Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant.

“…A viral detection DNA microarray composed of oligonucleotides corresponding to the most conserved sequences of all known viruses identified the presence of gammaretroviral sequences in cDNA samples from seven of 11 R462Q-homozygous (QQ) cases, and in one of eight heterozygous (RQ) and homozygous wild-type (RR) cases. …”
Get full text

Translation inhibition of the developmental cycle protein HctA by the small RNA IhtA is conserved across Chlamydia. by Jeremiah Tattersall, Geeta Vittal Rao, Justin Runac, Ted Hackstadt, Scott S Grieshaber, Nicole A Grieshaber

“…As biolayer interferometry studies indicate that IhtA interacts directly with hctA message for all species tested, we predict that conserved sequences of IhtA are necessary for function and/or binding.…”
Get full text

Mitochondrial genomes of three Tetrigoidea species and phylogeny of Tetrigoidea by Li-Liang Lin, Xue-Juan Li, Hong-Li Zhang, Zhe-Min Zheng

“…At the superfamily level, conserved sequences were observed in intergenic spacers, which can be used for superfamily level identification between Tetrigoidea and Acridoidea. …”
Get full text

Chromosome Unipolar Division and Low Expression of <i>Tws</i> May Cause Parthenogenesis of Rice Water Weevil (<i>Lissorhoptrus oryzophilus</i> Kuschel) by Pengcheng Wang, Fangyuan Yang, Zhuo Ma, Runzhi Zhang

“…Furthermore, we cloned the conserved sequences of parthenogenetic RWW <i>REC8</i> and <i>Tws</i>, and designed primers based on the parthenogenetic RWW sequence to detect expression patterns by quantitative PCR (Q-PCR). …”
Get full text

Gene diversity explains variation in biological features of insect killing fungus, Beauveria bassiana by Laila Gasmi, Sehyeon Baek, Jong Cheol Kim, Sihyeon Kim, Mi Rong Lee, So Eun Park, Tae Young Shin, Se Jin Lee, Bruce L. Parker, Jae Su Kim

“…DNA photolyase and cyclophilin B) that had relatively conserved sequences, had variable CNs across the isolates which were correlated with the variability of either virulence or thermotolerance of B. bassiana isolates. …”
Get full text

Conformational plasticity underlies membrane fusion induced by an HIV sequence juxtaposed to the lipid envelope by Igor de la Arada, Johana Torralba, Igor Tascón, Adai Colom, Iban Ubarretxena-Belandia, José L. R. Arrondo, Beatriz Apellániz, José L. Nieva

“…Abstract Envelope glycoproteins from genetically-divergent virus families comprise fusion peptides (FPs) that have been posited to insert and perturb the membranes of target cells upon activation of the virus-cell fusion reaction. Conserved sequences rich in aromatic residues juxtaposed to the external leaflet of the virion-wrapping membranes are also frequently found in viral fusion glycoproteins. …”
Get full text

Evaluation of the Effect of IL-22 on Human Cord Blood CD4+ T Cells by Javad Arasteh, Zahra Pourpak, Masoumeh Ebtekar, Ali Akbar Pourfathollah, Zuhair Mohammad Hassan, Tahereh Farahmandian, Hamid Mahmoudzadeh-Niknam

“…IL-22 has similarities with IL-10 including conserved sequences with IL-10. IL-22 receptor is also comprised of two chains known as L-22R1 and L-10R2; supporting the speculation that the two cytokines may have similar effects. …”
Get full text

The evolution of Great Apes has shaped the functional enhancers' landscape in human embryonic stem cells by Gennadi Glinsky, Tahsin Stefan Barakat

“…Collectively, these observations revealed thousands of evolutionarily conserved sequences that function as a core regulatory network in human embryonic stem cells which has recently undergone further extension after divergence of modern humans from our closest relatives, Chimpanzee and Bonobo.…”
Get full text

Genomic and Haplotype Comparison of Butanol Producing Bacteria Based on 16S rDNA by Ekwan Nofa Wiratno, Suharjono, Agustin Krisna Wardani

“…Conserved region of 16S rDNA (1044 bp) were consisted of 17 conserved sequences. The number of Parsimony Informative Site (PIS) was 319 spot and single tone was 48 spot. …”
Get full text

Analysis of newly detected tetracycline resistance genes and their flanking sequences in human intestinal bifidobacteria by Na Wang, Xiaomin Hang, Min Zhang, Xianglong Liu, Hong Yang

“…However, the characteristics of the spread and integration of tetracycline resistance genes into the human intestinal bifidobacteria chromosome are poorly understood. Here, conserved sequences were identified in bifidobacterial strains positive for tet(W), tet(O), or tet(S), including the tet(W), tet(O), or tet(S) and their partial flanking sequences, which exhibited identity with the sequences in multiple human intestinal pathogens, and genes encoding 23 S rRNA, an ATP transporter, a Cpp protein, and a membrane-spanning protein were flanking by the 1920-bp tet(W), 1920-bp tet(O), 1800-bp tet(O) and 252-bp tet(S) in bifidobacteria, respectively. …”
Get full text

Identification and Characterization of a Differentially Expressed Gene (07E12) in the Infective Larvae of the Parasitic Nematode Ascaris suum by Cuiqin Huang, Jingzhou You, Fangfang Nai

