Novel insights into the function of the conserved domain of the CAP superfamily of proteins by Nick K. Olrichs, J. Bernd Helms

“…Amyloid prediction analysis reveals the presence of potentially amyloidogenic sequences within the highly conserved sequence motifs of the CAP domain. This review will address the structural properties of GAPR-1 in combination with existing knowledge on CAP protein structure-function relationships. …”
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A single siRNA suppresses fatal encephalitis induced by two different flaviviruses. by Priti Kumar, Sang Kyung Lee, Premlata Shankar, N Manjunath

“…However, by targeting a cross-species conserved sequence within the cd loop, we were able to protect mice against encephalitis induced by both viruses. …”
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Plant dehydrins and dehydrin-like proteins: characterization and participation in abiotic stress response by Zofia Szlachtowska, Michał Rurek

“…Cellular components involved in the abiotic stress response include dehydrins, widely distributed proteins forming a class II of late embryogenesis abundant protein family with characteristic properties including the presence of evolutionarily conserved sequence motifs (including lysine-rich K-segment, N-terminal Y-segment, and often phosphorylated S motif) and high hydrophilicity and disordered structure in the unbound state. …”
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Specific and sensitive detection of H. pylori in biological specimens by real-time RT-PCR and in situ hybridization. by Hui Liu, Arifur Rahman, Cristina Semino-Mora, Sonia Q Doi, Andre Dubois

“…We sequenced two isolates from patients living in different continents and demonstrated that a 546-bp domain of the H. pylori 16S rRNA sequence was conserved in those strains and in published sequences. Within this conserved sequence, we defined a 229-bp domain that is 100% homologous in most H. pylori strains available in GenBank and also is specific for H. pylori. …”
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CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila by Nancy L. Tran, Samuel L. Goldsmith, Agapi Dimitriadou, Norma T. Takaesu, Christos Consoulas, Stuart J. Newfeld

“…Taken together, the data suggest that dCORL participates in a neural network connecting the insulin signaling pathway, longevity and mating. The conserved sequence and CNS specificity of all CORL proteins imply that this network may be operating in mammals.…”
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Complete mitochondrial genome sequence of Lepus yarkandensis Günther, 1875 (Lagomorpha, Leporidae): characterization and phylogenetic analysis by Wenjuan Shan, Mayinur Tursun, Shiyu Zhou, Yucong Zhang, Huiying Dai

“…The Ka/Ks values of ND1 (1.067) and ND6 (1.352) genes were >1, indicating positive selection, which might play an important role in the adaptation of L. yarkandensis to arid and hot environments. The conserved sequence block, the central conserved domain, and the extended termination-associated sequences of the control region and their features were identified and described. …”
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Genome-wide identification and analysis of the thiolase family in insects by Shou-Min Fang

“…Subcellular localization prediction indicated that all the thiolase proteins were mitochondrial, cytosolic, or peroxisomal enzymes. Four highly conserved sequence fingerprints were found in the insect thiolase proteins, including CxS-, NEAF-, GHP-, and CxGGGxG-motifs. …”
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Sequence features of <it>HLA-DRB1 </it>locus define putative basis for gene conversion and point mutations by von Salomé Jenny, Kukkonen Jyrki P

“…We also identified more complex, highly conserved sequence motifs in exon 2. Some of these can be identified as putative recombination motifs previously found in other genes, but most are previously unidentified.…”
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Extreme sequence divergence but conserved ligand-binding specificity in Streptococcus pyogenes M protein. by Jenny Persson, Bernard Beall, Sara Linse, Gunnar Lindahl

“…In spite of the sequence variability, a variable region commonly retains an important ligand-binding function, reflected in the presence of a highly conserved sequence motif. Here, we analyze the limits of sequence divergence in a ligand-binding region by characterizing the hypervariable region (HVR) of Streptococcus pyogenes M protein. …”
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Structure and evolution of the complete mitochondrial genome of the freshwater drum, Aplodinotus grunniens (Actinopterygii: Perciformes: Sciaenidae) by H. Wen, X. Ma, P. Xu, Z. Cao, B. Zheng, R. Gu, D. Hua, W. Jin, G. Sun

“…The architecture of the mitogenome (16487 bp in length) is standard for this family, and three typical elements were identified in the control region: extended termination associated sequences, central conserved region, and conserved sequence block. Poor availability of sciaenid mitogenomes (especially those belonging to different lineages) prevented us from resolving the phylogeny of this family with confidence. …”
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In silico analysis of class I adenylate-forming enzymes reveals family and group-specific conservations. by Louis Clark, Danielle Leatherby, Elizabeth Krilich, Alexander J Ropelewski, John Perozich

