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Large-scale analysis and computer modeling reveal hidden regularities behind variability of cell division patterns in Arabidopsis thaliana embryogenesis
Published 2022-11-01“…Taking advantage of the first-stereotyped-then-variable division patterns in the embryo of the model plant Arabidopsis thaliana, we combined 3D imaging and quantitative cell shape and cell lineage analysis together with mathematical and computer modeling to perform a large-scale, systematic analysis of variability in division plane orientation. …”
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A computational model of stem cells’ internal mechanism to recapitulate spatial patterning and maintain the self-organized pattern in the homeostasis state
Published 2024-01-01“…Our computational model focuses on early development, where the populations overall behavior is determined by stem cells and signaling molecules. …”
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Brain circuits underlying visual stability across eye movements - converging evidence for a neuro-computational model of area LIP
Published 2014-03-01Subjects: Get full text
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Twenty Significant Problems in AI Research, with Potential Solutions via the SP Theory of Intelligence and Its Realisation in the SP Computer Model
Published 2022-11-01“…This paper highlights 20 significant problems in AI research, with potential solutions via the <i>SP Theory of Intelligence</i> (SPTI) and its realisation in the <i>SP Computer Model</i>. With other evidence referenced in the paper, <i>this is strong evidence in support of the SPTI as a promising foundation for the development of human-level broad AI, aka artificial general intelligence</i>. …”
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Effective Computational Model for Determining the Geometry of the Transition Zone of End Coils of Machined Springs, Enabling Efficient Use of the Spring Material
Published 2024-03-01“…The results of these analyses were used to develop a computational model to estimate the minimum value of the rounding radius <i>ρ<sub>min</sub></i>, which ensures that the stresses in this zone are reduced to the level of the maximum coil stresses. …”
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Mechanistic insight into the functional role of human sinoatrial node conduction pathways and pacemaker compartments heterogeneity: A computer model analysis.
Published 2023-12-01“…To elucidate the role of these structural-molecular factors in the functional robustness of human SAN, we developed comprehensive biophysical computer models of the SAN based on 3D structural, functional and molecular mapping of ex-vivo human hearts. …”
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Multibody Computer Model of the Entire Equine Forelimb Simulates Forces Causing Catastrophic Fractures of the Carpus during a Traditional Race
Published 2022-03-01“…A catastrophic fracture of the radial carpal bone experienced by a racehorse during a Palio race was analyzed. Computational modelling of the carpal joint at the point of failure informed by live data was generated using a multibody code for dynamics simulation. …”
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Dual contribution of ASIC1a channels in the spinal processing of pain information by deep projection neurons revealed by computational modeling.
Published 2023-04-01“…Here, we combine both ex vivo and in vivo electrophysiological recordings of rat spinal neurons with computational modeling to demonstrate a role for ASIC1a-containing channels in the windup process. …”
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Solubility, Hansen Solubility Parameters and Thermodynamic Behavior of Emtricitabine in Various (Polyethylene Glycol-400 + Water) Mixtures: Computational Modeling and Thermodynamics
Published 2020-03-01Subjects: “…computational modeling…”
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Keratin Dynamics and Spatial Distribution in Wild-Type and K14 R125P Mutant Cells—A Computational Model
Published 2020-04-01Get full text
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