The Crystal Structure of the NHL Domain in Complex with RNA Reveals the Molecular Basis of Drosophila Brain-Tumor-Mediated Gene Regulation by Inga Loedige, Leonhard Jakob, Thomas Treiber, Debashish Ray, Mathias Stotz, Nora Treiber, Janosch Hennig, Kate B. Cook, Quaid Morris, Timothy R. Hughes, Julia C. Engelmann, Michael P. Krahn, Gunter Meister

“…Using RNA immunoprecipitation and RNAcompete, we identify Brat-bound mRNAs in Drosophila embryos and define consensus binding motifs for Brat as well as a number of additional TRIM-NHL proteins, indicating that TRIM-NHL proteins are conserved, sequence-specific RNA-binding proteins. We demonstrate that Brat-mediated repression and direct RNA-binding depend on the identified motif and show that binding of the localization factor Miranda to the Brat-NHL domain inhibits Brat activity. …”
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Optimal translational termination requires C4 lysyl hydroxylation of eRF1. by Feng, T, Yamamoto, A, Wilkins, SE, Sokolova, E, Yates, L, Münzel, M, Singh, P, Hopkinson, R, Fischer, R, Cockman, M, Shelley, J, Trudgian, D, Schödel, J, McCullagh, J, Ge, W, Kessler, B, Gilbert, R, Frolova, L, Alkalaeva, E, Ratcliffe, P, Schofield, C, Coleman, M

“…The N terminus of eRF1 contains highly conserved sequence motifs that couple stop codon recognition at the ribosomal A site to peptidyl-tRNA hydrolysis. …”

Panallergens and their impact on the allergic patient by Hauser Michael, Roulias Anargyros, Ferreira Fátima, Egger Matthias

“…Plant panallergens share highly conserved sequence regions, structure, and function. They are responsible for many IgE cross-reactions even between unrelated pollen and plant food allergen sources. …”
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Conformational preference of 'CαNN' short peptide motif towards recognition of anions. by Tridip Sheet, Subhrangshu Supakar, Raja Banerjee

“…To establish the significance of the conserved sequence and their intrinsic affinity for anions, a series of peptides containing the naturally occurring 'C(α)NN' motif at the N-terminus of a designed helix, have been modeled and studied in a context free system using computational techniques. …”
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UPF201 archaeal specific family members reveal structural similarity to RNA-binding proteins but low likelihood for RNA-binding function. by Krishnamurthy N Rao, Stephen K Burley, Subramanyam Swaminathan

“…Despite low pairwise amino acid sequence identities (10-40%) and the absence of conserved sequence motifs, the three-dimensional structures of these proteins are remarkably similar to one another. …”
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Connector inversion probe technology: a powerful one-primer multiplex DNA amplification system for numerous scientific applications. by Michael S Akhras, Magnus Unemo, Sreedevi Thiyagarajan, Pål Nyrén, Ronald W Davis, Andrew Z Fire, Nader Pourmand

“…As a proof-of-concept, this novel method, which employs a Connector Inversion Probe (CIPer), was tested as a genetic tool for pathogen diagnosis, typing, and antibiotic resistance screening with two distinct systems: i) a conserved sequence primer system for genotyping Human Papillomavirus (HPV), a cancer-associated viral agent and ii) screening for antibiotic resistance mutations in the bacterial pathogen Neisseria gonorrhoeae. …”
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Characterization of untranslated regions of the salmonid alphavirus 3 (SAV3) genome and construction of a SAV3 based replicon by Rimstad Espen, Villoing Stephane, Karlsen Marius, Nylund Are

“…The sequences of the UTRs are very similar to those of SAV1 and SAV2, but single nucleotide polymorphisms are present, also in the 3' - conserved sequence element (3'-CSE). Prediction of the RNA secondary structure suggested putative stem-loop structures in both the 5'- and 3'-ends, similar to those of alphaviruses from the terrestrial environment, indicating that the general genome replication initiation strategy for alphaviruses is also utilized by SAV. …”
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Drosophila functional elements are embedded in structurally constrained sequences. by Ephraim Kenigsberg, Amos Tanay

“…Here we show that in flies, local (30-70 bp) conserved sequence elements that are associated with multiple regulatory functions serve as focal points to a pattern of punctuated regional increase in G/C nucleotide frequencies. …”
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Mitochondrial genome of Geomydoecus aurei, a pocket-gopher louse. by Theresa A Spradling, Alexandra C Place, Ashley L Campbell, James W Demastes

“…Within the non-gene region of each chromosome, there was a 79-nt nucleotide sequence that was identical among chromosomes and a conserved sequence with secondary structure that was always followed by a poly-T region. …”
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New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. by Malene Hansen, Ao-Lin Hsu, Andrew Dillin, Cynthia Kenyon

