CX-5461 can destabilize replication forks in PARP inhibitor-resistant models of ovarian cancer by Jiachen Xuan, Richard B. Pearson, Elaine Sanij

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Ribosomal Dysregulation in Metastatic Laryngeal Squamous Cell Carcinoma: Proteomic Insights and CX-5461’s Therapeutic Promise by Miao Gao, Ting Liu, Kairui Hu, Songling Chen, Shixin Wang, Di Gan, Zhihan Li, Xiaohuang Lin

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Effects of the G-quadruplex-binding drugs quarfloxin and CX-5461 on the malaria parasite Plasmodium falciparum by Holly M. Craven, Guilherme Nettesheim, Pietro Cicuta, Andrew M. Blagborough, Catherine J. Merrick

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RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells by Christoph Otto, Carolin Kastner, Stefanie Schmidt, Konstantin Uttinger, Apoorva Baluapuri, Sarah Denk, Mathias T. Rosenfeldt, Andreas Rosenwald, Florian Roehrig, Carsten P. Ade, Christina Schuelein‐Voelk, Markus E. Diefenbacher, Christoph‐Thomas Germer, Elmar Wolf, Martin Eilers, Armin Wiegering

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Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands by Madeleine Bossaert, Angélique Pipier, Jean-Francois Riou, Céline Noirot, Linh-Trang Nguyên, Remy-Felix Serre, Olivier Bouchez, Eric Defrancq, Patrick Calsou, Sébastien Britton, Dennis Gomez

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Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age by Rita Ferreira, John S. Schneekloth, Konstantin I. Panov, Katherine M. Hannan, Ross D. Hannan

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NF45/NF90‐mediated rDNA transcription provides a novel target for immunosuppressant development by Hsiang‐i Tsai, Xiaobin Zeng, Longshan Liu, Shengchang Xin, Yingyi Wu, Zhanxue Xu, Huanxi Zhang, Gan Liu, Zirong Bi, Dandan Su, Min Yang, Yijing Tao, Changxi Wang, Jing Zhao, John E Eriksson, Wenbin Deng, Fang Cheng, Hongbo Chen

Subjects: “…CX5461…”
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A G-quadruplex stabilizer, CX-5461 combined with two immune checkpoint inhibitors enhances in vivo therapeutic efficacy by increasing PD-L1 expression in colorectal cancer by Shin-Yi Chung, Yu-Chan Chang, Dennis Shin-Shian Hsu, Ya-Chi Hung, Meng-Lun Lu, Yi-Ping Hung, Nai-Jung Chiang, Chun-Nan Yeh, Michael Hsiao, John Soong, Yeu Su, Ming-Huang Chen

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Plant exosomes fused with engineered mesenchymal stem cell‐derived nanovesicles for synergistic therapy of autoimmune skin disorders by Rufan Huang, Bo Jia, Dandan Su, Manchun Li, Zhanxue Xu, Chao He, Yisheng Huang, Hang Fan, Hongbo Chen, Fang Cheng

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Targeting RNA Polymerase I Transcription Activity in Osteosarcoma: Pre-Clinical Molecular and Animal Treatment Studies by Chang-Won Kang, Anneke C. Blackburn, Amos Hong Pheng Loh, Kuick Chick Hong, Jian Yuan Goh, Nadine Hein, Denis Drygin, Chris R. Parish, Ross D. Hannan, Katherine M. Hannan, Lucy A. Coupland

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CX-5461 is a potent immunosuppressant which inhibits T cell-mediated alloimmunity via p53-DUSP5 by Guopin Pan, Jing Zhang, Yu Han, Ye Chen, Xiaosun Guo, Xiaopei Cui, Mei Cheng, Haiqing Gao, Jianli Wang, Fan Jiang

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Molecular basis of CX-5461-induced DNA damage response in primary vascular smooth muscle cells by Tengfei Liu, Guopin Pan, Jing Zhang, Jianli Wang, Xiaosun Guo, Ye Chen, Xiaoyun Wang, Xiaopei Cui, Huiqing Liu, Fan Jiang

Subjects: “…CX-5461…”
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A transcriptional program associated with cell cycle regulation predominates in the anti-inflammatory effects of CX-5461 in macrophage by Jie Wang, Zhijian Zheng, Xiaopei Cui, Chaochao Dai, Jiaxin Li, Qunye Zhang, Mei Cheng, Fan Jiang

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Oral administration of Sophora Flavescens-derived exosomes-like nanovesicles carrying CX5461 ameliorates DSS-induced colitis in mice by Manqi Zhang, Xichao Xu, Liqian Su, Yuqing Zeng, Jingxiong Lin, Wenwen Li, Yigui Zou, Sicong Li, Boxian Lin, Ziyuan Li, Hu Chen, Yuheng Huang, Quanle Xu, Hongbo Chen, Fang Cheng, Dongling Dai

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Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461 by Guihong Li, Jing Shen, Junguo Cao, Guangtong Zhou, Ting Lei, Yuxue Sun, Haijun Gao, Yaonan Ding, Weidong Xu, Zhixin Zhan, Yong Chen, Haiyan Huang

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Targeting the ribosome to treat multiple myeloma by Kylee H. Maclachlan, Kezia Gitareja, Jian Kang, Andrew Cuddihy, Yuxi Cao, Nadine Hein, Carleen Cullinane, Ching-Seng Ang, Natalie Brajanovski, Richard B. Pearson, Amit Khot, Elaine Sanij, Ross D. Hannan, Gretchen Poortinga, Simon J. Harrison

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PHF6 functions as a tumor suppressor by recruiting methyltransferase SUV39H1 to nucleolar region and offers a novel therapeutic target for PHF6-muntant leukemia by Hsiang-i Tsai, Yanping Wu, Rui Huang, Dandan Su, Yingyi Wu, Xiaoyan Liu, Linglu Wang, Zhanxue Xu, Yuxin Pang, Chong Sun, Chao He, Fan Shu, Haitao Zhu, Dongqing Wang, Fang Cheng, Laiqiang Huang, Hongbo Chen

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rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461 by Jinbae Son, Jinbae Son, Katherine M. Hannan, Katherine M. Hannan, Gretchen Poortinga, Gretchen Poortinga, Gretchen Poortinga, Nadine Hein, Donald P. Cameron, Austen R. D. Ganley, Karen E. Sheppard, Karen E. Sheppard, Karen E. Sheppard, Richard B. Pearson, Richard B. Pearson, Richard B. Pearson, Richard B. Pearson, Ross D. Hannan, Ross D. Hannan, Ross D. Hannan, Ross D. Hannan, Ross D. Hannan, Ross D. Hannan, Elaine Sanij, Elaine Sanij, Elaine Sanij

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