Elevated Genetic Variation Within Virulence-Associated Botrytis cinerea Polygalacturonase Loci by Heather C. Rowe, Daniel J. Kliebenstein

“…BcPG1 and BcPG2 are highly polymorphic, particularly when compared with previously published data from nonpathogenicity loci, whereas BcPG3 is relatively conserved. Sequence variation at BcPG1 and BcPG2 did not appear to be associated with virulence on Arabidopsis leaves; however, BcPG2 variation showed a statistically significant association with growth rate on pectin. …”
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Damaging the Integrated HIV Proviral DNA with TALENs. by Christy L Strong, Horacio P Guerra, Kiran R Mathew, Nervik Roy, Lacy R Simpson, Martin R Schiller

“…In this study, we use transcription activator-like effector nucleases (TALENs) to target a highly conserved sequence in the transactivation response element (TAR) of the HIV-1 proviral DNA. …”
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Motif-Aware PRALINE: Improving the alignment of motif regions. by Maurits Dijkstra, Punto Bawono, Sanne Abeln, K Anton Feenstra, Wan Fokkink, Jaap Heringa

“…The generation of multiple sequence alignments (MSAs) with a correct alignment of the conserved sequence motifs is still difficult to achieve, due to the fact that the contribution of these typically short fragments is overshadowed by the rest of the sequence. …”
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Influence of Rotational Nucleosome Positioning on Transcription Start Site Selection in Animal Promoters. by René Dreos, Giovanna Ambrosini, Philipp Bucher

“…Core promoter elements (CPE) are conserved sequence motifs that guide Pol-II to the TSS by interacting with specific transcription factors (TFs). …”
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GOmotif: A web server for investigating the biological role of protein sequence motifs by He Runtao, Bristow Franklin, Van Domselaar Gary

“…<p>Abstract</p> <p>Background</p> <p>Many proteins contain conserved sequence patterns (motifs) that contribute to their functionality. …”
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Systematic analysis of lysine 2-hydroxyisobutyrylation posttranslational modification in wheat leaves. by Bo Feng, Shengdong Li, Zongshuai Wang, Fang Cao, Zheng Wang, Geng Li, Kaichang Liu

“…Structure characterization of these Khib peptides revealed 12 conserved sequence motifs. Function classification and enrichment analysis indicated these Khib proteins showed a wide function and pathway distribution, of which ribosome activity, protein biosynthesis and photosynthesis were the preferred biological processes. …”
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The structural basis for promoter -35 element recognition by the group IV sigma factors. by William J Lane, Seth A Darst

“…Despite similar function and secondary structure, the primary and group IV sigma factors recognize their -35 elements using distinct mechanisms. Conserved sequence elements of the sigma(E) -35 element induce a DNA geometry characteristic of AA/TT-tract DNA, including a rigid, straight double-helical axis and a narrow minor groove. …”
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Unravelling MADS-box gene family in Eucalyptus spp.: a starting point to an understanding of their developmental role in trees by Beatriz Fonseca de Oliveira Dias, Jean Luiz Simões-Araújo, Claudia A.M. Russo, Rogério Margis, Márcio Alves-Ferreira

“…Members of the MADS-box gene family share a highly conserved sequence of approximately 180 nucleotides that encodes a DNA-binding domain. …”
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Characterization of the TnsD-<it>attTn7 </it>complex that promotes site-specific insertion of <it>Tn7</it> by Mitra Rupak, McKenzie Gregory J, Yi Liang, Lee Cherline A, Craig Nancy L

“…TnsD is one of four transposon-encoded polypeptides (TnsABC+D) required for site-specific insertion of Tn<it>7 </it>into <it>attTn7</it>, and is the target site-selector that binds to a highly conserved sequence in the end of the <it>glmS </it>protein coding region. …”
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Cupin: A candidate molecular structure for the Nep1-like protein family by Pereira Gonçalo AG, Cabrera Odalys G, Echeverrigaray Sérgio, Lemke Ney, Sinigaglia Marialva, Cechin Adelmo L, Mombach José CM

“…We calculated a consensus sequence from 42 NLPs proteins, predicted its secondary structure and obtained a high quality alignment of this structure and conserved residues with the two Cupin superfamily motifs. The conserved sequence GHRHDWE and several common residues, especially some conserved histidines, in NLPs match closely the two cupin motifs. …”
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Genome-wide discovery of human splicing branchpoints. by Mercer, T, Clark, M, Andersen, S, Brunck, M, Haerty, W, Crawford, J, Taft, R, Nielsen, L, Dinger, M, Mattick, J

