy atrium form based on the vernacular design features to be used for computer modelling studies; calTying out field measurement and monitoring on an existing atrium building which provides validation data for dynamic thermal simulation program TAS: modelling exercise on the same monitored building using dynamic thermal modelling to develop confidence in cOlTectly modelling thermal stratification within the multi-level atrium: employing dynamic thermal modelling to model representative atrium forms (i.e. both side-lit and top-lit model) and examine quantitatively the effects of some of the key design parameters (i.e. wall-to-roof void area, roof overhangs, and internal solar blinds) on the thermal comfort and energy performance in atria due to both full natural ventilation and pressurised ventilation; and utilising computational Ouid dynamics (CFD) to complement the dynamic thermal simulation results, and to investigate quantitatively the thermal and ventilation performance within the atrium well in response to the changes of design parameters (i.e. varying the inlet to outlet opening area ratio and outlet" s alTangement). …”
Get full text

Simulation of the effects of bank vegetation on velocity profiles in a meandering compound channel by Abdul Shukor Lim, Abdul Haslim

“…The presence of vegetation significantly increased the level of complexity in cross-over regions, which contributed to high difference between model and measurement. In computational model, the effects are more significant during low relative depth. …”
Get full text

Leadless biventricular left bundle and endocardial lateral wall pacing versus left bundle only pacing in left bundle branch block patients by Marina Strocchi, Nadeev Wijesuriya, Nadeev Wijesuriya, Mark K. Elliott, Mark K. Elliott, Karli Gillette, Karli Gillette, Aurel Neic, Vishal Mehta, Vishal Mehta, Edward J. Vigmond, Edward J. Vigmond, Gernot Plank, Gernot Plank, Christopher A. Rinaldi, Christopher A. Rinaldi, Steven A. Niederer

“…Both pacing methods can be delivered through leadless pacing, to avoid risks associated with endocardial or transvenous leads. We used computational modelling to quantify synchrony induced by BIV-endo pacing and LBP through a leadless pacing system, and to investigate how the right-left ventricle (RV-LV) delay, RV lead location and type of left bundle capture affect response. …”
Get full text

Molecular Mechanism of Zinc-Dependent Oligomerization of Alzheimer’s Amyloid-β with Taiwan (D7H) Mutation by Olga I. Kechko, Alexei A. Adzhubei, Anna P. Tolstova, Maria I. Indeykina, Igor A. Popov, Sergey S. Zhokhov, Nikolay V. Gnuchev, Vladimir A. Mitkevich, Alexander A. Makarov, Sergey A. Kozin

“…In this study, the D7H-Aβ metal binding domain (D7H-Aβ₁₆) has been used as a model to establish the molecular mechanism of zinc-induced D7H-Aβ oligomerization through turbidimetry, dynamic light scattering, isothermal titration calorimetry, mass spectrometry, and computer modelling. Additionally, the modeling data showed that a molecule of D7H-Aβ, as well as isoD7-Aβ in combination with two Aβ molecules, renders a stable zinc-induced heterotrimer. …”
Get full text

Permissive Modulation of Sphingosine-1-Phosphate-Enhanced Intracellular Calcium on BK_Ca Channel of Chromaffin Cells by Adonis Z. Wu, Tzu-Lun Ohn, Ren-Jay Shei, Huei-Fang Wu, Yong-Cyuan Chen, Hsiang-Chun Lee, Dao-Fu Dai, Sheng-Nan Wu

“…Using multiple patch-clamp modes, Ca²⁺ imaging, and computational modeling, we evaluated the effects of S1P on the Ca²⁺-activated K⁺ currents (<i>I</i>_K(Ca)) in bovine adrenal chromaffin cells and in a pheochromocytoma cell line (PC12). …”
Get full text

An IoT System and MODIS Images Enable Smart Environmental Management for Mekong Delta by Vu Hien Phan, Danh Phan Hong Pham, Tran Vu Pham, Kashif Naseer Qureshi, Cuong Pham-Quoc

“…The system leverages telemetry data collected by IoT stations in combination with MODIS MOD09GA, MOD11A1, and MCD19A2 daily image products to develop computational models that calculate the values land surface temperature (LST), 2.5 and 10 (µm) particulate matter mass concentrations (PM2.5 and PM10) in areas without IoT stations. …”
Get full text

Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance of Staphylococcus saprophyticus by Kailun Zhang, Robert F. Potter, Jamie Marino, Carol E. Muenks, Matthew G. Lammers, Jennifer Dien Bard, Tanis C. Dingle, Romney Humphries, Lars F. Westblade, Carey-Ann D. Burnham, Gautam Dantas

“…The mecA gene could serve as a marker to infer cefoxitin and oxacillin resistance of S. saprophyticus, but the absence of this gene is not predictive of susceptibility. Utilizing computational modeling, we found several genes were associated with cefoxitin and oxacillin resistance in mecA− isolates, some of which have predicted functions in stress response and cell wall synthesis. …”
Get full text

Factors Influencing Continued Wearable Device Use in Older Adult Populations: Quantitative Study by Karla Muñoz Esquivel, James Gillespie, Daniel Kelly, Joan Condell, Richard Davies, Catherine McHugh, William Duffy, Elina Nevala, Antti Alamäki, Juha Jalovaara, Salvatore Tedesco, John Barton, Suzanne Timmons, Anna Nordström