“…Surprisingly, of the new genes that have conserved sequence domains, only one could not be associated with a known longevity pathway. …”
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The association of HLA DR beta alleles with self-limiting and persistent forms of early symmetrical polyarthritis. by Salmon, M, Wordsworth, P, Emery, P, Tunn, E, Bacon, P, Bell, J

“…RA is associated with a group of class II DR beta alleles, which share a conserved sequence in the third allelic hypervariable region (3AHVR). …”

Comparative genomic analysis of the COBRA genes in six Rosaceae species and expression analysis in Chinese white pear (Pyrus bretschneideri) by Yu Zhao, Xueqiang Su, Xinya Wang, Mengna Wang, Xiaofeng Feng, Muhammad Aamir Manzoor, Yongping Cai

“…We revealed the evolution of the COBRA gene in six Rosaceae species by phylogeny, gene structure, conservative sequence, hydrophobicity analysis, gene replication events and sliding window analysis. …”
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An Absolutely Conserved Tryptophan in the Stem of the Envelope Protein E of Flaviviruses Is Essential for the Formation of Stable Particles by Iris Medits, Franz X. Heinz, Karin Stiasny

“…In mature flavivirus particles, the stem is composed of two or three mostly amphipathic α-helices and a conserved sequence element (CS) with an undefined role in the viral life cycle. …”
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Organism-specific differences in the binding of ketoprofen to serum albumin by Mateusz P. Czub, Alan J. Stewart, Ivan G. Shabalin, Wladek Minor

“…Serum albumin is a circulatory transport protein that has a highly conserved sequence and structure across mammalian organisms. …”
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The lncRNA SLNCR1 Mediates Melanoma Invasion through a Conserved SRA1-like Region by Karyn Schmidt, Cailin E. Joyce, Frank Buquicchio, Adam Brown, Justin Ritz, Robert J. Distel, Charles H. Yoon, Carl D. Novina

“…Increased expression of this lncRNA, SLNCR1, mediates melanoma invasion through a highly conserved sequence similar to that of the lncRNA SRA1. Using a sensitive technique we term RATA (RNA-associated transcription factor array), we show that the brain-specific homeobox protein 3a (Brn3a) and the androgen receptor (AR) bind within and adjacent to SLNCR1’s conserved region, respectively. …”
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Sequence and structure of the mitochondrial control region of the Cuban rodent Capromys pilorides (Rodentia: Capromyidae) by Alejandro Silva, Adriana Artiles, William Suárez, Gilberto Silva

“…Our data were compatible with the proposal of three domains [extended terminal associated sequences (ETAS), central (CD), and conserved sequence blocks (CSB)] within the control region, as well as the subsequences ETAS1, ETAS2, CSB1, CSB2, and CSB3. …”
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Cellular Chaperone Function of Intrinsically Disordered Dehydrin ERD14 by Nikoletta Murvai, Lajos Kalmar, Beata Szabo, Eva Schad, András Micsonai, József Kardos, László Buday, Kyou-Hoon Han, Peter Tompa, Agnes Tantos

“…Dehydrins are characterized by the presence of different conserved sequence motifs that also serve as the basis for their categorization. …”
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PapG Gene cloning, Escherichia coli uropathogen and examination of its subsequence diversity by Faezeh Hamidiyeh, Mohammad Hassan Shirazi, Jalil Fallah Mehrabadi, Mohammadreza Pourmand, Samaneh Ostad Mohammadi, Hedrousha Molla agha Mirzaei, Davood Afshar

“…Conclusion: N terminal domain of PapG gene is a conserved sequence among clinical straines? And it could be used for designing a vaccine against urinary tract infection.…”
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Cas9-Mediated Gene Editing Using Receptor-Mediated Ovary Transduction of Cargo (ReMOT) Control in <i>Bombyx mori</i> by Bin Yu, Sichen Dong, Xiaoyu Jiang, Liang Qiao, Jie Chen, Tian Li, Guoqing Pan, Zeyang Zhou, Chunfeng Li

“…We identified a <i>B. mori</i> oocytes-targeting peptide ligand (BmOTP, a 29 aa of vitellogenin N-terminal of silkworms) with a highly conserved sequence in lepidopteran insects that could efficiently deliver mCherry into oocytes. …”
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Disorder and function: a review of the dehydrin protein family by Steffen P Graether, Kelly F Boddington

“…The protein architecture of dehydrins can be described by the presence of three types of conserved sequence motifs that have been named the K-, Y- and S-segments. …”
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