First mitochondrial genome from Yponomeutidae (Lepidoptera, Yponomeutoidea) and the phylogenetic analysis for Lepidoptera by Mingsheng Yang, Bingyi Hu, Lin Zhou, Xiaomeng Liu, Yuxia Shi, Lu Song, Yunshan Wei, Jinfeng Cao

“…A + T-rich regions exhibit substantial length variation among yponomeutoid mitogenomes, and conserved sequence blocks are recognized but some of them are not present in all species. …”
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Autotaxin is a novel target of microRNA‐101‐3p by Yuqin Wang, Lin Lyu, Xiaotian Zhang, Junjie Zhang

“…We found that miR‐101‐3p inhibits ATX regulation by directly targeting a conserved sequence in the ATX mRNA 3′UTR. Moreover, we observed an inverse correlation between ATX and miR‐101‐3p levels in various types of cancer cells. …”
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Targeted Myostatin Gene Editing in Multiple Mammalian Species Directed by a Single Pair of TALE Nucleases by Li Xu, Piming Zhao, Andrew Mariano, Renzhi Han

“…We designed a pair of MSTN TALENs to target a highly conserved sequence in the coding region of the myostatin gene. …”
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Identification of a genome-specific repetitive element in the Gossypium D genome by Hejun Lu, Xinglei Cui, Yanyan Zhao, Richard Odongo Magwanga, Pengcheng Li, Xiaoyan Cai, Zhongli Zhou, Xingxing Wang, Yuling Liu, Yanchao Xu, Yuqing Hou, Renhai Peng, Kunbo Wang, Fang Liu

“…The ICRd motif comprises two components, a variable tandem repeat (TR) region and a conservative sequence (CS). The two constituents each have hundreds of repeats that evenly distribute across 13 chromosomes of the D5genome. …”
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Conservation of land plant-specific receptor-like cytoplasmic kinase subfamily XI possessing a unique kinase insert domain by Joseph Yayen, Joseph Yayen, Joseph Yayen, Ching Chan, Ching-Mei Sun, Su-Fen Chiang, Tzyy-Jen Chiou, Tzyy-Jen Chiou, Tzyy-Jen Chiou

“…The KID shows a high propensity for being disordered, resembling the activation segment in the model kinase domain. Several conserved sequence motifs were annotated along the length of the KID. …”
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Mapping codon usage of the translation initiation region in porcine reproductive and respiratory syndrome virus genome by Dou Yong-xi, Ma Xu-sheng, Li Ji-dong, He Ya-li, Ma Xiao-xia, Su Jun-hong, Luo Xue-nong, Cai Xue-peng

“…Furthermore, our model of codon usage showed that the conserved pattern of CUB is not directly consensus with the conserved sequence, but shaped under the translation selection.…”
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Epilepsy, Behavioral Abnormalities, and Physiological Comorbidities in Syntaxin-Binding Protein 1 (STXBP1) Mutant Zebrafish. by Brian P Grone, Maria Marchese, Kyla R Hamling, Maneesh G Kumar, Christopher S Krasniak, Federico Sicca, Filippo M Santorelli, Manisha Patel, Scott C Baraban

“…Zebrafish STXBP1 homologs (stxbp1a and stxbp1b) have highly conserved sequence and are prominently expressed in the larval zebrafish brain. …”
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A galectin from the kuruma shrimp (Marsupenaeus japonicus) functions as an opsonin and promotes bacterial clearance from hemolymph. by Xiu-Zhen Shi, Lei Wang, Sen Xu, Xiao-Wen Zhang, Xiao-Fan Zhao, Gerardo Raul Vasta, Jin-Xing Wang

“…Galectins are a lectin family characterized by a conserved sequence motif in the carbohydrate recognition domain, which preferential binds to galactosyl moieties. …”
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The Mitochondrial Cytochrome Oxidase Subunit I Gene Occurs on a Minichromosome with Extensive Heteroplasmy in Two Species of Chewing Lice, Geomydoecus aurei and Thomomydoecus minor... by Lucas L Pietan, Theresa A Spradling, James W Demastes