“…The bespoke usability questionnaire determined that the 2 most important factors that influenced an intention to continue device use in an older adult cohort were device comfort (τ=0.34) and whether the device was fit for purpose (τ=0.34). A computational model providing an early identifier of intention to continue device use was developed using these 2 features. …”
Get full text

4DVAR assimilation of GNSS zenith path delays and precipitable water into a numerical weather prediction model WRF by W. Rohm, J. Guzikowski, K. Wilgan, K. Wilgan, M. Kryza

“…Data assimilation combines atmospheric measurements with knowledge of atmospheric behavior as codified in computer models. With this approach, the “best” estimate of current conditions consistent with both information sources is produced. …”
Get full text

Characterization of the Aeration and Hydrodynamics in Vertical-Wheel^™ Bioreactors by Pedro M. Neto, Diogo E. S. Nogueira, Yas Hashimura, Sunghoon Jung, Bruno Pedras, Mário N. Berberan-Santos, Tiago Palmeira, Brian Lee, Joaquim M. S. Cabral, Vitor Geraldes, Carlos A. V. Rodrigues

“…Overall, this work provides new data regarding oxygen mass transfer and hydrodynamics in the Vertical-Wheel bioreactor, as well as new insights for air-water mass transfer modeling in systems with low interface deformation, and a computational model that can be used for further studies.…”
Get full text

Discovery of putative inhibitors against main drivers of SARS-CoV-2 infection: Insight from quantum mechanical evaluation and molecular modeling by Toheeb A. Balogun, Onyeka S. Chukwudozie, Uchechukwu C. Ogbodo, Idris O. Junaid, Olugbodi A. Sunday, Oluwasegun M. Ige, Abdullahi T. Aborode, Abiola D. Akintayo, Emmanuel A. Oluwarotimi, Isaac O. Oluwafemi, Oluwatosin A. Saibu, Prosper Chuckwuemaka, Damilola A. Omoboyowa, Abdullahi O. Alausa, Nkechi H. Atasie, Ayooluwa Ilesanmi, Gbenga Dairo, Zainab A. Tiamiyu, Gaber E. Batiha, Afrah Fahad Alkhuriji, Wafa Abdullah I. Al-Megrin, Michel De Waard, Michel De Waard, Michel De Waard, Jean-Marc Sabatier

“…In support of these approaches, we used a series of computational modeling approaches to develop therapeutic agents against COVID-19. …”
Get full text

Allele-specific dysregulation of lipid and energy metabolism in early-stage hypertrophic cardiomyopathy by Arpana Vaniya, Anja Karlstaedt, Damla Gulkok, Tilo Thottakara, Yamin Liu, Sili Fan, Hannah Eades, Styliani Vakrou, Ryuya Fukunaga, Hilary J. Vernon, Oliver Fiehn, M. Roselle Abraham

“…Methods: We used a combination of echocardiography, transcriptomics, mass spectrometry-based untargeted metabolomics (GC-TOF, HILIC, CSH-QTOF), and computational modeling (CardioNet) to examine cardiac structural and metabolic remodeling at early disease stage (5 weeks of age) in R92W-TnT+/− and R403Q-MyHC+/− mutant mice. …”
Get full text

CO2, Water and N2 Injection for Enhanced Oil Recovery with Spatial Arrangement of Fractures in Tight-Oil Reservoirs Using Huff-‘n-puff by Jie Bai, Huiqing Liu, Jing Wang, Genbao Qian, Yongcan Peng, Yang Gao, Lin Yan, Fulin Chen

“…The equivalent core scale reservoir numerical models in depletion and huff-n-puff mode are then restored by numerical simulation with the Computer Modeling Group&mdash;Compositional &amp; Unconventional Reservoir Simulator (CMG GEM). …”
Get full text

From nonclinical research to clinical trials and patient-registries: challenges and opportunities in biomedical research by de la Torre Hernández, Jose, Edelman, Elazer R

“…In this article, we review the main stages and methods of biomedical research, from nonclinical studies with animal and computational models to randomized trials and clinical registries, focusing on their limitations and challenges, but also providing alternative solutions to overcome them. …”
Get full text

Educação permanente à distância sobre a prevenção de úlcera por pressão [Distance continuing education on prevention of pressure ulcer] by Ana Karine da Costa Monteiro, Ana Karoline da Costa Monteiro, Elaine Maria Leite Rangel Andrade, Maria Helena Barros Araújo Luz, Patrícia de Azevedo Lemos Cavalcanti

“…The program, hosted in a Moodle virtual learning environment, was developed and evaluated in the following stages: educational design, computational modeling, environment implementation, and ergonomic and pedagogical evaluation. …”
Get full text

Internal two-phase flow induced vibrations: A review by Samuel Gebremariam Haile, Elmar Woschke, Getachew Shunki Tibba, Vivek Pandey

“…They are limited to simple cases involving simplified computational models. Experimental efforts for large multistructural components involve the initial use of prototypes and can prove to be costly for fully developed industrial-scale rigs. …”
Get full text