“…It was shown that the gene 07E12 had 99% iden-tity with the corresponding sequences of the A. suum whole genome shotgun se-quence containing the homologous sequences with conserved sequences of Neu-ropeptide-Like Protein family member. …”
Get full text

Functionally Significant Features in the 5′ Untranslated Region of the ABCA1 Gene and Their Comparison in Vertebrates by Pavel Dvorak, Sarah Leupen, Pavel Soucek

“…Using the example of the ATP-binding cassette transporter A1 (<i>ABCA1</i>) gene (Tangier disease), we describe our algorithm for functionally significant sequence finding. 5&#8242;UTR features (upstream start and stop codons, open reading frames (ORFs), GC content, motifs, and secondary structures) were studied using freely available bioinformatics tools in 55 vertebrate orthologous genes obtained from Ensembl and UCSC. The most conserved sequences were suggested as hot spots. Exon and intron enhancers and silencers (sc35, ighg2 cgamma2, ctnt, gh-1, and fibronectin eda exon), transcription factors (TFIIA, TATA, NFAT1, NFAT4, and HOXA13), some of them cancer related, and microRNA (hsa-miR-4474-3p) were localized to these regions. …”
Get full text

Cloning and Expression of Cellular Glutathione Peroxidase (GPX1) in Japanese Quail (Coturnix japonica) by Sopon Wilaison, Makoto Mori

“…Degenerated primers were designed based on conserved sequences among five species (human, monkey, cattle, rat, and mouse) to amplify the quail fragment GPX1 with reverse transcription polymerase chain reaction. …”
Get full text

Functional studies of Plasmodium falciparum putative SURF1 in Saccharomyces cerevisiae by Savitha Chellappan, Subarna Roy, Jyoti M Nagmoti, Wahida Tabassum, Raja Vukanti, S L Hoti, Mrinal Kanti Bhattacharyya, Praveen Balabaskaran Nina

“…To identify the conserved sequences, domain search was done using Jalview version 2.8.2 (BLOSUM 62 scoring). …”
Get full text

Cellular responses to <it>Plasmodium falciparum</it> erythrocyte membrane protein-1: use of relatively conserved synthetic peptide pools to determine CD4 T cell responses in malari... by Sanni Ambaliou, Reubsaet Lieke, Allsopp Catherine EM, Sanni Latifu A, Newbold Chris, Chauhan Virander S, Langhorne Jean

“…Further testing of individual peptides in a positive pool will allow us to determine those conserved sequences recognised by many individuals. These types of assays may provide information on conserved peptides of PfEMP1 which could be useful for stimulating T cells to provide help to <it>P. falciparum</it> specific B cells.…”
Get full text

The PL6-Family Plasmids of Haloquadratum Are Virus-Related by Mike Dyall-Smith, Mike Dyall-Smith, Friedhelm Pfeiffer

“…Comparative analysis of all PL6-like plasmids provided better resolution of conserved sequences and coding regions, confirmed the strong link to haloviruses, and showed that their sequences are highly conserved among examples from Haloquadratum isolates and metagenomic data that collectively cover geographically distant locations, indicating that these genetic elements are widespread.…”
Get full text

Identification of conserved and HLA promiscuous DENV3 T-cell epitopes. by Eduardo J M Nascimento, Robbie B Mailliard, Asif M Khan, John Sidney, Alessandro Sette, Nicole Guzman, Michael Paulaitis, Andréa Barbosa de Melo, Marli T Cordeiro, Laura V G Gil, Françoir Lemonnier, Charles Rinaldo, J Thomas August, Ernesto T A Marques

“…These studies also characterized the HLA promiscuity of 23 HLA class II epitopes bearing highly conserved sequences, six of which could bind to more than 10 different HLA molecules representing a large percentage of the global population. …”
Get full text

Neonatal- maternal separation primes zymogenic cells in the rat gastric mucosa through glucocorticoid receptor activity by Daniela Ogias, Isadora C. Rattes, Larissa Y. M. Hosoya, Juliana G. Zulian, Chao Yun Irene Yan, Patrícia Gama

“…Finally, we searched for evolutionarily conserved sequences that contained GRE in genes involved in pepsinogen C secretion, and found that the genomic regions of Bhlha15 and PgC contained sites highly likely to be responsive to glucocorticoids. …”
Get full text

Identifying novel constrained elements by exploiting biased substitution patterns by Guttman, Mitchell, Garber, Manuel, Clamp, Michele, Zody, Michael C., Friedman, Nir, Xie, Xiaohui

“…Many methods have been developed to identify conserved sequences across species; however, existing methods only model conservation as a decrease in the rate of mutation and have ignored selection acting on the pattern of mutations. …”
Get full text

DETEKSI MOLEKULER Megalocytivirus PADA IKAN BUDIDAYA DENGAN METODE POLYMERASE CHAIN REACTION-RESTRICTION FRAGMENT LENGTH POLYMORPHISM by , LA ODE BAYTUL ABIDIN, S.Pi., , Dr. Ir. Murwantoko, M.Si.

“…A primer pair was designed base on the conserved sequences of ORF 120R-121L from ISKNV and the homologous sequences from other Megalocytivirus. …”