“…The highly variable non-gene regions of G. aurei and T. minor have little sequence similarity with one another except for a 19-bp region of phylogenetically conserved sequence with unknown function.…”
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Improvement and Evaluation of Loop-Mediated Isothermal Amplification for Rapid Detection of Toxoplasma gondii Infection in Human Blood Samples. by Xi-Meng Sun, Yong-Sheng Ji, Xian-Yong Liu, Mei Xiang, Guang He, Li Xie, Jing-Xia Suo, Xun Suo

“…In this study, species-specific LAMP primers were designed by targeting the AF146527 sequence, which was a conserved sequence of 200- to 300-fold repetitive 529 bp fragment of T.gondii. …”
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Molecular characterization and expression variation of the odorant receptor co-receptor in the Formosan subterranean termite. by Paula Castillo, Claudia Husseneder, Qian Sun

“…We found that C. formosanus Orco showed conserved sequence and structure compared with other insects. …”
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Conservation of regulatory elements between two species of Drosophila by Rajewsky Nikolaus, Emberly Eldon, Siggia Eric D

“…</p> <p>Results</p> <p>We find that 50%–70% of known binding sites reside in conserved sequence blocks, but these percentages are not greatly enriched over what is expected by chance. …”
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Extreme sequence divergence but conserved ligand-binding specificity in Streptococcus pyogenes M protein.

“…In spite of the sequence variability, a variable region commonly retains an important ligand-binding function, reflected in the presence of a highly conserved sequence motif. Here, we analyze the limits of sequence divergence in a ligand-binding region by characterizing the hypervariable region (HVR) of Streptococcus pyogenes M protein. …”
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Phylogenetic inference of the emergence of sequence modules and protein-protein interactions in the ADAMTS-TSL family. by Olivier Dennler, François Coste, Samuel Blanquart, Catherine Belleannée, Nathalie Théret

“…Here we propose an original approach based on 1) the detection of conserved sequence modules using partial local multiple alignment, 2) the phylogenetic inference of species/genes/modules/functions evolutionary histories, and 3) the identification of co-appearances of modules and functions. …”
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The Eps1p protein disulfide isomerase conserves classic thioredoxin superfamily amino acid motifs but not their functional geometries. by Shai Biran, Yair Gat, Deborah Fass

“…The Eps1p structures thus expand the documented diversity of the PDI oxidoreductase family and demonstrate that conserved sequence motifs in common folds do not guarantee structural or functional conservation.…”
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Accurate, automatic annotation of peptidases with hotpep-protease by Peter Kamp Busk

“…Identification of peptidases is a crucial step in their characterization but peptidase annotation is not a trivial task due to their large sequence diversity.In the present study short, conserved sequence profiles were generated for all peptidase families with more than four members in the comprehensive Merops peptidase database. …”
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Species-specific analysis of protein sequence motifs using mutual information by Weckwerth Wolfram, Keshvari Nima, Hummel Jan, Selbig Joachim

“…Such profiles conveniently reflect functional necessities by pointing out proximity at conserved sequence positions as well as depicting distances at variable positions. …”
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The 9aaTAD Is Exclusive Activation Domain in Gal4. by Martin Piskacek, Marek Havelka, Martina Rezacova, Andrea Knight

“…Importantly, the activation domain 9aaTAD, which is the exclusive activation domain in Gal4, is also the central part of a conserved sequence recognized by the inhibitory protein Gal80. …”
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Target SNP selection in complex disease association studies by Wjst Matthias

“…Other decision rules concern position within motifs, the validity of SNP database entries, the unique occurrence in the genome and conserved sequence context in other mammalian genomes.</p> <p>Conclusion</p> <p>Only 10% of all gene-based SNPs have sequence-predicted functional relevance making them a primary target for genotyping in association studies.…”
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Genetic diversity in oxytocin ligands and receptors in New World monkeys. by Dongren Ren, Guoqing Lu, Hideaki Moriyama, Aaryn C Mustoe, Emily B Harrison, Jeffrey A French

“…Eutherian mammals possess a highly conserved sequence of OXT (Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly). …”
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