“…Analysis of human branchpoints reveals numerous novel features, including distinct features of branchpoints for alternatively spliced exons and a family of conserved sequence motifs overlapping branchpoints we term B-boxes, which exhibit maximal nucleotide diversity while maintaining interactions with the keto-rich U2 snRNA. …”

A family of diatom-like silicon transporters in the siliceous loricate choanoflagellates. by Marron, A, Alston, M, Heavens, D, Akam, M, Caccamo, M, Holland, P, Walker, G

“…This hypothesis implies that biosilicification has evolved multiple times independently in the eukaryotes, and paves the way for a better understanding of the biochemical basis of silicon transport through identification of conserved sequence motifs.…”

Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. by Ponjavic, J, Ponting, C, Lunter, G

“…The proportion of conserved sequence (4.1%-5.5%) in these macroRNAs is comparable to the density of exons within protein-coding transcripts (5.2%). …”

Multifunctional pMGF505-7R Is a Key Virulence-Related Factor of African Swine Fever Virus by Li Huang, Li Huang, Jiangnan Li, Jiangnan Li, Jun Zheng, Jun Zheng, Dan Li, Changjiang Weng, Changjiang Weng

“…The members of the same MGF family are most similar and have conserved sequence motifs, whereas the genetic diversity of different MGF families varies widely. …”
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Establishment of TaqMan Real-time PCR Method for Detection of Wild Rice Derived Ingredients by Aifu YANG, Chao WAN, Xuehua LIU, Bing LIANG, Qiuyue ZHENG, Li JIANG

“…Specific primers and probes were designed according to conserved sequence of internal transcribed space (ITS) gene of Z. latifolia, Z. aquatica, Z. palustris and Z. texana to test the target gene fragment in the samples, and then species-specific detection, sensitivity detection and practical application detection were carried out. …”
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Identification of LAG3 high affinity aptamers by HT-SELEX and Conserved Motif Accumulation (CMA). by Mario Martínez Soldevilla, Sandra Hervas, Helena Villanueva, Teresa Lozano, Obdulia Rabal, Julen Oyarzabal, Juan José Lasarte, Maurizio Bendandi, Susana Inoges, Ascensión López-Díaz de Cerio, Fernando Pastor

“…The aptamer with the highest accumulation of these conserved sequence motifs displays the highest affinity to LAG3 recombinant soluble proteins and binds to LAG3-expressing lymphocytes. …”
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Evolution of Heme Peroxygenases: Ancient Roots and Later Evolved Branches by Marcel Zámocký, Jana Harichová

“…Our representative reconstruction revealed a high diversity but also well conserved sequence motifs within rather short protein molecules. …”
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The Arabidopsis DUF239 gene family encodes Neprosin‐like proteins that are widely expressed in seed endosperm by Valentin Vergès, Léo Bellenger, Olivier Pichon, Nathalie Giglioli‐Guivarc'h, Christelle Dutilleul, Eric Ducos

“…Abstract Domain of unknown function 239 (DUF239) is a conserved sequence found in the catalytic site of Neprosins which are specific secreted prolyl endopeptidases found in the Nepenthes genus. …”
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A bioinformatic strategy for the detection, classification and analysis of bacterial autotransporters. by Nermin Celik, Chaille T Webb, Denisse L Leyton, Kathryn E Holt, Eva Heinz, Rebecca Gorrell, Terry Kwok, Thomas Naderer, Richard A Strugnell, Terence P Speed, Rohan D Teasdale, Vladimir A Likić, Trevor Lithgow

“…In addition the barrel-domain-a characteristic feature of autotransporters-was found to be composed from seven conserved sequence segments that can be arranged in multiple ways in the tertiary structure of the assembled autotransporter. …”
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Probing the enzymatic activity and maturation process of the EcAIII Ntn-amidohydrolase using local random mutagenesis by Joanna I. Loch, Anna Ściuk, Anna Ściuk, Marta Kilichowska, Marta Kilichowska, Izabela Pieróg, Izabela Pieróg, Weronika Łukaszczyk, Katarzyna Zimowska, Mariusz Jaskolski, Mariusz Jaskolski

“…The results revealed that the majority of the new EcAIII variants have abolished or significantly reduced rate of autoprocessing, even if the mutation was not in a highly conserved sequence and structure regions. AlphaFold-predicted structures of the mutants suggest the role of selected residues in the positioning of the linker and stabilization of the scissile bond in precisely correct orientation, enabling the nucleophilic attack during the maturation process. …”
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