“…Conserved positions are involved in magnesium and AMP binding and maintaining enzyme structure. Also, ten conserved sequence motifs that included most of the conserved residues were identified. …”
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Genetically determined factors as predictors of radiological change in patients with early symmetrical arthritis. by Emery, P, Salmon, M, Bradley, H, Wordsworth, B, Tunn, E, Bacon, P, Waring, R

“…MAIN OUTCOME MEASURES: Conserved sequence of DR beta third allelic hypervariable region, sulphoxidation capacity, rheumatoid factor, and development of radiologically determined bone erosions. …”

Amphioxus and ascidian Dmbx homeobox genes give clues to the vertebrate origins of midbrain development. by Takahashi, T, Holland, P

“…Our analyses show that Dmbx genes form a distinct, ancient, homeobox gene family, with highly conserved sequence and genomic organisation, albeit more divergent in Ciona. …”

Non-inherited maternal HLA alleles are associated with rheumatoid arthritis. by Harney, S, Newton, J, Milicic, A, Brown, M, Wordsworth, B

“…BACKGROUND: Rheumatoid arthritis (RA) is strongly associated with a series of HLA-DRB1 alleles that encode a conserved sequence of amino acids ((70)Q/R K/R R A A(74)) in the DRbeta1 chain, known as the shared epitope (SE). …”

Transcription and replication of the influenza a virus genome. by Mikulásová, A, Varecková, E, Fodor, E

“…The virus encoded RNA-dependent RNA polymerase complex has to interact with both ends of the vRNA in order to generate capped RNA primers by endonucleolytic cleavage of cellular pre-mRNAs for the initiation of viral mRNA synthesis. Conserved sequence elements in the 5'-end, e.g. a polymerase binding site and a U(5-7) sequence are required for polyadenylation of virus-specific mRNAs. …”

Deciphering the 8q24.21 association for glioma. by Enciso-Mora, V, Hosking, F, Kinnersley, B, Wang, Y, Shete, S, Zelenika, D, Broderick, P, Idbaih, A, Delattre, J, Hoang-Xuan, K, Marie, Y, Di Stefano, A, Labussière, M, Dobbins, S, Boisselier, B, Ciccarino, P, Rossetto, M, Armstrong, G, Liu, Y, Gousias, K, Schramm, J, Lau, C, Hepworth, S, Strauch, K, Müller-Nurasyid, M

“…In the pooled analysis, the odds ratio for low-grade glioma associated with rs55705857 was 4.3 (P = 2.31 × 10(-94)). rs55705857 maps to a highly evolutionarily conserved sequence within the long non-coding RNA CCDC26 raising the possibility of direct functionality. …”

Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family. by Crompton, MR, Owens, R, Totty, N, Moss, SE, Waterfield, MD, Crumpton, M

“…The p68 amino acid sequence is internally repetitive, being constructed from eight repeats of varying lengths, each of which contains a highly conserved sequence. Multiple copies of the latter sequence are also present in the related proteins p36, lipocortin I and protein II. …”

Proteins Binding to the Carbohydrate HNK-1: Common Origins? by Gaston Castillo, Ralf Kleene, Melitta Schachner, Gabriele Loers, Andrew E. Torda

“…Although there are conserved regions and highly conserved sites within each of these protein families, there was no sequence similarity or conserved sequence motifs found to be shared by all families. …”
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Identification and Functional Characterization of a New Terpene Synthase Gene from Chrysanthemum indicum var. aromaticum by Yu Liu, Wenyue Ji, Xiang Wang, Bin Xia, Miao He, Yunwei Zhou

“…There is a monoterpene synthase conserved domain and a highly conserved sequence, DDXXD, (N,D)D(L,I,V)X(S,T)XXXE and RRX8W, respectively, which belong to the monoterpene synthase family. …”
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The Bcl-2 Family: Ancient Origins, Conserved Structures, and Divergent Mechanisms by Suresh Banjara, Chathura D. Suraweera, Mark G. Hinds, Marc Kvansakul

“…The Bcl-2 family is characterized by the presence of conserved sequence motifs called Bcl-2 homology motifs, as well as a transmembrane region, which form the interaction sites and intracellular location mechanism, respectively. …”
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