Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics? by Jeffrey R. McArthur, Oliver Knapp, David J. Adams

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Conotoxin protein classification using free scores of words and support vector machines by Nuel Gregory, Wolfsheimer Stefan, Zaki Nazar, Khuri Sawsan

“…With the rapidly growing interest in conotoxin, accurate conotoxin superfamily classification tools are desirable to systematize the increasing number of newly discovered sequences and structures. …”
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Principal Component and Structural Element Analysis Provide Insights into the Evolutionary Divergence of Conotoxins by Akira Kio V. Kikuchi, Lemmuel L. Tayo

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Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition by Nehan R. Munasinghe, MacDonald J. Christie

Subjects: “…conotoxins…”
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Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus by S. W. A. Himaya, Ai-Hua Jin, Brett Hamilton, Subash K. Rai, Paul Alewood, Richard J. Lewis

“…Given the high abundance of κA-conotoxins in the Pionoconus clade, we hypothesise that the κA-conotoxins have evolved through adaptive evolution following their repurposing from ancestral inhibitory A superfamily conotoxins to facilitate the dietary shift to fish hunting and species radiation in this clade.…”
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Synthesis of the Most Potent Isomer of μ-Conotoxin KIIIA Using Different Strategies by Xunxun Jian, Yong Wu, Zaoli Mei, Xiaopeng Zhu, Dongting Zhangsun, Sulan Luo

Subjects: “…μ-conotoxins KIIIA…”
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Aptamer Efficacies for In Vitro and In Vivo Modulation of αC-Conotoxin PrXA Pharmacology by Germain Sotoing Taiwe, Jérôme Montnach, Sébastien Nicolas, Stéphan De Waard, Emmanuelle Fiore, Eric Peyrin, Tarek Mohamed Abd El-Aziz, Muriel Amar, Jordi Molgó, Michel Ronjat, Denis Servent, Corinne Ravelet, Michel De Waard

Subjects: “…αC-conotoxin PrXA…”
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Structural and Functional Characterization of Conotoxins from <i>Conus achatinus</i> Targeting NMDAR by Xiujie Liu, Ge Yao, Kang Wang, Yanli Liu, Xiukun Wan, Hui Jiang

Subjects: “…conotoxins…”
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New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels by Lei Wen, Sheng Yang, Wenxia Zhou, Peitang Huang, Yongxiang Zhang

Subjects: “…É-conotoxins…”
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µ-Conotoxins Modulating Sodium Currents in Pain Perception and Transmission: A Therapeutic Potential by Elisabetta Tosti, Raffaele Boni, Alessandra Gallo

Subjects: “…conotoxin…”
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Systematic Study of Binding of μ-Conotoxins to the Sodium Channel NaV1.4 by Somayeh Mahdavi, Serdar Kuyucak

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Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (CaV) Channels by David Ramírez, Wendy Gonzalez, Rafael A. Fissore, Ingrid Carvacho

Subjects: “…conotoxins…”
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Characterisation of δ-Conotoxin TxVIA as a Mammalian T-Type Calcium Channel Modulator by Dan Wang, S.W.A. Himaya, Jean Giacomotto, Md. Mahadhi Hasan, Fernanda C. Cardoso, Lotten Ragnarsson, Richard J. Lewis

“…The 27-amino acid (aa)-long δ-conotoxin TxVIA, originally isolated from the mollusc-hunting cone snail <i>Conus textile</i>, slows voltage-gated sodium (Na_V) channel inactivation in molluscan neurons, but its mammalian ion channel targets remain undetermined. …”
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Cloning, Synthesis and Functional Characterization of a Novel α-Conotoxin Lt1.3 by Jinqin Chen, Li Liang, Huying Ning, Fengtao Cai, Zhuguo Liu, Longxiao Zhang, Liangyi Zhou, Qiuyun Dai

Subjects: “…α-conotoxins…”
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Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds by Alexey Y. Khruschov, Victor I. Tsetlin, Igor E. Kasheverov, Maxim N. Zhmak

Subjects: “…α-conotoxin analogs…”
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Rationally Designed α-Conotoxin Analogues Maintained Analgesia Activity and Weakened Side Effects by Chen Liu, Pengxiang Wu, He Zhu, Paolo Grieco, Ruihe Yu, Xinmei Gao, Guiyue Wu, Dong Wang, Hanmei Xu, Weiyan Qi

Subjects: “…conotoxin…”
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Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research by Walden E. Bjørn-Yoshimoto, Iris Bea L. Ramiro, Mark Yandell, J. Michael McIntosh, Baldomero M. Olivera, Lars Ellgaard, Helena Safavi-Hemami

Subjects: “…conotoxin…”
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The Tetrodotoxin Receptor of Voltage-Gated Sodium Channels—Perspectives from Interactions with μ-Conotoxins by Baldomero M. Olivera, Michael F. Sheets, Robert J. French, Doju Yoshikami

“…Subsequent studies showed that peptide μ-conotoxins competed for binding at site 1. All of these natural inhibitors block single sodium channels in an all-or-none manner on binding. …”
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Identification of Crucial Residues in α-Conotoxin EI Inhibiting Muscle Nicotinic Acetylcholine Receptor by Jiong Ning, Jie Ren, Yang Xiong, Yong Wu, Manqi Zhangsun, Dongting Zhangsun, Xiaopeng Zhu, Sulan Luo

“…&#945;-Conotoxins (&#945;-CTxs) are small disulfide-rich peptides from venom of <i>Conus</i> species that target nicotinic acetylcholine receptors (nAChRs). …”
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Subcutaneous ω-Conotoxins Alleviate Mechanical Pain in Rodent Models of Acute Peripheral Neuropathy by Md. Mahadhi Hasan, Hana Starobova, Alexander Mueller, Irina Vetter, Richard J. Lewis

Subjects: “…ω-conotoxins…”
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